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Sex Differences in the Rapid Cell Signaling Mechanisms Underlying the Memory-Enhancing Effects of 17β-Estradiol

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Renal Metabolic Programming Is Linked to the Dynamic Regulation of a Leptin-Klf15 Axis and Akt/AMPKα Signaling in Male Offspring of Obese Dams

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The microbiota coordinates diurnal rhythms in innate immunity with the circadian clock

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Many si/shRNAs can kill cancer cells by targeting multiple survival genes through an off-target mechanism.

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Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation

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Sugar causes obesity and metabolic syndrome in mice independently of sweet taste

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Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4+ endothelial cells

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Angiotensin-(1–7)/Mas Axis Improves Pancreatic β-Cell Function in Vitro and in Vivo

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Small Heterodimer Partner Regulates Dichotomous T Cell Expansion by Macrophages

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SMC complexes are guarded by the SUMO protease Ulp2 against SUMO-chain-mediated turnover

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AhR ligand aminoflavone suppresses α6‐integrin–Src–Akt signaling to attenuate tamoxifen resistance in breast cancer cells

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Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

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Acetylation of Cytidine in mRNA Promotes Translation Efficiency

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CRISPR/Cas9-Mediated Knock-Out of KrasG12D Mutated Pancreatic Cancer Cell Lines

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Systematic detection of m6A-modified transcripts at single-molecule and single-cell resolution

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Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain

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Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice

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Cdc42 and its BORG2 and BORG3 effectors control the subcellular localization of septins between actin stress fibers and microtubules

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ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids

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Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication

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Region-specific blood–brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer’s disease

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lncRNA XIST attenuates hypoxia-induced H9c2 cardiomyocyte injury by targeting the miR-122-5p/FOXP2 axis

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Complement C3a induces axonal hypomyelination in the periventricular white matter through activation of WNT/β‐catenin signal pathway in septic neonatal rats experimentally induced by lipopolysaccharide

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Multisensory Logic of Infant-Directed Aggression by Males

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Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations

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Metabolically controlled histone H4K5 acylation/acetylation ratio drives BRD4 genomic distribution

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Intrinsic High Aerobic Capacity in Male Rats Protects Against Diet-Induced Insulin Resistance

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Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells

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Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies

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Silenced ZNF154 Is Associated with Longer Survival in Resectable Pancreatic Cancer

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BPS Publications

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Pathogenic <i>FAM83G</i> palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling.

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Predicted Benign and Synonymous Variants in CYP11A1 Cause Primary Adrenal Insufficiency Through Missplicing

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Endoplasmic Reticulum Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS

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N6-methyladenine DNA Modification in Glioblastoma

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PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism

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The mitochondria-targeted antioxidant MitoQ inhibits memory loss, neuropathology, and extends lifespan in aged 3xTg-AD mice

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Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity

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Heparan Sulfate Proteoglycan Sulfation Regulates Uterine Differentiation and Signaling During Embryo Implantation

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Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells

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Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis

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CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors

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Caprine herpesvirus 1 (CpHV-1) as a potential candidate for oncolytic virotherapy

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Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice

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Changes in cellular Ca2+ and Na+ regulation during the progression towards heart failure in the guinea pig

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  antiu2010rabbit IgGu2010HRP secondary antibody
  
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A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype

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lncRNA PVT1 aggravates doxorubicin-induced cardiomyocyte apoptosis by targeting the miR-187-3p/AGO1 axis

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  CST_7074
  
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Synaptic protein changes after a chronic period of sensorimotor perturbation in adult rats: a potential role of phosphorylation/O‐GlcNAcylation interplay

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An ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors

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  AB_2099233
  
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bio-protocol.org bio-protocol.org

Efficient Generation of Multi-gene Knockout Cell Lines and ...

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  RRID:AB_10697506
  
  DOI: 10.21769/BioProtoc.2222
  
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The Polyploid State Plays a Tumor-Suppressive Role in the Liver

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Derivation of Human Trophoblast Stem Cells

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Arid1a Has Context-Dependent Oncogenic and Tumor Suppressor Functions in Liver Cancer

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  RRID:AB_209923
  
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The Pseudomonas aeruginosa lectin LecA triggers host cell signalling by glycosphingolipid-dependent phosphorylation of the adaptor protein CrkII

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  AB_2099233
  
  DOI: 10.1016/j.bbamcr.2017.04.005
  
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  AB_2099233
  
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Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination

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Lack of the Transient Receptor Potential Vanilloid 1 Shifts Cannabinoid-Dependent Excitatory Synaptic Plasticity in the Dentate Gyrus of the Mouse Brain Hippocampus

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An optogenetic proximity labeling approach to probe the composition of inducible biomolecular condensates in cultured cells

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  RRID:AB_2099233
  
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Rapid manipulation of mitochondrial morphology in a living cell with iCMM

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  RRID:AB_2099233
  
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Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy

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  RRID:AB_2099233
  
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The histone chaperone HIR maintains chromatin states to control nitrogen assimilation and fungal virulence

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  RRID:AB_2099233
  
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Perturbed DNA methylation by Gadd45b induces chromatin disorganization, DNA strand breaks and dopaminergic neuron death

2
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  RRID:AB_2099233
  
  DOI: 10.1016/j.isci.2021.102756
  
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ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function

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Peroxisomes in the mouse parotid glands: An in-depth morphological and molecular analysis

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  RRID:AB_2099233
  
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β2-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression

1
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  DOI: 10.1016/j.immuni.2021.07.002
  
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Regulation of Neural Circuit Development by Cadherin-11 Provides Implications for Autism

1
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  DOI: 10.1523/ENEURO.0066-21.2021
  
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Thyroid hormone receptor beta inhibits the PI3K-Akt-mTOR signaling axis in anaplastic thyroid cancer cell lines via genomic mechanisms

1
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Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis

1
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  RRID:AB_2099233
  
  DOI: 10.1016/j.celrep.2021.109361
  
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FANCI functions as a repair/apoptosis switch in response to DNA crosslinks

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Hepatoblastoma: glutamine depletion hinders cell viability in the embryonal subtype but high GLUL expression is associated with better overall survival

1
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  DOI: 10.1007/s00432-021-03713-4
  
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Splicing factor SRSF1 is indispensable for regulatory T cell homeostasis and function

1
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Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock

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  DOI: 10.1016/j.celrep.2021.109336
  
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The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance

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Morphological profiling of human T and NK lymphocytes by high-content cell imaging

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Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

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Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer

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Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy

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Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

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Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment.

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Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition

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RAL GTPases mediate EGFR-driven intestinal stem cell proliferation and tumourigenesis

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Pentraxin 3 secreted by human adipose-derived stem cells promotes dopaminergic neuron repair in Parkinson's disease via the inhibition of apoptosis

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Nitric Oxide and heme-NO stimulate superoxide production by NADPH Oxidase 5

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LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes

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Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1

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Autophagy suppresses the formation of hepatocyte-derived cancer-initiating ductular progenitor cells in the liver

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Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid

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Glutamine regulates ovarian cancer cell migration and invasion through ETS1

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A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways

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Oncogene-regulated release of extracellular vesicles

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Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

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Enhanced C/EBP binding to G·T mismatches facilitates fixation of CpG mutations in cancer and adult stem cells

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Generation of a homozygous knock-in human embryonic stem cell line expressing SNAP-tagged SOD1

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ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia

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NF1 mutation drives neuronal activity-dependent initiation of optic glioma

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SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARγ

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Peptide-tiling screens of cancer drivers reveal oncogenic protein domains and associated peptide inhibitors

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SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2

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A systematic analysis of signaling reactivation and drug resistance

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Phase separation of OCT4 controls TAD reorganization to promote cell fate transitions

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BPS Publications

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Human telomerase is directly regulated by non-telomeric TRF2-G-quadruplex interaction

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β-Glucan-stimulated neutrophil secretion of IL-1α is independent of GSDMD and mediated through extracellular vesicles

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The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer

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Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice

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Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway

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Anacardium Occidentale L. Leaf Extracts Protect Against Glutamate/H2O2-Induced Oxidative Toxicity and Induce Neurite Outgrowth: The Involvement of SIRT1/Nrf2 Signaling Pathway and Teneurin 4 Transmembrane Protein

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DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

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RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes

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Lipotoxicity dysregulates immunoproteasome in podocytes and kidneys of type 2 diabetes

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Acetyl-CoA regulation, OXPHOS integrity and leptin level are different in females with different onsets of obesity

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The β1 integrin plays a key role in lymphatic endothelial cell invasion in an optimized 3D Collagen matrix model

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Removal of epididymal visceral adipose tissue prevents obesity-induced multi-organ insulin resistance in male mice

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Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains

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Loss of tRNA-modifying enzyme Elp3 activates a p53-dependent antitumor checkpoint in hematopoiesis

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Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice

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Hdac9 inhibits medial artery calcification through down-regulation of Osterix

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Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes

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MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases

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Thymoquinone administration ameliorates Alzheimer's disease-like phenotype by promoting cell survival in the hippocampus of amyloid beta1-42 infused rat model

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Diazepam and SL-327 synergistically attenuate anxiety-like behaviours in mice – Possible hippocampal MAPKs specificity

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DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells

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TopBP1 assembles nuclear condensates to switch on ATR signaling

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PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells

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ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis

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Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling

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Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy

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m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development

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In-gel proteasome assay to determine the activity, amount, and composition of proteasome complexes from mammalian cells or tissues

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Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains

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Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications

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Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile Cilia

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The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction

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Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response

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Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

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Feedforward Regulation of Glucose Metabolism by Steroid Hormones Drives a Developmental Transition in Drosophila

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Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging

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Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers

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CRISPR screens in physiologic medium reveal conditionally essential genes in human cells

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Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification

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LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

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Hyocholic acid species improve glucose homeostasis through a distinct TGR5 and FXR signaling mechanism

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The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation

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High‐risk endometrial cancer proteomic profiling reveals that FBXW7 mutation alters L1CAM and TGM2 protein levels

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  DOI: 10.1002/cncr.33567
  
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Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3

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  anti-rabbit IgG, Horseradish peroxidase-conjugated
  
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Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer

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Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation

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SARS-CoV-2 colonization of maternal and fetal cells of the human placenta promotes alteration of local renin-angiotensin system

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  DOI: 10.1016/j.medj.2021.04.009
  
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Deletion of Fructokinase in the Liver or in the Intestine Reveals Differential Effects on Sugar-Induced Metabolic Dysfunction

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Y box binding protein 1 inhibition as a targeted therapy for ovarian cancer

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Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine

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  DOI: 10.1016/j.molcel.2021.03.020
  
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Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma

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Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic Reticulum

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A Method for Conditional Regulation of Protein Stability in Native or Near-Native Form

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Dioctatin Activates ClpP to Degrade Mitochondrial Components and Inhibits Aflatoxin Production

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Triplexed Affinity Reagents to Sample the Mammalian Inositol Pyrophosphate Interactome

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A Photo-clickable ATP-Mimetic Reveals Nucleotide Interactors in the Membrane Proteome

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LncRNA CALB2 sponges miR-30b-3p to promote odontoblast differentiation of human dental pulp stem cells via up-regulating RUNX2

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Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output

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An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

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iPSC modeling of stage-specific leukemogenesis reveals BAALC as a key oncogene in severe congenital neutropenia

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  DOI: 10.1016/j.stem.2021.03.023
  
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ATP Synthase c-Subunit Leak Causes Aberrant Cellular Metabolism in Fragile X Syndrome

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