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  2. aacrjournals.org aacrjournals.org
    Mesothelin Secretion by Pancreatic Cancer Cells Co-opts Macrophages and Promotes Metastasis
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    1. scibot 19 Apr 2024
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      DOI: 10.1158/0008-5472.CAN-23-1542

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    Luciferase- and HaloTag-based reporter assays to measure small-molecule-induced degradation pathway in living cells
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    Context-dependent roles for ubiquitous mitochondrial creatine kinase CKMT1 in breast cancer progression
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    1. scibot 19 Apr 2024
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    Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model
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    NINJ1 mediates plasma membrane rupture by cutting and releasing membrane disks
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    Spatial and single-cell colocalisation analysis reveals MDK-mediated immunosuppressive environment with regulatory T cells in colorectal carcinogenesis
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    The nociceptive activity of peripheral sensory neurons is modulated by the neuronal membrane proteasome
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    Suppression of Cofilin function in the somatosensory cortex alters social contact behavior in the BTBR mouse inbred line
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  11. Apr 2024
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    EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission
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    SWI/SNF complex-mediated chromatin remodelling in Candida glabrata promotes immune evasion
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    Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1
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    The activation of LBH-CRYAB signaling promotes cardiac protection against ischemia-reperfusion injury by inhibiting apoptosis and ferroptosis
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    Oxygen levels affect oviduct epithelium functions in air–liquid interface culture
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    1. scibot 11 Apr 2024
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    Inhibition of NEK2 Promotes Chemosensitivity and Reduces KSHV-positive Primary Effusion Lymphoma Burden
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    1. scibot 11 Apr 2024
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    Islet resident macrophage-derived miR-155 promotes β-cell decompensation via targeting PDX1
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    Insulin receptor signaling engages bladder urothelial defenses that limit urinary tract infection
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    β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
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    1. scibot 10 Apr 2024
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    Babaodan overcomes cisplatin resistance in cholangiocarcinoma via inhibiting YAP1
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    1. scibot 10 Apr 2024
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    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
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    Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates
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    Aging-related defects in macrophage function are driven by MYC and USF1 transcriptional programs
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    A light-controlled phospholipase C for imaging of lipid dynamics and controlling neural plasticity
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    Gut bacteria-driven homovanillic acid alleviates depression by modulating synaptic integrity
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    NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation
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    Bacterial muropeptides promote OXPHOS and suppress mitochondrial stress in mammals
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    Oncostatin M signaling drives cancer-associated skeletal muscle wasting
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    Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss
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    Impaired growth plate maturation in XLH is due to both excess FGF23 and decreased 1,25Dihydroxyvitamin D signaling
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    Endometrial BMP2 Deficiency Impairs ITGB3-Mediated Trophoblast Invasion in Women with Repeated Implantation Failure
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    Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade
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    Pyroptotic T cell-derived active IL-16 has a driving function in ovarian endometriosis development
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    Sexual Dimorphism of Circadian Liver Transcriptome.
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    An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade
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    Targeting DNMT3A-mediated oxidative phosphorylation to overcome ibrutinib resistance in mantle cell lymphoma
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    Extracellular signal‐regulated kinases 2 (Erk2) and Erk5 in the central nervous system differentially contribute to central sensitization in male mice
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  39. Mar 2024
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    S-nitrosylation-triggered unfolded protein response maintains hematopoietic progenitors in Drosophila
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    Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape
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    Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression
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    CRIP1 involves the pathogenesis of multiple myeloma via dual-regulation of proteasome and autophagy
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    Tonic Activation of NR2D-Containing NMDARs Exacerbates Dopaminergic Neuronal Loss in MPTP-Injected Parkinsonian Mice
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    Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors
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    Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signaling pathway
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    Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives
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    Ethanol induces replication fork stalling and membrane stress in immortalized laryngeal cells
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    The Crucial Role of Single-Stranded DNA Binding in Enhancing Sensitivity to DNA-Damaging Agents for Schlafen 11 and Schlafen 13
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    Glucose restriction enhances oxidative fiber formation: A multi-omic signal network involving AMPK and CaMK2
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    Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth
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    ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors
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