3,429 Matching Annotations
  1. Mar 2023
  2. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The effect of KTKEGV repeat motif and intervening ATVA sequence on α-synuclein solubility and assembly
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15763
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    SYNGAP1 deficiency disrupts neoteny in human cortical neurons in vivo
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    biorxiv.org/content/10.1101/2023.01.14.524054v1
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    Inactivation of SARS-CoV-2 on Surfaces by Cold-Plasma-Generated Reactive Species
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    mdpi.com/2306-5354/10/3/280
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    A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses
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    sciencedirect.com/science/article/pii/S089662732300082X
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    Mapping the dynamic cell surface interactome of high-density lipoprotein reveals Aminopeptidase N as modulator of its endothelial uptake
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    biorxiv.org/content/10.1101/2023.01.03.522574v1
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    EVL and MIM/MTSS1 regulate actin cytoskeletal remodeling to promote dendritic filopodia in neurons
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    rupress.org/jcb/article/222/5/e202106081/213902/EVL-and-MIM-MTSS1-regulate-actin-cytoskeletal
  8. Feb 2023
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    Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules
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    sciencedirect.com/science/article/pii/S2211124723001456
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HER2-driven breast cancer suppression by the JNK signaling pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC9942916/
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    An adverse tumor-protective effect of IDO1 inhibition
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    sciencedirect.com/science/article/pii/S2666379123000332
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    Checkpoint TIPE2 Limits the Helper Functions of NK Cells in Supporting Antitumor CD8+ T Cells
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    onlinelibrary.wiley.com/doi/10.1002/advs.202207499
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    PRC2 Heterogeneity Drives Tumor Growth in Medulloblastoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC9388591/
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9929516/
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    Archaic humans have contributed to large-scale variation in modern human T cell receptor genes
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    sciencedirect.com/science/article/pii/S1074761323000389
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    Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs
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    ncbi.nlm.nih.gov/pmc/articles/PMC9910744/
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    CRISPR-based large-scale modeling of loss-of-function mutations to investigate mechanisms of stress resistance in cancer
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    sciencedirect.com/science/article/pii/S2666166723000552
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    ERdj5 protects goblet cells from endoplasmic reticulum stress-mediated apoptosis under inflammatory conditions
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    nature.com/articles/s12276-023-00945-x
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency
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    ncbi.nlm.nih.gov/pmc/articles/PMC9907829/
  20. aacrjournals.org aacrjournals.org
    PINK1-mediated mitophagy promotes oxidative phosphorylation and redox homeostasis to induce drug-tolerant persister cancer cells
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    aacrjournals.org/cancerres/article/83/3/398/716188/PINK1-Mediated-Mitophagy-Promotes-Oxidative
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    Monitoring cell fate in 3D organotypic human squamous epithelial cultures
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    sciencedirect.com/science/article/pii/S266616672300059X
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    Piperlongumine conjugates induce targeted protein degradation
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    sciencedirect.com/science/article/pii/S2451945623000272
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stress Granules determine the Development of Obesity-associated Pancreatic Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9357213/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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    ncbi.nlm.nih.gov/pmc/articles/PMC9884621/
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    Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
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    sciencedirect.com/science/article/pii/S1097276523000382
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    A FRET sensor for the real-time detection of long chain acyl-CoAs and synthetic ABHD5 ligands
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    sciencedirect.com/science/article/pii/S2667237523000012
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity
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    ncbi.nlm.nih.gov/pmc/articles/PMC9883198/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The endothelial-enriched lncRNA LINC00607 mediates angiogenic function
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    ncbi.nlm.nih.gov/pmc/articles/PMC9879848/
  29. Jan 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation
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    sciencedirect.com/science/article/pii/S221112472201796X
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Kaposi’s sarcoma-associated herpesvirus (KSHV) utilizes the NDP52/CALCOCO2 selective autophagy receptor to disassemble processing bodies
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    ncbi.nlm.nih.gov/pmc/articles/PMC9876383/
  32. www.mdpi.com www.mdpi.com
    Comparison of a Genotype 1 and a Genotype 2 Macaque Foamy Virus env Gene Indicates Distinct Infectivity and Cell-Cell Fusion but Similar Tropism and Restriction of Cell Entry by Interferon-Induced Transmembrane Proteins
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    mdpi.com/1999-4915/15/2/262
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CoQ Regulates Brown Adipose Tissue Respiration and Uncoupling Protein 1 Expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC9854525/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Attenuating iPSC reprogramming stress with dominant-negative BET peptides
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    ncbi.nlm.nih.gov/pmc/articles/PMC9860338/
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    Optimized protocols for chromatin immunoprecipitation of exogenously expressed epitope-tagged proteins
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    sciencedirect.com/science/article/pii/S2666166723000084
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    Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling
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    sciencedirect.com/science/article/pii/S2211124723000426
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    TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis
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    sciencedirect.com/science/article/pii/S2211124723000232
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    Protocol to study presynaptic protein synthesis in ex vivo mouse hippocampal slices using HaloTag technology
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    sciencedirect.com/science/article/pii/S2666166722008668
  39. www.biorxiv.org www.biorxiv.org
    Actin nucleators safeguard replication forks by limiting nascent strand degradation
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    biorxiv.org/content/10.1101/2023.01.12.523639v1
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    Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons
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    sciencedirect.com/science/article/pii/S1934590922004945
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    An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes
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    sciencedirect.com/science/article/pii/S0092867422015380
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    Controlling organoid symmetry breaking uncovers an excitable system underlying human axial elongation
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    sciencedirect.com/science/article/pii/S0092867422015860
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction
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    ncbi.nlm.nih.gov/pmc/articles/PMC9839780/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identifying the Transcriptional Drivers of Metastasis Embedded within Localized Melanoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC9827116/
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
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    ncbi.nlm.nih.gov/pmc/articles/PMC9827110/
  46. journals.lww.com journals.lww.com
    Oncogenic BRAFV600E induces microglial proliferation... : Neural Regeneration Research
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    journals.lww.com/nrronline/Fulltext/2023/07000/Oncogenic_BRAFV600E_induces_microglial.38.aspx
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    Acute COG inactivation unveiled its immediate impact on Golgi and illuminated the nature of intra-Golgi recycling vesicles
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    onlinelibrary.wiley.com/doi/10.1111/tra.12876
  48. link.springer.com link.springer.com
    Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
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    link.springer.com/article/10.1007/s00125-022-05856-6
  49. rupress.org rupress.org
    Fibroblasts secrete fibronectin under lamellipodia in a microtubule- and myosin II–dependent fashion
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    rupress.org/jcb/article/222/2/e202204100/213712/Fibroblasts-secrete-fibronectin-under-lamellipodia
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    DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling
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    sciencedirect.com/science/article/pii/S2211124722018903
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A whole genome CRISPR screen identifies AHR loss as a mechanism of PARP7 inhibitor resistancePARP7 inhibitor CRISPR screen
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    ncbi.nlm.nih.gov/pmc/articles/PMC9769698/
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nonstructural protein 1 widespread RNA decay phenotype varies among coronaviruses
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    ncbi.nlm.nih.gov/pmc/articles/PMC9794394/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Proximity biotinylation to define the local environment of the protein kinase A catalytic subunit in adrenal cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC9826815/
  54. www.sciencedirect.com www.sciencedirect.com
    Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin
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    sciencedirect.com/science/article/pii/S009286742201529X
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    Resurrection of endogenous retroviruses during aging reinforces senescence
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    sciencedirect.com/science/article/pii/S0092867422015306
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MOZ and Menin-MLL Complexes are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor
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    ncbi.nlm.nih.gov/pmc/articles/PMC9453853/
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    Ribosomal RNA-based epitranscriptomic regulation of chondrocyte translation and proteome in osteoarthritis
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    sciencedirect.com/science/article/pii/S1063458423000018
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    METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism
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    sciencedirect.com/science/article/pii/S1934590922004908
  59. www.cell.com www.cell.com
    Genetic and pharmacological modulation of DNA mismatch repair heterogeneous tumors promotes immune surveillance
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    cell.com/cancer-cell/fulltext/S1535-6108(22)00589-X
  60. Dec 2022
  61. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Caspase-Mediated Regulation and Cellular Heterogeneity of the cGAS/STING Pathway in Kaposi’s Sarcoma-Associated Herpesvirus Infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC9765453/
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IL-1β expression driven by androgen receptor absence or inactivation promotes prostate cancer bone metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC9770512/
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Virus-like particle – mediated delivery of the RIG-I agonist M8 induces a type I interferon response and protects cells against viral infection
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    ncbi.nlm.nih.gov/pmc/articles/PMC9795031/
  64. link.springer.com link.springer.com
    The US9-Derived Protein gPTB9TM Modulates APP Processing Without Targeting Secretase Activities
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    link.springer.com/article/10.1007/s12035-022-03153-2
  65. aacrjournals.org aacrjournals.org
    IL-1β expression driven by androgen receptor absence or inactivation promotes prostate cancer bone metastasis
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    aacrjournals.org/cancerrescommun/article/2/12/1545/711358/IL1-Expression-Driven-by-Androgen-Receptor-Absence
  66. aacrjournals.org aacrjournals.org
    Efficient Correction of Oncogenic KRAS and TP53 Mutations through CRISPR Base Editing
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    aacrjournals.org/cancerres/article/82/17/3002/708290/Efficient-Correction-of-Oncogenic-KRAS-and-TP53
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    IL-17/CXCL5 signaling within the oligovascular niche mediates human and mouse white matter injury
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    sciencedirect.com/science/article/pii/S2211124722017405
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    ΔNp63/p73 drive metastatic colonization by controlling a regenerative epithelial stem cell program in quasi-mesenchymal cancer stem cells
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    sciencedirect.com/science/article/pii/S1534580722008152
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    AP1/Fra1 confers resistance to MAPK cascade inhibition in pancreatic cancer
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    link.springer.com/article/10.1007/s00018-022-04638-y
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    The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response
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    sciencedirect.com/science/article/pii/S2211124722017119
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    Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection
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    sciencedirect.com/science/article/pii/S2211124722017090
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation and Analysis of hTERT-RPE1 VPS54 Knock-Out and Rescued Cell Lines
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    ncbi.nlm.nih.gov/pmc/articles/PMC10026839/
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    Rapid COG Depletion in Mammalian Cell by Auxin-Inducible Degradation System
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    link.springer.com/protocol/10.1007/978-1-0716-2639-9_23
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    Engineered cell entry links receptor biology with single-cell genomics
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    sciencedirect.com/science/article/pii/S009286742201460X
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    A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates
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    sciencedirect.com/science/article/pii/S0092867422014155
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    USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction
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    sciencedirect.com/science/article/pii/S2211124722015248
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    PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing
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    sciencedirect.com/science/article/pii/S1097276522010991
  78. aacrjournals.org aacrjournals.org
    Serial profiling of circulating tumor DNA identifies dynamic evolution of clinically actionable genomic alterations in high-risk neuroblastoma
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    aacrjournals.org/cancerdiscovery/article/12/12/2800/711177/Serial-Profiling-of-Circulating-Tumor-DNA
  79. www.embopress.org www.embopress.org
    IMPDH inhibition activates TLR-VCAM1 pathway and suppresses the development of MLL-fusion leukemia
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    embopress.org/doi/10.15252/emmm.202115631
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    SETD1A regulates transcriptional pause release of heme biosynthesis genes in leukemia
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    sciencedirect.com/science/article/pii/S2211124722016059
  81. www.sciencedirect.com www.sciencedirect.com
    BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site-specific metastasis by stimulating glutathione synthesis
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    sciencedirect.com/science/article/pii/S2211124722016060
  82. Nov 2022
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    Dynamic quality control machinery that operates across compartmental borders mediates the degradation of mammalian nuclear membrane proteins
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    sciencedirect.com/science/article/pii/S2211124722015492
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    Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies
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    sciencedirect.com/science/article/pii/S2211124722015522
  85. 52.53.155.43 52.53.155.43
    Nuclear envelope protein LBR protects the genome from chromosomal instability and tumorigenesis
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    52.53.155.43/cc79e40c92dade70c5729b9199717becabfd0bfe/ddac235-html.html
  86. aacrjournals.org aacrjournals.org
    p53 inhibits Bmi-1-driven self-renewal and defines salivary gland cancer stemness
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    aacrjournals.org/clincancerres/article/28/21/4757/709842/p53-Inhibits-Bmi-1-driven-Self-Renewal-and-Defines
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GPI-Anchored Ligand-BioID2-Tagging System Identifies Galectin-1 Mediating Zika Virus Entry
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    ncbi.nlm.nih.gov/pmc/articles/PMC9668739/
  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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    ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
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    Tetraspanin-5–mediated MHC class I clustering is required for optimal CD8 T cell activation
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    pnas.org/doi/abs/10.1073/pnas.2122188119
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    The adhesion G-protein-coupled receptor Gpr116 is essential to maintain the skeletal muscle stem cell pool
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    sciencedirect.com/science/article/pii/S2211124722015169
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    Re-purposing the pro-senescence properties of doxorubicin to introduce immunotherapy in breast cancer brain metastasis
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