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CRISPR activation screens map the genomic landscape of cancer glycome remodeling

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1. scibot 29 Jan 2026
  
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  Addgene12259
  
  DOI: 10.1016/j.xgen.2026.101139
  
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sciencedirect.com/science/article/pii/S2666979X26000017
54.241.53.176 54.241.53.176

1-s2.0-S2589004226001665-main-html.html

1
1. scibot 29 Jan 2026
  
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  RRID: Addgene_12259
  
  DOI: 10.1016/j.isci.2026.114791
  
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54.241.53.176/bd43b4cd05646581a5879b7d9668bddfe2e52bf6/1-s2.0-S2589004226001665-main-html.html
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Scalable TCR synthesis and screening enable antigen reactivity mapping in vitiligo

1
1. scibot 29 Jan 2026
  
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  12259
  
  DOI: 10.1016/j.immuni.2026.01.001
  
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sciencedirect.com/science/article/pii/S1074761326000014
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Cholesterol-DNA Origami Nanostructures for Synthetic Lipid Rafts Induce Early T Cell Activation Signals

1
1. scibot 29 Jan 2026
  
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  plasmid # 12259
  
  DOI: 10.1002/admi.202500806
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/admi.202500806
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FAM43A coordinates mtDNA replication and mitochondrial biogenesis in response to mtDNA depletion

1
1. scibot 28 Jan 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1083/jcb.202311082
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11770945/
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Generation of an iPSC-derived alveolar rhabdomyosarcoma cell line during directed endothelial differentiation

1
1. scibot 28 Jan 2026
  
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  Addgene_12259
  
  DOI: 10.1016/j.scr.2025.103871
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12829486/
54.241.53.176 54.241.53.176

2026.01.19.700398v1.full-html.html

1
1. scibot 27 Jan 2026
  
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  12259
  
  DOI: 10.64898/2026.01.19.700398
  
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54.241.53.176/920dac77fb602c31bea028e2a56d4a986d400748/2026.01.19.700398v1.full-html.html
54.241.53.176 54.241.53.176

e013832.full-html.html

1
1. scibot 27 Jan 2026
  
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  RRID:Ad-dgene_12259
  
  DOI: 10.1136/jitc-2025-013832
  
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54.241.53.176/ca60c4c2a1e906c1762fed2c822dc77ccf0438f0/e013832.full-html.html
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Pregnenolone promotes immune evasion through blocking endogenous retrovirus expression

1
1. scibot 27 Jan 2026
  
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  addgeneCat# 12259
  
  DOI: 10.1016/j.cmet.2025.12.020
  
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sciencedirect.com/science/article/pii/S1550413125005844
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Dual targeting of AMRC12 and Malassezia globosa disrupts MYC liquid condensates-driven nuclear pore complex biogenesis in neuroblastoma

1
1. scibot 26 Jan 2026
  
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  pMD2G
  
  DOI: 10.7150/thno.120935
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12775802/
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Genome-wide CRISPR screening identifies CLDN1 as a central node in the anticancer mechanisms of berberine and as a therapeutic target in lung cancer

1
1. scibot 26 Jan 2026
  
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  12259
  
  DOI: 10.3892/ol.2025.15415
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12690534/
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MRTF-dependent cytoskeletal dynamics drive efficient cell cycle progression

1
1. scibot 26 Jan 2026
  
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  12259
  
  DOI: 10.1242/jcs.264444
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12813672/
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Ribosome-binding protein 1 maintains peroxisome biogenesis

1
1. scibot 26 Jan 2026
  
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  12259
  
  DOI: 10.1242/jcs.264075
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12752496/
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NF2 loss malignantly transforms human pancreatic acinar cells and enhances cell fitness under environmental stress

1
1. scibot 26 Jan 2026
  
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  12259
  
  DOI: 10.1172/JCI194395
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12721884/
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Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcoma

1
1. scibot 26 Jan 2026
  
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  12259
  
  DOI: 10.1126/sciadv.ady0550
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12822632/
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EMT activates ER-to-Golgi trafficking through upregulation of REEP2 to promote lung cancer progression

1
1. scibot 26 Jan 2026
  
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  12259
  
  DOI: 10.1101/2025.11.12.688098
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12642484/
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Anti-CRISPR-mediated continuous directed evolution of CRISPR-Cas9 in human cells

1
1. scibot 26 Jan 2026
  
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  Addgene_12259
  
  DOI: 10.64898/2025.12.11.693673
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12710652/
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A Novel Diagnostic Tool for West Nile Virus Lineage 1a and 2 Using a CRISPR-Cas12a System

1
1. scibot 26 Jan 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.3390/bios15120807
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12730693/
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Discovering the complete enhancer map of human herpesviruses using a natural language processing model

1
1. scibot 26 Jan 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1038/s41467-025-66861-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12780183/
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Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth

1
1. scibot 23 Jan 2026
  
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  AddgeneCat# #12259
  
  DOI: 10.1016/j.ccell.2025.12.021
  
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sciencedirect.com/science/article/pii/S1535610825005550
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

The hemopexin domain of matrix metalloproteinase-9 attenuates lipopolysaccharide-induced interleukin-6 secretion in liver

1
1. scibot 23 Jan 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1038/s41598-025-32379-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12820117/
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Myomaker and ether lipids cooperate to promote fusion-competent membrane states

1
1. scibot 23 Jan 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.celrep.2025.116900
  
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sciencedirect.com/science/article/pii/S2211124725016729
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IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma

1
1. scibot 23 Jan 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.ccell.2025.12.019
  
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sciencedirect.com/science/article/pii/S1535610825005537
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

1
1. scibot 23 Jan 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1002/advs.202509148
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12822389/
Jan 2026
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Context-specific Angiogenin-mediated tRNA fragments (tDRs) biogenesis shapes the mitochondrial stress response.

1
1. scibot 22 Jan 2026
  
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  Addgene, Cat# 12259
  
  DOI: 10.1016/j.redox.2026.104038
  
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sciencedirect.com/science/article/pii/S2213231726000364
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CLN3 mediates chloride efflux from lysosomes

2
1. scibot 22 Jan 2026
  
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  Addgene Cat# 12259
  
  DOI: 10.1016/j.neuron.2025.11.013
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.neuron.2025.11.013
  
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sciencedirect.com/science/article/pii/S0896627325008864
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Loss of EHMT2 enhances NK cell-driven anti-tumor immunity through TGF-β1 suppression

1
1. scibot 22 Jan 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1038/s44321-025-00357-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12808752/
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Regulation of stress tolerance by CREB1 sustains multiple myeloma cell survival

1
1. scibot 22 Jan 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1038/s41419-025-08246-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12811356/
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CRISPR screens in the context of immune selection identify CHD1 and MAP3K7 as mediators of cancer immunotherapy resistance

1
1. scibot 22 Jan 2026
  
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  Addgene_12259
  
  DOI: 10.1016/j.xcrm.2025.102565
  
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sciencedirect.com/science/article/pii/S266637912500638X
54.241.53.176 54.241.53.176

1-s2.0-S295032992600010X-main-html.html

1
1. scibot 22 Jan 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.omton.2026.201134
  
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54.241.53.176/6413cd4b258c3152566ed3954512080de8edd63d/1-s2.0-S295032992600010X-main-html.html
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Rhinovirus triggers distinct host responses through differential engagement of epithelial innate immune signaling

1
1. scibot 22 Jan 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.cpblue.2025.100001
  
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sciencedirect.com/science/article/pii/S3051383925000015
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Single-cell screens identify ADAM12 as a fibroblast checkpoint impeding anti-tumor immunity

1
1. scibot 16 Jan 2026
  
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  AddgeneCat# 12259
  
  DOI: 10.1016/j.ccell.2025.12.018
  
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sciencedirect.com/science/article/pii/S1535610825005525
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Multiomic integration reveals tumoral heterogeneity of lipid dependence within lethal group 3 medulloblastoma

1
1. scibot 16 Jan 2026
  
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  Addgene #12259
  
  DOI: 10.1016/j.ccell.2025.12.012
  
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sciencedirect.com/science/article/pii/S153561082500546X
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Human organoid tumor transplantation identifies functional glioblastoma-microenvironment communication mediated by PTPRZ1

1
1. scibot 16 Jan 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.celrep.2025.116848
  
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sciencedirect.com/science/article/pii/S2211124725016201
www.nature.com www.nature.com

Inhibiting macrophage-derived lactate transport restores cGAS–STING signalling and enhances antitumour immunity in glioblastoma

1
1. scibot 15 Jan 2026
  
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  Addgene, 12259
  
  DOI: 10.1038/s41556-025-01839-y
  
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nature.com/articles/s41556-025-01839-y
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A combinatorial transcription factor screening platform for immune cell reprogramming

1
1. scibot 15 Jan 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.cels.2025.101457
  
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sciencedirect.com/science/article/pii/S240547122500290X
elifesciences.org elifesciences.org

Nonlinear transcriptional responses to gradual modulation of transcription factor dosage

1
1. scibot 15 Jan 2026
  
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  RRID:Addgene:_12259
  
  DOI: 10.7554/eLife.100555
  
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  Curator: @dhovakimyan1
  
  SciCrunch record: RRID:Addgene_12259
  
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54.241.53.176 54.241.53.176

2026.01.07.697614v1.full-html.html

1
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  12259
  
  DOI: 10.64898/2026.01.07.697614
  
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Protocols to evaluate mutant specificity of an oncogene-targeting siRNA using orthogonal in vitro and in vivo approaches

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  AddgeneCat #12259
  
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2026.01.09.698661v1.full-html.html

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  RRID:Addgene_12259
  
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54.241.53.176/229f150d292937106a4e15fcfbf1923f59503af0/2026.01.09.698661v1.full-html.html
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Polyclonal and single clonal patient-derived organoid models of Barrett oesophagus and oesophageal adenocarcinoma establish a platform for the analysis of heterogeneity in disease progression and therapy response

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  RRID:Addgene_12259
  
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Characterization of the p38α MAPK allosteric inhibition by a single chain Fv antibody

1
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  RRID:Addgene_12259
  
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Skin-derived α-synuclein strains from PD, DLB, and MSA induce distinct intracellular pathology and neurodegeneration

1
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  Addgene plasmid # 12259
  
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Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia

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  Addgene: Cat# 12259
  
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DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signaling

1
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  AddgeneCat#12259
  
  DOI: 10.1016/j.celrep.2025.116796
  
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Integrative proteogenomic analysis provides molecular insights and clinical significance in gallbladder cancer

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  AddgeneCat# 12259
  
  DOI: 10.1016/j.ccell.2025.12.014
  
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Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage

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  AddgeneCat# 12259
  
  DOI: 10.1016/j.ccell.2025.12.013
  
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SMC5/6-mediated plasmid silencing is directed by SIMC1–SLF2 and antagonized by the SV40 large T antigen

1
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  Addgene_12259
  
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Viral infection and brain inflammation with seizures in PARK7 deficiency

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  Addgene_12259
  
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rupress.org/jhi/article/2/2/e20250044/278754/Viral-infection-and-brain-inflammation-with
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

LncRNA DANCR Activates p38/mTOR‐Mediated Autophagy via ANXA2 to Exacerbate Oxygen‐Induced Retinal Neovascularization in Mice

1
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  RRID: Addgene_12259
  
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ANP32A-mediated Histone 3 K27 Acetylation is Essential for Sotorasib Activity in KRAS-mutant Non-Small Cell Lung Cancer

1
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  RRID: Addgene_12259
  
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Uridine depletion impairs CD8⁺ T cell antitumor activity through N-glycosylation

1
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  AddgeneCat# 12259
  
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AARS1-mediated AKR1B10 lactylation stabilizes an aerobic glycolysis-positive feedback loop to drive lenvatinib resistance in hepatocellular carcinoma

1
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  Addgene #12259
  
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onlinelibrary.wiley.com/doi/full/10.1002/ctm2.70561
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Frizzled 6 Drives EMT and Stromal Remodeling Downstream of SP1 in Basal-like Pancreatic Cancer

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  Addgene_12259
  
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RNA-coupled CRISPR screens reveal ZNF207 as a regulator of LMNA aberrant splicing in progeria

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  Addgene_12259
  
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Comparative theranostic efficacy of 177Lu- and 161Tb-labeled A1K2 SdAb in mesothelin-positive tumors

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  RRID:Addgene_12259
  
  DOI: 10.1007/s00259-025-07723-z
  
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link.springer.com/article/10.1007/s00259-025-07723-z
Dec 2025
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TDP-43 suppression of ATP8A2 cryptic splicing implicates phosphatidylserine-driven neuroinflammation in ALS/FTD

1
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  Addgene_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12697532/
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Immunopeptidomics combined with full-length transcriptomics uncovers diverse neoantigens

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  RRID:Addgene_12259
  
  DOI: 10.1016/j.celrep.2025.116781
  
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Pathogenic podocin variants exhibit distinct defects in trafficking, membrane organization, and degradation pathways

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  RRID:Addgene_12259
  
  DOI: 10.1016/j.ejcb.2025.151526
  
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54.241.53.176 54.241.53.176

2025.12.11.693653.full-html.html

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  Addgene, 12259
  
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54.241.53.176/eeb2e165aaf812b2d72265420a95a1c3229b6f15/2025.12.11.693653.full-html.html
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Retroviral insertions contributed to the divergence of human and chimpanzee brains

1
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  Addgene_12259
  
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Downregulation of ZBTB7A/LRF increases fetal hemoglobin expression in β0-thalassemia/hemoglobin E erythroid cells

1
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  RRID:Addgene_12259
  
  DOI: 10.1038/s41598-025-30762-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12715185/
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The TIM22 carrier translocase supports cell proliferation by facilitating mitochondrial iron uptake for Fe-S biogenesis

1
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.molcel.2025.11.022
  
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sciencedirect.com:5037/science/article/pii/S1097276525009396
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RAS mutation–specific responses to paralog- and state-selective RAS inhibitors

1
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  RRID:Addgene_12259
  
  DOI: 10.1158/1541-7786.MCR-25-0319
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12710464/
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D3-GPC2-directed CAR T cells are safe and efficacious in preclinical models of neuroblastoma and small cell lung cancer

1
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  RRID:Addgene_12259
  
  DOI: 10.1158/1078-0432.CCR-25-0089
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12699724/
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Dual roles of TRPV2 in the innate immune response to cytosolic DNA: Arresting dormant and boosting activated STING

1
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  RRID: Addgene_12259
  
  DOI: 10.1016/j.celrep.2025.116745
  
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sciencedirect.com:5037/science/article/pii/S2211124725015177
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LAMP2A regulates endosomal protein composition and membrane identity in exosome biogenesis

1
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  Addgene_12259
  
  DOI: 10.1016/j.isci.2025.114305
  
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Liprin-α1 enhances PHLDB3 oncogenic function in colorectal cancer via activation of mTORC2-AKT1 pathway

1
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  AddgeneCat# 12259
  
  DOI: 10.1016/j.celrep.2025.116722
  
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sciencedirect.com:5037/science/article/pii/S2211124725014949
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Lymphodepleting chemotherapy potentiates neoantigen-directed T cell therapy by enhancing antigen presentation

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  Addgene_12259
  
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sciencedirect.com:5037/science/article/pii/S2666379125005798
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A cell-state axis underlying colonization in carcinomas with implications for metastasis risk prediction and interception

1
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  Addgene12259
  
  DOI: 10.1016/j.celrep.2025.116701
  
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ARAP2 regulates responses to interferon-gamma by restricting SOCS1

1
1. scibot 16 Dec 2025
  
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  AddgeneCat# 12259
  
  DOI: 10.1016/j.celrep.2025.116667
  
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sciencedirect.com:5037/science/article/pii/S2211124725014391
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

Genome-Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle-Mediated siRNA Delivery

1
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  Addgene #12 259
  
  DOI: 10.1002/advs.202517617
  
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advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202517617
54.241.53.176 54.241.53.176

2025.12.05.692654.full-html.html

1
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  plasmid_12259
  
  DOI: 10.64898/2025.12.05.692654
  
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Sec61 translocon inhibitor flavitransin blocks selectively dengue virus polyprotein insertion in the ER with pan-orthoflavivirus antiviral potency

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TDP-43 dysfunction compromises UPF1-dependent mRNA metabolism in ALS

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Tumor-initiating stem cells fine-tune the plasticity of neutrophils to sculpt a protective niche

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Visualizing infection by single positive-sense RNA viruses using virus infection real-time imaging (VIRIM)

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The TCR-SUB1-DOCK2 axis promotes autoimmunity by driving pathogenic CD4+ T cell tissue infiltration

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Post-transcriptional control of HIF-1α by MBNL1 restrains hypoxia-driven stemness in GBM

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Arp2/3-dependent regulation of ciliogenesis governs adaptive distal tubular epithelial cell states in kidney disease

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Priming with DNMT Inhibitors Potentiates PD-1 Immunotherapy by Triggering Viral Mimicry in Relapsed/Refractory NK/T-cell Lymphoma

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KSR1 mediates small-cell lung carcinoma tumor initiation and cisplatin resistance

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Bioenergetic responses to β-adrenergic stimulation in beige adipocyte depend on actomyosin driven forces

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Interferon dependent immune memory during HSV-1 neuronal latency via increased H3K9me3 and restriction by ATRX

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Eph receptors activate myeloid checkpoint receptor LILRB5 to support tumor development

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1-s2.0-S2589004225025428-main-html.html

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Protocol to track single-cell-derived clones using DNA barcoding combined with single-cell RNA sequencing

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NAT10 promotes cancer metastasis by modulating p300/CBP activity through chromatin-associated tRNA

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High-throughput mapping of modular regulatory domains in human RNA-binding proteins

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Targeting TET3 suppresses group 3 medulloblastoma stemness and progression via impairing hypomethylation of Otx2 super-enhancer

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Membrane potential mediates the cellular response to mechanical pressure

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Human RAP2A homolog of the Drosophila asymmetric cell division regulator Rap2l targets the stemness of glioblastoma stem cells

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  Plasmid_12259
  
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Arp2/3-dependent regulation of ciliogenesis governs adaptive distal tubular epithelial cell states in kidney disease

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  plasmid_12259
  
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Lysine methylation-mediated SMYD2 degradation by casticin sensitizes non-small-cell lung cancer cells to osimertinib therapy

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A Clickable CoQ Imaging Probe reveals that Cellular Uptake and Lysosomal Trafficking depend on CD36 and NPC1

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IL-13 protects epithelial cells from SARS-CoV-2 infection by inhibiting ACE2-mediated virus binding and cell entry

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Targeting peptide–MHC complexes with designed T cell receptors and antibodies

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The oxidative modification of transcription factor FOXM1 by Peroxiredoxin1 facilitates DNA damage repair and cancer progression

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Stimulator of interferon genes signaling network-driven prognostic signature for pancreatic cancer: Hub gene discovery with multimodal validation

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TWEAK modulates the characteristics of periodontal ligament stem cells via the Fn14/NF-κB pathway

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HDAC11-Mediated Deacetylation of Triosephosphate Isomerase 1 Promotes Idiopathic Pulmonary Fibrosis

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ARID1A Governs Genomic Stability and Proliferation in SCLC via c-MYC/PARP1 Suppression Driving Vulnerability to BET Inhibitors

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Artemis (DCLRE1C) Acts as a Target to Enhance Radiotherapy Response in Triple-Negative Breast Cancer

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SIK2 activates the autophagy‒apoptosis pathway through SP1 regulation to inhibit the progression of hepatocellular carcinoma

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Developing and optimizing a biocompatible tauopathy model using extracellular vesicle-mediated gene delivery

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New mechanistic insights into macrophage extracellular trap formation induced by a parasitic nematode, Strongyloides stercoralis

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C1orf50 Accelerates Epithelial-Mesenchymal Transition and the Cell Cycle of Hepatocellular Carcinoma

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Role and mechanism of ubiquitin-specific protease 35 in ferroptosis of rheumatoid arthritis-fibroblast like synoviocytes

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UBXN7 facilitates SARS-CoV-2 replication via inhibiting the K48-linked ubiquitination of viral N protein

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pmc.ncbi.nlm.nih.gov/articles/PMC12520364/
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Structure and function of Full-length Tau

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pmc.ncbi.nlm.nih.gov/articles/PMC12578172/
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A distal enhancer of Pparα regulates thermogenesis and mitochondrial function in brown fat

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pmc.ncbi.nlm.nih.gov/articles/PMC12574865/
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The miR-34/449 clusters regulate the differentiation of ciliated cells in the oviduct via the Wnt/β-catenin signaling pathway

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  PMD2.G
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12492746/
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Stable production of immortalized hPC-MSC-derived extracellular vesicles: integrated cargo analysis and functional validation

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pmc.ncbi.nlm.nih.gov/articles/PMC12590667/
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FGD3 mediates lytic cell death, enhancing efficacy and immunogenicity of chemotherapy agents in breast cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12613929/
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RUNX2 cooperates with SREBP1 to rewire cancer metabolism and promote aggressiveness

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pmc.ncbi.nlm.nih.gov/articles/PMC12577400/
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Modulation of transferrin receptor by HIV-2

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  pMD
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12639691/
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ARFGAP1 serves as a critical host factor during E30 infection: QS11 inhibits viral pathogenesis in hFcRn-IFNAR−/− mice

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pmc.ncbi.nlm.nih.gov/articles/PMC12573814/
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Multi-omics analysis reveals the crosstalk of epigenetic regulatory networks in cutaneous squamous cell carcinoma progression

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  DOI: 10.1186/s12967-025-07262-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12613370/
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USP13 promotes colorectal cancer progression by deubiquitinating and stabilizing HIF-1α

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pmc.ncbi.nlm.nih.gov/articles/PMC12639959/
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Effect of heme oxygenase-1 on the expression of interferon-stimulated genes

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pmc.ncbi.nlm.nih.gov/articles/PMC12512898/
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Lung endothelial PEAR1 induces tumor cell dormancy

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pmc.ncbi.nlm.nih.gov/articles/PMC12581312/
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BRD9-p53-E2F1 circuit orchestrates cell growth and DNA damage repair in gastric cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12492862/
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A Notch signal pathway related gene signature predicts overall survival in colorectal cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12506287/
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Systematic Engineering of TROP2-Targeted CAR T-Cell Therapy Overcomes Resistance Pathways in Solid Tumors

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  DOI: 10.1158/2326-6066.CIR-25-0527
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12580781/
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P3H4 Enhances the Proliferation, Invasion, and Glycolysis of Hepatocellular Carcinoma Cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12597767/
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Stromal cells modulate innate immune cell phenotype and function in colorectal cancer via the Sialic acid/Siglec axis

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pmc.ncbi.nlm.nih.gov/articles/PMC12542748/
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EP300 compromises antitumor immunity by increasing SOCS1 expression

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pmc.ncbi.nlm.nih.gov/articles/PMC12530425/
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DKK3-LRP1 complex and a chemical inhibitor regulate Aβ clearance in models of Alzheimer’s disease

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pmc.ncbi.nlm.nih.gov/articles/PMC12594171/
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PLAMseq enables the proteo-genomic characterization of chromatin-associated proteins and protein interactions in a single workflow

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pmc.ncbi.nlm.nih.gov/articles/PMC12594174/
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ASPL couples the assembly of stress granules with their VCP-mediated disassembly

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pmc.ncbi.nlm.nih.gov/articles/PMC12506973/
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Resistance to radiation enhances metastasis by altering RNA metabolism

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pmc.ncbi.nlm.nih.gov/articles/PMC12533556/
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Mechanochemical waves in focal adhesions during cell migration

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pmc.ncbi.nlm.nih.gov/articles/PMC12494029/
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Melatonin Overcomes Cancer Multidrug Resistance by Downregulating ABCB1 Expression and Modulating Mitochondrial Function

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pmc.ncbi.nlm.nih.gov/articles/PMC12586911/
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3D-bioprinted liver cancer models derived from primary hepatocytes for simulating cancer initiation and drug screening

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  pMD2.G
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12506986/
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mRNA turnover dynamics are affected by cell differentiation and loss of the cytosine methyltransferase Nsun2

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pmc.ncbi.nlm.nih.gov/articles/PMC12529931/
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Transcription factor 4 maintains endothelial cell identity by inhibiting endothelial to mesenchymal transition

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pmc.ncbi.nlm.nih.gov/articles/PMC12571441/
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FCRL3 is an immunoregulatory receptor that restrains the activation of human memory T lymphocytes

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  DOI: 10.1084/jem.20242474
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12524113/
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Moesin controls cell–cell fusion and osteoclast function

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pmc.ncbi.nlm.nih.gov/articles/PMC12558046/
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Porcine reproductive and respiratory syndrome virus activates the pentose phosphate pathway via the ROS/HIF-1α/G6PD axis to promote viral replication

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pmc.ncbi.nlm.nih.gov/articles/PMC12599336/
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Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility

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pmc.ncbi.nlm.nih.gov/articles/PMC12519202/
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LeGO-3D: 3D imaging of lung metastases and vascularisation using light sheet fluorescence microscopy

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pmc.ncbi.nlm.nih.gov/articles/PMC12595114/
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Pyroglutamation of cell surface proteins CD47 and TRP1 by glutaminyl cyclase modulates therapeutic antibody binding

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pmc.ncbi.nlm.nih.gov/articles/PMC12615796/
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ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver

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pmc.ncbi.nlm.nih.gov/articles/PMC12491593/
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DeepTarget predicts anti-cancer mechanisms of action of small molecules by integrating drug and genetic screens

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pmc.ncbi.nlm.nih.gov/articles/PMC12589559/
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Claudin-4 as a dual regulator of genome stability and immune evasion in high grade serous ovarian cancer

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  DOI: 10.1038/s41598-025-23137-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12603150/
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Combined effects of restriction factors and transduction adjuvants on lentiviral vector gene transfer efficacy

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pmc.ncbi.nlm.nih.gov/articles/PMC12586428/
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Villin like suppresses nasopharyngeal carcinoma proliferation by downregulating MYC

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  DOI: 10.1038/s41598-025-21495-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12569157/
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Immunocompetent C57BL/6 syngeneic mouse ovarian cancer models with defined genetic alterations

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pmc.ncbi.nlm.nih.gov/articles/PMC12504517/
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Dipeptidase 1 is a functional receptor for a porcine coronavirus

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pmc.ncbi.nlm.nih.gov/articles/PMC12578638/
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Epigenetic alterations facilitate transcriptional and translational programs in hypoxia

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pmc.ncbi.nlm.nih.gov/articles/PMC12611764/
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Optical mapping of the interface between iPSC-derived grafts and swine myocardium suggests potential arrhythmia mechanisms

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pmc.ncbi.nlm.nih.gov/articles/PMC12583502/
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Targeting GD2 with naxitamab overcomes GD3 synthase-driven immune suppression in triple-negative breast cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12586714/
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A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release

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pmc.ncbi.nlm.nih.gov/articles/PMC12639036/
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LUBAC modulates CBM complex functions downstream of TRAF6 in T cells

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pmc.ncbi.nlm.nih.gov/articles/PMC12602705/
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A yeast surface display platform for characterizing CAR T cell responses to cancer antigens

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pmc.ncbi.nlm.nih.gov/articles/PMC12638309/
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Multiplex neurodegeneration proteotoxicity platform reveals DNAJB6 promotes non-toxic FUS condensate gelation and inhibits neurotoxicity

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pmc.ncbi.nlm.nih.gov/articles/PMC12638947/
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Modeling and addressing on-target/off-tumor toxicity of claudin 18.2 targeted immunotherapies

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Topoisomerase IIb binding delineates localized mutational processes and driver mutations in cancer genomes

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pmc.ncbi.nlm.nih.gov/articles/PMC12638796/
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The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs

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pmc.ncbi.nlm.nih.gov/articles/PMC12618888/
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qMaLioffG: a genetically encoded green fluorescence lifetime-based indicator enabling quantitative imaging of intracellular ATP

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pmc.ncbi.nlm.nih.gov/articles/PMC12615622/
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WEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2

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pmc.ncbi.nlm.nih.gov/articles/PMC12511557/
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MTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes

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pmc.ncbi.nlm.nih.gov/articles/PMC12494973/
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The inner nuclear membrane protein LEMD3 organizes the 3D chromatin architecture to maintain vascular smooth muscle cell identity

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pmc.ncbi.nlm.nih.gov/articles/PMC12495022/
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Cell cycle regulator MYBL2 is a distinct vulnerability in acute myeloid leukemia

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pmc.ncbi.nlm.nih.gov/articles/PMC12537973/
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Chemically induced dimerization of GSDMD C-terminal domain blocks GSDMD N-terminal domain-mediated pyroptosis

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pmc.ncbi.nlm.nih.gov/articles/PMC12518871/
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PFKFB3 as a multifaceted driver and therapeutic target in castration-resistant prostate cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12552466/
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CLN7 protein functions at the interface between endolysosomes and stress granules to promote cell survival

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pmc.ncbi.nlm.nih.gov/articles/PMC12579238/
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Targeting the Met-RIPK1 signaling axis to enforce apoptosis and necroptosis in colorectal cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12537949/
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Cytosolic phospholipase A2 as a therapeutic target for degenerative joint diseases

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pmc.ncbi.nlm.nih.gov/articles/PMC12528370/
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shRNAI: A deep neural network for the design of highly potent shRNAs

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pmc.ncbi.nlm.nih.gov/articles/PMC12596542/
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SLC20A1 knockout to stably express a fusogenic gibbon ape leukemia virus envelope glycoprotein for lentiviral vector production

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pmc.ncbi.nlm.nih.gov/articles/PMC12639841/
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1-s2.0-S258900422501987X-main-html.html

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pmc.ncbi.nlm.nih.gov/articles/PMC12595127/
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rs604702 confers breast cancer risk by influencing PCAT18/miR-759/SPRR3 axis

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pmc.ncbi.nlm.nih.gov/articles/PMC12589711/
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Malignant progression of MES-like cells mediated by COL22A1 in the spatial heterogeneity of glioblastoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12500492/
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A matrix stiffness gene signature identifies SLC20A1 as a novel mechano-immunological checkpoint enabling synergistic immunotherapy in pancreatic ductal adenocarcinoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12612327/
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Epigenetic regulation of TIPE3 in nasopharyngeal carcinoma and its impact on the hedgehog signaling pathway

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pmc.ncbi.nlm.nih.gov/articles/PMC12615883/
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Small Extracellular Vesicles From Radioresistant H3K27M‐Pediatric Diffuse Midline Glioma Cells Modulate Tumor Phenotypes and Radiation Response

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pmc.ncbi.nlm.nih.gov/articles/PMC12575060/
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Generation of Human 3D Airway Assembloids for Advanced Modeling

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pmc.ncbi.nlm.nih.gov/articles/PMC12594573/
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Promoter Frame Position Affects Strength and Nature of Circadian Oscillations in hPER2 Luciferase Reporters

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pmc.ncbi.nlm.nih.gov/articles/PMC12608312/
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HTLV-1 p12 is cleaved to p8 by the signal peptidase complex and its inhibition impairs p8-dependent transmission

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pmc.ncbi.nlm.nih.gov/articles/PMC12513584/
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Mammalian antiviral proteins ZAP and KHNYN can independently restrict CpG-enriched avian viruses

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pmc.ncbi.nlm.nih.gov/articles/PMC12582503/
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Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming

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pmc.ncbi.nlm.nih.gov/articles/PMC12535130/
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Pooled overexpression screening identifies PIPPI as a novel microprotein involved in the ER stress response

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pmc.ncbi.nlm.nih.gov/articles/PMC12596725/
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BTK autoinhibition analyzed by high-throughput swaps of SH2 domains

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pmc.ncbi.nlm.nih.gov/articles/PMC12541323/
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MMP9 shapes cell mechanics to enable collective invasion in cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12572407/
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Reversion of passaged nucleus pulposus cells to notochordal-type cells by FoxA2 upregulation

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1. scibot 24 Nov 2025
  
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  plasmid_12259
  
  DOI: 10.1038/s41536-025-00437-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12578846/
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Molecular basis for selection and inhibition of HIV-1 escape virus by T cells and KIR2DL2+NK cells

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1. scibot 24 Nov 2025
  
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  plasmid_12259
  
  DOI: 10.1038/s41467-025-64768-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12592487/
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Pre-established ATF4 occupancy and chromatin organization instruct selective transcription activation during integrated stress response

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1. scibot 24 Nov 2025
  
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  Addgene_12259
  
  DOI: 10.1038/s41467-025-64577-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12569010/
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Large transient assemblies of Apaf1 constitute the apoptosome in cells

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1. scibot 24 Nov 2025
  
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  Addgene_12259
  
  DOI: 10.1038/s41467-025-64478-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12552632/
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Muscle-specific gene editing therapy via mammalian fusogen-directed virus-like particles

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1. scibot 24 Nov 2025
  
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  plasmid_12259
  
  DOI: 10.1038/s41467-025-64200-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12528695/
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A microRNA CRISPR screen reveals microRNA-483-3p as an apoptotic regulator in prostate cancer cells

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1. scibot 24 Nov 2025
  
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  Addgene_12259
  
  DOI: 10.1038/s41419-025-08098-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12552650/
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Reproducible Human Neural Circuits Printed with Single-Cell Precision Reveal the Functional Roles of Ephaptic Coupling

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1. scibot 24 Nov 2025
  
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  Addgene_12259
  
  DOI: 10.1021/acsnano.5c11482
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12613839/
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SLC25A45 is required for mitochondrial uptake of methylated amino acids and de novo carnitine biosynthesis

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1. scibot 24 Nov 2025
  
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  Plasmid_12259
  
  DOI: 10.1016/j.molcel.2025.08.018
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12594208/
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The Antisense Protein ASP of HIV-1 Enhances Viral Entry in CD4+ T Cells

1
1. scibot 23 Nov 2025
  
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  DOI: 10.3390/v17101332
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12568219/
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Human Retinal Organoid Modeling Defines Developmental Window and Therapeutic Vulnerabilities in MYCN-Amplified Retinoblastoma

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1. scibot 23 Nov 2025
  
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  DOI: 10.3390/ijms26178675
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12429095/
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The Influence of Short Peptides on Cell Senescence and Neuronal Differentiation

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1. scibot 23 Nov 2025
  
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  DOI: 10.3390/cimb47090739
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12468822/
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A Novel Early Memory-Enriched Allogeneic NKG2D CAR-T Cell Therapy Based on CRISPR/Cas9 Technology for Solid Tumors

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1. scibot 23 Nov 2025
  
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  DOI: 10.3390/cancers17193186
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12523248/
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Hemopexin Suppresses Hepatocellular Carcinoma via TNF-α-Mediated Mitochondrial Apoptosis

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1. scibot 23 Nov 2025
  
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  pVSV-G
  
  DOI: 10.3390/cancers17182969
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12468737/

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