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Mechanosensitive interactions between Jag1 and Myo1c control Jag1 trafficking in endothelial cells

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1. scibot 02 Apr 2025
  
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  DOI: 10.1101/2025.03.27.645426
  
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biorxiv.org/content/10.1101/2025.03.27.645426v1
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A stress-dependent TDP-43 SUMOylation program preserves neuronal function

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1. scibot 02 Apr 2025
  
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  Addgene_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11951803/
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  DOI: 10.1158/2326-6066.cir-24-0737
  
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52.53.155.43/6082e85085e2ed08cbf86aa32472ba192b5c95f0/PDF-html.html
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Loss of H3K9me3 maintenance in human neural progenitor cells leads to transcriptional activation of L1 retrotransposons

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1. scibot 02 Apr 2025
  
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biorxiv.org/content/10.1101/2025.03.28.645885v1
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SWI/SNF complex-mediated ZNF410 cooperative binding maintains chromatin accessibility and enhancer activity

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1. scibot 02 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115476
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00247-5
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PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth

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1. scibot 29 Mar 2025
  
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  AddgeneCat# 12259
  
  DOI: 10.1016/j.molcel.2025.02.024
  
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sciencedirect.com/science/article/pii/S1097276525001868
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The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.immuni.2025.02.026
  
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sciencedirect.com/science/article/pii/S1074761325000937
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The actin and microtubule network regulator WHAMM is identified as a key kidney disease risk gene

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1. scibot 29 Mar 2025
  
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  12259, Addgene
  
  DOI: 10.1016/j.celrep.2025.115462
  
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sciencedirect.com/science/article/pii/S2211124725002335
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Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations

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1. scibot 29 Mar 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.xgen.2025.100818
  
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sciencedirect.com/science/article/pii/S2666979X25000746
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The HAVCR1-centric host factor network drives Zika virus vertical transmission

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115464
  
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sciencedirect.com/science/article/pii/S2211124725002359
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Orchestration of pluripotent stem cell genome reactivation during mitotic exit

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1. scibot 28 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115486
  
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sciencedirect.com/science/article/pii/S2211124725002578
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Entinostat, a histone deacetylase inhibitor, enhances CAR-NK cell anti-tumor activity by sustaining CAR expression

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1. scibot 28 Mar 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.3389/fimmu.2025.1533044
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11925867/
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A large-scale sORF screen identifies putative microproteins involved in cancer cell fitness

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1. scibot 28 Mar 2025
  
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  DOI: 10.1016/j.isci.2025.111884
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11929002/
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Translation dysregulation in cancer as a source for targetable antigens

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1. scibot 28 Mar 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.ccell.2025.03.003
  
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sciencedirect.com/science/article/pii/S1535610825000820
Mar 2025
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In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer

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1. scibot 26 Mar 2025
  
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  plasmid_12259
  
  DOI: 10.1101/2025.03.20.644389
  
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biorxiv.org/content/10.1101/2025.03.20.644389v1
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17q21.31 locus regulates Parkinson’s disease relevant pathways through KANSL1 activity

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1. scibot 26 Mar 2025
  
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  RRID:Addgene_12259
  
  DOI: 10.1101/2025.03.17.641409
  
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biorxiv.org/content/10.1101/2025.03.17.641409v1
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The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis

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1. scibot 24 Mar 2025
  
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  RRID: Addgene_ 12259
  
  DOI: 10.1101/2025.03.18.644053
  
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biorxiv.org/content/10.1101/2025.03.18.644053v1
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Targeting platinum-resistant ovarian cancer by disrupting histone and RAD51 lactylation

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.7150/thno.104858
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11898288/
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Glioblastoma progression is hindered by melatonin-primed mesenchymal stromal cells through dynamic intracellular and extracellular reorganizations

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.7150/thno.104143
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11898303/
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Enhanced therapeutic efficacy of anti-PD-1 blockade by targeting LAMP2A inhibits lysosomal degradation of STING and TBK1

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.7150/thno.103426
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11898276/
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CRISPR screening reveals ZNF217 as a vulnerability in high-risk B-cell acute lymphoblastic leukemia

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1. scibot 23 Mar 2025
  
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  pMD2.G
  
  DOI: 10.7150/thno.100295
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11905140/
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Heme oxygenase 1‑overexpressing bone marrow mesenchymal stem cell‑derived exosomes suppress interleukin‑1 beta‑induced apoptosis and aging of nucleus pulposus cells

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.3892/mmr.2025.13481
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11905203/
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Development and Characterization of Three Novel FGFR Inhibitor Resistant Cervical Cancer Cell Lines to Help Drive Cervical Cancer Research

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.3390/ijms26051799
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11898767/
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NLRP4 unlocks an NK/macrophages-centered ecosystem to suppress non-small cell lung cancer

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.1186/s40364-025-00756-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11909883/
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RNA-binding protein SAMD4A targets FGF2 to regulate cardiomyocyte lineage specification from human embryonic stem cells

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.1186/s13287-025-04269-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11921648/
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Enhancement of functional insulin-producing cell differentiation from embryonic stem cells through MST1-silencing

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1. scibot 23 Mar 2025
  
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  pMD2.G
  
  DOI: 10.1186/s13098-025-01666-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11924671/
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RNF20 dual regulation of MDA5 signaling to maintain immune homeostasis in chickens

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.1128/jvi.02008-24
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11915864/
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STT3B promotes porcine epidemic diarrhea virus replication by regulating N-glycosylation of PEDV S protein

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.1128/jvi.00018-25
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11915848/
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Collaborative role of two distinct cilium-specific cytoskeletal systems in driving Hedgehog-responsive transcription factor trafficking

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.1126/sciadv.adt5439
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11900865/
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Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.1126/sciadv.adt1241
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11900879/
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Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae from the blood circulation of mice

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1. scibot 23 Mar 2025
  
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  pMD2.G
  
  DOI: 10.1126/sciadv.adq6399
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11900858/
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A genome wide CRISPR screen reveals novel determinants of long-lived plasma cell secretory capacity

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.1101/2025.02.28.640639
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11888458/
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A comprehensive map of missense trafficking variants in rhodopsin and their response to pharmacologic correction

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.1101/2025.02.27.640335
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11908143/
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Sulfinyl Aziridines as Stereoselective Covalent Destabilizing Degraders of the Oncogenic Transcription Factor MYC

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.1101/2025.02.24.639755
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11888305/
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Multiplexed in vivo base editing identifies functional gene-variant-context interactions

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.1101/2025.02.23.639770
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11888363/
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The Adhesion GPCR ADGRL2 engages Ga13 to Enable Epidermal Differentiation

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1. scibot 23 Mar 2025
  
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  pMD2.G
  
  DOI: 10.1101/2025.02.19.639154
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11888183/
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Resistance to Radiation Enhances Metastasis by Altering RNA Metabolism

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.1101/2025.02.19.638943
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11888214/
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An RNA Splicing System that Excises Transposons from Animal mRNAs

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1. scibot 23 Mar 2025
  
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  12259
  
  DOI: 10.1101/2025.02.14.638102
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11870413/
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TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress

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  DOI: 10.1093/narcan/zcaf009
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11923746/
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Lanatoside C activates the E3 ligase STUB1 to inhibit FOXP3 transcriptional activity and promote antitumor immunity

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  DOI: 10.1038/s44321-025-00200-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11904033/
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HSC70 coordinates COP9 signalosome and SCF ubiquitin ligase activity to enable a prompt stress response

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  DOI: 10.1038/s44319-025-00376-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11894141/
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Mutations in the kinesin KIF12 promote MASH in humans and mice by disrupting lipogenic enzyme turnover

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pmc.ncbi.nlm.nih.gov/articles/PMC11914266/
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Comprehensive genomic dependency landscape of a human colon cancer organoid

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pmc.ncbi.nlm.nih.gov/articles/PMC11906589/
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Targeting USP8 causes synthetic lethality through degradation of FGFR2 in ARID1A-deficient ovarian clear cell carcinoma

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pmc.ncbi.nlm.nih.gov/articles/PMC11903656/
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A genome-wide atlas of human cell morphology

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  DOI: 10.1038/s41592-024-02537-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11903339/
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Intrinsic electrical activity drives small-cell lung cancer progression

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pmc.ncbi.nlm.nih.gov/articles/PMC11922742/
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Tumour-wide RNA splicing aberrations generate actionable public neoantigens

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pmc.ncbi.nlm.nih.gov/articles/PMC11903331/
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Massively parallel characterization of transcriptional regulatory elements

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pmc.ncbi.nlm.nih.gov/articles/PMC11903340/
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FoxO3 controls cardiomyocyte proliferation and heart regeneration by regulating Sfrp2 expression in postnatal mice

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pmc.ncbi.nlm.nih.gov/articles/PMC11909131/
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Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function

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  DOI: 10.1038/s41467-025-57744-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11910630/
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Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanoma

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pmc.ncbi.nlm.nih.gov/articles/PMC11893775/
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TET2 deficiency increases the competitive advantage of hematopoietic stem and progenitor cells through upregulation of thrombopoietin receptor signaling

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pmc.ncbi.nlm.nih.gov/articles/PMC11894142/
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Guanine nucleotide biosynthesis blockade impairs MLL complex formation and sensitizes leukemias to menin inhibition

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pmc.ncbi.nlm.nih.gov/articles/PMC11920272/
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Suppression of stress granule formation is a vulnerability imposed by mutant p53

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pmc.ncbi.nlm.nih.gov/articles/PMC11894096/
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USP7 V517F mutation as a mechanism of inhibitor resistance

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pmc.ncbi.nlm.nih.gov/articles/PMC11909274/
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A positive feedback loop between SMAD3 and PINK1 in regulation of mitophagy

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pmc.ncbi.nlm.nih.gov/articles/PMC11894195/
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Trans-Golgi network tethering factors regulate TBK1 trafficking and promote the STING-IFN-I pathway

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pmc.ncbi.nlm.nih.gov/articles/PMC11914254/
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Ubiquitination of gasdermin D N-terminal domain directs its membrane translocation and pore formation during pyroptosis

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  pMD2.G
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11914233/
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Self-organization of mouse embryonic stem cells into reproducible pre-gastrulation embryo models via CRISPRa programming

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  Addgene Cat#12259
  
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cell.com/cell-stem-cell/fulltext/S1934-5909(25)00083-9
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LncRNA APTR amplification serves as a potential glioma biomarker and promotes glioma progression via miR-6734-5p/ TCF7/LEF1 axis

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  pMD2.G
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11914771/
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Small-molecule RNA therapeutics to target prostate cancer

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  RRID: Addgene_12259
  
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cell.com/cancer-cell/fulltext/S1535-6108(25)00079-0
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Crip2 affects vascular development by fine-tuning endothelial cell aggregation and proliferation

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pmc.ncbi.nlm.nih.gov/articles/PMC11904032/
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Next Generation Aqueous Two‐Phase System for Gentle, Effective, and Timely Extracellular Vesicle Isolation and Transcriptomic Analysis

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  DOI: 10.1002/jev2.70058
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11923243/
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CXCR4 Inhibition Enhances the Efficacy of CD19 Monoclonal Antibody-Mediated Extermination of B-Cell Lymphoma

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pmc.ncbi.nlm.nih.gov/articles/PMC11899823/
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Acute GARP Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and O‐Glycosylation

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  Addgene_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11917462/
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Interaction with tumor cell spheroids induces suppression in primary human cytotoxic T cells

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  DOI: 10.1101/2025.03.18.643973
  
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biorxiv.org/content/10.1101/2025.03.18.643973v1
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The costimulatory domain influences CD19 CAR-T cell resistance development in B-cell malignancies

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  DOI: 10.1101/2025.02.28.640707
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11908201/
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Succinate dehydrogenase activity supports de novo purine synthesis

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  Addgene_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11888382/
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Epigenetic deprogramming by disruption of CIZ1-RNA nuclear assemblies in early-stage breast cancers

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  plasmid_12259
  
  DOI: 10.1083/jcb.202409123
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11895699/
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Sensitive detection and propagation of brain-derived tau assemblies in HEK293-based wild-type tau seeding assays[image]

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  Addgene_12259
  
  DOI: 10.1016/j.jbc.2025.108245
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11910105/
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Tumor Cell‐Expressed Herpesvirus Entry Mediator Regulates Proliferation and Adaptive Immunity in Ovarian Cancer

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  Addgene_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11921469/
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Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism

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  AddgeneCat# 12259
  
  DOI: 10.1016/j.cmet.2025.02.008
  
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sciencedirect.com/science/article/pii/S155041312500066X
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A microglia clonal inflammatory disorder in Alzheimer’s disease

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  RRID:Addgene_12259
  
  DOI: 10.7554/eLife.96519
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11908784/
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Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity

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  Addgene_12259
  
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sciencedirect.com/science/article/pii/S2666379125000941
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Spatial control of m6A deposition on enhancer and promoter RNAs through co-acetylation of METTL3 and H3K27 on chromatin

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  DOI: 10.1016/j.molcel.2025.02.016
  
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sciencedirect.com/science/article/pii/S1097276525001479
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DAP12-associated synthetic antigen receptors enable multi-targeting of T cells with independent chimeric receptors in a small genetic payload

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  RRID:Addgene_12259
  
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Glutamine binds HSC70 to transduce signals inhibiting IFN-β-mediated immunogenic cell death

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YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells

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Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits

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PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTD

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Protein phosphatase EYA1 regulates the dephosphorylation and turnover of BCL2L12 to promote glioma development

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pmc.ncbi.nlm.nih.gov/articles/PMC11781168/
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Association of Selected STAT Inhibitors with Prolactin-Induced Protein (PIP) in Breast Cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC11855718/
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Onvansertib and Navitoclax Combination as a New Therapeutic Option for Mucinous Ovarian Carcinoma

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Screening Methods to Discover the FDA-Approved Cancer Drug Encorafenib as Optimally Selective for Metallothionein Gene Loss Ovarian Cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC11764637/
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ATF3-SLC7A7 Axis Regulates mTORC1 Signaling to Suppress Lipogenesis and Tumorigenesis in Hepatocellular Carcinoma

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  12259
  
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Combinational Inhibition of MEK and AKT Synergistically Induces Melanoma Stem Cell Apoptosis and Blocks NRAS Tumor Growth

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  pMD2.G
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11852824/
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Recognition of MR1-antigen complexes by TCR Vγ9Vδ2

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  12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11876030/
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Sodium valproate enhances efficacy of NKG2D CAR-T cells against glioblastoma

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pmc.ncbi.nlm.nih.gov/articles/PMC11772361/
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Rac1 overexpression promotes Treg-derived cytokines to mediate choroidal neovascularization in wet age-related macular degeneration

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  pMD2.g
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11884777/
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Mis-splicing drives loss of function of p53E224D point mutation

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pmc.ncbi.nlm.nih.gov/articles/PMC11882087/
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Glutathione peroxidase 4 (GPX4) and obesity interact to impact tumor progression and treatment response in triple negative breast cancer

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  pMD2.G
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11863593/
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A benchmark comparison of CRISPRn guide-RNA design algorithms and generation of small single and dual-targeting libraries to boost screening efficiency

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pmc.ncbi.nlm.nih.gov/articles/PMC11863645/
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Development and characterization of a double-fluorescent HIV-1 reporter cellular model to tackle the Rev-dependent export pathway

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  12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11878058/
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Norovirus co-opts NINJ1 for selective protein secretion

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  12259
  
  DOI: 10.1126/sciadv.adu7985
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11870086/
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Local soft niches in mechanically heterogeneous primary tumors promote brain metastasis via mechanotransduction-mediated HDAC3 activity

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pmc.ncbi.nlm.nih.gov/articles/PMC11864190/
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Identification of C/EBPδ‐Modifying Compounds as Potential Anticancer Agents Using a High‐Throughput Drug Screen

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  122
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11783153/
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Succinate Dehydrogenase loss causes cascading metabolic effects that impair pyrimidine biosynthesis

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pmc.ncbi.nlm.nih.gov/articles/PMC11870577/
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Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements

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pmc.ncbi.nlm.nih.gov/articles/PMC11870553/
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Optical Pooled Screening for the Discovery of Regulators of the Alternative Lengthening of Telomeres Pathway

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pmc.ncbi.nlm.nih.gov/articles/PMC11844499/
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Pyrimethamine and a potent analogue WCDD115 inhibit NRF2 by suppressing DHFR and one-carbon metabolism

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pmc.ncbi.nlm.nih.gov/articles/PMC11870417/
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CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation

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pmc.ncbi.nlm.nih.gov/articles/PMC11844498/
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Genomic and functional adaptations in guanylate-binding protein 5 (GBP5) highlight specificities of bat antiviral innate immunity

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pmc.ncbi.nlm.nih.gov/articles/PMC11844482/
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EndoMAP.v1, a Structural Protein Complex Landscape of Human Endosomes

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pmc.ncbi.nlm.nih.gov/articles/PMC11839024/
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Target cell adhesion limits macrophage phagocytosis and promotes trogocytosis

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pmc.ncbi.nlm.nih.gov/articles/PMC11839035/
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Listeria monocytogenes cell-to-cell spread bypasses nutrient limitation for replicating intracellular bacteria

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pmc.ncbi.nlm.nih.gov/articles/PMC11838505/
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Higher throughput assays for understanding the pathogenicity of variants of unknown significance (VUS) in the RPE65 gene

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pmc.ncbi.nlm.nih.gov/articles/PMC11838478/
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Haplotype rather than single causal variants effects contribute to regulatory gene expression associations in human myeloid cells

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pmc.ncbi.nlm.nih.gov/articles/PMC11838257/
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Astrocytic-supplied cholesterol drives synaptic gene expression programs in developing neurons and downstream astrocytic transcriptional programs

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pmc.ncbi.nlm.nih.gov/articles/PMC11838310/
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Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors

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pmc.ncbi.nlm.nih.gov/articles/PMC11785141/
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Signal peptide-independent secretion of keratin-19 by pancreatic cancer cells

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pmc.ncbi.nlm.nih.gov/articles/PMC11785074/
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Harnessing Extracellular Vesicles for Stabilized and Functional IL-10 Delivery in Macrophage Immunomodulation

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pmc.ncbi.nlm.nih.gov/articles/PMC11761701/
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Human cytomegalovirus gH/gL/gO binding to PDGFRα provides a regulatory signal activating the fusion protein gB that can be blocked by neutralizing antibodies

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pmc.ncbi.nlm.nih.gov/articles/PMC11741351/
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Cardiolipin deficiency disrupts CoQ-complex III interface in steatohepatitis

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pmc.ncbi.nlm.nih.gov/articles/PMC11482932/
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The SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunity

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pmc.ncbi.nlm.nih.gov/articles/PMC11838211/
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Multiplex, multimodal mapping of variant effects in secreted proteins

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pmc.ncbi.nlm.nih.gov/articles/PMC11838247/
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Trans-synaptic molecular context of NMDA receptor nanodomains

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pmc.ncbi.nlm.nih.gov/articles/PMC10769418/
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Deletion of Xist repeat B disrupts cell cycle and asymmetric cell division through Usp9x hyperactivation in mice

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pmc.ncbi.nlm.nih.gov/articles/PMC11880805/
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c-JUN: a chromatin repressor that limits mesoderm differentiation in human pluripotent stem cells

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pmc.ncbi.nlm.nih.gov/articles/PMC11760979/
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Harnessing transcriptional regulation of alternative end-joining to predict cancer treatment

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pmc.ncbi.nlm.nih.gov/articles/PMC11886861/
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The IGF2BP1 oncogene is a druggable m6A-dependent enhancer of YAP1-driven gene expression in ovarian cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC11850222/
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Deciphering the interplay between SETD2 mediated H3K36me3 and RNA N6-methyladenosine in clear cell renal cell carcinoma (ccRCC)

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pmc.ncbi.nlm.nih.gov/articles/PMC11776469/
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High CDC20 levels increase sensitivity of cancer cells to MPS1 inhibitors

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pmc.ncbi.nlm.nih.gov/articles/PMC11850905/
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The proximity-based protein interactome and regulatory logics of the transcription factor p65 NF-κB/RELA

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pmc.ncbi.nlm.nih.gov/articles/PMC11850942/
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Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1–HER3 signaling

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pmc.ncbi.nlm.nih.gov/articles/PMC11779641/
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Nematode serine protease inhibitor SPI-I8 negatively regulates host NF-κB signalling by hijacking MKRN1-mediated polyubiquitination of RACK1

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pmc.ncbi.nlm.nih.gov/articles/PMC11876351/
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TDP-43 nuclear retention is antagonized by hypo-phosphorylation of its C-terminus in the cytoplasm

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pmc.ncbi.nlm.nih.gov/articles/PMC11775348/
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Impaired MC3T3-E1 osteoblast differentiation triggered by oncogenic HRAS is rescued by the farnesyltransferase inhibitor Tipifarnib

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pmc.ncbi.nlm.nih.gov/articles/PMC11861272/
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A study on the production of extracellular vesicles derived from novel immortalized human placental mesenchymal stromal cells

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pmc.ncbi.nlm.nih.gov/articles/PMC11775310/
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Proteomic profiling identifies upregulation of aurora kinases causing resistance to taxane-type chemotherapy in triple negative breast cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC11762698/
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SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO

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pmc.ncbi.nlm.nih.gov/articles/PMC11864980/
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Structure-function relationship of ASH1L and histone H3K36 and H3K4 methylation

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pmc.ncbi.nlm.nih.gov/articles/PMC11883000/
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Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites

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pmc.ncbi.nlm.nih.gov/articles/PMC11876333/
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ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation

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pmc.ncbi.nlm.nih.gov/articles/PMC11871226/
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EZH2 serves as a viable therapeutic target for myeloma-induced osteolytic bone destruction

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pmc.ncbi.nlm.nih.gov/articles/PMC11782520/
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Cell adhesion and spreading on fluid membranes through microtubules-dependent mechanotransduction

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pmc.ncbi.nlm.nih.gov/articles/PMC11782702/
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A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC11772776/
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Genetic coupling of enhancer activity and connectivity in gene expression control

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pmc.ncbi.nlm.nih.gov/articles/PMC11772589/
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Gut dysbiosis conveys psychological stress to activate LRP5/β-catenin pathway promoting cancer stemness

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pmc.ncbi.nlm.nih.gov/articles/PMC11880501/
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Distinct outcomes from targeted perturbations of the multi-subunit SCFSkp2 E3 ubiquitin ligase in blocking Trp53/Rb1-null prostate tumorigenesis

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pmc.ncbi.nlm.nih.gov/articles/PMC11846996/
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Protocol for the purification and analysis of nuclear UFMylated proteins

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pmc.ncbi.nlm.nih.gov/articles/PMC11869847/
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FNDC5/irisin mitigates the cardiotoxic impacts of cancer chemotherapeutics by modulating ROS-dependent and -independent mechanisms

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pmc.ncbi.nlm.nih.gov/articles/PMC11850786/
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TMEM97 governs partial epithelial-mesenchymal transition of retinal pigment epithelial cells via the CTNND2-ADAM10 axis

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pmc.ncbi.nlm.nih.gov/articles/PMC11848774/
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Targeted nanoparticle delivery system for tumor-associated macrophage reprogramming to enhance TNBC therapy

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pmc.ncbi.nlm.nih.gov/articles/PMC11890257/
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Genome‐wide profiling of N6‐methyladenosine‐modified pseudogene‐derived long noncoding RNAs reveals the tumour‐promoting and innate immune‐restraining function of RPS15AP12 in ovarian cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC11859666/
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γ-secretase facilitates retromer-mediated retrograde transport

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  Addgene_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11883284/
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Isocyanic acid–mediated NLRP3 carbamoylation reduces NLRP3-NEK7 interaction and limits inflammasome activation

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  Addgene_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11887815/
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CellFIE: Integrating Pathway Discovery With Pooled Profiling of Perturbations Uncovers Pathways of Huntington’s Disease, Including Genetic Modifiers of Neuronal Development and Morphology

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pmc.ncbi.nlm.nih.gov/articles/PMC11870572/
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Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid

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  plasmid_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11871043/
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Activation of the imprinted Prader-Willi syndrome locus by CRISPR-based epigenome editing

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  Addgene_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11872474/
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Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson’s disease

1
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  RRID:Addgene_12259
  
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SOX9 haploinsufficiency reveals SOX9-Noggin interaction in BMP-SMAD signaling pathway in chondrogenesis

1
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  plasmid_12259
  
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RNF7‐Mediated ROS Targets Malignant Phenotype and Radiotherapy Sensitivity in Glioma With Different IDH1 Genotypes

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1. scibot 11 Mar 2025
  
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A functional map of phosphoprotein phosphatase regulation identifies an evolutionary conserved reductase for the catalytic metal ions

1
1. scibot 08 Mar 2025
  
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  RRID:Addgene_12259
  
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A novel alpha-synuclein K58N missense variant in a patient with Parkinson’s disease

1
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  RRID:Addgene_12259
  
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Lymph node macrophages drive immune tolerance and resistance to cancer therapy by induction of the immune-regulatory cytokine IL-33

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1. scibot 07 Mar 2025
  
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  RRID: Addgene_12259
  
  DOI: 10.1016/j.ccell.2025.02.017
  
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Metabolic engineering to facilitate anti-tumor immunity

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  12259
  
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Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells

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  plasmid_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11873113/
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Hypoxia inducible factor-1α drives cancer resistance to cuproptosis

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  Addgene_12259
  
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Blocking WNT7A Enhances MHC-I Antigen Presentation and Enhances the Effectiveness of Immune Checkpoint Blockade Therapy

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  RRID: Addgene 12259
  
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aacrjournals.org/cancerimmunolres/article/13/3/400/752015/Blocking-WNT7A-Enhances-MHC-I-Antigen-Presentation
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Mitochondrial fusion and cristae reorganization facilitate acquisition of cardiomyocyte identity during reprogramming of murine fibroblasts

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  Addgene_12259
  
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Tuning the tropism and infectivity of SARS-CoV-2 virus-like particles for mRNA delivery

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  RRID:Addgene_12259
  
  DOI: 10.1093/nar/gkaf133
  
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ENKD1 modulates innate immune responses through enhanced geranylgeranyl pyrophosphate synthase activity

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Adhesion strength of tumor cells predicts metastatic disease in vivo

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  RRID:Addgene_12259
  
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NGF regulates survival and differentiation of umbilical mesenchymal stem/stromal cells into GABAergic, dopaminergic and cholinergic lineages

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  RRID:Addgene_12
  
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HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy

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  AddgeneCat# 12259
  
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Large Donor CRISPR for Whole-Coding Sequence Replacement of Cell Adhesion Molecule LRRTM2

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  RRID:Addgene_12259
  
  DOI: 10.1523/JNEUROSCI.1461-24.2024
  
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jneurosci.org/content/45/7/e1461242024
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Dickkopf-1 promotes tumor progression of gefitinib- resistant non-small cell lung cancer through cancer cell-fibroblast interactions

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  RRID:Addgene_12259
  
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Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells

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The NF1 tumor suppressor regulates PD-L1 and immune evasion in melanoma

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Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer

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  RRID:Addgene_12259
  
  DOI: 10.1186/s13046-025-03334-6
  
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Feb 2025
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Deletions in Glial Fibrillary Acidic Protein Leading to Alterations in Intermediate Filament Assembly and Network Formation

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1. scibot 28 Feb 2025
  
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  Addgene, Cat. #12259
  
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mdpi.com/1422-0067/26/5/1913
52.53.155.43 52.53.155.43

PDF-html.html

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Endothelial Jagged1 levels and distribution are post-transcriptionally controlled by ZFP36 decay proteins

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  RRID: Addgene_12259
  
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Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors

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Potentiating anti-tumor immunity by re-engaging immune synapse molecules

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  RRID: Addgene_12259
  
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Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP

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  AddgeneCat# 12259
  
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translational-medicine.biomedcentral.com translational-medicine.biomedcentral.com

Integration of single-cell and bulk RNA sequencing to identify a distinct tumor stem cells and construct a novel prognostic signature for evaluating prognosis and immunotherapy in LUAD

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  plasmid_12
  
  DOI: 10.1186/s12967-025-06243-6
  
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translational-medicine.biomedcentral.com/articles/10.1186/s12967-025-06243-6
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Rapid and high-throughput screening of proteolysis targeting chimeras using a dual-reporter system expressing fluorescence protein and luciferase

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  12,259
  
  DOI: 10.1186/s12915-025-02153-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11846234/
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Massively parallel assessment of gene regulatory activity at human cortical structure associated variants

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  12259/)
  
  DOI: 10.1101/2025.02.08.635393
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11839127/
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Epigenetic priming promotes acquisition of tyrosine kinase inhibitor resistance and oncogene amplification in human lung cancer

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  12259
  
  DOI: 10.1101/2025.01.26.634826
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11838195/
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CPT1A-mediated MFF succinylation promotes stemness maintenance in ovarian cancer stem cells

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  pMD2.G
  
  DOI: 10.1038/s42003-025-07720-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11830779/
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Protocol for assessing the clogging of the mitochondrial translocase of the outer membrane by precursor proteins in human cells

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  plasmid_12259
  
  DOI: 10.1016/j.xpro.2025.103617
  
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Cullin-RING ligase BioE3 reveals molecular-glue-induced neosubstrates and rewiring of the endogenous Cereblon ubiquitome

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  12,259
  
  DOI: 10.1186/s12964-025-02091-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11841277/
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PARP7 inhibits type I interferon signaling to prevent autoimmunity and lung disease

1
1. scibot 23 Feb 2025
  
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  12259
  
  DOI: 10.1084/jem.20241184
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11837972/
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CRISPR screen reveals modifiers of rAAV production including known rAAV infection genes playing an unexpected role in vector production

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  12259
  
  DOI: 10.1016/j.omtm.2025.101408
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11840188/
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Mechanism of Centrosomal Protein 55 (CEP55) Loading Into Exosomes

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1. scibot 23 Feb 2025
  
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  pMD2.G
  
  DOI: 10.1002/jev2.70046
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11840697/
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Single-cell sequencing elucidates the mechanism of NUSAP1 in glioma and its diagnostic and prognostic significance

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  RRID:Addgene_12259
  
  DOI: 10.3389/fimmu.2025.1512867
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11835852/
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Chlamydia trachomatis impairs T cell priming by inducing dendritic cell death

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  Addgene_12259
  
  DOI: 10.1128/iai.00402-24
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11834465/
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TRIP13 protects pancreatic cancer cells against intrinsic and therapy-induced DNA replication stress

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pmc.ncbi.nlm.nih.gov/articles/PMC11838190/
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Non-AUG HIV-1 uORF translation elicits specific T cell immune response and regulates viral transcript expression

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  RRID:Addgene_12259
  
  DOI: 10.1038/s41467-025-56772-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11836288/
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RSAD2: A pathogenic interferon-stimulated gene at the maternal-fetal interface of patients with systemic lupus erythematosus

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1. scibot 21 Feb 2025
  
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  DOI: 10.1016/j.xcrm.2025.101974
  
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sciencedirect.com/science/article/pii/S2666379125000473
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Repurposing NAMPT inhibitors for germinal center B-cell-like diffuse large B-cell lymphoma

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  DOI: 10.1158/2643-3230.BCD-24-0020
  
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aacrjournals.org/bloodcancerdiscov/article/5/6/417/749227/Repurposing-NAMPT-Inhibitors-for-Germinal-Center-B
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Hyperthermic intrathoracic chemotherapy modulates the immune microenvironment of pleural mesothelioma and improves the impact of dual immune checkpoint inhibition

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1. scibot 20 Feb 2025
  
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  DOI: 10.1158/2326-6066.CIR-24-0245
  
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aacrjournals.org/cancerimmunolres/article/13/2/185/751253/Hyperthermic-Intrathoracic-Chemotherapy-Modulates
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Comprehensive Pan-Cancer Analysis of RAC1 Decoding the Impact on Cancer Prognosis and B cell immune Regulation

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pmc.ncbi.nlm.nih.gov/articles/PMC11783080/
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A self-activated and protective module enhances the preclinical performance of allogeneic anti-CD70 CAR-T cells

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pmc.ncbi.nlm.nih.gov/articles/PMC11792090/
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Host 3’ flap endonuclease Mus81 plays a critical role in trimming the terminal redundancy of hepatitis B virus relaxed circular DNA during covalently closed circular DNA formation

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1. scibot 18 Feb 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11801639/
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A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs

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pmc.ncbi.nlm.nih.gov/articles/PMC11801721/
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SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation

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pmc.ncbi.nlm.nih.gov/articles/PMC11800516/
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Multidimensional, integrative profiling identifies BCL2L1 methylation as a predictor of MCL1 dependency in pediatric malignancies

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Fusobacterium nucleatum promotes colorectal cancer through neogenesis of tumor stem cells

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1. scibot 18 Feb 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11785920/

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