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309 Matching Annotations

Dec 2022
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Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer

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1. scibot 17 Dec 2022
  
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  DOI: 10.1016/j.ccell.2022.11.016
  
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sciencedirect.com/science/article/pii/S1535610822005633
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Original research: Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity

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1. scibot 01 Dec 2022
  
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  DOI: 10.1136/jitc-2022-004806
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9703354/
Nov 2022
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STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2Dhi CD8+ T cell dysregulation and accumulation

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1. scibot 29 Nov 2022
  
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  DOI: 10.1016/j.immuni.2022.11.001
  
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sciencedirect.com/science/article/pii/S107476132200591X
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Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop

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1. scibot 24 Nov 2022
  
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  DOI: 10.1016/j.ccell.2022.11.002
  
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cell.com/cancer-cell/fulltext/S1535-6108(22)00549-9
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The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity

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1. scibot 15 Nov 2022
  
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  DOI: 10.1016/j.immuni.2022.10.020
  
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sciencedirect.com/science/article/pii/S1074761322005611
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Obesity enhances antiviral immunity in the genital mucosa through a microbiota-mediated effect on γδ T cells

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1. scibot 10 Nov 2022
  
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  DOI: 10.1016/j.celrep.2022.111594
  
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sciencedirect.com/science/article/pii/S2211124722014590
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Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma

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1. scibot 04 Nov 2022
  
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  DOI: 10.1016/j.ccell.2022.10.012
  
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sciencedirect.com/science/article/pii/S1535610822005037
Oct 2022
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Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy

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1. scibot 20 Oct 2022
  
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  DOI: 10.1016/j.immuni.2022.09.014
  
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sciencedirect.com/science/article/pii/S1074761322005088
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NOTCH induced MDSC recruitment after oHSV virotherapy in CNS cancer models modulates anti-tumor immunotherapy

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1. scibot 04 Oct 2022
  
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  DOI: 10.1158/1078-0432.CCR-21-2347
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8976724/
Sep 2022
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The ketone body β-hydroxybutyrate mitigates ILC2-driven airway inflammation by regulating mast cell function

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1. scibot 28 Sep 2022
  
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  DOI: 10.1016/j.celrep.2022.111437
  
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sciencedirect.com/science/article/pii/S2211124722012785
Jul 2022
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cir-22-0088-html.html

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1. scibot 29 Jul 2022
  
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  DOI: 10.1158/2326-6066.CIR-22-0088
  
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52.53.155.43/a65b09b78e7767f723c9ad153c89aec9ed13d4e6/cir-22-0088-html.html
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Group 3 innate lymphocytes make a distinct contribution to Type 17 immunity in bladder defence

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1. scibot 09 Jul 2022
  
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  DOI: 10.1016/j.isci.2022.104660
  
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sciencedirect.com/science/article/pii/S2589004222009324
Jun 2022
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Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes

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1. scibot 29 Jun 2022
  
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  DOI: 10.1016/j.celrep.2022.111011
  
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sciencedirect.com/science/article/pii/S2211124722008002
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PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment

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1. scibot 09 Jun 2022
  
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  DOI: 10.1016/j.celrep.2022.110914
  
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sciencedirect.com/science/article/pii/S221112472200691X
May 2022
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WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC

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1. scibot 19 May 2022
  
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  DOI: 10.1016/j.celrep.2022.110814
  
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sciencedirect.com/science/article/pii/S221112472200585X
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Topical therapy for regression and melanoma prevention of congenital giant nevi

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1. scibot 13 May 2022
  
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  DOI: 10.1016/j.cell.2022.04.025
  
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sciencedirect.com/science/article/pii/S009286742200472X
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Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

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1. scibot 12 May 2022
  
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  DOI: 10.1016/j.cell.2022.04.019
  
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sciencedirect.com/science/article/pii/S0092867422004664
Apr 2022
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Immunosuppressive tumor microenvironment in Uterine Serous Carcinoma via CCL7 signal with myeloid-derived suppressor cells

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1. scibot 29 Apr 2022
  
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  RRID:AB_1107780
  
  DOI: 10.1093/carcin/bgac032
  
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academic.oup.com/carcin/advance-article/doi/10.1093/carcin/bgac032/6556146
Mar 2022
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The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer

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1. scibot 15 Mar 2022
  
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  DOI: 10.1016/j.cmet.2022.02.010
  
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sciencedirect.com/science/article/pii/S1550413122000547
Feb 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity

2
1. scibot 11 Feb 2022
  
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  DOI: 10.1016/j.immuni.2022.01.006
  
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2. scibot 09 Feb 2022
  
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  RRID:AB_1107780
  
  DOI: 10.1016/j.immuni.2022.01.006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8888129/
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Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy

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1. scibot 04 Feb 2022
  
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  DOI: 10.1016/j.ccell.2022.01.002
  
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sciencedirect.com/science/article/pii/S1535610822000046
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ICAM-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression

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1. scibot 02 Feb 2022
  
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  DOI: 10.1016/j.devcel.2022.01.002
  
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sciencedirect.com/science/article/pii/S1534580722000028
Jan 2022
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MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells

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1. scibot 26 Jan 2022
  
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  DOI: 10.1016/j.ccell.2021.12.009
  
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sciencedirect.com/science/article/pii/S1535610821006620
Dec 2021
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Virulence factors perforate the pathogen-containing vacuole to signal efferocytosis

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1. scibot 24 Dec 2021
  
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  DOI: 10.1016/j.chom.2021.12.001
  
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sciencedirect.com/science/article/pii/S1931312821005667
mcr.aacrjournals.org mcr.aacrjournals.org

Opposing Effects of Granulocyte Colony-Stimulating Factor on the Initiation and Progression of Breast Cancer Bone Metastases

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1. scibot 22 Dec 2021
  
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  DOI: 10.1158/1541-7786.MCR-21-0243
  
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mcr.aacrjournals.org/content/19/12/2110
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Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance

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1. scibot 11 Dec 2021
  
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  DOI: 10.1038/s41467-021-27349-7
  
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nature.com/articles/s41467-021-27349-7
Oct 2021
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Cold exposure protects from neuroinflammation through immunologic reprogramming

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1. scibot 23 Oct 2021
  
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  DOI: 10.1016/j.cmet.2021.10.002
  
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sciencedirect.com/science/article/pii/S1550413121004800
Sep 2021
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Live Imaging of SARS-CoV-2 Infection in Mice Reveals that Neutralizing Antibodies Require Fc Function for Optimal Efficacy

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1. scibot 23 Sep 2021
  
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  DOI: 10.1016/j.immuni.2021.08.015
  
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Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma

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1. scibot 15 Sep 2021
  
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  DOI: 10.1016/j.xcrm.2021.100399
  
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sciencedirect.com/science/article/pii/S2666379121002573
Aug 2021
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Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope

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1. scibot 20 Aug 2021
  
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  DOI: 10.1016/j.cell.2021.07.006
  
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sciencedirect.com/science/article/pii/S0092867421008321
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Identification of a Locus in Mice that Regulates the Collateral Damage and Lethality of Virus Infection

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1. scibot 13 Aug 2021
  
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  DOI: 10.1016/j.celrep.2019.04.004
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6508094/
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Untitled document

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1. scibot 11 Aug 2021
  
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  DOI: 10.1016/j.immuni.2017.11.003
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5759774/
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Untitled document

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1. scibot 09 Aug 2021
  
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  DOI: 10.1016/j.immuni.2018.10.007
  
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sciencedirect.com/science/article/pii/S1074761318304485
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Untitled document

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1. scibot 09 Aug 2021
  
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  DOI: 10.1016/j.cell.2018.10.014
  
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sciencedirect.com/science/article/pii/S0092867418313229
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Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells

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1. scibot 01 Aug 2021
  
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  DOI: 10.1016/j.immuni.2018.11.014
  
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sciencedirect.com/science/article/pii/S1074761318305223
Jul 2021
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Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection

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Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells

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  InVivoMab rat IgG2b isotype control clone LTF-2
  
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Untitled document

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Untitled document

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T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation

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Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

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Untitled document

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A safe and effective mucosal RSV vaccine in mice consisting of RSV phosphoprotein and flagellin variant

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Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity

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Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity

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A vaccine inducing solely cytotoxic T lymphocytes fully prevents Zika virus infection and fetal damage

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Gut microbiota condition the therapeutic efficacy of trastuzumab in HER2-positive breast cancer

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Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis

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Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity

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Production of the Cytokine VEGF-A by CD4+ T and Myeloid Cells Disrupts the Corneal Nerve Landscape and Promotes Herpes Stromal Keratitis

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Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma

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CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance

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Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells

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HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins

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Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis

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CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

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The Intestinal Microbiome Restricts Alphavirus Infection and Dissemination through a Bile Acid-Type I IFN Signaling Axis

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Origin and Function of Stress-Induced IL-6 in Murine Models

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Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance

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Targeting obesity-induced macrophages during preneoplastic growth promotes mammary epithelial stem/progenitor activity, DNA damage and tumor formation

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Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure

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Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response

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GM-CSF Calibrates Macrophage Defense and Wound Healing Programs during Intestinal Infection and Inflammation

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Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response

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Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts

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TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes

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Coordinated Viral Control by Cytotoxic Lymphocytes Ensures Optimal Adaptive NK Cell Responses

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Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis

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Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction

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Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

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Th1-Th2 Cross-Regulation Controls Early Leishmania Infection in the Skin by Modulating the Size of the Permissive Monocytic Host Cell Reservoir

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Multifaceted Effects of Antigen Valency on B Cell Response Composition and Differentiation In Vivo

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CD4+ T Cells Cross-Reactive with Dengue and Zika Viruses Protect against Zika Virus Infection

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Hookworms Evade Host Immunity by Secreting a Deoxyribonuclease to Degrade Neutrophil Extracellular Traps

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ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis

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PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells

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Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors

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CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

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PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways

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EphA2 Is a Neutrophil Receptor for Candida albicans that Stimulates Antifungal Activity during Oropharyngeal Infection

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PD-1 Signaling Promotes Control of Chronic Viral Infection by Restricting Type-I-Interferon-Mediated Tissue Damage

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Neutrophil Extracellular Traps Initiate Gallstone Formation

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Proliferating Transitory T Cells with an Effector-like Transcriptional Signature Emerge from PD-1+ Stem-like CD8+ T Cells during Chronic Infection

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Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

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Untitled document

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Untitled document

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The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity

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Untitled document

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Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice

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Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection

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Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

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Mechanisms of Tumor-Induced Lymphovascular Niche Formation in Draining Lymph Nodes

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CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity

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LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance

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Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping

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LIGHT-HVEM Signaling in Innate Lymphoid Cell Subsets Protects Against Enteric Bacterial Infection

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LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis

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Non-conventional Inhibitory CD4+Foxp3−PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity

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Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis

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Daily Rhythms of TNFα Expression and Food Intake Regulate Synchrony of Plasmodium Stages with the Host Circadian Cycle

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Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

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Untitled document

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  RRID:AB_1107780
  
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cell.com/cell-host-microbe/abstract/S1931-3128(18)30217-8
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

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1. scibot 05 Nov 2018
  
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  RRID:AB_1107780
  
  Curator: @evieth
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5720393/
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Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction

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1. scibot 05 Nov 2018
  
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  RRID:AB_1107780
  
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sciencedirect.com/science/article/pii/S1074761317304806
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Staphylococcus aureus Virulent PSMα Peptides Induce Keratinocyte Alarmin Release to Orchestrate IL-17-Dependent Skin Inflammation

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1931312817304432
Nov 2017
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Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade

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1. scibot 08 Nov 2017
  
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  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1535610817302982

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