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396 Matching Annotations

Dec 2022
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DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma

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1. scibot 31 Dec 2022
  
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  DOI: 10.15252/embj.2022111961
  
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Gut microbiota-mediated nucleotide synthesis attenuates the response to neoadjuvant chemoradiotherapy in rectal cancer

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1. scibot 24 Dec 2022
  
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  DOI: 10.1016/j.ccell.2022.11.013
  
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p53/p21 pathway activation contributes to the ependymal fate decision downstream of GemC1

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  DOI: 10.1016/j.celrep.2022.111810
  
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sciencedirect.com/science/article/pii/S2211124722016989
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Allosteric regulation of DNA binding and target residence time drive the cytotoxicity of phthalazinone-based PARP-1 inhibitors

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1. scibot 11 Dec 2022
  
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  DOI: 10.1016/j.chembiol.2022.11.006
  
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sciencedirect.com/science/article/pii/S2451945622004123
Nov 2022
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Inhibition of glutaminolysis restores mitochondrial function in senescent stem cells

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sciencedirect.com/science/article/pii/S2211124722016229
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POLθ processes ssDNA gaps and promotes replication fork progression in BRCA1-deficient cells

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  DOI: 10.1016/j.celrep.2022.111716
  
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Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

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1. scibot 16 Nov 2022
  
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  DOI: 10.1016/j.neuron.2022.10.028
  
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sciencedirect.com/science/article/pii/S0896627322009618
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  DOI: 10.21203/rs.3.rs-658360/v1
  
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Physical confinement promotes mesenchymal trans-differentiation of invading transformed cells in vivo

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1. scibot 10 Nov 2022
  
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  DOI: 10.1016/j.isci.2022.105330
  
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Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death

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1. scibot 03 Nov 2022
  
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  DOI: 10.1016/j.chembiol.2022.10.005
  
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sciencedirect.com/science/article/pii/S2451945622003592
Oct 2022
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PARP-inhibition reprograms macrophages toward an anti-tumor phenotype

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1. scibot 13 Oct 2022
  
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  DOI: 10.1016/j.celrep.2022.111462
  
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sciencedirect.com/science/article/pii/S2211124722013079
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C9orf72 functions in the nucleus to regulate DNA damage repair

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1. scibot 12 Oct 2022
  
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  DOI: 10.1038/s41418-022-01074-0
  
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nature.com/articles/s41418-022-01074-0
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Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization

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1. scibot 07 Oct 2022
  
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  DOI: 10.1016/j.chembiol.2022.09.002
  
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Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival

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1. scibot 05 Oct 2022
  
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  DOI: 10.1016/j.celrep.2022.111435
  
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Sep 2022
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Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair

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1. scibot 29 Sep 2022
  
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  DOI: 10.15252/embr.202154136
  
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MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

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1. scibot 24 Sep 2022
  
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  DOI: 10.1016/j.ccell.2022.08.015
  
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sciencedirect.com/science/article/pii/S1535610822003798
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Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development

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1. scibot 15 Sep 2022
  
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  DOI: 10.1016/j.celrep.2022.111350
  
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sciencedirect.com/science/article/pii/S2211124722011780
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Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells

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1. scibot 13 Sep 2022
  
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  DOI: 10.1016/j.molcel.2022.08.017
  
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Aug 2022
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Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop

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1. scibot 30 Aug 2022
  
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  DOI: 10.1016/j.isci.2022.104944
  
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sciencedirect.com/science/article/pii/S2589004222012160
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Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells

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1. scibot 26 Aug 2022
  
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  DOI: 10.1016/j.molcel.2022.07.011
  
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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

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1. scibot 22 Aug 2022
  
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  DOI: 10.1016/j.ccell.2022.07.011
  
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Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer

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1. scibot 17 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111218
  
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Jun 2022
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mcr-21-0960-html.html

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1. scibot 30 Jun 2022
  
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  DOI: 10.1158/1541-7786.mcr-21-0960
  
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Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD

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1. scibot 30 Jun 2022
  
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  DOI: 10.1016/j.devcel.2022.06.003
  
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The SETDB1–TRIM28 complex suppresses antitumor immunity

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1. scibot 07 Jun 2022
  
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  DOI: 10.1158/2326-6066.CIR-21-0754
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8647838/
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MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression

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1. scibot 03 Jun 2022
  
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  DOI: 10.1016/j.celrep.2022.110879
  
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May 2022
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A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination

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1. scibot 25 May 2022
  
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Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis

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1. scibot 12 May 2022
  
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  DOI: 10.1016/j.celrep.2022.110761
  
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The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress

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1. scibot 11 May 2022
  
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  DOI: 10.7554/eLife.69255
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9064299/
Apr 2022
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Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS

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  DOI: 10.1016/j.molcel.2022.03.034
  
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Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage

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  DOI: 10.1016/j.devcel.2022.03.019
  
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Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies

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1. scibot 05 Apr 2022
  
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  DOI: 10.7554/eLife.73006
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8975554/
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A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress

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1. scibot 05 Apr 2022
  
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  DOI: 10.1038/s41598-022-09308-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8971416/
Mar 2022
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Chromatin-associated orphan snoRNA regulates DNA damage-mediated differentiation via a non-canonical complex

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1. scibot 30 Mar 2022
  
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  DOI: 10.1016/j.celrep.2022.110421
  
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Indirubin-3’-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma

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1. scibot 27 Mar 2022
  
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  DOI: 10.1016/j.ebiom.2022.103950
  
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Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration

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1. scibot 09 Mar 2022
  
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  DOI: 10.1016/j.celrep.2022.110473
  
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Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer

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SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage

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An oncogenic enhancer encodes selective selenium dependency in AML

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The cross-talk between Bax, Bcl2, caspases, and DNA damage in bystander HepG2 cells is regulated by γ-radiation dose and time of conditioned media transfer

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A stress-reduced passaging technique improves the viability of human pluripotent cells

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Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells

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A functional taxonomy of tumor suppression in oncogenic KRAS-driven lung cancer

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Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage

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Assessing kinetics and recruitment of DNA repair factors using high content screens

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EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion

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Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer

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Dynamic stem cell selection safeguards the genomic integrity of the epidermis

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DNA repair factor KAT5 prevents ischemic acute kidney injury through glomerular filtration regulation

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NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis

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Nephroprotective Effects of Synthetic Flavonoid Hidrosmin in Experimental Diabetic Nephropathy

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CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment

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The ESCRT machinery counteracts Nesprin-2G-mediated mechanical forces during nuclear envelope repair

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Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity

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Modulation of fracture healing by the transient accumulation of senescent cells

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NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer

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Isolation of human and murine hematopoietic stem cells for DNA damage and DNA repair assays

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CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models

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Long noncoding RNA lnc-POP1-1 upregulated by VN1R5 promotes cisplatin resistance in head and neck squamous cell carcinoma through interaction with MCM5

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Reading ADP-ribosylation signaling using chemical biology and interaction proteomics

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Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids

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GAGE mediates radio resistance in cervical cancers via the regulation of chromatin accessibility

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Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis

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RNF8 is not required for histone-to-protamine exchange in spermiogenesis

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Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis | The FASEB Journal

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Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe

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The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number

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  DOI: 10.1016/j.devcel.2018.09.021
  
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The SIAH1–HIPK2–p53ser46 Damage Response Pathway is Involved in Temozolomide-Induced Glioblastoma Cell Death

1
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  anti-γH2AX
  
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mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability

1
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  Phospho-Histone H2A.X S139
  
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Differential Sensitivity to CDK2 Inhibition Discriminates the Molecular Mechanisms of CHK1 Inhibitors as Monotherapy or in Combination with the Topoisomerase I Inhibitor SN38

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Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer’s disease and frontotemporal dementia

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Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

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Meiotic recombination mirrors patterns of germline replication in mice and humans

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Protein phosphatase 1 acts as a RIF1 effector to suppress DSB resection prior to Shieldin action

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Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target

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A non-genetic, cell cycle-dependent mechanism of platinum resistance in lung adenocarcinoma

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MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway

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A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways

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Bacterial genotoxins induce T cell senescence

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Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis

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BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse

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Mutations in Spliceosomal Genes PPIL1 and PRP17 Cause Neurodegenerative Pontocerebellar Hypoplasia with Microcephaly

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DNA Damage Promotes TMPRSS2-ERG Oncoprotein Destruction and Prostate Cancer Suppression via Signaling Converged by GSK3β and WEE1

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HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis

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Homology-directed repair protects the replicating genome from metabolic assaults

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Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability

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DNA Damage Promotes Epithelial Hyperplasia and Fate Mis-specification via Fibroblast Inflammasome Activation

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AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis

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Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment

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Defined p16High Senescent Cell Types Are Indispensable for Mouse Healthspan

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Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma

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Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity

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Influence of the microenvironment on modulation of the host response by typhoid toxin

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The multitargeted kinase inhibitor KW-2449 ameliorates cisplatin-induced nephrotoxicity by targeting RIPK1-mediated necroptosis

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  anti-phospho-γH2AX
  
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On the role of p53 in the cellular response to aneuploidy

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PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells

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Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice

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FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

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Differential Sensitivity to CDK2 Inhibition Discriminates the Molecular Mechanisms of CHK1 Inhibitors as Monotherapy or in Combination with the Topoisomerase I Inhibitor SN38

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The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure

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Tyrosine kinase inhibitors protect the salivary gland from radiation damage by increasing DNA double strand break repair

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Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51

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Schistosoma mansoni eggs induce Wnt/β-catenin signaling and activate the protooncogene c-Jun in human and hamster colon

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Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε

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Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells

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TNF Receptor 1 Promotes Early-Life Immunity and Protects against Colitis in Mice

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Persistent DNA Damage and Senescence in the Placenta Impacts Developmental Outcomes of Embryos

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A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer

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TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

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MYC Promotes Bone Marrow Stem Cell Dysfunction in Fanconi Anemia

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Phosphorylation of T107 by CamKIIδ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1

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Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis

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Activation of the Met receptor attenuates doxorubicin‐induced cardiotoxicity in vivo and in vitro

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BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation

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Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome

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METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation

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Single-Cell Transcriptomic Atlas of Primate Ovarian Aging

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Cerebral Dopamine Neurotrophic Factor Is Essential for Enteric Neuronal Development, Maintenance and Regulation of Gastrointestinal Transit

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BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancer

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Phospho-Ser784-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer

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PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

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Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes

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Hedgehog signaling enables repair of ribosomal DNA double-strand breaks

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Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

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Drug GRADE: An Integrated Analysis of Population Growth and Cell Death Reveals Drug-Specific and Cancer Subtype-Specific Response Profiles

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MicroRNA‐127‐5p impairs function of granulosa cells via HMGB2 gene in premature ovarian insufficiency

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TMEM173 Drives Lethal Coagulation in Sepsis

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Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy

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BPS Publications

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p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

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Stress-Induced Changes in Bone Marrow Stromal Cell Populations Revealed through Single-Cell Protein Expression Mapping

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Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization

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Amelioration of age‐related brain function decline by Bruton's tyrosine kinase inhibition

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Development and Characterization of a Wee1 Kinase Degrader

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CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

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Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium

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Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation

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A Yap-Myc-Sox2-p53 Regulatory Network Dictates Metabolic Homeostasis and Differentiation in Kras-Driven Pancreatic Ductal Adenocarcinomas

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Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells

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Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B

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Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity

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Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection

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Small-Molecule MYC Inhibitors Suppress Tumor Growth and Enhance Immunotherapy

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Patterns of Early p21 Dynamics Determine Proliferation-Senescence Cell Fate after Chemotherapy

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Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer

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Cerebral dopamine Neurotrophic factor–deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice

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Fibroblasts from patients with idiopathic pulmonary fibrosis are resistant to cisplatin-induced cell death via enhanced CK2-dependent XRCC1 activity

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High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells

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DNA Damage Signaling-Induced Cancer Cell Reprogramming as a Driver of Tumor Relapse

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JARID1B expression and its function in DNA damage repair are tightly regulated by miRNAs in breast cancer

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Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis

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TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency

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FXR Regulates Intestinal Cancer Stem Cell Proliferation

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Pregnancy in human <Emphasis Type="Italic">IAPP</Emphasis> transgenic mice recapitulates beta cell stress in type 2 diabetes

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The Cdkn1aSUPER Mouse as a Tool to Study p53-Mediated Tumor Suppression

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Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells

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Multi-level Proteomics Identifies CT45 as a Chemosensitivity Mediator and Immunotherapy Target in Ovarian Cancer

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Histone Ubiquitination by the DNA Damage Response Is Required for Efficient DNA Replication in Unperturbed S Phase

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Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion

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Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging

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MAST1 Drives Cisplatin Resistance in Human Cancers by Rewiring cRaf-Independent MEK Activation

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Untitled document

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Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling

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Detection of DNA Double Strand Breaks by γH2AX Does Not Result in 53bp1 Recruitment in Mouse Retinal Tissues

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SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation

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A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline

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PAF-Myc-Controlled Cell Stemness Is Required for Intestinal Regeneration and Tumorigenesis

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An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance

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Myeloid Cell-Derived Reactive Oxygen Species Induce Epithelial Mutagenesis

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Melanocyte Stem Cell Activation and Translocation Initiate Cutaneous Melanoma in Response to UV Exposure

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MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma

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A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development

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Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses

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A Sacrifice-for-Survival Mechanism Protects Root Stem Cell Niche from Chilling Stress

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Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes that Are Eliminated by the Immune System

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DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging

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BTBD18 Regulates a Subset of piRNA-Generating Loci through Transcription Elongation in Mice

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Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1

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In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

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MATE transport of the E. coli-derived genotoxin colibactin

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