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    Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging
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  3. Nov 2024
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    Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer
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    Chelating drug-induced labile Zn2+ with nanoparticle-encapsulated TPEN at low dose enhances lung cancer chemotherapy through inhibiting ABCB1
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  6. Oct 2024
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    Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer
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    Simple aneuploidy evades p53 surveillance and promotes niche factor-independent growth in human intestinal organoids
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    PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443213/
  10. Sep 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Disruption of perinatal myeloid niches impacts the aging clock of pancreatic β cells
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    gp78-regulated KAP1 phosphorylation induces radioresistance in breast cancer by facilitating PPP1CC/PPP2CA ubiquitination
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    In vivo DNA replication dynamics unveil aging-dependent replication stress
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    The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency
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    Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer
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    Protein UFMylation regulates early events during ribosomal DNA-damage response
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    Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer
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    Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy
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  19. Aug 2024
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    On the role of p53 in the cellular response to aneuploidy
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    Tumor Vessel Normalization via PFKFB3 Inhibition Alleviates Hypoxia and Increases Tumor Necrosis in Rectal Cancer upon Radiotherapy
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    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function
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    Senescent endometrial stromal cells transmit reactive oxygen species to the trophoblast-like cells and impair spreading of blastocyst-like spheroids
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    Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models
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      γ-H2AX

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  26. Jul 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-Myristoyltransferase Inhibition causes Mitochondrial Iron Overload and Parthanatos in TIM17A-dependent Aggressive Lung Carcinoma
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    Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling
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    A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer
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    The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway
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    Table 1 Antibody table.
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    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    Pancreatic cancer organoid-screening captures personalized sensitivity and chemoresistance suppression upon CYP3A5-targeted inhibition
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    Deubiquitylase OTUD3 regulates integrated stress response to suppress progression and sorafenib resistance of liver cancer
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    ADP-ribosylome analysis reveals homogeneous DNA-damage-induced serine ADP-ribosylation across wild-type and BRCA-mutant breast cancer cell lines
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    A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence
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    cell.com/cell/fulltext/S0092-8674(24)00693-7
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    CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer
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    cell.com/iscience/abstract/S2589-0042(24)01200-8
  38. Jun 2024
  39. www.cell.com www.cell.com
    Chemotherapy-induced intestinal epithelial damage directly promotes galectin-9-driven modulation of T cell behavior
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    cell.com/iscience/abstract/S2589-0042(24)01297-5
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    DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks
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    The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress
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  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC11167441/
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    Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice
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    Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress
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  45. May 2024
  46. 52.53.155.43 52.53.155.43
    Mechanisms Driving Fasting-Induced Protection from Genotoxic Injury in the Small Intestine
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      DOI: 10.1152/ajpgi.00126.2023

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    52.53.155.43/930a5a5a8b2489c0ec72d025108e06cc5c87d2d2/deans-fielder-et-al-2024-mechanisms-driving-fasting-induced-protection-from-genotoxic-injury-in-the-small-intestine-html.html
  47. journals.biologists.com journals.biologists.com
    Myc promotes polyploidy in murine trophoblast cells and suppresses senescence
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    TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks
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    CDK4/6 activity is required during G2 arrest to prevent stress-induced endoreplication
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    Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition
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    RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells
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    Selective DNA-PK inhibition enhances chemotherapy and ionizing radiation activity in soft-tissue sarcomas
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    Osteoclast-Cancer Cell Metabolic Crosstalk Confers PARP Inhibitor Resistance in Bone Metastatic Breast Cancer
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    Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence
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    D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder
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  89. www.mdpi.com www.mdpi.com
    The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian Insufficiency
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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody–Drug Conjugate for Targeting Melanoma
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  91. Nov 2023
  92. www.sciencedirect.com www.sciencedirect.com
    Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
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    Stress-induced β cell early senescence confers protection against type 1 diabetes
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  94. www.biorxiv.org www.biorxiv.org
    Endonucleosis mediates internalization of cytoplasm into the nucleus in senescent cells
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    Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors
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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
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  97. Oct 2023
  98. www.sciencedirect.com www.sciencedirect.com
    Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages
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    An activity-based functional test for identifying homologous recombination deficiencies across cancer types in real time
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    Synergistic antitumor efficacy of rMV-Hu191 and Olaparib in pancreatic cancer by generating oxidative DNA damage and ROS-dependent apoptosis
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    WIP1 is a novel specific target for growth hormone action
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  102. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LINE-1 activation in the cerebellum drives ataxia
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity
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    The splicing factor DHX38 enables retinal development through safeguarding genome integrity
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    Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells
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    Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases
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  108. Sep 2023
  109. www.sciencedirect.com www.sciencedirect.com
    WNK1 is required during male pachynema to sustain fertility.
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    The interplay of TARG1 and PARG protects against genomic instability
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    Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor
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    Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation
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  114. Aug 2023
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    Apical extrusion prevents apoptosis from activating an acute inflammatory program in epithelia
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    Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress
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    Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression
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  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer
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  120. 52.53.155.43 52.53.155.43
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  121. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
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    The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway
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    C1orf112 teams up with FIGNL1 to facilitate RAD51 filament disassembly and DNA interstrand cross-link repair
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    Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation
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    Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells
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  126. Jul 2023
  127. 52.53.155.43 52.53.155.43
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  128. Jun 2023
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    Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response
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    FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics
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    Detection of endogenous translesion DNA synthesis in single mammalian cells
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    Epithelial tissue confinement inhibits cell growth and leads to volume-reducing divisions
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    Cancer cell-autonomous cGAS-STING response confers drug resistance
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  136. May 2023
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    Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy
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    Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival
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  181. Sep 2022
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    Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
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    MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer
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    Endothelial cells regulated by RNF20 orchestrate the proliferation and differentiation of neural precursor cells during embryonic development
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    Error-prone repair of stalled replication forks drives mutagenesis and loss of heterozygosity in haploinsufficient BRCA1 cells
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  186. Aug 2022
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    Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop
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    Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells
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    Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer
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  191. Jun 2022
  192. 52.53.155.43 52.53.155.43
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    Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD
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    The SETDB1–TRIM28 complex suppresses antitumor immunity
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    MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression
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  196. May 2022
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    A PARylation-phosphorylation cascade promotes TOPBP1 loading and RPA-RAD51 exchange in homologous recombination
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    Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis
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  200. Apr 2022
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    Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
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    Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage
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    Dual signaling via interferon and DNA damage response elicits entrapment by giant PML nuclear bodies
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    A clinically relevant heterozygous ATR mutation sensitizes colorectal cancer cells to replication stress
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  205. Mar 2022
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    Chromatin-associated orphan snoRNA regulates DNA damage-mediated differentiation via a non-canonical complex
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    Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration
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    Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
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    SPARCLE, a p53-induced lncRNA, controls apoptosis after genotoxic stress by promoting PARP-1 cleavage
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    An oncogenic enhancer encodes selective selenium dependency in AML
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  213. Jan 2022
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    The cross-talk between Bax, Bcl2, caspases, and DNA damage in bystander HepG2 cells is regulated by γ-radiation dose and time of conditioned media transfer
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    Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells
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    A functional taxonomy of tumor suppression in oncogenic KRAS-driven lung cancer
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    Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage
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  219. Dec 2021
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    EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion
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    Multiomic analysis identifies CPT1A as a potential therapeutic target in platinum-refractory, high-grade serous ovarian cancer
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    Dynamic stem cell selection safeguards the genomic integrity of the epidermis
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    DNA repair factor KAT5 prevents ischemic acute kidney injury through glomerular filtration regulation
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    NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis
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    Nephroprotective Effects of Synthetic Flavonoid Hidrosmin in Experimental Diabetic Nephropathy
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