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Aug 2025
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Beauvericin disrupts G2/M transition and induces meiotic arrest during mouse oocyte maturation

1
1. scibot 20 Aug 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.reprotox.2025.109032
  
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sciencedirect.com/science/article/pii/S0890623825002035
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RNA Pol II inhibition activates cell death independently from the loss of transcription

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1. scibot 19 Aug 2025
  
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  DOI: 10.1016/j.cell.2025.07.034
  
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Inhibition of the minor spliceosome restricts the growth of a broad spectrum of cancers | EMBO reports

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1. scibot 12 Aug 2025
  
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  DOI: 10.1038/s44319-025-00511-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12332006/
Jul 2025
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Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer

1
1. scibot 29 Jul 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.xcrm.2025.102251
  
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sciencedirect.com/science/article/pii/S2666379125003246
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Comprehensive human proteome profiles across a 50-year lifespan reveal aging trajectories and signatures

1
1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.cell.2025.06.047
  
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cell.com/cell/abstract/S0092-8674(25)00749-4
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Retinoic acid-induced 2 deficiency impairs genomic stability in breast cancer

2
1. scibot 25 Jul 2025
  
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  DOI: 10.1186/s13058-025-02085-8
  
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2. scibot 25 Jul 2025
  
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  DOI: 10.1186/s13058-025-02085-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12285165/
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Divergent sex-specific effects on a ketogenic diet: Male, but not female, mice exhibit oxidative stress and cellular senescence

1
1. scibot 22 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116026
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00797-1
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Inhibition of the minor spliceosome restricts the growth of a broad spectrum of cancers

1
1. scibot 15 Jul 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1038/s44319-025-00511-8
  
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embopress.org/doi/10.1038/s44319-025-00511-8
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Oxidative stress and Kras mutation in Mist1+ cells act in a double-hit manner to drive gastric tumorigenesis

1
1. scibot 15 Jul 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.celrep.2025.116014
  
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sciencedirect.com/science/article/pii/S2211124725007855
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The ESCRT protein CHMP5 restricts bone formation by controlling endolysosome-mitochondrion-mediated cell senescence

1
1. scibot 08 Jul 2025
  
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  RRID:AB_2118009
  
  DOI: 10.7554/eLife.101984
  
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elifesciences.org/articles/101984
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Exposing the DNA methylation-responsive compartment of the leukaemic genome in T-ALL cell lines support its potential as a novel therapeutic target in T-ALL

1
1. scibot 08 Jul 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1186/s13148-025-01915-y
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12224799/
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Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer

1
1. scibot 02 Jul 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.xcrm.2025.102211
  
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sciencedirect.com/science/article/pii/S2666379125002848
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Combined Radiation and Endocrine Therapies Elicit Benefit in ER+ Breast Cancer

1
1. scibot 02 Jul 2025
  
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  RRID:AB_2118009
  
  DOI: 10.3390/cancers17121921
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12190792/
Jun 2025
www.cell.com www.cell.com

Systematic profiling reveals betaine as an exercise mimetic for geroprotection

1
1. scibot 26 Jun 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.cell.2025.06.001
  
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cell.com/cell/fulltext/S0092-8674(25)00635-X
52.53.155.43 52.53.155.43

eScholarship UC item 3v56z133-html.html

1
1. scibot 15 Jun 2025
  
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  RRID:AB_21180
  
  DOI: 10.1002/wsbm.1646
  
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52.53.155.43/979f92c97b68bc09dd7865dff874c1f59072c065/eScholarship UC item 3v56z133-html.html
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A precision image-guided model of stereotactic ablative radiotherapy for hepatocellular carcinoma

1
1. scibot 12 Jun 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1242/dmm.052301
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12128222/
52.53.155.43 52.53.155.43

1-s2.0-S2589004225011216-main-html.html

1
1. scibot 11 Jun 2025
  
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  AB_2118009
  
  DOI: 10.1016/j.isci.2025.112860
  
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52.53.155.43/2abcfe5fe766e4300373f461f78d375160fe8922/1-s2.0-S2589004225011216-main-html.html
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Microglial STING is a central safeguard against neurological decline with age

1
1. scibot 10 Jun 2025
  
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  RRID:AB_3696807
  
  DOI: 10.1016/j.celrep.2025.115749
  
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sciencedirect.com/science/article/pii/S2211124725005200
May 2025
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Functional analysis of pathological mutations in DNA topoisomerase 3A

1
1. scibot 31 May 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.celrep.2025.115764
  
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sciencedirect.com/science/article/pii/S2211124725005352
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YTHDF1 differentiates the contributing roles of mTORC1 in aging

1
1. scibot 29 May 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.molcel.2025.05.003
  
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sciencedirect.com/science/article/pii/S1097276525004083
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Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway

1
1. scibot 22 May 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.celrep.2025.115733
  
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sciencedirect.com/science/article/pii/S2211124725005042
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Convergent Genetic Adaptation in Human Tumors Developed Under Systemic Hypoxia and in Populations Living at High Altitudes

1
1. scibot 20 May 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1158/2159-8290.CD-24-0943
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12046333/
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CDK4/6 activity is required during G2 arrest to prevent stress induced endoreplication

1
1. scibot 20 May 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1126/science.adi2421
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11305671/
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Genomic context influences translesion synthesis DNA polymerase-dependent mechanisms of micronuclei induction by G-quadruplexes

1
1. scibot 17 May 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.celrep.2025.115706
  
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sciencedirect.com/science/article/pii/S2211124725004772
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Genetic modeling of ELP1-associated Sonic hedgehog medulloblastoma identifies MDM2 as a selective therapeutic target

1
1. scibot 17 May 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.ccell.2025.04.014
  
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sciencedirect.com/science/article/pii/S1535610825001734
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Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors

1
1. scibot 16 May 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.cell.2025.04.012
  
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sciencedirect.com/science/article/pii/S0092867425004143
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Fatty acid metabolism suppresses neonatal cardiomyocyte proliferation by increasing PDK4 and HMGCS2 expression through PPARδ

1
1. scibot 16 May 2025
  
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  RRID:AB_10121789
  
  DOI: 10.1371/journal.pone.0318178
  
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  RRID:AB_2118009 RRIDCUR:Unresolved
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pmc.ncbi.nlm.nih.gov/articles/PMC12061097/
Apr 2025
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The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy

1
1. scibot 19 Apr 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.celrep.2025.115605
  
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sciencedirect.com/science/article/pii/S2211124725003766
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Co-targeting BMI1 and MYC to eliminate cancer stem cells in squamous cell carcinoma

1
1. scibot 18 Apr 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.xcrm.2025.102077
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12147845/
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Alpha-synuclein regulates nucleolar DNA double-strand break repair in melanoma

1
1. scibot 16 Apr 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1126/sciadv.adq2519
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11980859/
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Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway

1
1. scibot 09 Apr 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.immuni.2025.03.005
  
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sciencedirect.com/science/article/pii/S1074761325001244
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PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma

1
1. scibot 08 Apr 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.celrep.2025.115541
  
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sciencedirect.com/science/article/pii/S2211124725003122
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Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner

1
1. scibot 05 Apr 2025
  
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  RRID:AB_2118009
  
  DOI: 10.3389/fonc.2025.1554059
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11967197/
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DSCC1 restrains 53BP1/RIF1 signaling at DNA double-strand breaks to promote homologous recombination repair

1
1. scibot 01 Apr 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.celrep.2025.115452
  
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sciencedirect.com/science/article/pii/S2211124725002232
Mar 2025
52.53.155.43 52.53.155.43

1-s2.0-S258900422500536X-main-html.html

2
1. scibot 29 Mar 2025
  
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  RRID:AB_2118009
  
  DOI: 10.1016/j.isci.2025.112275
  
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2. scibot 29 Mar 2025
  
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Targeting WEE1 kinase as a therapeutic strategy in ATIP3-deficient breast cancers

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Hepatic sphingomyelin phosphodiesterase 3 promotes steatohepatitis by disrupting membrane sphingolipid metabolism

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Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma

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A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair

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A non-catalytic function for Rad18 in sustaining glioblastoma proliferation

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Transketolase attenuates the chemotherapy sensitivity of glioma cells by modulating R-loop formation

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Mechanical Force-Induced cGAS Activation in Carcinoma Cells Facilitates Splenocytes into Liver to Drive Metastasis

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Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma

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Elraglusib Induces Cytotoxicity via Direct Microtubule Destabilization Independently of GSK3 Inhibition

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Alpha-synuclein knockout impairs melanoma development and alters DNA damage repair in the TG3 mouse model in a sex-dependent manner

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Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer

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Spatial organizations of heterochromatin underpin nuclear structural integrity of ventricular cardiomyocytes against mechanical stress

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Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging

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Distinct effects of sacituzumab govitecan and berzosertib on DNA damage response in ovarian cancer

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Chelating drug-induced labile Zn2+ with nanoparticle-encapsulated TPEN at low dose enhances lung cancer chemotherapy through inhibiting ABCB1

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Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer

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Simple aneuploidy evades p53 surveillance and promotes niche factor-independent growth in human intestinal organoids

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PKMYT1 Is a Marker of Treatment Response and a Therapeutic Target for CDK4/6 Inhibitor-Resistance in ER+ Breast Cancer

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Disruption of perinatal myeloid niches impacts the aging clock of pancreatic β cells

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gp78-regulated KAP1 phosphorylation induces radioresistance in breast cancer by facilitating PPP1CC/PPP2CA ubiquitination

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In vivo DNA replication dynamics unveil aging-dependent replication stress

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The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency

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Transient splicing inhibition causes persistent DNA damage and chemotherapy vulnerability in triple-negative breast cancer

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Protein UFMylation regulates early events during ribosomal DNA-damage response

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Enhancing efficacy of the MEK inhibitor trametinib with paclitaxel in KRAS-mutated colorectal cancer

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Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy

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On the role of p53 in the cellular response to aneuploidy

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Tumor Vessel Normalization via PFKFB3 Inhibition Alleviates Hypoxia and Increases Tumor Necrosis in Rectal Cancer upon Radiotherapy

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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

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Intermittent clearance of p21-highly-expressing cells extends lifespan and confers sustained benefits to health and physical function

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Senescent endometrial stromal cells transmit reactive oxygen species to the trophoblast-like cells and impair spreading of blastocyst-like spheroids

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Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models

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N-Myristoyltransferase Inhibition causes Mitochondrial Iron Overload and Parthanatos in TIM17A-dependent Aggressive Lung Carcinoma

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Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling

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A highly potent bi-thiazole inhibitor of LOX rewires collagen architecture and enhances chemoresponse in triple-negative breast cancer

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The splicing factor CCAR1 regulates the Fanconi anemia/BRCA pathway

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Table 1 Antibody table.

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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

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Pancreatic cancer organoid-screening captures personalized sensitivity and chemoresistance suppression upon CYP3A5-targeted inhibition

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Deubiquitylase OTUD3 regulates integrated stress response to suppress progression and sorafenib resistance of liver cancer

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ADP-ribosylome analysis reveals homogeneous DNA-damage-induced serine ADP-ribosylation across wild-type and BRCA-mutant breast cancer cell lines

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A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence

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CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer

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Chemotherapy-induced intestinal epithelial damage directly promotes galectin-9-driven modulation of T cell behavior

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DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks

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The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress

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Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity

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Pervasive nuclear envelope ruptures precede ECM signaling and disease onset without activating cGAS-STING in Lamin-cardiomyopathy mice

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Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

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Mechanisms Driving Fasting-Induced Protection from Genotoxic Injury in the Small Intestine

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Myc promotes polyploidy in murine trophoblast cells and suppresses senescence

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TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks

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ol_28_1_14449_PDF-html.html

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CDK4/6 activity is required during G2 arrest to prevent stress-induced endoreplication

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Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

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PRMT1 promotes epigenetic reprogramming associated with acquired chemoresistance in pancreatic cancer

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DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice

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Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication

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gaae015-html.html

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RAD52-dependent mitotic DNA synthesis is required for genome stability in Cyclin E1-overexpressing cells

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Y chromosome damage underlies testicular abnormalities in ATR-X syndrome

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Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates

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Telomere dysfunction alters intestinal stem cell dynamics to promote cancer

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SETD2 loss and ATR inhibition synergize to promote cGAS signaling and immunotherapy response in renal cell carcinoma

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Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape

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SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis

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First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

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CDK-independent role of D-type cyclins in regulating DNA mismatch repair

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A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis

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Selective DNA-PK inhibition enhances chemotherapy and ionizing radiation activity in soft-tissue sarcomas

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Osteoclast-Cancer Cell Metabolic Crosstalk Confers PARP Inhibitor Resistance in Bone Metastatic Breast Cancer

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Sphingolipid metabolism controls mammalian heart regeneration

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Targeting BCL2 overcomes resistance and augments response to aurora kinase B inhibition by AZD2811 in small cell lung cancer

1
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Identification of a First-in-Class Small Molecule Inhibitor of the eIF4E-RBM38 Complex that Enhances wild-type p53 Protein Translation for Tumor Growth Suppression

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Temozolomide sensitizes ARID1A-mutated cancers to PARP inhibitors

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Specialized replication mechanisms maintain genome stability at human centromeres

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Proline restores mitochondrial function and reverses aging hallmarks in senescent cells

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IGFBP3 Promotes Resistance to Olaparib via Modulating EGFR Signaling in Advanced Prostate Cancer

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RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma

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Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging

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O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK

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Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor

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Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence

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Therapy-induced normal tissue damage promotes breast cancer metastasis

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Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives

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FBXW7-loss sensitizes cells to ATR inhibition through induced mitotic catastrophe

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D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder

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The Role of Cellular Senescence in Cyclophosphamide-Induced Primary Ovarian Insufficiency

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A Cell Surface-Binding Antibody Atlas Nominates a MUC18-Directed Antibody–Drug Conjugate for Targeting Melanoma

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Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition

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Stress-induced β cell early senescence confers protection against type 1 diabetes

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Endonucleosis mediates internalization of cytoplasm into the nucleus in senescent cells

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Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors

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Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers

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Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages

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An activity-based functional test for identifying homologous recombination deficiencies across cancer types in real time

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Synergistic antitumor efficacy of rMV-Hu191 and Olaparib in pancreatic cancer by generating oxidative DNA damage and ROS-dependent apoptosis

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WIP1 is a novel specific target for growth hormone action

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LINE-1 activation in the cerebellum drives ataxia

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Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

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The splicing factor DHX38 enables retinal development through safeguarding genome integrity

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Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells

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Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases

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ccr-23-0103-html.html

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WNK1 is required during male pachynema to sustain fertility.

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The interplay of TARG1 and PARG protects against genomic instability

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Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor

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Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation

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Apical extrusion prevents apoptosis from activating an acute inflammatory program in epithelia

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Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress

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Aberrant accumulation of Kras-dependent pervasive transcripts during tumor progression renders cancer cells dependent on PAF1 expression

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Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer

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ccr-23-0103-html.html

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crc-23-0268-html.html

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Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine

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The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway

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C1orf112 teams up with FIGNL1 to facilitate RAD51 filament disassembly and DNA interstrand cross-link repair

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Elevated pre-mRNA 3′ end processing activity in cancer cells renders vulnerability to inhibition of cleavage and polyadenylation

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Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells

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ccr-23-0103-html.html

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Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response

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FIRRM/C1orf112 is synthetic lethal with PICH and mediates RAD51 dynamics

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Detection of endogenous translesion DNA synthesis in single mammalian cells

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Epithelial tissue confinement inhibits cell growth and leads to volume-reducing divisions

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DHX9-mediated pathway contributes to the malignant phenotype of Myelodysplastic syndromes

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Disease Tolerance Acquired Through Repeated Plasmodium Infection Involves Epigenetic Reprogramming of Innate Immune Cells

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Cancer cell-autonomous cGAS-STING response confers drug resistance

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ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis

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CKB regulates BCAR1 phosphorylation to facilitate DNA damage repair

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Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in β cells

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HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways

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Loss of fibroblast growth factor receptor 2 (FGFR2) leads to defective bladder urothelial regeneration after Cyclophosphamide injury

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Replication stress impairs chromosome segregation and preimplantation development in human embryos

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  DOI: 10.1016/j.cell.2022.06.028
  
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The p-rpS6-zone delineates wounding responses and the healing process

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1. scibot 26 Apr 2023
  
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Bromodomain protein BRD8 regulates cell cycle progression in colorectal cancer cells through a TIP60-independent regulation of the pre-RC complex

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N6-Methyladenosine RNA Modifications Regulate the Response to Platinum through Nicotinamide N-methyltransferase

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Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity

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Transcriptional-translational conflict is a barrier to cellular transformation and cancer progression

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Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response

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A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer

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Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis

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Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases

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Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy

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Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation

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Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow

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Mar 2023
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IFNγ blockade in capillary leak site improves tumour chemotherapy by inhibiting lactate-induced endocytosis of vascular endothelial-cadherins

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Loss of the Volume-regulated Anion Channel Components LRRC8A and LRRC8D Limits Platinum Drug Efficacy

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Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner

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Jan 2023
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Elevated PAF1-RAD52 axis confers chemoresistance to human cancers

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Loss of RanGAP1 drives chromosome instability and rapid tumorigenesis of osteosarcoma

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DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma

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