259 Matching Annotations
  1. Sep 2020
  2. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Occludin degradation makes brain microvascular endothelial cells more vulnerable to reperfusion injury in vitro
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    1. scibot 08 Sep 2020
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      DOI: 10.1111/jnc.15102

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15102
  3. www.cell.com www.cell.com
    The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
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    1. scibot 04 Sep 2020
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      DOI: 10.1016/j.celrep.2018.11.097

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    cell.com/cell-reports/fulltext/S2211-1247(18)31888-6
  4. www.nature.com www.nature.com
    GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic reticulum stress
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    1. scibot 03 Sep 2020
      anti-PARP1

      DOI: 10.1038/s41419-020-2255-0

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    nature.com/articles/s41419-020-2255-0
  5. Jan 2020
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    A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.ccell.2019.06.002

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    sciencedirect.com/science/article/pii/S1535610819302934
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    Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7
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      DOI: 10.1016/j.neuron.2019.11.019

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    sciencedirect.com/science/article/pii/S0896627319309833
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    TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma
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      DOI: 10.1016/j.celrep.2019.12.017

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    sciencedirect.com/science/article/pii/S2211124719316675
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    Development and Characterization of a Wee1 Kinase Degrader
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      DOI: 10.1016/j.chembiol.2019.10.013

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    sciencedirect.com/science/article/pii/S2451945619303587
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    The N-Degron Pathway Mediates ER-phagy
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      DOI: 10.1016/j.molcel.2019.06.028

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    sciencedirect.com/science/article/pii/S109727651930485X
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    Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.celrep.2019.11.007

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    sciencedirect.com/science/article/pii/S2211124719314780
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Immunometabolic Cross-Talk and Regulation of Endocrine and Metabolic Functions: Transgenic overexpression of CTRP3 prevents alcohol-induced hepatic triglyceride accumulation
    1
    1. scibot 13 Jan 2020
      AB_2160739

      DOI: 10.1152/ajpendo.00050.2018

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    ncbi.nlm.nih.gov/pmc/articles/PMC6415714/
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    21-benzylidene digoxin decreases proliferation by inhibiting the egfr/erk signaling pathway and induces apoptosis in hela cells
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      DOI: 10.1016/j.steroids.2019.108551

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    sciencedirect.com/science/article/pii/S0039128X19302417
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    BPS Publications
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    1. scibot 13 Jan 2020
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      DOI: 10.1111/bph.14713

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    Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.molcel.2019.06.040

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    sciencedirect.com/science/article/pii/S1097276519304976
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    Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets
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      DOI: 10.1016/j.chembiol.2019.06.003

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    sciencedirect.com/science/article/pii/S2451945619302041
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    Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.celrep.2019.09.009

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    sciencedirect.com/science/article/pii/S2211124719311866
  18. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Salidroside Protects Dopaminergic Neurons by Regulating the Mitochondrial MEF2D‐ND6 Pathway in the MPTP/MPP+‐Induced Model of Parkinson's Disease
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    1. scibot 13 Jan 2020
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      DOI: 10.1111/jnc.14868

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14868
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    Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss
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      DOI: 10.1016/j.celrep.2019.05.043

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    sciencedirect.com/science/article/pii/S2211124719306631
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NRG1 is a critical regulator of differentiation in TP63-driven squamous cell carcinoma
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      DOI: 10.7554/eLife.46551

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    ncbi.nlm.nih.gov/pmc/articles/PMC6606022/
  21. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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      RRID:AB_2160739

      DOI: 10.1016/j.celrep.2018.11.097

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    sciencedirect.com/science/article/pii/S2211124718318886
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    1. scibot 13 Jan 2020
      RRID:AB_2160739

      DOI: 10.1016/j.neuron.2019.01.001

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    sciencedirect.com/science/article/pii/S0896627319300029
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      RRID:AB_2160739

      DOI: 10.1016/j.molcel.2018.11.018

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    sciencedirect.com/science/article/pii/S1097276518309882
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    Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression
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      DOI: 10.1016/j.ebiom.2019.02.015

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    sciencedirect.com/science/article/pii/S2352396419300878
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      DOI: 10.1016/j.chembiol.2019.02.012

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    sciencedirect.com/science/article/pii/S2451945619300674
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    Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS
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      DOI: 10.1016/j.cels.2018.10.010

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    sciencedirect.com/science/article/pii/S2405471218304356
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      DOI: 10.1016/j.celrep.2018.11.099

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    sciencedirect.com/science/article/pii/S2211124718318904
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      DOI: 10.1016/j.molcel.2019.04.010

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    sciencedirect.com/science/article/pii/S1097276519302801
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      DOI: 10.1016/j.scr.2019.101390

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    sciencedirect.com/science/article/pii/S1873506119300200
  30. Nov 2018
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC6085539/
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    TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging
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    sciencedirect.com/science/article/pii/S0092867418309693
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    sciencedirect.com/science/article/pii/S2211124718312348
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    Subcellular Hsp70 Inhibitors Promote Cancer Cell Death via Different Mechanisms
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    sciencedirect.com/science/article/pii/S2451945618302241
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    sciencedirect.com/science/article/pii/S235239641830238X
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    ncbi.nlm.nih.gov/pmc/articles/PMC6037479/
  37. www.cell.com www.cell.com
    EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma
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    cell.com/cancer-cell/fulltext/S1535-6108(17)30561-5
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    Selective Loss of PARG Restores PARylation and Counteracts PARP Inhibitor-Mediated Synthetic Lethality
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    sciencedirect.com/science/article/pii/S1535610818302228
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    Elucidating the Role of the Maternal Embryonic Leucine Zipper Kinase in Adrenocortical Carcinoma
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    academic.oup.com/endo/article/159/7/2532/4999689
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    The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression
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    sciencedirect.com/science/article/pii/S1097276518300406
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    Genomic Aberrations that Activate D-type Cyclins Are Associated with Enhanced Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib
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    sciencedirect.com/science/article/pii/S1535610817305093
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SYK Inhibition Induces Apoptosis in Germinal Center-Like B Cells by Modulating the Antiapoptotic Protein Myeloid Cell Leukemia-1, Affecting B-Cell Activation and Antibody Production
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    ncbi.nlm.nih.gov/pmc/articles/PMC5928208/
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    Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy
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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe
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  45. www.sciencedirect.com www.sciencedirect.com
    Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy
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    Very Long Chain Fatty Acids Are Functionally Involved in Necroptosis
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  47. Nov 2017
  48. www.sciencedirect.com www.sciencedirect.com
    Chemical Proteomics Identifies Druggable Vulnerabilities in a Genetically Defined Cancer
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  49. www.sciencedirect.com www.sciencedirect.com
    A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development
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  50. academic.oup.com academic.oup.com
    Untitled document
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      Curator: @patriciaelyse_

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  51. www.sciencedirect.com www.sciencedirect.com
    Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication
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      Rabbit polyclonal anti-PARPCell SignalingCat# 9542

      Curator: @Jmenke

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    Paraoxonase 2 Facilitates Pancreatic Cancer Growth and Metastasis by Stimulating GLUT1-Mediated Glucose Transport
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  53. www.sciencedirect.com www.sciencedirect.com
    Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the TIM22 Protein Translocase in Mitochondria
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      Curator: @chewbeccax

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  54. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Clk1 –regulated aerobic glycolysis is involved in gliomas chemoresistance
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      Curator: @chewbeccax

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    BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment
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  56. www.sciencedirect.com www.sciencedirect.com
    RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma
    1
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      AB_2160739

      Curator: @gabimpine

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  57. journals.plos.org journals.plos.org
    Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival
    1
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      AB_2160739

      Curator: @Zeljana_Babic

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  58. www.sciencedirect.com www.sciencedirect.com
    Celastrol-Induced Nur77 Interaction with TRAF2 Alleviates Inflammation by Promoting Mitochondrial Ubiquitination and Autophagy
    1
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      AB_2160739

      Curator: @Zeljana_Babic

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  59. www.sciencedirect.com www.sciencedirect.com
    Pyroptosis and Apoptosis Pathways Engage in Bidirectional Crosstalk in Monocytes and Macrophages
    1
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      AB_2160739

      Curator: @Zeljana_Babic

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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sam68/KHDRBS1-dependent NF-κB activation confers radioprotection to the colon epithelium in γ-irradiated mice
    1
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      AB_2160739

      Curator: @gabimpine

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  61. www.sciencedirect.com www.sciencedirect.com
    The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes
    1
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      RIID: AB_2160739

      Curator: @jcabotaj

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  62. www.sciencedirect.com www.sciencedirect.com
    Acute administration of ucf-101 ameliorates the locomotor impairments induced by a traumatic spinal cord injury
    1
    1. scibot 08 Nov 2017
      AB_2160739

      Curator: @jcabotaj

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    sciencedirect.com/science/article/pii/S0306452215004789