239 Matching Annotations
  1. Jun 2024
  2. www.sciencedirect.com www.sciencedirect.com
    The ribotoxic stress response drives UV-mediated cell death
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    sciencedirect.com/science/article/pii/S0092867424005270
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hippo-PKCζ-NFκB signaling axis: A druggable modulator of chondrocyte responses to mechanical stress
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  4. May 2024
  5. www.sciencedirect.com www.sciencedirect.com
    TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks
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  6. 52.53.155.43 52.53.155.43
    ol_28_1_14449_PDF-html.html
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  7. www.biorxiv.org www.biorxiv.org
    Enhancement of colorectal cancer therapy through interruption of the HSF1-HSP90 axis by p53 activation or cell cycle inhibition
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    1. scibot 16 May 2024
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  8. www.cell.com www.cell.com
    Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma
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    cell.com/cell-reports-medicine/abstract/S2666-3791(24)00188-5
  9. Apr 2024
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11034028/
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Frequent loss of FAM126A expression in colorectal cancer results in selective FAM126B dependency
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  12. www.embopress.org www.embopress.org
    PARG-deficient tumor cells have an increased dependence on EXO1/FEN1-mediated DNA repair
    1
    1. scibot 18 Apr 2024
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    embopress.org/doi/full/10.1038/s44318-024-00043-2
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of NEK2 Promotes Chemosensitivity and Reduces KSHV-positive Primary Effusion Lymphoma Burden
    1
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  14. www.sciencedirect.com www.sciencedirect.com
    Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy
    1
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    sciencedirect.com/science/article/pii/S0006295224001813
  15. Mar 2024
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    Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L
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    1. scibot 29 Mar 2024
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    sciencedirect.com/science/article/pii/S2211124724003267
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
    2
    1. scibot 08 Mar 2024
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    sciencedirect.com/science/article/pii/S1097276524001291
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma
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  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A beneficial adaptive role for CHOP in driving cell fate selection during ER stress
    1
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  20. Feb 2024
  21. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  22. www.sciencedirect.com www.sciencedirect.com
    Visualization of translation reorganization upon persistent ribosome collision stress in mammalian cells
    1
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  23. www.biorxiv.org www.biorxiv.org
    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
    3
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    biorxiv.org/content/10.1101/2023.12.05.570182v1
  24. www.sciencedirect.com www.sciencedirect.com
    H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells
    2
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    sciencedirect.com/science/article/pii/S2211124724000354
  25. Jan 2024
  26. aacrjournals.org aacrjournals.org
    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
    1
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    aacrjournals.org/cancerrescommun/article/4/1/5/732220/Inhibition-of-PRL2-Upregulates-PTEN-and-Attenuates
  27. Dec 2023
  28. www.sciencedirect.com www.sciencedirect.com
    The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
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    sciencedirect.com/science/article/pii/S2211124723015930
  29. Nov 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Optimal inhaled oxygen and carbon dioxide concentrations for post-cardiac arrest cerebral reoxygenation and neurological recovery
    1
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      DOI: 10.1016/j.isci.2023.108476

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    sciencedirect.com/science/article/pii/S2589004223025531
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Entinostat Enhances the Efficacy of Chemotherapy in Small Cell Lung Cancer Through S-phase Arrest and Decreased Base Excision Repair
    1
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      DOI: 10.1158/1078-0432.CCR-23-1795

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    ncbi.nlm.nih.gov/pmc/articles/PMC10644001/
  32. www.sciencedirect.com www.sciencedirect.com
    Inhibiting G6PD by quercetin promotes degradation of EGFR T790M mutation
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    sciencedirect.com/science/article/pii/S2211124723014298
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A beneficial adaptive role for CHOP in driving cell fate selection during ER stress
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10055232/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia
    1
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      DOI: 10.1172/jci.insight.170065

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    ncbi.nlm.nih.gov/pmc/articles/PMC10619439/
  35. Oct 2023
  36. www.sciencedirect.com www.sciencedirect.com
    Methotrexate-based PROTACs as DHFR-specific chemical probes
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      DOI: 10.1016/j.chembiol.2023.09.014

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    sciencedirect.com/science/article/pii/S2451945623003331
  37. www.sciencedirect.com www.sciencedirect.com
    Breast Cancer Cells are Sensitized by Piperine to Radiotherapy through Estrogen Receptor-α mediated modulation of a Key NHEJ repair protein- DNA-PK
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    sciencedirect.com/science/article/pii/S0944711323004865
  38. Sep 2023
  39. dx.doi.org dx.doi.org
    TRβ Agonism Induces Tumor Suppression and Enhances Drug Efficacy in Anaplastic Thyroid Cancer in Female Mice
    1
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      DOI: 10.1210/endocr/bqad135

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    dx.doi.org/10.1210/endocr/bqad135
  40. Aug 2023
  41. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    HIF-1α inhibition in macrophages preserves acute liver failure by reducing IL-1β production
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      DOI: 10.1096/fj.202300428RR

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202300428RR
  42. www.sciencedirect.com www.sciencedirect.com
    Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules
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  43. 52.53.155.43 52.53.155.43
    Journal of Neurochemistry - 2023 - Kamte-html.html
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  44. 52.53.155.43 52.53.155.43
    mct-23-0025 (1)-html.html
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  45. 52.53.155.43 52.53.155.43
    SSRN-id4513724-html.html
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  46. Jul 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis
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    sciencedirect.com/science/article/pii/S2211124723008124
  48. www.biorxiv.org www.biorxiv.org
    Histone H1.2 Dependent Translocation of Poly (ADP-ribose) Initiates Parthanatos
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    biorxiv.org/content/10.1101/2023.06.18.545460v3
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    The RIG-I agonist M8 triggers cell death and natural killer cell activation in human papillomavirus-associated cancer and potentiates cisplatin cytotoxicity
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      DOI: 10.1007/s00262-023-03483-7

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  50. Jun 2023
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    ROS Induction Targets Persister Cancer Cells with Low Metabolic Activity in NRAS-Mutated Melanoma
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  52. May 2023
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    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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  55. Apr 2023
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    Stress granule formation inhibits stress-induced apoptosis by selectively sequestering executioner caspases
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    DNA-initiated epigenetic cascades driven by C9orf72 hexanucleotide repeat
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    The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia
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  59. Mar 2023
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    Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo
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    The effect of KTKEGV repeat motif and intervening ATVA sequence on α-synuclein solubility and assembly
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  62. Feb 2023
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    Beta-coronaviruses exploit cellular stress responses by modulating TFEB and TFE3 activity
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    IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells
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  68. Jan 2023
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    Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
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    SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD
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    The NLRP1 and CARD8 inflammasomes detect reductive stress
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    Decitabine enhances the tumoricidal potential of TRAIL via the epigenetic regulation of death receptor 4 in gastric cancer
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    Artesunate, a new antimalarial clinical drug, exhibits potent anti-AML activity by targeting the ROS/Bim and TFRC/Fe2+ pathways
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    NF-κB/RelA controlled A20 limits TRAIL-induced apoptosis in pancreatic cancer
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  77. Dec 2022
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    Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD+ regeneration in KRas-mutant lung adenocarcinoma
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    Raptinal induces Gasdermin E-dependent pyroptosis in naive and therapy-resistant melanoma
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  82. Nov 2022
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    Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression
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  91. Sep 2022
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    Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
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    GSK3β Inhibition Is the Molecular Pivot That Underlies the Mir-210-Induced Attenuation of Intrinsic Apoptosis Cascade during Hypoxia
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  98. Jul 2022
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    Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression
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    A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions
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    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
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    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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    Targeting the miR-34a/LRPPRC/MDR1 axis collapse the chemoresistance in P53 inactive colorectal cancer
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    Melanomas with concurrent BRAF non-p.V600 and NF1 loss-of-function mutations are targetable by BRAF/MEK inhibitor combination therapy
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    Indirubin-3’-monoxime acts as proteasome inhibitor: Therapeutic application in multiple myeloma
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    Autophagic and apoptotic cell death induced by the quinoline derivative 2-(6-methoxynaphthalen-2-yl)quinolin-4-amine in pancreatic cancer cells is via ER stress and inhibition of Akt/mTOR signaling pathway
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    Acetyl-CoA production by specific metabolites promotes cardiac repair after myocardial infarction via histone acetylation
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    AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia
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    Halofuginone Sensitizes Lung Cancer Organoids to Cisplatin via Suppressing PI3K/AKT and MAPK Signaling Pathways
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  135. Nov 2021
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    ERα determines the chemoresistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions
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    Synergistic PIM kinase and proteasome inhibition as a therapeutic strategy for MYC-overexpressing triple-negative breast cancer
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    The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors
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  151. academic.oup.com academic.oup.com
    Hormonal and Growth Regulation of Epithelial and Stromal Cells From the Normal and Malignant Endometrium by Pigment Epithelium-Derived Factor
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  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  153. Jul 2021
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    Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate
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  155. www.nature.com www.nature.com
    Targeting Wnt/EZH2/microRNA-708 signaling pathway inhibits neuroendocrine differentiation in prostate cancer
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  156. rupress.org rupress.org
    Chemotherapy-induced senescent cancer cells engulf other cells to enhance their survival
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    The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number
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    mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
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  160. academic.oup.com academic.oup.com
    IGFBP-3 Induced by Ribotoxic Stress Traffics From the Endoplasmic Reticulum to the Nucleus in Mammary Epithelial Cells
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  162. www.sciencedirect.com www.sciencedirect.com
    Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer
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    Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm
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    FANCI functions as a repair/apoptosis switch in response to DNA crosslinks
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    Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency
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    Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
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  167. Jun 2021
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    Revealing molecular pathways for cancer cell fitness through a genetic screen of the cancer translatome
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    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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    Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs
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    Intracellular H2S production is an autophagy-dependent adaptive response to DNA damage
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  173. May 2021
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    Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells
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    Integrated Screens Identify CDK1 as a Therapeutic Target in Advanced Gastrointestinal Stromal Tumors
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    A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade
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    Epigenetic Regulation of DNA Repair Pathway Choice by MacroH2A1 Splice Variants Ensures Genome Stability
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    Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability
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    Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells
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    Transcriptional control of DNA repair networks by CDK7 regulates sensitivity to radiation in MYC-driven medulloblastoma
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    Endogenous retrovirus expression activates type-I interferon signaling in an experimental mouse model of mesothelioma development
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    CARM1 regulates replication fork speed and stress response by stimulating PARP1
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    Control of replication stress and mitosis in colorectal cancer stem cells through the interplay of PARP1, MRE11 and RAD51
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    FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells
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    Physical activity and advanced cancer: evidence of exercise‐sensitive genes regulating prostate cancer cell proliferation and apoptosis
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  195. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRD4-mediated repression of p53 is a target for combination therapy in AML
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    Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity
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    Schistosoma mansoni eggs induce Wnt/β-catenin signaling and activate the protooncogene c-Jun in human and hamster colon
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  198. Dec 2020
  199. www.sciencedirect.com www.sciencedirect.com
    Defective ALC1 nucleosome remodeling confers PARPi sensitization and synthetic lethality with HRD
    1
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      RRID:AB_216073

      DOI: 10.1016/j.molcel.2020.12.006

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  200. Nov 2020
  201. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TSPAN1: A Novel Protein Involved in Head and Neck Squamous Cell Carcinoma Chemoresistance
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      PARP1

      DOI: 10.3390/cancers12113269

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  202. Oct 2020
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    A uro-protective agent with restorative actions on urethral and striated muscle morphology
    1
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      DOI: 10.1007/s00345-020-03492-6

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    A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis
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      DOI: 10.1016/j.celrep.2020.108284

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    Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG
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    Glycometabolic Regulation of the Biogenesis of Small Extracellular Vesicles
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    Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis
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  208. Sep 2020
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    Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer
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    Novel HDAC inhibitor MAKV-8 and imatinib synergistically kill chronic myeloid leukemia cells via inhibition of BCR-ABL/MYC-signaling: effect on imatinib resistance and stem cells
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    Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction
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    MYC Dysregulates Mitosis, Revealing Cancer Vulnerabilities
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    PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response
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    BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancer
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    Nutlin-Induced Apoptosis Is Specified by a Translation Program Regulated by PCBP2 and DHX30
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    FBXW7 Confers Radiation Survival by Targeting p53 for Degradation
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      DOI: 10.1016/j.celrep.2019.12.032

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  218. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Synthesis, biological evaluation and toxicity of novel tetrandrine analogues
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    SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP
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    Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma
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    Occludin degradation makes brain microvascular endothelial cells more vulnerable to reperfusion injury in vitro
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      DOI: 10.1111/jnc.15102

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    The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
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      DOI: 10.1016/j.celrep.2018.11.097

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    GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic reticulum stress
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      anti-PARP1

      DOI: 10.1038/s41419-020-2255-0

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  224. Jan 2020
  225. www.sciencedirect.com www.sciencedirect.com
    A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor
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      RRID:AB_2160739

      DOI: 10.1016/j.ccell.2019.06.002

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    Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7
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      DOI: 10.1016/j.neuron.2019.11.019

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    TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma
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    Development and Characterization of a Wee1 Kinase Degrader
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    The N-Degron Pathway Mediates ER-phagy
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    Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes
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    Immunometabolic Cross-Talk and Regulation of Endocrine and Metabolic Functions: Transgenic overexpression of CTRP3 prevents alcohol-induced hepatic triglyceride accumulation
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    Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover
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    Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets
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    Salidroside Protects Dopaminergic Neurons by Regulating the Mitochondrial MEF2D‐ND6 Pathway in the MPTP/MPP+‐Induced Model of Parkinson's Disease
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    1. scibot 13 Jan 2020
      RRID:AB_2160739

      DOI: 10.1016/j.neuron.2019.01.001

      Resource: (Cell Signaling Technology Cat# 9542, RRID:AB_2160739)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_2160739

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      RRID:AB_2160739 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0896627319300029