131 Matching Annotations
  1. Oct 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Leucine restriction ameliorates Fusobacterium nucleatum-driven malignant progression and radioresistance in nasopharyngeal carcinoma
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    1. scibot 02 Oct 2024
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      DOI: 10.1016/j.xcrm.2024.101753

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    sciencedirect.com/science/article/pii/S266637912400483X
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application
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    1. scibot 02 Oct 2024
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      DOI: 10.1038/s41467-024-52110-1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11427689/
  4. Sep 2024
  5. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Neuronal and glial cell alterations involved in the retinal degeneration of the familial dysautonomia optic neuropathy
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    1. scibot 27 Sep 2024
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      DOI: 10.1002/glia.24612

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    onlinelibrary.wiley.com/doi/10.1002/glia.24612
  6. www.mdpi.com www.mdpi.com
    Structure–Activity Relationships and Molecular Docking Analysis of Mcl-1 Targeting Renieramycin T Analogues in Patient-derived Lung Cancer Cells
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    1. scibot 25 Sep 2024
      RRID:AB_2160739

      DOI: 10.3390/cancers12040875

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    mdpi.com/2072-6694/12/4/875
  7. www.sciencedirect.com www.sciencedirect.com
    Starvation-induced phosphorylation activates gasdermin A to initiate pyroptosis
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    1. scibot 11 Sep 2024
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      DOI: 10.1016/j.celrep.2024.114728

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    sciencedirect.com/science/article/pii/S2211124724010799
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    Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma
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    1. scibot 05 Sep 2024
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    sciencedirect.com/science/article/pii/S2666379124004270
  9. Aug 2024
  10. www.cell.com www.cell.com
    Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation
    1
    1. scibot 13 Aug 2024
      RRID: 659884

      DOI: 10.4414/saez.2012.00493

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    cell.com/cell-reports/fulltext/S2211-1247(24)00493-5
  11. cellandbioscience.biomedcentral.com cellandbioscience.biomedcentral.com
    Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma
    1
    1. scibot 02 Aug 2024
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    cellandbioscience.biomedcentral.com/article/10.1186/s13578-021-00640-2
  12. Jul 2024
  13. www.cell.com www.cell.com
    Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK
    1
    1. scibot 30 Jul 2024
      RRID:AB_659884

      DOI: 10.1016/j.chom.2024.07.001

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    cell.com/cell-host-microbe/abstract/S1931-3128(24)00254-3
  14. www.sciencedirect.com www.sciencedirect.com
    Translocational attenuation mediated by the PERK-SRP14 axis is a protective mechanism of unfolded protein response
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    1. scibot 23 Jul 2024
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    sciencedirect.com/science/article/pii/S2211124724007307
  15. www.biorxiv.org www.biorxiv.org
    Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor
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    1. scibot 04 Jul 2024
      RRID:AB_659884

      DOI: 10.1101/2024.06.11.598518

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    biorxiv.org/content/10.1101/2024.06.11.598518v2
  16. Jun 2024
  17. www.sciencedirect.com www.sciencedirect.com
    The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress
    1
    1. scibot 21 Jun 2024
      RRID:AB_659884

      DOI: 10.1016/j.celrep.2024.114366

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    sciencedirect.com/science/article/pii/S2211124724006946
  18. May 2024
  19. www.nature.com www.nature.com
    Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer
    1
    1. scibot 30 May 2024
      RRID:AB_659884

      DOI: 10.1038/s41416-024-02697-5

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    nature.com/articles/s41416-024-02697-5
  20. www.sciencedirect.com www.sciencedirect.com
    Targeted blocking of EGFR and GLUT1 by compound H reveals a new strategy for treatment of triple-negative breast cancer and nasopharyngeal carcinoma
    1
    1. scibot 07 May 2024
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    sciencedirect.com/science/article/pii/S0928098724001003
  21. Apr 2024
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells
    1
    1. scibot 10 Apr 2024
      RRID:AB_659884

      DOI: 10.1158/2767-9764.CRC-23-0488

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    ncbi.nlm.nih.gov/pmc/articles/PMC10993856/
  23. www.sciencedirect.com www.sciencedirect.com
    The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity
    1
    1. scibot 02 Apr 2024
      CSTCat# 9532S; RRID:AB_659884

      DOI: 10.1016/j.cell.2024.03.002

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    sciencedirect.com/science/article/pii/S0092867424002502
  24. Mar 2024
  25. www.nature.com www.nature.com
    Light-mediated intracellular polymerization
    1
    1. scibot 26 Mar 2024
      RRID:AB_659884

      DOI: 10.1038/s41596-024-00970-8

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    nature.com/articles/s41596-024-00970-8
  26. Feb 2024
  27. www.sciencedirect.com www.sciencedirect.com
    Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
    1
    1. scibot 23 Feb 2024
      RRID:AB_659884

      DOI: 10.1016/j.celrep.2024.113845

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    sciencedirect.com/science/article/pii/S2211124724001736
  28. www.mdpi.com www.mdpi.com
    Lumbricus Extract Prevents LPS-Induced Inflammatory Activation of BV2 Microglia and Glutamate-Induced Hippocampal HT22 Cell Death by Suppressing MAPK/NF-κB/NLRP3 Signaling and Oxidative Stress
    1
    1. scibot 13 Feb 2024
      AB_659884

      DOI: 10.3390/cimb45120620

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    mdpi.com/1467-3045/45/12/620
  29. Jan 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning
    1
    1. scibot 23 Jan 2024
      RRID: AB_659884

      DOI: 10.1186/s13578-023-01179-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC10800076/
  31. www.sciencedirect.com www.sciencedirect.com
    Lymph node and tumor-associated PD-L1+ macrophages antagonize dendritic cell vaccines by suppressing CD8+ T cells
    1
    1. scibot 19 Jan 2024
      RRID:AB_659884

      DOI: 10.1016/j.xcrm.2023.101377

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    sciencedirect.com/science/article/pii/S2666379123006067
  32. Dec 2023
  33. www.sciencedirect.com www.sciencedirect.com
    The Crucial Role of Single-Stranded DNA Binding in Enhancing Sensitivity to DNA-Damaging Agents for Schlafen 11 and Schlafen 13
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    1. scibot 21 Dec 2023
      RRID:AB_659884

      DOI: 10.1016/j.isci.2023.108529

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    sciencedirect.com/science/article/pii/S2589004223026068
  34. Nov 2023
  35. www.sciencedirect.com www.sciencedirect.com
    MiR-337-3p improves metabolic-associated fatty liver disease through regulation of glycolipid metabolism
    1
    1. scibot 29 Nov 2023
      RRID:AB_659884

      DOI: 10.1016/j.isci.2023.108352

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    sciencedirect.com/science/article/pii/S258900422302429X
  36. www.sciencedirect.com www.sciencedirect.com
    A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.xcrm.2023.101286

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    sciencedirect.com/science/article/pii/S2666379123004809
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins
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    1. scibot 11 Nov 2023
      RRID:AB_659884

      DOI: 10.1097/BS9.0000000000000168

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      RRID:AB_659884

      DOI: 10.1097/BS9.0000000000000168

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    ncbi.nlm.nih.gov/pmc/articles/PMC10629731/
  38. Oct 2023
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inducing Mitotic Catastrophe as a Therapeutic Approach to Improve Outcomes in Ewing Sarcoma
    1
    1. scibot 31 Oct 2023
      RRID:AB_659884

      DOI: 10.3390/cancers15204911

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    ncbi.nlm.nih.gov/pmc/articles/PMC10605681/
  40. 52.53.155.43 52.53.155.43
    Preprints202309.2164.v1-html.html
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      DOI: 10.20944/preprints202309.2164.v1

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    52.53.155.43/90a9b3d86bbedfe17ef71e7103069ab41e9b198e/Preprints202309.2164.v1-html.html
  41. Sep 2023
  42. www.nature.com www.nature.com
    Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
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    1. scibot 22 Sep 2023
      RRID:AB_659884

      DOI: 10.1038/s41422-023-00874-4

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    nature.com/articles/s41422-023-00874-4
  43. www.embopress.org www.embopress.org
    CCDC50 promotes tumor growth through regulation of lysosome homeostasis
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      DOI: 10.15252/embr.202356948

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    embopress.org/doi/full/10.15252/embr.202356948
  44. www.sciencedirect.com www.sciencedirect.com
    PARP1 inhibition protects mice against Japanese encephalitis virus infection
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      DOI: 10.1016/j.celrep.2023.113103

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    sciencedirect.com/science/article/pii/S2211124723011142
  45. Aug 2023
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activator protein-1 (AP-1) signaling inhibits the growth of Ewing sarcoma cells in response to DNA replication stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC10434289/
  47. 52.53.155.43 52.53.155.43
    crc-23-0268-html.html
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  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma
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      DOI: 10.1016/j.isci.2023.107369

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    ncbi.nlm.nih.gov/pmc/articles/PMC10393801/
  49. www.nature.com www.nature.com
    Molecular basis for nuclear accumulation and targeting of the inhibitor of apoptosis BIRC2
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      DOI: 10.1038/s41594-023-01044-1

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    nature.com/articles/s41594-023-01044-1
  50. Jun 2023
  51. www.sciencedirect.com www.sciencedirect.com
    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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      DOI: 10.1016/j.celrep.2023.112632

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    sciencedirect.com/science/article/pii/S2211124723006435
  52. onlinelibrary.wiley.com onlinelibrary.wiley.com
    PICT-1 regulates p53 splicing and sensitivity of medullary thyroid carcinoma cells to Everolimus
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      DOI: 10.1111/jne.13187

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    onlinelibrary.wiley.com/doi/10.1111/jne.13187
  53. www.sciencedirect.com www.sciencedirect.com
    Cancer cell-autonomous cGAS-STING response confers drug resistance
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      RRID:AB_659884

      DOI: 10.1016/j.chembiol.2023.05.005

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    sciencedirect.com/science/article/pii/S2451945623001411
  54. Apr 2023
  55. www.sciencedirect.com www.sciencedirect.com
    DTX3L E3 ligase targets p53 for degradation at poly ADP-ribose polymerase-associated DNA damage sites
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      RRID:AB_659884

      DOI: 10.1016/j.isci.2023.106444

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    sciencedirect.com/science/article/pii/S2589004223005217
  56. Mar 2023
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Harnessing transcriptionally driven chromosomal instability adaptation to target therapy-refractory lethal prostate cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC9975292/
  58. Jan 2023
  59. aacrjournals.org aacrjournals.org
    ER-001259851-000, a novel selective inhibitor of AXL, overcomes resistance to antimitotic drugs
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    DGKB mediates radioresistance by regulating DGAT1-dependent lipotoxicity in glioblastoma
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  61. Dec 2022
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    Neuroprotective and Anti-Neuroinflammatory Properties of Vignae Radiatae Semen in Neuronal HT22 and Microglial BV2 Cell Lines
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    Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling
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    Selaginella tamariscina Inhibits Glutamate-Induced Autophagic Cell Death by Activating the PI3K/AKT/mTOR Signaling Pathways
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    Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer
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    The Neuroprotective Effects of Arecae Pericarpium against Glutamate-Induced HT22 Cell Cytotoxicity
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  67. Nov 2022
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    circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells
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    Identification of phosphorylation site on PARP1 mediating its cytosolic translocation in virus-infected HeLa cells
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    Targeting the MITF/APAF-1 axis as salvage therapy for MAPK inhibitors in resistant melanoma
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    P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection
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  73. Oct 2022
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    PARP-inhibition reprograms macrophages toward an anti-tumor phenotype
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  75. Sep 2022
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    The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling
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    Targeting of c-MET and AXL by cabozantinib is a potential therapeutic strategy for patients with head and neck cell carcinoma
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    Combined treatment of marizomib and cisplatin modulates cervical cancer growth and invasion and enhances antitumor potential in vitro and in vivo
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  79. Aug 2022
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    Identification of Src as a Therapeutic Target in Oesophageal Adenocarcinoma through Functional Genomic and High-Throughput Drug Screening Approaches
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  82. Jul 2022
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    Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines
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    Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma
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    LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance
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  86. Jun 2022
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    Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
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    Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators
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    miR-4463 Regulates Hypoxia-Induced Autophagy and Apoptosis by Targeting ULK1 in Endothelial Cells
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    Neuregulin-1/ErbB4 signaling modulate Plasmodium falciparum HRP2-induced damage to brain cortical organoids
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  92. Apr 2022
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    Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS
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  94. Mar 2022
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    Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness
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    Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments
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  97. Feb 2022
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    LncRNA SNHG1 Promotes the Progression of Pancreatic Cancer by Regulating FGFR1 Expression via Competitively Binding to miR-497
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  99. Jan 2022
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    The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis
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    PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma
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  102. Dec 2021
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  104. Nov 2021
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    The mitochondrial iron transporter ABCB7 is required for B cell development, proliferation, and class switch recombination in mice
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  106. Oct 2021
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    ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells
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  109. Sep 2021
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    CD4+ T cell-mimicking nanoparticles encapsulating DIABLO/SMAC mimetics broadly neutralize HIV-1 and selectively kill HIV-1-infected cells
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  111. Aug 2021
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    The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway
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    Y-box binding protein 1 augments sorafenib resistance via the PI3K/Akt signaling pathway in hepatocellular carcinoma
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  115. cancerres.aacrjournals.org cancerres.aacrjournals.org
    SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer
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    Blockade of the LRP16-PKR-NF-κB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy
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  117. Jul 2021
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    Contribution of synergism between PHF8 and HER2 signalling to breast cancer development and drug resistance
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    Kinome-wide RNAi screening for mediators of ABT-199 resistance in breast cancer cells identifies Wee1 as a novel therapeutic target
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  121. May 2021
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    Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells
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    Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment
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  124. Apr 2021
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    Apaf-1 Pyroptosome Senses Mitochondrial Permeability Transition
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    Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation
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    Concise Chemoenzymatic Total Synthesis and Identification of Cellular Targets of Cepafungin I
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    A pan-cancer transcriptome analysis of exitron splicing identifies novel cancer driver genes and neoepitopes
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    PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK
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  130. Mar 2021
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  132. Feb 2021
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    CARM1 regulates replication fork speed and stress response by stimulating PARP1
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    AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ
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  137. Jan 2021
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    RAD52 Adjusts Repair of Single-Strand Breaks via Reducing DNA-Damage-Promoted XRCC1/LIG3α Co-localization
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  139. Dec 2020
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    From a Medicinal Mushroom Blend a Direct Anticancer Effect on Triple-Negative Breast Cancer: A Preclinical Study on Lung Metastases
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    Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma
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    Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness
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    Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis
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    CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma
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    Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity
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      PARP (46D11) Rabbit mAb

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      monoclonal rabbit anti-PARP

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      anti‐rabbit PARP

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    Targeting DGAT1 Ameliorates Glioblastoma by Increasing Fat Catabolism and Oxidative Stress
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  151. Aug 2020
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    Adaptive RSK‐EphA2‐GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer
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      PARP

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  153. Jan 2020
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    CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress
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    Hantavirus Inhibits TRAIL-Mediated Killing of Infected Cells by Downregulating Death Receptor 5
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    Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity
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    Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy
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    sciencedirect.com/science/article/pii/S1934590919304266
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    Poly(ADP-Ribose) Polymerase 2 Recruits Replication Protein A to Sites of LINE-1 Integration to Facilitate Retrotransposition
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    RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer
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    The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability
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    KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis
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    Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling
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    A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
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    PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1
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      DOI: 10.1016/j.molcel.2019.08.006

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    A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer
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      DOI: 10.1016/j.cmet.2019.09.014

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    Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility
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      DOI: 10.1016/j.cell.2019.06.026

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      DOI: 10.1016/j.celrep.2019.03.067

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      DOI: 10.1016/j.celrep.2019.02.076

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    sciencedirect.com/science/article/pii/S2211124719302621
  169. Nov 2018
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    Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation
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    Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation
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    Bacteroides fragilis Toxin Coordinates a Pro-carcinogenic Inflammatory Cascade via Targeting of Colonic Epithelial Cells
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    sciencedirect.com/science/article/pii/S1931312818300428
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    CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness
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    Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH
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    sciencedirect.com/science/article/pii/S1097276517307967