328 Matching Annotations
  1. Aug 2021
  2. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    1. scibot 02 Aug 2021
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      DOI: 10.1002/cne.24206

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    onlinelibrary.wiley.com/doi/full/10.1002/cne.24206
  3. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    1. scibot 02 Aug 2021
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      DOI: 10.1111/jnc.14579

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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14579
  4. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    1. scibot 02 Aug 2021
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      DOI: 10.1002/brb3.403

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    onlinelibrary.wiley.com/doi/full/10.1002/brb3.403
  5. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    1. scibot 02 Aug 2021
      RRID:AB_2224402

      DOI: 10.1002/glia.23523

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    onlinelibrary.wiley.com/doi/full/10.1002/glia.23523
  6. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Enriched environment provides neuroprotection against experimental glaucoma
    1
    1. scibot 01 Aug 2021
      RRID:AB_2224402

      DOI: 10.1111/jnc.14885

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14885
  7. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Targeting aurora kinase B alleviates spinal microgliosis and neuropathic pain in a rat model of peripheral nerve injury
    1
    1. scibot 01 Aug 2021
      RRID:AB_2224402

      DOI: 10.1111/jnc.14883

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14883
  8. Jul 2021
  9. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Activation of spinal PDGFRβ in microglia promotes neuronal autophagy via p38 MAPK pathway in morphine-tolerant rats
    1
    1. scibot 31 Jul 2021
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      DOI: 10.1111/jnc.15383

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15383
  10. onlinelibrary.wiley.com onlinelibrary.wiley.com
    L‐alpha‐aminoadipic acid restricts dopaminergic neurodegeneration and motor deficits in an inflammatory model of Parkinson’s disease in male rats
    1
    1. scibot 31 Jul 2021
      RRID:AB_2224402

      DOI: 10.1002/jnr.24420

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    onlinelibrary.wiley.com/doi/full/10.1002/jnr.24420
  11. www.sciencedirect.com www.sciencedirect.com
    Microglial Phagocytosis of Newborn Cells Is Induced by Endocannabinoids and Sculpts Sex Differences in Juvenile Rat Social Play
    1
    1. scibot 31 Jul 2021
      RRID:AB_2224402

      DOI: 10.1016/j.neuron.2019.02.006

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    sciencedirect.com/science/article/pii/S0896627319301151
  12. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    1. scibot 31 Jul 2021
      RRID:AB_2224402

      DOI: 10.1002/cne.24604

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    onlinelibrary.wiley.com/doi/full/10.1002/cne.24604
  13. www.jneurosci.org www.jneurosci.org
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    1. scibot 31 Jul 2021
      RRID:AB_2224402

      DOI: 10.1523/JNEUROSCI.3621-17.2018

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    jneurosci.org/content/38/26/5949
  14. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    1. scibot 30 Jul 2021
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      DOI: 10.1111/jnc.14604

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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14604
  15. www.sciencedirect.com www.sciencedirect.com
    Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures
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    1. scibot 30 Jul 2021
      AB_2224402

      DOI: 10.1016/j.neuron.2017.04.043

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    sciencedirect.com/science/article/pii/S0896627317304002
  16. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    1. scibot 30 Jul 2021
      RRID:AB_2224402

      DOI: 10.1002/cne.24462

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    onlinelibrary.wiley.com/doi/full/10.1002/cne.24462
  17. www.sciencedirect.com www.sciencedirect.com
    Evaluation of Fluoro-Jade C Staining: Specificity and Application to Damaged Immature Neuronal Cells in the Normal and Injured Mouse Brain
    1
    1. scibot 29 Jul 2021
      RRID: AB 2224402

      DOI: 10.1016/j.neuroscience.2019.11.029

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    sciencedirect.com/science/article/pii/S0306452219308127
  18. www.jneurosci.org www.jneurosci.org
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    1. scibot 29 Jul 2021
      RRID:AB_2224402

      DOI: 10.1523/JNEUROSCI.1353-14.2014

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    jneurosci.org/content/34/41/13629
  19. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Spatiotemporal distribution of glia in and around the developing mouse optic tract
    1
    1. scibot 29 Jul 2021
      RRID:AB_2224402

      DOI: 10.1002/cne.24462

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    onlinelibrary.wiley.com/doi/abs/10.1002/cne.24462
  20. www.sciencedirect.com www.sciencedirect.com
    The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes
    2
    1. scibot 27 Jul 2021
      RIID: AB_306831

      DOI: 10.1016/j.nbd.2014.06.008

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    2. scibot 27 Jul 2021
      RIID: AB_2224402

      DOI: 10.1016/j.nbd.2014.06.008

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    sciencedirect.com/science/article/pii/S0969996114001727
  21. www.hindawi.com www.hindawi.com
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    1. scibot 27 Jul 2021
      AB_2224402

      DOI: 10.1155/2018/3706047

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    hindawi.com/journals/bmri/2018/3706047/
  22. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Differential neuronal and glial expression of nuclear factor I proteins in the cerebral cortex of adult mice
    2
    1. scibot 27 Jul 2021
      AB_2224402

      DOI: 10.1002/cne.24206

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    2. scibot 27 Jul 2021
      AB_2224402

      DOI: 10.1002/cne.24206

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    onlinelibrary.wiley.com/doi/10.1002/cne.24206/full
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Contextual Fear Memory Maintenance Changes Expression of pMAPK, BDNF and IBA-1 in the Pre-limbic Cortex in a Layer-Specific Manner
    1
    1. scibot 23 Jul 2021
      RRID:AB_2224402

      DOI: 10.3389/fncir.2021.660199

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    ncbi.nlm.nih.gov/pmc/articles/PMC8291085/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD206 Expression in Induced Microglia-Like Cells From Peripheral Blood as a Surrogate Biomarker for the Specific Immune Microenvironment of Neurosurgical Diseases Including Glioma
    1
    1. scibot 15 Jul 2021
      RRID:AB_2224402

      DOI: 10.3389/fimmu.2021.670131

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    ncbi.nlm.nih.gov/pmc/articles/PMC8276757/
  25. www.sciencedirect.com www.sciencedirect.com
    Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain
    1
    1. scibot 07 Jul 2021
      RRID:AB_2224402

      DOI: 10.1016/j.celrep.2021.109313

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    sciencedirect.com/science/article/pii/S2211124721006896
  26. www.sciencedirect.com www.sciencedirect.com
    Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines
    1
    1. scibot 07 Jul 2021
      RRID:AB_2224402

      DOI: 10.1016/j.neuron.2021.06.012

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    sciencedirect.com/science/article/pii/S089662732100427X
  27. Jun 2021
  28. www.sciencedirect.com www.sciencedirect.com
    A mouse model of microglia-specific ablation in the embryonic central nervous system
    1
    1. scibot 24 Jun 2021
      RRID:AB_2224402

      DOI: 10.1016/j.neures.2021.06.002

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    sciencedirect.com/science/article/pii/S0168010221001437
  29. May 2021
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and β-amyloid pathology
    1
    1. scibot 28 May 2021
      ab5076

      DOI: 10.1126/sciadv.abe4601

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    ncbi.nlm.nih.gov/pmc/articles/PMC8139596/
  31. www.sciencedirect.com www.sciencedirect.com
    Brain glycogen serves as a critical glucosamine cache required for protein glycosylation
    1
    1. scibot 27 May 2021
      RRID:AB_2224402

      DOI: 10.1016/j.cmet.2021.05.003

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    sciencedirect.com/science/article/pii/S1550413121002205
  32. www.sciencedirect.com www.sciencedirect.com
    Treg cell-derived osteopontin promotes microglia-mediated white matter repair after ischemic stroke
    1
    1. scibot 20 May 2021
      RRID:AB_2224402

      DOI: 10.1016/j.immuni.2021.04.022

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    sciencedirect.com/science/article/pii/S1074761321001849
  33. www.sciencedirect.com www.sciencedirect.com
    Isolation of adult mouse microglia using their in vitro adherent properties
    1
    1. scibot 09 May 2021
      RRID:AB_2224402

      DOI: 10.1016/j.xpro.2021.100518

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    sciencedirect.com/science/article/pii/S2666166721002252
  34. www.sciencedirect.com www.sciencedirect.com
    Adult Neural Stem Cells Are Alerted by Systemic Inflammation through TNF-α Receptor Signaling
    1
    1. scibot 09 May 2021
      RRID:AB_2224402

      DOI: 10.1016/j.stem.2020.10.016

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    sciencedirect.com/science/article/pii/S1934590920305105
  35. www.sciencedirect.com www.sciencedirect.com
    Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology
    1
    1. scibot 08 May 2021
      RRID:AB_2224402

      DOI: 10.1016/j.neuron.2021.02.010

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    sciencedirect.com/science/article/pii/S0896627321000842
  36. www.sciencedirect.com www.sciencedirect.com
    The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte Elimination
    1
    1. scibot 06 May 2021
      RRID:AB_2224402

      DOI: 10.1016/j.immuni.2020.07.021

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    sciencedirect.com/science/article/pii/S1074761320303289
  37. Apr 2021
  38. www.sciencedirect.com www.sciencedirect.com
    Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia
    1
    1. scibot 24 Apr 2021
      RRID:AB_2224402

      DOI: 10.1016/j.cell.2020.07.011

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    sciencedirect.com/science/article/pii/S009286742030876X
  39. www.sciencedirect.com www.sciencedirect.com
    Theta burst stimulation ameliorates symptoms of experimental autoimmune encephalomyelitis and attenuates reactive gliosis
    1
    1. scibot 16 Apr 2021
      RRID:AB_222402

      DOI: 10.1016/j.brainresbull.2020.06.013

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    sciencedirect.com/science/article/pii/S0361923020305384
  40. www.sciencedirect.com www.sciencedirect.com
    Modeling the mature CNS: A predictive screening platform for neurodegenerative disease drug discovery
    1
    1. scibot 13 Apr 2021
      RRID:AB_2224402

      DOI: 10.1016/j.jneumeth.2021.109180

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    sciencedirect.com/science/article/pii/S0165027021001151
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optogenetic activation of spinal microglia triggers chronic pain in mice
    1
    1. scibot 10 Apr 2021
      RRID:AB_2224402

      DOI: 10.1371/journal.pbio.3001154

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    ncbi.nlm.nih.gov/pmc/articles/PMC8011727/
  42. www.sciencedirect.com www.sciencedirect.com
    Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia
    1
    1. scibot 09 Apr 2021
      RRID:AB_2224402

      DOI: 10.1016/j.neuron.2021.03.024

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    sciencedirect.com/science/article/pii/S089662732100194X
  43. Mar 2021
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Poly I:C Activated Microglia Disrupt Perineuronal Nets and Modulate Synaptic Balance in Primary Hippocampal Neurons in vitro
    1
    1. scibot 12 Mar 2021
      RRID:AB_2224402

      DOI: 10.3389/fnsyn.2021.637549

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    ncbi.nlm.nih.gov/pmc/articles/PMC7940526/
  45. www.sciencedirect.com www.sciencedirect.com
    Brainstem local microglia induce whisker map plasticity in the thalamus after peripheral nerve injury
    1
    1. scibot 10 Mar 2021
      AB_2224402

      DOI: 10.1016/j.celrep.2021.108823

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    sciencedirect.com/science/article/pii/S2211124721001376
  46. www.sciencedirect.com www.sciencedirect.com
    Functional characterization of the dural sinuses as a neuroimmune interface
    1
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  47. Feb 2021
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    Resolvin D1 Attenuates Innate Immune Reactions in Experimental Subarachnoid Hemorrhage Rat Model
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    Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss
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      DOI: 10.7554/eLife.39159

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  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Role of Spinal Cord Akt-mTOR Signaling Pathways in Postoperative Hyperalgesia Induced by Plantar Incision in Mice
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    MiR-146a Ameliorates Hemoglobin-Induced Microglial Inflammatory Response via TLR4/IRAK1/TRAF6 Associated Pathways
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    Glial cell line‐derived neurotrophic factor increases matrix metallopeptidase 9 and 14 expression in microglia and promotes microglia‐mediated glioma progression
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    TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression
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  54. Jan 2021
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    Rab6A as a Pan-Astrocytic Marker in Mouse and Human Brain, and Comparison with Other Glial Markers (GFAP, GS, Aldh1L1, SOX9)
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  56. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  57. Dec 2020
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis
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      DOI: 10.7554/eLife.58765

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  59. www.sciencedirect.com www.sciencedirect.com
    Atorvastatin alleviates microglia-mediated neuroinflammation via modulating the microbial composition and the intestinal barrier function in ischemic stroke mice
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  61. Nov 2020
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    Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures
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  63. Sep 2020
  64. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Transient sublethal hypoxia in neonatal rats causes reduced dendritic spines, aberrant synaptic plasticity, and impairments in memory
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  65. link.springer.com link.springer.com
    Functions of resolvin D1-ALX/FPR2 receptor interaction in the hemoglobin-induced microglial inflammatory response and neuronal injury
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      DOI: 10.1186/s12974-020-01918-x

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  66. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction
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      DOI: 10.15252/embj.2020104464

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    Pathogenic DDX3X Mutations Impair RNA Metabolism and Neurogenesis during Fetal Cortical Development
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    25C-NBF, a new psychoactive substance, has addictive and neurotoxic potential in rodents
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    Neonatal nutritional programming induces gliosis and alters the expression of T-cell protein tyrosine phosphatase and connexins in male rats
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      DOI: 10.1016/j.yhbeh.2020.104690

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  70. www.sciencedirect.com www.sciencedirect.com
    Protocol for Co-culture of Microglia with Axons
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      DOI: 10.1016/j.xpro.2020.100111

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  71. elifesciences.org elifesciences.org
    Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models
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      DOI: 10.7554/eLife.54083

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  72. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Central nervous system‐infiltrated immune cells induce calcium increase in astrocytes via astroglial purinergic signaling
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      DOI: 10.1002/jnr.24699

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  73. www.sciencedirect.com www.sciencedirect.com
    Netrin-G1 Regulates Microglial Accumulation along Axons and Supports the Survival of Layer V Neurons in the Postnatal Mouse Brain
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    Interneuron Accumulation of Phosphorylated tau Impairs Adult Hippocampal Neurogenesis by Suppressing GABAergic Transmission
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      DOI: 10.1016/j.stem.2019.12.015

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  75. www.sciencedirect.com www.sciencedirect.com
    Presynaptic Homeostasis Opposes Disease Progression in Mouse Models of ALS-Like Degeneration: Evidence for Homeostatic Neuroprotection
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      IBA-1 Antibody (1:500)

      DOI: 10.1016/j.neuron.2020.04.009

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    Radiation Triggers a Dynamic Sequence of Transient Microglial Alterations in Juvenile Brain
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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Wnt signaling contributes to withdrawal symptoms from opioid receptor activation induced by morphine exposure or chronic inflammation
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      DOI: 10.1097/j.pain.0000000000001738

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  78. www.sciencedirect.com www.sciencedirect.com
    The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice
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      DOI: 10.1016/j.neuron.2020.03.005

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  79. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Impact of neural stem cell‐derived extracellular vesicles on mitochondrial dysfunction, sirtuin 1 level and synaptic deficits in Alzheimer’s disease
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      DOI: 10.1111/jnc.15001

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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Role of Spinal Cord Akt-mTOR Signaling Pathways in Postoperative Hyperalgesia Induced by Plantar Incision in Mice
    1
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      DOI: 10.3389/fnins.2020.00766

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  81. link.springer.com link.springer.com
    Silencing the Cytoskeleton Protein Iba1 (Ionized Calcium Binding Adapter Protein 1) Interferes with BV2 Microglia Functioning
    1
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      rabbit anti-Iba1

      DOI: 10.1007/s10571-020-00790-w

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  82. www.jneurosci.org www.jneurosci.org
    A role of low-density lipoprotein receptor-related protein 4 (LRP4) in astrocytic Aβ clearance
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      DOI: 10.1523/JNEUROSCI.0250-20.2020

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  83. Jan 2020
  84. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The expression of keratan sulfate reveals a unique subset of microglia in the mouse hippocampus after pilocarpine‐induced status epileptics
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      DOI: 10.1002/cne.24734

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    Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain
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      DOI: 10.1016/j.celrep.2019.05.087

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    TET2 Regulates the Neuroinflammatory Response in Microglia
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    Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons
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    let-7 MicroRNAs Regulate Microglial Function and Suppress Glioma Growth through Toll-Like Receptor 7
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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sphingomyelin Synthase 2 Inhibition Ameliorates Cerebral Ischemic Reperfusion Injury Through Reducing the Recruitment of Toll‐Like Receptor 4 to Lipid Rafts
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      DOI: 10.1161/JAHA.119.012885

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    Evaluation of Fluoro-Jade C Staining: Specificity and Application to Damaged Immature Neuronal Cells in the Normal and Injured Mouse Brain
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      DOI: 10.1016/j.neuroscience.2019.11.029

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    L‐alpha‐aminoadipic acid restricts dopaminergic neurodegeneration and motor deficits in an inflammatory model of Parkinson’s disease in male rats
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    Recombinant interleukin‐4 alleviates mechanical allodynia via injury‐induced interleukin‐4 receptor alpha in spinal microglia in a rat model of neuropathic pain
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  128. Nov 2017
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    Siglec‐H is a microglia‐specific marker that discriminates microglia from CNS‐associated macrophages and CNS‐infiltrating monocytes
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      RRID:AB_2224402 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0896627317302866
  133. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Extracellular ATP induces graded reactive response of astrocytes and strengthens their antioxidative defense in vitro
    1
    1. scibot 08 Nov 2017
      AB_2224402

      Curator: @gabimpine

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      (Abcam Cat# ab5076, RRID:AB_2224402)

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      RRID:AB_2224402 RRIDCUR:Validated
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    onlinelibrary.wiley.com/doi/10.1002/jnr.23950/full
  134. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Anatomical evidence that the uninjured adjacent L4 nerve plays a significant role in the development of peripheral neuropathic pain after L5 spinal nerve ligation in rats
    1
    1. scibot 08 Nov 2017
      AB_2224402

      Curator: @gabimpine

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      (Abcam Cat# ab5076, RRID:AB_2224402)

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      RRID:AB_2224402
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    onlinelibrary.wiley.com/doi/10.1002/cne.23750/full
  135. onlinelibrary.wiley.com onlinelibrary.wiley.com
    A postnatal peak in microglial development in the mouse hippocampus is correlated with heightened sensitivity to seizure triggers
    2
    1. scibot 08 Nov 2017
      AB_2224402

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      (Abcam Cat# ab5076, RRID:AB_2224402)

      SciCrunch record: RRID:AB_2224402

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      RRID:AB_2224402 RRIDCUR:Unresolved
    2. scibot 08 Nov 2017
      AB_2224402

      Curator: @jcabotaj

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      (Abcam Cat# ab5076, RRID:AB_2224402)

      SciCrunch record: RRID:AB_2224402

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      RRID:AB_2224402 RRIDCUR:Validated
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    onlinelibrary.wiley.com/doi/10.1002/brb3.403/full
  136. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Glial activation in the periaqueductal gray promotes descending facilitation of neuropathic pain through the p38 MAPK signaling pathway
    1
    1. scibot 08 Nov 2017
      AB_2224402

      Curator: @jcabotaj

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      (Abcam Cat# ab5076, RRID:AB_2224402)

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      RRID:AB_2224402 RRIDCUR:Validated
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    onlinelibrary.wiley.com/doi/10.1002/jnr.23672/full
  137. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Distribution of the creatine transporter throughout the human brain reveals a spectrum of creatine transporter immunoreactivity
    1
    1. scibot 08 Nov 2017
      AB_2224402

      Curator: @jcabotaj

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      (Abcam Cat# ab5076, RRID:AB_2224402)

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      RRID:AB_2224402 RRIDCUR:Validated
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    onlinelibrary.wiley.com/doi/10.1002/cne.23667/full
  138. www.jneurosci.org www.jneurosci.org
    Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates
    1
    1. scibot 08 Nov 2017
      AB_2224402

      Curator: @gabimpine

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      (Abcam Cat# ab5076, RRID:AB_2224402)

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      RRID:AB_2224402 RRIDCUR:Validated
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    jneurosci.org/content/34/41/13629.long
  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    n-3 polyunsaturated fatty acids supplementation enhances hippocampal functionality in aged mice
    1
    1. scibot 08 Nov 2017
      AB_2224402

      Curator: @jcabotaj

      Resource used:

      (Abcam Cat# ab5076, RRID:AB_2224402)

      SciCrunch record: RRID:AB_2224402

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      RRID:AB_2224402 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC4142709/