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Apr 2021
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β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells

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cell.com/current-biology/abstract/S0960-9822(21)00146-9
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Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors

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The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

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  DOI: 10.7554/eLife.63326
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7997658/
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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

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sciencedirect.com/science/article/pii/S1097276521001775
Mar 2021
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Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis

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Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function

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Feb 2021
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BPS Publications

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  DOI: 10.1111/bph.15350
  
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bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.15350
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Vitamin D-regulated gene expression profiles: species-specificity and cell-specific effects on metabolism and immunity

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  DOI: 10.1210/endocr/bqaa218
  
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academic.oup.com/endo/article/162/2/bqaa218/6010291
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Translation in amino-acid-poor environments is limited by tRNAGln charging

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  DOI: 10.7554/eLife.62307
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7744096/
Nov 2020
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A Broad Response to Intracellular Long-Chain Polyphosphate in Human Cells

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sciencedirect.com/science/article/pii/S2211124720313073
Sep 2020
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Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition

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sciencedirect.com/science/article/pii/S2211124720301054
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Integrating Mouse and Human Genetic Data to Move beyond GWAS and Identify Causal Genes in Cholesterol Metabolism

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  DOI: 10.1016/j.cmet.2020.02.015
  
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cell.com/cell-metabolism/fulltext/S1550-4131(20)30074-7
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Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States

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1. scibot 15 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107980
  
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sciencedirect.com/science/article/pii/S2211124720309657
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BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells

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1. scibot 14 Sep 2020
  
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sciencedirect.com/science/article/pii/S2211124720303521
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A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve

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1. scibot 13 Sep 2020
  
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  DOI: 10.1210/endocr/bqaa037
  
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academic.oup.com/endo/article/161/4/bqaa037/5788411
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Three-dimensional growth of breast cancer cells potentiates the anti-tumor effects of unacylated ghrelin and AZP-531

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1. scibot 08 Sep 2020
  
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  DOI: 10.7554/eLife.56913
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7363447/
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Ubiquitylation of the ER-Shaping Protein Lunapark via the CRL3KLHL12 Ubiquitin Ligase Complex

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1. scibot 08 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.107664
  
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sciencedirect.com/science/article/pii/S2211124720306173
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mTORC1 Deficiency Modifies Volume Homeostatic Responses to Dietary Sodium in a Sex-Specific Manner

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1. scibot 07 Sep 2020
  
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  DOI: 10.1210/endocr/bqaa041
  
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academic.oup.com/endo/article/161/5/bqaa041/5802448
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BPS Publications

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1. scibot 06 Sep 2020
  
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  DOI: 10.1111/bph.15080
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15080
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Metabolic Control over mTOR-Dependent Diapause-like State

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  DOI: 10.1016/j.devcel.2019.12.018
  
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sciencedirect.com/science/article/pii/S1534580719310676
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A non‐covalent inhibitor XMU‐MP‐3 overrides ibrutinib‐resistant BtkC481S mutation in B‐cell malignancies

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1. scibot 03 Sep 2020
  
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  DOI: 10.1111/bph.14809
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14809
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IRF4 in Skeletal Muscle Regulates Exercise Capacity via PTG/Glycogen Pathway

1
1. scibot 03 Sep 2020
  
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  DOI: 10.1002/advs.202001502
  
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onlinelibrary.wiley.com/doi/10.1002/advs.202001502
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Environmental arginine controls multinuclear giant cell metabolism and formation

1
1. scibot 03 Sep 2020
  
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  p-pS6K T389
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6976629/
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Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM

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  p-S6K1
  
  DOI: 10.1158/1541-7786.MCR-20-0024
  
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mcr.aacrjournals.org/content/18/8/1142
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Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1

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1. scibot 03 Sep 2020
  
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  phospho-S6K
  
  DOI: 10.1093/jb/mvaa076
  
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academic.oup.com/jb/article/doi/10.1093/jb/mvaa076/5870373
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Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation

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A common genetic variant in zinc transporter ZnT2 (Thr288Ser) is present in women with low milk volume and alters lysosome function and cell energetics | American Journal of Physiology-Cell Physiology

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journals.physiology.org/doi/full/10.1152/ajpcell.00383.2019
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Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

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  DOI: 10.1016/j.celrep.2019.07.084
  
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sciencedirect.com/science/article/pii/S2211124719310009
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NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

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sciencedirect.com/science/article/pii/S2211124719308654
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The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing

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  DOI: 10.1074/jbc.AC119.010671
  
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jbc.org/content/294/45/16527.full
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Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

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  DOI: 10.1016/j.immuni.2019.06.007
  
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sciencedirect.com/science/article/pii/S1074761319302778
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Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters

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  DOI: 10.1016/j.chembiol.2019.05.009
  
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sciencedirect.com/science/article/pii/S2451945619301783
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TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling

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  DOI: 10.1016/j.celrep.2019.07.086
  
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Mechanical loading stimulates hypertrophy in tissue‐engineered skeletal muscle: Molecular and phenotypic responses

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Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2

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Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells

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Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs

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Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice

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Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

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Lovastatin, not Simvastatin, Corrects Core Phenotypes in the Fragile X Mouse Model

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Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK

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Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

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Lysosome Positioning Influences mTORC2 and AKT Signaling

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PI3K inhibitors protect against glucocorticoid-induced skin atrophy

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The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability

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Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination

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New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis

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TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress

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Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling

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TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy

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Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides

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Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

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Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin

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Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers

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In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver

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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

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mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation

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Deletion of Tsc2 in Nociceptors Reduces Target Innervation, Ion Channel Expression, and Sensitivity to Heat

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The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma

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SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation

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Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy

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A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline

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Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance

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GRASP55 Senses Glucose Deprivation through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion

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Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin

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Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells

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Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations

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mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis

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As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid

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Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling

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Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation

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Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system

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Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward

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A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

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Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism

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Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

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Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase

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DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy

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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

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Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

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Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes

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SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise

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