267 Matching Annotations
  1. Jan 2020
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    TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling
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    Mechanical loading stimulates hypertrophy in tissue‐engineered skeletal muscle: Molecular and phenotypic responses
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    Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2
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    Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells
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    Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
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    Effects of the presence and absence of amino acids on translation, signaling and long‐term depression in hippocampal slices from Fmr1 knockout mice
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    Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors
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    Lovastatin, not Simvastatin, Corrects Core Phenotypes in the Fragile X Mouse Model
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    Transient Receptor Potential V Channels Are Essential for Glucose Sensing by Aldolase and AMPK
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    Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons
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    Lysosome Positioning Influences mTORC2 and AKT Signaling
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    PI3K inhibitors protect against glucocorticoid-induced skin atrophy
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    The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability
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      DOI: 10.1016/j.ccell.2018.10.002

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    sciencedirect.com/science/article/pii/S0304394018308048
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    Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination
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    New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis
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  30. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      DOI: 10.1111/bph.14626

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    TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress
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    Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling
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  33. Nov 2018
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    TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy
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    Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides
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    Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A
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    Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin
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    Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers
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    In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver
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    sciencedirect.com/science/article/pii/S240547121830231X
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    Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
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    mTORC1 Is Transiently Reactivated in Injured Nerves to Promote c-Jun Elevation and Schwann Cell Dedifferentiation
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    jneurosci.org/content/38/20/4811
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deletion of Tsc2 in Nociceptors Reduces Target Innervation, Ion Channel Expression, and Sensitivity to Heat
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  44. www.sciencedirect.com www.sciencedirect.com
    The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma
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  45. www.eneuro.org www.eneuro.org
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    SOD1 Phosphorylation by mTORC1 Couples Nutrient Sensing and Redox Regulation
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    Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy
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    A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline
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    Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance
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    GRASP55 Senses Glucose Deprivation through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion
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  51. elifesciences.org elifesciences.org
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  52. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    Roquin Suppresses the PI3K-mTOR Signaling Pathway to Inhibit T Helper Cell Differentiation and Conversion of Treg to Tfr Cells
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    Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations
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    mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis
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    As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid
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    Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
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    Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation
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  59. Nov 2017
  60. elifesciences.org elifesciences.org
    Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
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    elifesciences.org/articles/29241
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    Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward
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    A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice
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    Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism
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    Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
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    Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase
    1
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      CSTCat#9234

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    DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy
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    Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
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  68. elifesciences.org elifesciences.org
    Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator
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    Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
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  70. elifesciences.org elifesciences.org
    SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise
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