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54.241.53.176 54.241.53.176

Complex I protein NDUFB9 is a metabolic vulnerability in triple negative breast cancer brain metastases

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1. scibot 07 Jul 2026
  
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  DOI: 10.1038/s41467-026-72927-2
  
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54.241.53.176/fbba371e047a1863a9be5a679e9c16c3020d9509/s41467-026-72927-2_reference-html.html
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Norepinephrine Couples Astrocytic Metabolism to mTOR-Driven Protein Synthesis

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1. scibot 03 Jul 2026
  
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  DOI: 10.1111/jnc.70507
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.70507
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Trans-synaptic signaling through GRID1/glutamate receptor delta-1 and CBLN1/cerebellin-1 facilitates autophagic flux in central amygdala and prevents chronic pain

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1. scibot 03 Jul 2026
  
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  DOI: 10.1080/15548627.2025.2574968
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12758341/
Jul 2026
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Translational resistance to amino acid starvation in breast cancer cells revealed by ribosome profiling

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1. scibot 01 Jul 2026
  
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  DOI: 10.1016/j.isci.2026.116627
  
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sciencedirect.com/science/article/pii/S2589004226020031
Jun 2026
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A negative regulator of mitochondrial complex I assembly adapts respiration to cellular energy demand

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1. scibot 27 Jun 2026
  
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  DOI: 10.1016/j.molcel.2026.06.018
  
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sciencedirect.com/science/article/pii/S1097276526003898
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Suppression of ATM kinase signaling accelerates cellular senescence

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1. scibot 13 Jun 2026
  
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  DOI: 10.1016/j.stemcr.2026.102956
  
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sciencedirect.com/science/article/pii/S2213671126001670
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AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth

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1. scibot 06 Jun 2026
  
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  DOI: 10.1016/j.devcel.2025.05.008
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12258181/
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Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice

1
1. scibot 02 Jun 2026
  
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  DOI: 10.1038/s42255-026-01520-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13218935/
May 2026
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An appendiceal cancer organoid biobank identifies phenotypic evolution and druggable dependencies of peritoneal carcinomatosis

1
1. scibot 29 May 2026
  
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  DOI: 10.1016/j.devcel.2026.04.014
  
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sciencedirect.com/science/article/pii/S1534580726001619
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High protein ingestion does not affect whole-body insulin sensitivity in individuals with overweight or obesity

1
1. scibot 20 May 2026
  
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  RRID:AB_2269803
  
  DOI: 10.1210/jendso/bvag013
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13166155/
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The REDD1–NF-κB–miRNAs–eNOS/SIRT1 axis mediates obesity-induced endothelial cell senescence and hypertension

1
1. scibot 15 May 2026
  
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  DOI: 10.1038/s41467-026-70601-1
  
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nature.com/articles/s41467-026-70601-1
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PrPC-facilitated cell signaling activates phospholipase Cɣ1 and triggers an Arc/Arg3.1 response in mouse and iPSC-derived human neurons

1
1. scibot 15 May 2026
  
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  DOI: 10.1016/j.stemcr.2026.102924
  
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sciencedirect.com/science/article/pii/S2213671126001359
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Maternal hyperglycemia disrupts cardiomyocyte maturation via aberrant nucleotide metabolism and suppression of AMPK signaling

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1. scibot 06 May 2026
  
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  DOI: 10.1016/j.celrep.2026.117321
  
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sciencedirect.com/science/article/pii/S2211124726003992
Apr 2026
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Global genetic interaction network of a human cell maps conserved principles and informs functional interpretation of gene co-essentiality profiles

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1. scibot 29 Apr 2026
  
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  DOI: 10.1016/j.cell.2026.03.044
  
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sciencedirect.com/science/article/pii/S0092867426003454
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B cell deficiency limits exercise capacity by remodeling liver glutamate metabolism

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1. scibot 18 Apr 2026
  
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  DOI: 10.1016/j.cell.2026.03.039
  
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sciencedirect.com/science/article/pii/S0092867426003405
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Oxytocin signaling in adipocytes is required for normal milk fat production

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1. scibot 17 Apr 2026
  
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  RRID:AB_2269803
  
  DOI: 10.1016/j.cmet.2026.03.013
  
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sciencedirect.com/science/article/pii/S1550413126001075
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Graded activation of the CLEAR network through mTORC1 suppression on cargo-harboring lysosomes

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1. scibot 11 Apr 2026
  
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  DOI: 10.1016/j.celrep.2026.117228
  
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sciencedirect.com/science/article/pii/S2211124726003062
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Nutrient Availability Dictates Cancer Metabolism–Based Therapeutic Responses to Nononcology Drugs

1
1. scibot 09 Apr 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-1123
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13055633/
Mar 2026
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MYCT1–IFITM2/3 interaction links endothelial endolysosomal trafficking to white adipose tissue expansion

1
1. scibot 27 Mar 2026
  
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  DOI: 10.1084/jem.20251497
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13016079/
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Targeting the ferritinophagy-lysosome axis as a therapeutic vulnerability in gastroenteropancreatic neuroendocrine tumors

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1. scibot 26 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102695
  
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sciencedirect.com/science/article/pii/S2666379126001126
www.biorxiv.org www.biorxiv.org

A Niclosamide Prodrug SSL-0024 with Enhanced Bioavailability Suppresses Hepatocellular Carcinoma via Multi-Pathway Signaling Inhibition

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1. scibot 19 Mar 2026
  
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  RRID:AB_2269803
  
  DOI: 10.64898/2026.03.06.710248
  
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biorxiv.org/content/10.64898/2026.03.06.710248v1
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Eukaryote initiation factor 6 modulates small-cell lung carcinoma plasticity via the integrin-FAK signaling axis

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1. scibot 03 Mar 2026
  
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  DOI: 10.1038/s41467-026-69899-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12946193/
Feb 2026
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BPS Publications

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1. scibot 26 Feb 2026
  
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  DOI: 10.1111/bph.70353
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70353
54.241.53.176 54.241.53.176

1-s2.0-S2589004226003718-main-html.html

1
1. scibot 13 Feb 2026
  
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  RRID:AB_2269803
  
  DOI: 10.1016/j.isci.2026.114996
  
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54.241.53.176/f373af50e20ad2f683c3912e0dfb19a86e14ace7/1-s2.0-S2589004226003718-main-html.html
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p53 Drives Lung Cancer Regression through a TSC2/TFEB-dependent Senescence Program

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1. scibot 10 Feb 2026
  
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  DOI: 10.1158/2159-8290.CD-25-0525
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12877752/
Jan 2026
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Lysosome-localized IRTKS condensates promote mTORC1 activity leading to MASLD and HCC

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1. scibot 23 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116893
  
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sciencedirect.com/science/article/pii/S2211124725016651
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PDX1 phosphorylation at S61 by mTORC1 links nutrient signaling to β cell function and metabolic disease

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1. scibot 13 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116811
  
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sciencedirect.com/science/article/pii/S2211124725015839
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CASTOR1 and CASTOR2 respond to different arginine levels to regulate mTORC1 activity

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.molcel.2025.12.016
  
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sciencedirect.com/science/article/pii/S1097276525010159
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Endometrial stromal cell-derived TMAO sustains decidualization to prevent recurrent spontaneous abortion

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.cmet.2025.11.014
  
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sciencedirect.com/science/article/pii/S1550413125005285
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Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.chembiol.2025.12.002
  
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sciencedirect.com/science/article/pii/S2451945625003952
Dec 2025
www.sciencedirect.com:5037 www.sciencedirect.com:5037

Mitochondrial VHL rewires cell metabolism in hypoxia

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.cmet.2025.11.013
  
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sciencedirect.com:5037/science/article/pii/S1550413125005273
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TXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence

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1. scibot 06 Dec 2025
  
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  DOI: 10.1038/s44318-025-00608-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12669767/
Nov 2025
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Vitamin B6 preserves the stemness-like phenotypes and antitumor ability of CD8+ T cells

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1. scibot 29 Nov 2025
  
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  DOI: 10.1016/j.devcel.2025.10.017
  
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sciencedirect.com:5037/science/article/pii/S1534580725006914
54.241.53.176 54.241.53.176

1-s2.0-S2589004225023466-main-html.html

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.isci.2025.114085
  
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54.241.53.176/a053b2a5d4ede28eba1a3146a4418fab52740b98/1-s2.0-S2589004225023466-main-html.html
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Lactylation of mTOR enhances autophagy in skeletal muscle during exercise

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1. scibot 13 Nov 2025
  
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  DOI: 10.1016/j.chembiol.2025.10.007
  
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Oct 2025
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AMPKα2 signals amino acid insufficiency to inhibit protein synthesis

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mTOR inhibition reprograms cellular lipid homeostasis by inducing alternative lipid uptake and promoting cholesterol transport

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Novel Metastasis Suppressor PI3KC2β Is Mediated by mTORC1 Signaling in Breast Cancer

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Multi-dimensional metabolomic remodeling under diverse muscle atrophic stimuli in vivo

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Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice

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PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth

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Transfer RNA acetylation regulates in vivo mammalian stress signaling

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RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation

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YTHDF1 differentiates the contributing roles of mTORC1 in aging

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PIM kinase control of CD8 T cell protein synthesis and cell trafficking

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mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

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Nrf2- and p53-inducible REDD2/DDiT4L/Rtp801L confers pancreatic β-cell dysfunction, leading to glucose intolerance in high-fat diet-fed mice

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Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration | Molecular Biology of the Cell

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Rab10 regulates neuropeptide release by maintaining Ca2+ homeostasis and protein synthesis

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Remote limb ischemic conditioning alleviates steatohepatitis via extracellular vesicle-mediated muscle-liver crosstalk

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Short internal open reading frames repress the translation of N-terminally truncated proteoforms

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The carnosinase dipeptidase CNDP1 is a novel metabolic vulnerability in brain metastasis

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Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression

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Transfer RNA acetylation regulates in vivo mammalian stress signaling

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Sub-Immunosuppressive Tacrolimus Ameliorates Amyloid-Beta and Tau Pathology in 3xTg-AD Mice

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CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

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Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

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RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis

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mTORC2 Regulates Actin Polymerization in Auditory Cells

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Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint

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mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase

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Non-cell-autonomous regulation of mTORC2 by Hedgehog signaling maintains lipid homeostasis

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Gut bacterial L-lysine alters metabolism and histone methylation to drive dendritic cell tolerance

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Lithocholic acid phenocopies anti-ageing effects of calorie restriction

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MAPK14/p38α shapes the molecular landscape of endometrial cancer and promotes tumorigenic characteristics

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The ATAC complex represses the transcriptional program of the autophagy-lysosome pathway via its E3 ubiquitin ligase activity

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CD97 maintains tumorigenicity of glioblastoma stem cells via mTORC2 signaling and is targeted by CAR Th9 cells

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Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma

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Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing

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Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

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Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis

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Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration

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Nitrous oxide induces hypothermia and TrkB activation: Maintenance of body temperature abolishes antidepressant-like effects in mice

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A TBK1-independent primordial function of STING in lysosomal biogenesis

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mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux

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Activating mTOR mutations are detrimental in nutrient-poor conditions

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Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts

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BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism

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Sestrin2 drives ER-phagy in response to protein misfolding

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mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology

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Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells

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1-s2.0-S2589004224017851-main-html.html

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Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease

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Electron transport chain inhibition increases cellular dependence on purine transport and salvage

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mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway

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Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy

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p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

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p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol

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HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression

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25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages

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Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy

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SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis

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Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats

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Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling

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HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance

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Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy

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Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells

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MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension

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Nutrient-regulated control of lysosome function by signaling lipid conversion

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Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition

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The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency

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PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2

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An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant

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Acid ceramidase regulates innate immune memory

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Breast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism

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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

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A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer

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Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses

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Myotube growth is associated with cancer-like metabolic reprogramming and is limited by phosphoglycerate dehydrogenase

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Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity

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Spatiotemporal Regulation of De Novo and Salvage Purine Synthesis during Brain Development

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Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells

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A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection

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mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching

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ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway

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Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells

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Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”

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PICT-1 regulates p53 splicing and sensitivity of medullary thyroid carcinoma cells to Everolimus

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May 2023
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FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation

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MTHFD2 reprograms macrophage polarization by inhibiting PTEN

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A nanotherapeutic strategy that engages cytotoxic and immunosuppressive activities for the treatment of cancer recurrence following organ transplantation

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eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content

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Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

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ZFP36-mediated mRNA decay regulates metabolism

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A Novel Method for Visualizing In-Vivo Rates of Protein Degradation Provides Insight into how TRIM28 Regulates Muscle Size

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Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response

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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

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TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy

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VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma

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NRF3 activates mTORC1 arginine-dependently for cancer cell viability

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STRA6 promotes thyroid carcinoma progression via activation of the ILK/AKT/mTOR axis in cells and female nude mice

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Correction: Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis

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Transcriptome, proteome, and protein synthesis within the intracellular cytomatrix

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Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model

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Jan 2023
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Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation

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TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis

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GOT1 regulates CD8+ effector and memory T cell generation

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The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model

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Ring domains are essential for GATOR2-dependent mTORC1 activation

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AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance

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Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

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Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha

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Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response

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TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways

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Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein

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COMPREHENSIVE DRUG RESPONSE PROFILING AND PAN-OMIC ANALYSIS IDENTIFIED THERAPEUTIC CANDIDATES AND PROGNOSTIC BIOMARKERS FOR ASIAN CHOLANGIOCARCINOMA

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Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites

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DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting

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Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction

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A sphingolipid-mTORC1 nutrient-sensing pathway regulates animal development by an intestinal peroxisome relocation-based gut-brain crosstalk

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Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome

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Protein signaling in response to ex vivo dynamic contractions is independent of training status in rat skeletal muscle

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Manipulating bovine granulosa cell energy metabolism limits inflammation

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Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling

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The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis

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Pharmacological inhibition of sphingolipid synthesis reduces ferroptosis by stimulating the HIF-1 pathway.

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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis

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Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation

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DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production

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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis

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The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth

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Lack of Tgfbr1 and Acvr1b synergistically stimulates myofibre hypertrophy and accelerates muscle regeneration

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A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration

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Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake

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Glutamine-dependent signaling controls pluripotent stem cell fate

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Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling

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DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions

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YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth

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The KRAS-G12D mutation induces Metabolic Vulnerability in B-cell Acute Lymphoblastic Leukemia

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Blockage of citrate export prevents TCA cycle fragmentation via Irg1 inactivation

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A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring

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E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression

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Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism

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Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation

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NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis

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GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway

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Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment

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Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation

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Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly

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japplphysiol.00107.2021-html.html

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ajpcell.00385.2020-html.html

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m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity

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Protocol for the assessment of mTOR activity in mouse primary hepatocytes

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Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity

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Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability

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Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase

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Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1

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Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns

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Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer

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The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis

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Untitled document

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  DOI: 10.1016/j.celrep.2019.03.067
  
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Untitled document

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  DOI: 10.1016/j.molcel.2017.04.027
  
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Untitled document

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Untitled document

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  DOI: 10.1016/j.chom.2018.11.006
  
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