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    25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages
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  3. Apr 2024
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    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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  5. Mar 2024
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    SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis
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    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
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  8. Feb 2024
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    Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling
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    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
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    biorxiv.org/content/10.1101/2023.12.05.570182v1
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    Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy
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  12. Jan 2024
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    Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells
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    MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
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  15. Dec 2023
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    Nutrient-regulated control of lysosome function by signaling lipid conversion
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    sciencedirect.com/science/article/pii/S0092867423010814
  17. Nov 2023
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    Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
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    The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency
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    PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2
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    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
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    Acid ceramidase regulates innate immune memory
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    Breast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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  25. Oct 2023
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    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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    Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses
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    Myotube growth is associated with cancer-like metabolic reprogramming and is limited by phosphoglycerate dehydrogenase
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    Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity
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    Spatiotemporal Regulation of De Novo and Salvage Purine Synthesis during Brain Development
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  31. Sep 2023
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    Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells
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  33. Aug 2023
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    A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selection
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  35. Jul 2023
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway
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    Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells
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  39. Jun 2023
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    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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    PICT-1 regulates p53 splicing and sensitivity of medullary thyroid carcinoma cells to Everolimus
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  42. May 2023
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    FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation
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    MTHFD2 reprograms macrophage polarization by inhibiting PTEN
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    A nanotherapeutic strategy that engages cytotoxic and immunosuppressive activities for the treatment of cancer recurrence following organ transplantation
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    eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content
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  47. Apr 2023
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    Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
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    ZFP36-mediated mRNA decay regulates metabolism
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    A Novel Method for Visualizing In-Vivo Rates of Protein Degradation Provides Insight into how TRIM28 Regulates Muscle Size
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    Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response
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    CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth
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  53. Mar 2023
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    TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis
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    COMPREHENSIVE DRUG RESPONSE PROFILING AND PAN-OMIC ANALYSIS IDENTIFIED THERAPEUTIC CANDIDATES AND PROGNOSTIC BIOMARKERS FOR ASIAN CHOLANGIOCARCINOMA
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    A sphingolipid-mTORC1 nutrient-sensing pathway regulates animal development by an intestinal peroxisome relocation-based gut-brain crosstalk
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    Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome
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    The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
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    Glutamine-dependent signaling controls pluripotent stem cell fate
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    Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling
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    YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
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  112. Jan 2022
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  114. Dec 2021
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    Aging Does Not Exacerbate Muscle Loss During Denervation and Lends Unique Muscle-Specific Atrophy Resistance With Akt Activation
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  120. Nov 2021
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    Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
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  122. 52.53.155.43 52.53.155.43
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  123. 52.53.155.43 52.53.155.43
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  124. www.sciencedirect.com www.sciencedirect.com
    m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity
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    Protocol for the assessment of mTOR activity in mouse primary hepatocytes
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  126. Oct 2021
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    Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity
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    Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability
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    Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase
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    Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1
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  131. Sep 2021
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    Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns
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  133. Aug 2021
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    Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer
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    The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis
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    Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation
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    Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes
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  144. Jul 2021
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    Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and Apoptosis
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      rabbit anti‐P‐S6K (P‐p70S6K)

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    mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
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      Phospho-p70 S6 Kinase T389

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    Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder
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    Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth
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    Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
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    Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs
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    SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice
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    DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity
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    The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding
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    Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK
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    Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation
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    Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility
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    Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity
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    NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
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    Coordinate regulation of the senescent state by selective autophagy
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    Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade
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    Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer
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    An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
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    β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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    Mapping of the contraction-induced phosphoproteome identifies TRIM28 as a significant regulator of skeletal muscle size and function
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    A Broad Response to Intracellular Long-Chain Polyphosphate in Human Cells
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    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
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    1. scibot 13 Jan 2020
      RRID:AB_2269803

      DOI: 10.1016/j.cmet.2019.02.002

      Resource: (Cell Signaling Technology Cat# 9234, RRID:AB_2269803)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_2269803

      What is this?

      RRID:AB_2269803 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S155041311930066X