267 Matching Annotations
  1. Nov 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC11542922/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis
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    1. scibot 07 Nov 2024
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      DOI: 10.1007/s11357-024-01187-z

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    pmc.ncbi.nlm.nih.gov/articles/PMC11493941/
  4. Oct 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adaptive protein synthesis in genetic models of copper deficiency and childhood neurodegeneration
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    ncbi.nlm.nih.gov/pmc/articles/PMC11419079/
  6. www.sciencedirect.com www.sciencedirect.com
    Nitrous oxide induces hypothermia and TrkB activation: Maintenance of body temperature abolishes antidepressant-like effects in mice
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    sciencedirect.com/science/article/pii/S0028390824003411
  7. Sep 2024
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    A TBK1-independent primordial function of STING in lysosomal biogenesis
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S1097276524007032
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    mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S1097276519305519
  10. aacrjournals.org aacrjournals.org
    Activating mTOR mutations are detrimental in nutrient-poor conditions
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    1. scibot 12 Sep 2024
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      DOI: 10.1158/0008-5472.CAN-22-0121

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    aacrjournals.org/cancerres/article/82/18/3263/709030/Activating-mTOR-Mutations-Are-Detrimental-in
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
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    1. scibot 05 Sep 2024
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  12. Aug 2024
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    BCAA-producing Clostridium symbiosum promotes colorectal tumorigenesis through the modulation of host cholesterol metabolism
    1
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    sciencedirect.com/science/article/pii/S1931312824002713
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    Sestrin2 drives ER-phagy in response to protein misfolding
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    1. scibot 18 Aug 2024
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  15. journals.physiology.org journals.physiology.org
    mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology
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    1. scibot 02 Aug 2024
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      DOI: 10.1152/ajpcell.00385.2020

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  16. Jul 2024
  17. www.sciencedirect.com www.sciencedirect.com
    Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells
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  18. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004224017851-main-html.html
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    1. scibot 25 Jul 2024
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  19. elifesciences.org elifesciences.org
    Novel autophagy inducers by accelerating lysosomal clustering against Parkinson’s disease
    1
    1. scibot 04 Jul 2024
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      DOI: 10.7554/eLife.98649

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  20. Jun 2024
  21. www.sciencedirect.com www.sciencedirect.com
    Electron transport chain inhibition increases cellular dependence on purine transport and salvage
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    1. scibot 21 Jun 2024
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    sciencedirect.com/science/article/pii/S1550413124001906
  22. May 2024
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    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
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    1. scibot 24 May 2024
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    sciencedirect.com/science/article/pii/S1097276524003939
  24. www.sciencedirect.com www.sciencedirect.com
    Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy
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    sciencedirect.com/science/article/pii/S2666379124002441
  25. www.science.org www.science.org
    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
    1
    1. scibot 09 May 2024
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      DOI: 10.1126/sciadv.adl6082

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    science.org/doi/10.1126/sciadv.adl6082
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol
    1
    1. scibot 05 May 2024
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      DOI: 10.1126/sciadv.adl6082

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    ncbi.nlm.nih.gov/pmc/articles/PMC11068011/
  27. Apr 2024
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
    1
    1. scibot 24 Apr 2024
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      DOI: 10.1093/narcan/zcae018

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    ncbi.nlm.nih.gov/pmc/articles/PMC11034028/
  29. www.sciencedirect.com www.sciencedirect.com
    25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages
    1
    1. scibot 19 Apr 2024
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      DOI: 10.1016/j.immuni.2024.03.021

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    sciencedirect.com/science/article/pii/S1074761324001420
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    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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    1. scibot 11 Apr 2024
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    sciencedirect.com/science/article/pii/S2352396424001348
  31. Mar 2024
  32. www.sciencedirect.com www.sciencedirect.com
    SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis
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      DOI: 10.1016/j.celrep.2024.113975

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    sciencedirect.com/science/article/pii/S2211124724003036
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10920058/
  34. Feb 2024
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular mechanism of S-adenosylmethionine sensing by SAMTOR in mTORC1 signaling
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      DOI: 10.1126/sciadv.abn3868

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    ncbi.nlm.nih.gov/pmc/articles/PMC10883374/
  36. www.biorxiv.org www.biorxiv.org
    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
    3
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      DOI: 10.1101/2023.12.05.570182

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    biorxiv.org/content/10.1101/2023.12.05.570182v1
  37. www.sciencedirect.com www.sciencedirect.com
    Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy
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    sciencedirect.com/science/article/pii/S2211124724000408
  38. Jan 2024
  39. www.sciencedirect.com www.sciencedirect.com
    Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells
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    sciencedirect.com/science/article/pii/S1534580724000029
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
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    ncbi.nlm.nih.gov/pmc/articles/PMC10798563/
  41. Dec 2023
  42. www.sciencedirect.com www.sciencedirect.com
    Nutrient-regulated control of lysosome function by signaling lipid conversion
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    sciencedirect.com/science/article/pii/S0092867423010814
  43. Nov 2023
  44. www.sciencedirect.com www.sciencedirect.com
    Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition
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    sciencedirect.com/science/article/pii/S1097276523008547
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    The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency
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    sciencedirect.com/science/article/abs/pii/S1550413123003856
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    PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2
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    sciencedirect.com/science/article/abs/pii/S1550413123004114
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    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
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    sciencedirect.com/science/article/pii/S2211124723014961
  48. www.sciencedirect.com www.sciencedirect.com
    Acid ceramidase regulates innate immune memory
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    sciencedirect.com/science/article/pii/S2211124723014705
  49. www.embopress.org www.embopress.org
    Breast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism
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      DOI: 10.15252/embr.202357339

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    embopress.org/doi/full/10.15252/embr.202357339
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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      DOI: 10.1016/j.molcel.2021.03.009

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    sciencedirect.com/science/article/pii/S1097276521001775
  51. Oct 2023
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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      DOI: 10.3390/cancers15205082

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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    ALKBH5 causes retinal pigment epithelium anomalies and choroidal neovascularization in age-related macular degeneration via the AKT/mTOR pathway
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    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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    FOXK1 promotes nonalcoholic fatty liver disease by mediating mTORC1-dependent inhibition of hepatic fatty acid oxidation
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    A Novel Method for Visualizing In-Vivo Rates of Protein Degradation Provides Insight into how TRIM28 Regulates Muscle Size
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    Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response
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    TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy
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    TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis
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    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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    COMPREHENSIVE DRUG RESPONSE PROFILING AND PAN-OMIC ANALYSIS IDENTIFIED THERAPEUTIC CANDIDATES AND PROGNOSTIC BIOMARKERS FOR ASIAN CHOLANGIOCARCINOMA
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    Obese Skeletal Muscle-Expressed Interferon Regulatory Factor 4 Transcriptionally Regulates Mitochondrial Branched-Chain Aminotransferase Reprogramming Metabolome
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  155. www.sciencedirect.com www.sciencedirect.com
    Serum- and glucocorticoid-induced kinase drives hepatic insulin resistance by directly inhibiting AMP-activated protein kinase
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    Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1
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  157. Sep 2021
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    Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns
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  159. Aug 2021
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    Loss of tyrosine catabolic enzyme HPD promotes glutamine anaplerosis through mTOR signaling in liver cancer
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      RRID:AB_2269803

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    The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis
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      RRID:AB_2891006

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  163. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Food Perception Primes Hepatic ER Homeostasis via Melanocortin-Dependent Control of mTOR Activation
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    Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes
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  170. Jul 2021
  171. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Effects of the Antifungal Agent Ciclopirox in HPV‐Positive Cancer Cells: Repression of Viral E6/E7 Oncogene Expression and Induction of Senescence and Apoptosis
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      rabbit anti‐P‐S6K (P‐p70S6K)

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    mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability
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      Phospho-p70 S6 Kinase T389

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    Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder
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    Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive Growth
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      AB_823494

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      AB_10121787

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  176. www.sciencedirect.com www.sciencedirect.com
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    Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
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    Glycerol-3-phosphate biosynthesis regenerates cytosolic NAD+ to alleviate mitochondrial disease
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    Thyroid hormone receptor beta inhibits the PI3K-Akt-mTOR signaling axis in anaplastic thyroid cancer cell lines via genomic mechanisms
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    Inhibition of Rag GTPase signaling in mice suppresses B cell responses and lymphomagenesis with minimal detrimental trade-offs
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    Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock
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    SREBP-1c impairs ULK1 sulfhydration-mediated autophagic flux to promote hepatic steatosis in high-fat-diet-fed mice
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  183. Jun 2021
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    DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity
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    MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages
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    Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner
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  187. May 2021
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    The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding
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    Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK
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    Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation
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    Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function
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    Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility
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    Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity
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    ERK2 Phosphorylates PFAS to Mediate Posttranslational Control of De Novo Purine Synthesis
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    NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C
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    AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis
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    Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology
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    Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth
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    Macropinocytosis Renders a Subset of Pancreatic Tumor Cells Resistant to mTOR Inhibition
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    Genetic dissection of Ragulator structure and function in amino acid-dependent regulation of mTORC1
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    A common genetic variant in zinc transporter ZnT2 (Thr288Ser) is present in women with low milk volume and alters lysosome function and cell energetics | American Journal of Physiology-Cell Physiology
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    Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming
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    NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression
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    The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing
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    Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
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    Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters
    1
    1. scibot 13 Jan 2020
      RRID:AB_2269803

      DOI: 10.1016/j.chembiol.2019.05.009

      Resource: (Cell Signaling Technology Cat# 9234, RRID:AB_2269803)

      Curator: @Naa003

      SciCrunch record: RRID:AB_2269803

      What is this?

      RRID:AB_2269803 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2451945619301783