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Apr 2022
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Tissue remodeling by an opportunistic pathogen triggers allergic inflammation

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1. scibot 28 Apr 2022
  
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  DOI: 10.1016/j.immuni.2022.04.001
  
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sciencedirect.com/science/article/pii/S1074761322001728
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Astrocytic GABA transporter controls sleep by modulating GABAergic signaling in Drosophila circadian neurons

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1. scibot 23 Apr 2022
  
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  DOI: 10.1016/j.cub.2022.02.066
  
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sciencedirect.com/science/article/pii/S0960982222003360
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The GADD45G/p38 MAPK/CDC25B signaling pathway enhances neurite outgrowth by promoting microtubule polymerization

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1. scibot 07 Apr 2022
  
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  DOI: 10.1016/j.isci.2022.104089
  
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sciencedirect.com/science/article/pii/S2589004222003595
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Comparative distribution of Arcadlin/Protocadherin-8 mRNA in the intact and ischemic brains of adult mice

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1. scibot 05 Apr 2022
  
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  DOI: 10.1002/cne.25319
  
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onlinelibrary.wiley.com/doi/10.1002/cne.25319
Mar 2022
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Human Placental Tissue Contains a Placental Lactogen Derived Vasoinhibin

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1. scibot 11 Mar 2022
  
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  DOI: 10.1210/jendso/bvac029
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8900287/
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Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy

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1. scibot 09 Mar 2022
  
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  DOI: 10.1016/j.celrep.2022.110475
  
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sciencedirect.com/science/article/pii/S221112472200208X
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RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1

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1. scibot 04 Mar 2022
  
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  DOI: 10.1016/j.molcel.2022.01.025
  
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sciencedirect.com/science/article/pii/S1097276522001010
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Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy

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1. scibot 04 Mar 2022
  
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  DOI: 10.1016/j.neuron.2022.01.035
  
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sciencedirect.com/science/article/pii/S0896627322001052
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Alzheimer’s disease and cerebrovascular pathology alter brain endothelial inward rectifier potassium (KIR2.1) channels

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1. scibot 02 Mar 2022
  
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  DOI: 10.1111/bph.15751
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15751
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An HNF1α truncation associated with maturity-onset diabetes of the young impairs pancreatic progenitor differentiation by antagonizing HNF1β function

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1. scibot 02 Mar 2022
  
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  DOI: 10.1016/j.celrep.2022.110425
  
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sciencedirect.com/science/article/pii/S2211124722001498
Feb 2022
bmcbiol.biomedcentral.com bmcbiol.biomedcentral.com

Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways

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1. scibot 19 Feb 2022
  
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  DOI: 10.1186/s12915-022-01252-z
  
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bmcbiol.biomedcentral.com/articles/10.1186/s12915-022-01252-z
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Dual Sensing of Physiologic pH and Calcium by EFCAB9 Regulates Sperm Motility

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1. scibot 04 Feb 2022
  
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  DOI: 10.1016/j.cell.2019.03.047
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8808721/
Jan 2022
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Histone Acetylation Defects in Brain Precursor Cells: A Potential Pathogenic Mechanism Causing Proliferation and Differentiation Dysfunctions in Mitochondrial Aspartate-Glutamate Carrier Isoform 1 Deficiency

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1. scibot 28 Jan 2022
  
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  RRID:AB_230739
  
  DOI: 10.3389/fncel.2021.773709
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8790092/
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MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells

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1. scibot 26 Jan 2022
  
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  DOI: 10.1016/j.ccell.2021.12.009
  
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sciencedirect.com/science/article/pii/S1535610821006620
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Compartmentalization of telomeres through DNA-scaffolded phase separation

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1. scibot 26 Jan 2022
  
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  DOI: 10.1016/j.devcel.2021.12.017
  
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sciencedirect.com/science/article/pii/S1534580721010376
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Endoplasmic reticulum-translocation is essential for APOL1 cellular toxicity

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1. scibot 14 Jan 2022
  
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  DOI: 10.1016/j.isci.2021.103717
  
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sciencedirect.com/science/article/pii/S2589004221016874
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C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane

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1. scibot 08 Jan 2022
  
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  DOI: 10.1016/j.celrep.2021.110226
  
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sciencedirect.com/science/article/pii/S2211124721017307
Dec 2021
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Kel1 is a phosphorylation-regulated noise suppressor of the pheromone signaling pathway

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1. scibot 29 Dec 2021
  
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  DOI: 10.1016/j.celrep.2021.110186
  
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sciencedirect.com/science/article/pii/S2211124721016867
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Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway

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1. scibot 22 Dec 2021
  
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  DOI: 10.1007/s10863-018-9750-3
  
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link.springer.com/article/10.1007/s10863-018-9750-3
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Disrupted expression of mitochondrial NCLX sensitizes neuroglial networks to excitotoxic stimuli and renders synaptic activity toxic

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1. scibot 21 Dec 2021
  
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  DOI: 10.1016/j.jbc.2021.101508
  
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sciencedirect.com/science/article/pii/S0021925821013181
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Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity

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1. scibot 21 Dec 2021
  
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  DOI: 10.1016/j.devcel.2021.11.020
  
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sciencedirect.com/science/article/pii/S1534580721009448
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Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease

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1. scibot 15 Dec 2021
  
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  DOI: 10.7554/eLife.73753
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8660019/
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Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes

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1. scibot 11 Dec 2021
  
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  DOI: 10.7554/eLife.70504
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8654371/
Nov 2021
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Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response

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1. scibot 17 Nov 2021
  
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  DOI: 10.1016/j.celrep.2021.110004
  
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Molecular and functional architecture of striatal dopamine release sites

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1. scibot 12 Nov 2021
  
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  DOI: 10.1016/j.neuron.2021.10.028
  
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sciencedirect.com/science/article/pii/S0896627321008436
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Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction

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1. scibot 11 Nov 2021
  
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  DOI: 10.1016/j.stem.2021.10.009
  
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Non-genomic rewiring of vitamin D receptor to p53 as a key to Alzheimer's disease

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1. scibot 04 Nov 2021
  
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  DOI: 10.1111/acel.13509
  
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onlinelibrary.wiley.com/doi/10.1111/acel.13509
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ajpcell.00116.2021-html.html

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1. scibot 03 Nov 2021
  
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  DOI: 10.1021/ja00738a045.
  
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52.53.155.43/fafb728e049342254e71087f77ca6df045c9004b/ajpcell.00116.2021-html.html
Oct 2021
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Munc13-1 is a Ca2+-phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission

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1. scibot 27 Oct 2021
  
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  DOI: 10.1016/j.neuron.2021.09.054
  
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sciencedirect.com/science/article/pii/S0896627321007273
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ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells

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1. scibot 27 Oct 2021
  
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  DOI: 10.1016/j.celrep.2021.109880
  
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sciencedirect.com/science/article/pii/S2211124721013504
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Cell geometry, signal dampening, and a bimodal transcriptional response underlie the spatial precision of an ERK-mediated embryonic induction

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1. scibot 21 Oct 2021
  
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  DOI: 10.1016/j.devcel.2021.09.025
  
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sciencedirect.com/science/article/pii/S1534580721007693
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An in vitro system to silence mitochondrial gene expression

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1. scibot 21 Oct 2021
  
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  DOI: 10.1016/j.cell.2021.09.033
  
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sciencedirect.com/science/article/pii/S0092867421011168
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Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice

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1. scibot 13 Oct 2021
  
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  DOI: 10.1016/j.celrep.2021.109831
  
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sciencedirect.com/science/article/pii/S221112472101295X
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Multiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment

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1. scibot 06 Oct 2021
  
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  DOI: 10.1016/j.celrep.2021.109797
  
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sciencedirect.com/science/article/pii/S2211124721012572
Sep 2021
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Revisiting astrocyte to neuron conversion with lineage tracing in vivo

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1. scibot 28 Sep 2021
  
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  DOI: 10.1016/j.cell.2021.09.005
  
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Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway

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TCF/LEF regulation of the topologically associated domain ADI promotes mESCs to exit the pluripotent ground state

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Secreted retrovirus-like GAG-domain-containing protein PEG10 is regulated by UBE3A and is involved in Angelman syndrome pathophysiology

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Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed

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Spatially Restricted Regulation of Spätzle/Toll Signaling during Cell Competition

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FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue

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ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation

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The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output

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The Anti-amyloid Compound DO1 Decreases Plaque Pathology and Neuroinflammation-Related Expression Changes in 5xFAD Transgenic Mice

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Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes

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NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress

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A critical role of VMP1 in lipoprotein secretion

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Maternal vitamin C regulates reprogramming of DNA methylation and germline development

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Mechanism of pharmacochaperoning in a mammalian KATP channel revealed by cryo-EM

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NMDA receptor blockade ameliorates abnormalities of spike firing of subthalamic nucleus neurons in a parkinsonian nonhuman primate

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Intrinsically Disordered Protein TEX264 Mediates ER-phagy

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The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage

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Highly efficient manipulation of nervous system gene expression with NEPTUNE

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Knock-Out of Tenascin-C Ameliorates Ischemia-Induced Rod-Photoreceptor Degeneration and Retinal Dysfunction

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Ribosome stalling caused by the Argonaute-microRNA-SGS3 complex regulates the production of secondary siRNAs in plants

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Mice lacking PC1/3 expression in POMC-expressing cells do not develop obesity

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VEGFC/FLT4-induced cell-cycle arrest mediates sprouting and differentiation of venous and lymphatic endothelial cells

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Structural insight into BRCA1-BARD1 complex recruitment to damaged chromatin

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A Novel Methodology Using Dexamethasone to Induce Neuronal Differentiation in the CNS-Derived Catecholaminergic CAD Cells

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Pridopidine reduces mutant huntingtin-induced endoplasmic reticulum stress by modulation of the Sigma-1 receptor

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RNA degradation is required for the germ-cell to maternal transition in Drosophila

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Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells

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Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes

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Glucagon Receptor Inhibition Reduces Hyperammonemia and Lethality in Male Mice with Urea Cycle Disorder

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Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging

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A Mechanism for microRNA Arm Switching Regulated by Uridylation

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Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage

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A Membrane-Tethered Ubiquitination Pathway Regulates Hedgehog Signaling and Heart Development

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Comprehensive Analysis of G1 Cyclin Docking Motif Sequences that Control CDK Regulatory Potency In Vivo

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Cargo Release from Myosin V Requires the Convergence of Parallel Pathways that Phosphorylate and Ubiquitylate the Cargo Adaptor

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eEF2/eEF2K Pathway in the Mature Dentate Gyrus Determines Neurogenesis Level and Cognition

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Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation

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Functional Genomics In Vivo Reveal Metabolic Dependencies of Pancreatic Cancer Cells

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Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing

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Induction of mutant Sik3Sleepy allele in neurons in late infancy increases sleep need

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The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr

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Progesterone and estrogen regulate NALCN expression in human myometrial smooth muscle cells

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The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts

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cell.com/immunity/fulltext/S1074-7613(21)00115-1
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HspB5/αB‐crystallin phosphorylation at S45 and S59 is essential for protection of the dendritic tree of rat hippocampal neurons

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onlinelibrary.wiley.com/doi/10.1111/jnc.15247
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3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice

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Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex

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cell.com/developmental-cell/abstract/S1534-5807(20)30420-2
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Degron capability of the hydrophobic C‐terminus of the polyglutamine disease protein, ataxin‐3

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Integrated pharmaco-proteogenomics defines two subgroups in isocitrate dehydrogenase wild-type glioblastoma with prognostic and therapeutic opportunities

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Water‐Soluble Variant of Human Lynx1 Positively Modulates Synaptic Plasticity and Ameliorates Cognitive Impairment Associated with a7‐nAChR Dysfunction

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Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

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Modulation of the functions of myeloid‐derived suppressor cells : a new strategy of hydrogen sulfide anti‐cancer effects

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c–Jun N–terminal Kinase Mediates Ligand-independent p75NTR Signaling in Mesencephalic Cells Subjected to Oxidative Stress

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Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution

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Autophagy Is Required for Maturation of Surfactant-Containing Lamellar Bodies in the Lung and Swim Bladder

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Shigella flexneri Disruption of Cellular Tension Promotes Intercellular Spread

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Essentiality of CENP-A Depends on Its Binding Mode to HJURP

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BUBR1 Pseudokinase Domain Promotes Kinetochore PP2A-B56 Recruitment, Spindle Checkpoint Silencing, and Chromosome Alignment

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TORC1 selectively regulates synaptic maturation and input convergence in the developing visual system

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Enzymatic Activity of CD73 Modulates Invasion of Gliomas via Epithelial–Mesenchymal Transition-Like Reprogramming

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Restoration of Cingulate Long-Term Depression by Enhancing Non-apoptotic Caspase 3 Alleviates Peripheral Pain Hypersensitivity

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Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex

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Olfactory Stimulation Regulates the Birth of Neurons That Express Specific Odorant Receptors

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An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

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Metabolic Imaging Detects Resistance to PI3Kα Inhibition Mediated by Persistent FOXM1 Expression in ER+ Breast Cancer

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CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development

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Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis

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TACAN Is an Ion Channel Involved in Sensing Mechanical Pain

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JNK signalling regulates antioxidant responses in neurons

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Endocrine-Exocrine Signaling Drives Obesity-Associated Pancreatic Ductal Adenocarcinoma

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Lipoprotein receptor loss in forebrain radial glia results in neurological deficits and severe seizures

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The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer

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Mechanistic Target of Rapamycin Regulates the Oligodendrocyte Cytoskeleton during Myelination

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Cytoskeletal remodeling slows cross‐bridge cycling and ATP hydrolysis rates in airway smooth muscle

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AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

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Extracellular Acidosis and mTOR Inhibition Drive the Differentiation of Human Monocyte-Derived Dendritic Cells

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Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian Neurons

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A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2

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The Absence of HIF-1α Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis

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Precise Temporal Regulation of Post-transcriptional Repressors Is Required for an Orderly Drosophila Maternal-to-Zygotic Transition

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The Mitochondria-Associated ER Membranes Are Novel Subcellular Locations Enriched for Inflammatory-Responsive MicroRNAs

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BPS Publications

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The RNA-Binding Protein Rasputin/G3BP Enhances the Stability and Translation of Its Target mRNAs

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Defining the Substrate Spectrum of the TIM22 Complex Identifies Pyruvate Carrier Subunits as Unconventional Cargos

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Wild‐type and Mutant SOD1 Localizes to RNA‐Rich Structures in Cells and Mice But Does Not Bind RNA

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The Synaptic Vesicle Priming Protein CAPS-1 Shapes the Adaptation of Sensory Evoked Responses in Mouse Visual Cortex

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Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development

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Different functions of two putative Drosophila α 2 δ subunits in the same identified motoneurons

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Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced Nfe2l1 expression

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Reduced stability and pH-dependent activity of a common obesity-linked PCSK1 polymorphism, N221D

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A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling

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Concerted 2-5A-Mediated mRNA Decay and Transcription Reprogram Protein Synthesis in the dsRNA Response

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Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer

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Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled

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DUX4-Induced Histone Variants H3.X and H3.Y Mark DUX4 Target Genes for Expression

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Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons

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The Spatiotemporal Pattern and Intensity of p53 Activation Dictates Phenotypic Diversity in p53-Driven Developmental Syndromes

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Spatiotemporal Organization of the E. coli Transcriptome: Translation Independence and Engagement in Regulation

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Mutations in ANKLE2, a ZIKA Virus Target, Disrupt an Asymmetric Cell Division Pathway in Drosophila Neuroblasts to Cause Microcephaly

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Endogenous IGF Signaling Directs Heterogeneous Mesoderm Differentiation in Human Embryonic Stem Cells

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Mechanisms underlying TNFα‐induced enhancement of force generation in airway smooth muscle

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Miro1 Marks Parkinson’s Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson’s Models

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Mg2+-ATP Sensing in CNNM, a Putative Magnesium Transporter

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DUX4 Suppresses MHC Class I to Promote Cancer Immune Evasion and Resistance to Checkpoint Blockade

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HIV-1 nuclear import in macrophages is regulated by CPSF6-capsid interactions at the nuclear pore complex

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Fibroblast Growth Factor 21 Drives Dynamics of Local and Systemic Stress Responses in Mitochondrial Myopathy with mtDNA Deletions

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Simultaneous Activation of Mu and Delta Opioid Receptors Reduces Allodynia and Astrocytic Connexin 43 in an Animal Model of Neuropathic Pain

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NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25

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Allosteric Regulation of NCLX by Mitochondrial Membrane Potential Links the Metabolic State and Ca2+ Signaling in Mitochondria

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Mapping Local and Global Liquid Phase Behavior in Living Cells Using Photo-Oligomerizable Seeds

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The Expression of Key Guidance Genes at a Forebrain Axon Turning Point Is Maintained by Distinct Fgfr Isoforms but a Common Downstream Signal Transduction Mechanism

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Single-Molecule Analysis Reveals Linked Cycles of RSC Chromatin Remodeling and Ace1p Transcription Factor Binding in Yeast

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Pharmacological Induction of RAS-GTP Confers RAF Inhibitor Sensitivity in KRAS Mutant Tumors

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A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival

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Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency

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The Inhibitory Innate Immune Sensor NLRP12 Maintains a Threshold against Obesity by Regulating Gut Microbiota Homeostasis

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Small-Molecule TLR8 Antagonists via Structure-Based Rational Design

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Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State

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Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency

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Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis

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The pro-apoptotic JNK scaffold POSH/SH3RF1 mediates CHMP2BIntron5-associated toxicity in animal models of frontotemporal dementia

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Radial Glial Fibers Promote Neuronal Migration and Functional Recovery after Neonatal Brain Injury

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https://www.ncbi.nlm.nih.gov/pubmed/29290584

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TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2.

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Membrane-Associated Effects of Glucocorticoid on BACE1 Upregulation and Aβ Generation: Involvement of Lipid Raft-Mediated CREB Activation

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A synthetic planar cell polarity system reveals localized feedback on Fat4-Ds1 complexes

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Elucidating the Biological Roles of Insulin and Its Receptor in Murine Intestinal Growth and Function

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Protein sorting by lipid phase-like domains supports emergent signaling function in B lymphocyte plasma membranes

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Diverse stimuli engage different neutrophil extracellular trap pathways

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LTR-Retrotransposon Control by tRNA-Derived Small RNAs

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