1,106 Matching Annotations
  1. Dec 2023
  2. www.sciencedirect.com www.sciencedirect.com
    Epinephrine inhibits PI3Kα via the Hippo kinases
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    1. scibot 20 Dec 2023
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    sciencedirect.com/science/article/pii/S2211124723015474
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    Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
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      DOI: 10.1016/j.xcrm.2023.101341

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    sciencedirect.com/science/article/pii/S266637912300558X
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    Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling
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    1. scibot 19 Dec 2023
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    sciencedirect.com/science/article/pii/S1534580723006214
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    An oncogenic phenoscape of colonic stem cell polarization
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    1. scibot 17 Dec 2023
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    sciencedirect.com/science/article/pii/S0092867423012217
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    Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses
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    sciencedirect.com/science/article/pii/S0092867423012205
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    Reprogramming of tumor-associated macrophages via NEDD4-mediated CSF1R degradation by targeting USP18
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    sciencedirect.com/science/article/pii/S2211124723015723
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    Heterogeneity and transcriptional drivers of triple-negative breast cancer
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    1. scibot 16 Dec 2023
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    sciencedirect.com/science/article/pii/S2211124723015760
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    Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions
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    ncbi.nlm.nih.gov/pmc/articles/PMC10687339/
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    Akt/mTOR Pathway Agonist SC79 Inhibits Autophagy and Apoptosis of Oligodendrocyte Precursor Cells Associated with Neonatal White Matter Dysplasia
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    link.springer.com/article/10.1007/s11064-023-04057-w
  11. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Lysoglycosphingolipids have the ability to induce cell death through direct PI3K inhibition
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    1. scibot 01 Dec 2023
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    onlinelibrary.wiley.com/doi/10.1111/jnc.16012
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    Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway
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    1. scibot 01 Dec 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC10682431/
  13. Nov 2023
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    1. scibot 30 Nov 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC10675918/
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    Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.isci.2023.108399

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    sciencedirect.com/science/article/pii/S2589004223024768
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    A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment
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    1. scibot 28 Nov 2023
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    sciencedirect.com/science/article/pii/S2666379123004809
  17. www.cell.com www.cell.com
    Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
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    cell.com/molecular-cell/fulltext/S1097-2765(23)00857-2
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    The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency
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    sciencedirect.com/science/article/abs/pii/S1550413123003856
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    Fibroblast Growth Factor 23 Neutralizing Antibody Ameliorates Abnormal Renal Phosphate Handling in Sickle Cell Disease Mice
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    1. scibot 26 Nov 2023
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      DOI: 10.1210/endocr/bqad173

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    dx.doi.org/10.1210/endocr/bqad173
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    Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration
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    sciencedirect.com/science/article/pii/S1550413123003868
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The myocardium utilizes a platelet-derived growth factor receptor alpha (Pdgfra)–phosphoinositide 3-kinase (PI3K) signaling cascade to steer toward the midline during zebrafish heart tube formation
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    1. scibot 18 Nov 2023
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      DOI: 10.7554/eLife.85930

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    ncbi.nlm.nih.gov/pmc/articles/PMC10651176/
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    Enniatin A inhibits the chaperone Hsp90 and unleashes the immune system against triple-negative breast cancer
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    1. scibot 18 Nov 2023
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      DOI: 10.1016/j.isci.2023.108308

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    sciencedirect.com/science/article/pii/S2589004223023854
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    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
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      DOI: 10.1016/j.xcrm.2023.101285

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    sciencedirect.com/science/article/pii/S2666379123004792
  24. www.embopress.org www.embopress.org
    Breast adipose tissue-derived extracellular vesicles from obese women alter tumor cell metabolism
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      DOI: 10.15252/embr.202357339

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  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Smith–Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling
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    1. scibot 15 Nov 2023
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      DOI: 10.7554/eLife.90333

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    Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria
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    sciencedirect.com/science/article/pii/S2211124723014018
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    Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk
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      DOI: 10.1016/j.stem.2023.08.002

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  28. 52.53.155.43 52.53.155.43
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  29. dx.doi.org dx.doi.org
    cwad087-html.html
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    WIPF1 promotes gastric cancer progression by regulating PI3K/Akt signaling in a myocardin-dependent manner
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  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRL2 inhibition elevates PTEN protein and ameliorates progression of acute myeloid leukemia
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      DOI: 10.1172/jci.insight.170065

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    ncbi.nlm.nih.gov/pmc/articles/PMC10619439/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
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    ncbi.nlm.nih.gov/pmc/articles/PMC10618648/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts
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    ncbi.nlm.nih.gov/pmc/articles/PMC10618743/
  34. www.tandfonline.com www.tandfonline.com
    Rapamycin attenuates pyroptosis by suppressing mTOR phosphorylation and promoting autophagy in LPS-induced bronchopulmonary dysplasia
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      DOI: 10.1080/01902148.2023.2266236

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    tandfonline.com/doi/abs/10.1080/01902148.2023.2266236
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    MFGE-8 identified in fetal mesenchymal-stromal-cell-derived exosomes ameliorates acute hepatic failure pathology
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    sciencedirect.com/science/article/pii/S2589004223021776
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    Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S2589004223022952
  37. Oct 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Blocking AMPKαS496 phosphorylation improves mitochondrial dynamics and hyperglycemia in aging and obesity
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      DOI: 10.1016/j.chembiol.2023.09.017

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    sciencedirect.com/science/article/pii/S2451945623003367
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    Collagen 1-mediated CXCL1 secretion in tumor cells activates fibroblasts to promote radioresistance of esophageal cancer
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    sciencedirect.com/science/article/pii/S2211124723012822
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    Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis
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      DOI: 10.1016/j.stem.2023.09.012

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    sciencedirect.com/science/article/pii/S1934590923003594
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    Myotube growth is associated with cancer-like metabolic reprogramming and is limited by phosphoglycerate dehydrogenase
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    sciencedirect.com/science/article/pii/S0014482723003713
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    Temporal dynamics of BDNF signaling recruitment in the rat prefrontal cortex and hippocampus following a single infusion of a translational dose of ketamine
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      DOI: 10.1016/j.neuropharm.2023.109767

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    Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
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    DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer
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    Hypomorphism of a Novel Long ERα Isoform Causes Severe Reproductive Dysfunctions in Female Mice
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    Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer
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    RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition
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    Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis
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    INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model
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    Genetic deletion of skeletal muscle iPLA2γ results in mitochondrial dysfunction, muscle atrophy and alterations in whole-body energy metabolism
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    Increased fibrosis in white adipose tissue of male and female bGH transgenic mice appears independent of TGF-β action
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    Cadmium-induced Sertoli cell injury through p38-MAPK and related signaling proteins – a study by RNA sequencing
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    The activation of GIP/GIPR axis via Sonic hedgehog signaling promotes the bridging of gapped nerves in sciatic nerve injury
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  136. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Injury-induced activation of the endocannabinoid system promotes axon regeneration
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    Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced arthritis in mice
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    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
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    Actuation of single downstream nodes in growth factor network steers immune cell migration
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    Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma
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    Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials
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    Trigeminal nerve derived-substance P regulates limbal stem cells by the PI3K-AKT pathway
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    Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment
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    VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection
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    Venlafaxine antagonizes the noradrenaline-promoted colon cancer progression by inhibiting the norepinephrine transporter
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    A nanotherapeutic strategy that engages cytotoxic and immunosuppressive activities for the treatment of cancer recurrence following organ transplantation
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    Loss of fibroblast growth factor receptor 2 (FGFR2) leads to defective bladder urothelial regeneration after Cyclophosphamide injury
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    Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease
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    Prenatal overexpression of platelet-derived growth factor receptor A results in central nervous system hypomyelination
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    Fluid shear stress generates a unique signaling response by activating multiple TGFβ family type I receptors in osteocytes
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    Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance
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  154. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional requirements for a Samd14-capping protein complex in stress erythropoiesis
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    RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition
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  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calcium released by osteoclastic resorption stimulates autocrine/paracrine activities in local osteogenic cells to promote coupled bone formation
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    Emx1-Cre-mediated inactivation of PDK1 prevents plaque deposition in an Alzheimer’s disease-like mouse model
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    A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression
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    Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System
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    Optimal HSF1 activation in response to acute cold stress in BAT requires nuclear TXNIP
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  162. www.thelancet.com www.thelancet.com
    Metabolic role of the hepatic valine/3-hydroxyisobutyrate (3-HIB) pathway in fatty liver disease
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    IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma
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    Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System
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    Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models
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