1,413 Matching Annotations
  1. Jun 2025
  2. www.sciencedirect.com www.sciencedirect.com
    PTEN protein phosphatase activity regulates metastasis by targeting PKCδ
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    sciencedirect.com/science/article/pii/S2589004225010028
  3. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    The Effect of FPR2 on the Regulation of Trophoblast Autophagy via the PI3K/AKT/mTOR Signaling Pathway in Preeclampsia
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202402938RR
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Muscle metabolic resilience and enhanced exercise adaptation by Esr1-induced remodeling of mitochondrial cristae-nucleoid architecture in males
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147913/
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    MT-125 inhibits non-muscle myosin IIA and IIB and prolongs survival in glioblastoma
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    sciencedirect.com/science/article/pii/S0092867425005690
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Nerve growth factor signaling tunes axon maintenance protein abundance and kinetics of Wallerian degeneration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12005098/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ROUX-en-Y gastric bypass surgery improves metabolic syndrome–related erectile dysfunction in mice via the IRS-1/PI3K/AKT/eNOS pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC11134102/
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    Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation
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    sciencedirect.com/science/article/pii/S2451945625001667
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    Cholesterol metabolism regulated by CAMKK2-CREB signaling promotes castration-resistant prostate cancer
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    sciencedirect.com/science/article/pii/S2211124725005637
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    PIN1 serves as a prognostic and therapeutic biomarker in lung adenocarcinoma
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    link.springer.com/article/10.1007/s10142-025-01629-7
  11. 52.53.155.43 52.53.155.43
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    Amiloride synergizes with EGFR PROTACs and inhibitors to overcome therapeutic resistance in NSCLC
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    sciencedirect.com/science/article/pii/S0045206825005218
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    Triflumizole induces excessive reactive oxygen species, inhibits the GPR30/PI3K/AKT pathway, and triggers apoptosis and autophagy in GC-1 spermatogonia cells
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    sciencedirect.com/science/article/pii/S0048357525001993
  15. May 2025
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    YTHDF1 differentiates the contributing roles of mTORC1 in aging
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    sciencedirect.com/science/article/pii/S1097276525004083
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Focal Adhesion Kinase Orchestrates GLUT4 Translocation and Glucose Uptake via Cytoskeletal Turnover in Primary Adipocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12093284/
  18. academic.oup.com academic.oup.com
    12-Lipoxygenase inhibition improves glycemia and obesity-associated inflammation in male human gene replacement mice
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    academic.oup.com/endo/article-abstract/166/6/bqaf069/8106702
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    Stress-induced pro-inflammatory glioblastoma stem cells secrete TNFAIP6 to enhance tumor growth and induce suppressive macrophages
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    sciencedirect.com/science/article/pii/S1534580725002874
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KRAS G12V mutation-selective requirement for ACSS2 in colorectal adenoma formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12091147/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identifying antisense oligonucleotides for targeted inhibition of insulin receptor isoform A
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    pmc.ncbi.nlm.nih.gov/articles/PMC12038057/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
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    pmc.ncbi.nlm.nih.gov/articles/PMC12046322/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modulation of HER2 internalization enhances single-dose antibody-drug potency in HER2+ gastric cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12081668/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lipolysis-derived fatty acids are needed for homeostatic control of sterol element-binding protein-1c driven hepatic lipogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11982389/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel TRKB-activating internal tandem duplication characterizes a new mechanism of receptor tyrosine kinase activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12065843/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147910/
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    The biased OTR ligands -atosiban and carbetocin- differentially inhibit early or late formalin-induced nociception in rats
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  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells
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    Semaphorin7A and PD-L1 cooperatively drive immunosuppression during mammary involution and breast cancer
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    Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling
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    sciencedirect.com/science/article/pii/S2211124725004188
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    Stromal lipid species dictate melanoma metastasis and tropism
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  32. Apr 2025
  33. 52.53.155.43 52.53.155.43
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    Targeting IRE1α improves insulin sensitivity and thermogenesis and suppresses metabolically active adipose tissue macrophages in male obese mice
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    elifesciences.org/articles/100581
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    Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling
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  38. www.nature.com www.nature.com
    Jorunnamycin A induces apoptosis in pancreatic ductal adenocarcinoma cells, spheroids, and patient-derived organoids by modulating KRAS-mediated survival pathways
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    nature.com/articles/s41598-025-95766-5
  39. link.springer.com link.springer.com
    Ursodeoxycholic acid prompts glycolytic dominance, reductive stress and epithelial-to-mesenchymal transition in ovarian cancer cells through NRF2 activation
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    link.springer.com/article/10.1038/s41420-025-02398-9
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    Oncogenic KRAS Addiction States Differentially Influence MTH1 Expression and 8-oxodGTPase Activity in Lung Adenocarcinoma
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    Scutellaria barbata ameliorates acute respiratory distress syndrome by inhibiting neutrophil-mediated inflammatory responses
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  42. Mar 2025
  43. www.sciencedirect.com www.sciencedirect.com
    PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth
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    sciencedirect.com/science/article/pii/S1097276525001868
  44. www.biorxiv.org www.biorxiv.org
    In vivo validation of the palmitoylation cycle as a therapeutic target in NRAS-mutant cancer
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    biorxiv.org/content/10.1101/2025.03.20.644389v1
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Induction of Triple-Negative Breast Cancer Cell Death and Chemosensitivity Using mTORC2-Directed RNAi Nanomedicine
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    pmc.ncbi.nlm.nih.gov/articles/PMC11921867/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Safety and Efficacy of Copanlisib in Combination with Nivolumab: A Phase Ib Study in Patients with Advanced Solid Tumors
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    pmc.ncbi.nlm.nih.gov/articles/PMC11907410/
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    T-bet+ CXCR3+ B cells drive hyperreactive B-T cell interactions in multiple sclerosis
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    sciencedirect.com/science/article/pii/S2666379125001004
  48. link.springer.com link.springer.com
    A phase II trial of mTORC1/2 inhibition in STK11 deficient non small cell lung cancer
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    link.springer.com/article/10.1038/s41698-025-00838-4
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    Phosphatase PHLPP1 is an alveolar-macrophage-intrinsic transcriptional checkpoint controlling pulmonary fibrosis
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    sciencedirect.com/science/article/pii/S2211124725001706
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    YAP1 is a key regulator of EWS::FLI1-dependent malignant transformation upon IGF-1-mediated reprogramming of bone mesenchymal stem cells
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    sciencedirect.com/science/article/pii/S2211124725001524
  51. journals.lww.com journals.lww.com
    The compound... : Neural Regeneration Research
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    journals.lww.com/nrronline/fulltext/2025/11000/the_compound.34.aspx
  52. journals.lww.com journals.lww.com
    Treadmill exercise in combination with acousto-optic and... : Neural Regeneration Research
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    journals.lww.com/nrronline/fulltext/2025/09000/treadmill_exercise_in_combination_with.31.aspx
  53. www.mdpi.com www.mdpi.com
    Cytotoxic Autophagy: A Novel Treatment Paradigm against Breast Cancer Using Oleanolic Acid and Ursolic Acid
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    mdpi.com/2072-6694/16/19/3367
  54. Feb 2025
  55. 52.53.155.43 52.53.155.43
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    FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma
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    sciencedirect.com/science/article/pii/S1535610825000534
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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    pmc.ncbi.nlm.nih.gov/articles/PMC11951025/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genome-wide transcriptome analysis and drug target discovery reveal key genes and pathways in thyroid cancer metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11847698/
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    Enhanced viability and functional maturity of iPSC-derived islet organoids by collagen-VI-enriched ECM scaffolds
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    sciencedirect.com/science/article/pii/S1934590925000402
  60. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cannabinoid Receptor Type 2 Agonist, GW405833, Reduced the Impacts of MDA-MB-231 Breast Cancer Cells on Bone Cells
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    onlinelibrary.wiley.com/doi/10.1002/cam4.70709
  61. dx.doi.org dx.doi.org
    The TSH receptor antibody reactome contributes to retro-orbital inflammation
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    dx.doi.org/10.1210/jendso/bvae182
  62. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation
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  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Sotorasib resistance triggers epithelial-mesenchymal transition and activates AKT and P38-mediated signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC11821485/
  65. elifesciences.org elifesciences.org
    Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway
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    elifesciences.org/articles/97268
  66. aacrjournals.org aacrjournals.org
    Peptide PDHPS1 inhibits ovarian cancer growth through disrupting YAP signaling
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    aacrjournals.org/mct/article/21/7/1160/705294/Peptide-PDHPS1-Inhibits-Ovarian-Cancer-Growth
  67. aacrjournals.org aacrjournals.org
    Cancer-Associated Fibroblasts Expressing Sulfatase 1 Facilitate VEGFA-Dependent Microenvironmental Remodeling to Support Colorectal Cancer
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    aacrjournals.org/cancerres/article/84/20/3371/749080/Cancer-Associated-Fibroblasts-Expressing-Sulfatase
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    TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma
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    aacrjournals.org/cancerres/article/83/13/2262/727433/TGF-Antagonizes-IFN-Mediated-Adaptive-Immune
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    mTORC2 Regulates Actin Polymerization in Auditory Cells
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    onlinelibrary.wiley.com/doi/10.1111/jnc.70012
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    hERG activators exhibit antitumor effects in breast cancer through calcineurin and β-catenin-mediated signaling pathways
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    pmc.ncbi.nlm.nih.gov/articles/PMC11799564/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11791202/
  72. 52.53.155.43 52.53.155.43
    The propensity of fructose to induce metabolic dysfunction is dependent on the baseline diet, length of the dietary exposure, and sex of the mice
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    The coagulation and tumor system are directly linked through the proteolysis and activation of epidermal growth factor receptor by thrombin
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    nature.com/articles/s41388-025-03296-1
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    Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy
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    Dab1 expression level controls Reelin-induced PI3K-Akt activation in early GABAergic neurons
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    sciencedirect.com/science/article/pii/S0006291X25001585
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    Meteorin-like alleviates hepatic steatosis by regulating hepatic triglyceride secretion and fatty acid oxidation
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    Exercise-induced adipokine Nrg4 alleviates MASLD by disrupting hepatic cGAS-STING signaling
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    sciencedirect.com/science/article/pii/S2211124725000221
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    Clioquinol inhibits angiogenesis by promoting VEGFR2 degradation and synergizes with AKT inhibition to suppress triple-negative breast cancer vascularization
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    link.springer.com/article/10.1007/s10456-024-09965-1
  80. Jan 2025
  81. www.sciencedirect.com www.sciencedirect.com
    Neoadjuvant immunotherapy with or without chemotherapy in locally advanced oral squamous cell carcinoma: Randomized, two-arm, phase 2 trial
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    sciencedirect.com/science/article/pii/S2666379125000035
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    Lactate homeostasis is maintained through regulation of glycolysis and lipolysis
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    Nutrient-sensing alteration leads to age-associated distortion of intestinal stem cell differentiating direction
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    nature.com/articles/s41467-024-53675-7
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    OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth
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  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor–Ligand Interactions That Instructs Intratumoral γδT-cell Activity
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    Hyperacute rejection-engineered oncolytic virus for interventional clinical trial in refractory cancer patients
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    sciencedirect.com/science/article/pii/S0092867424014235
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    Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint
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    pmc.ncbi.nlm.nih.gov/articles/PMC11735390/
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    Maternal circadian rhythms during pregnancy dictate metabolic plasticity in offspring
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    Non-cell-autonomous regulation of mTORC2 by Hedgehog signaling maintains lipid homeostasis
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    Downregulation of semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis
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  181. Jul 2024
  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  183. www.sciencedirect.com www.sciencedirect.com
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  186. www.sciencedirect.com www.sciencedirect.com
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  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  189. www.cell.com www.cell.com
    RHOF Activation of AKT/β-Catenin Signaling Pathway Drives Acute Myeloid Leukemia Progression and Chemotherapy Resistance
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  190. www.sciencedirect.com www.sciencedirect.com
    PIK3CA mutations enhance the adipogenesis of ADSCs in facial infiltrating lipomatosis through TRPV1
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  191. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  193. www.cell.com www.cell.com
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  194. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors
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  198. www.biorxiv.org www.biorxiv.org
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  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  200. Jun 2024
  201. www.cell.com www.cell.com
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    Evaluation of the role of AXL in fusion-positive pediatric rhabdomyosarcoma identifies the small-molecule inhibitor bemcentinib (BGB324) as potent chemosensitizer
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    Exosomes derived from vMIP-II-Lamp2b gene-modified M2 cells provide neuroprotection by targeting the injured spinal cord, inhibiting chemokine signals and modulating microglia/macrophage polarization in mice
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  206. May 2024
  207. www.nature.com www.nature.com
    Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer
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