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    Reprogramming of fibroblasts into cancer-associated fibroblasts via IGF2-mediated autophagy promotes metastasis of lung cancer cells
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    Bilateral regulation of EGFR activity and local PI(4,5)P2 dynamics in mammalian cells observed with superresolution microscopy
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    Dietary or pharmacological inhibition of insulin-like growth factor-1 protects from renal ischemia-reperfusion injury in mice
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    Intra-tumoral YAP and TAZ heterogeneity drives collective NSCLC invasion that is targeted by SUMOylation inhibitor TAK-981
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  6. Nov 2024
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    USP7 deubiquitinates KRAS and promotes non-small cell lung cancer
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    Insulin Mediates Lipopolysaccharide-Induced Inflammatory Responses and Oxidative Stress in BV2 Microglia
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    Chelating drug-induced labile Zn2+ with nanoparticle-encapsulated TPEN at low dose enhances lung cancer chemotherapy through inhibiting ABCB1
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    Mitochondrial transplantation confers protection against the effects of ischemic stroke by repressing microglial pyroptosis and promoting neurogenesis
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    Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation
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    Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development
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    Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females
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    Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis
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  15. Oct 2024
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    Neuregulin 1 signaling attenuates tumor necrosis factor-α induced female rat luteal cell death
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    NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs
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    Identification of Predictive ERBB Mutations by Leveraging Publicly Available Cell Line Databases
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    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
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    Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming
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    QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction
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  22. Sep 2024
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    Intracerebroventricular insulin injection acutely normalizes the augmented exercise pressor reflex in male rats with type 2 diabetes mellitus
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    TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus
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    A novel inhibitor of class IIa histone deacetylases attenuates collagen-induced arthritis
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    mTOR activity paces human blastocyst stage developmental progression
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    Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription
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    Ceramide synthesis inhibitors prevent lipid-induced insulin resistance through the DAG-PKCε-insulin receptorT1150 phosphorylation pathway
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    FNIP1 suppresses colorectal cancer progression through inhibiting STAT3 phosphorylation and nuclear translocation
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    mCAUSE: Prioritizing Mitochondrial Targets that Alleviate Pancreatic Cancer Cell Phenotypes
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    IGFBP7 is upregulated in islets from T2D donors and reduces insulin secretion
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    Impact of WIN site inhibitor on the WDR5 interactome
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    Obesity Augments Glucocorticoid-Dependent Muscle Atrophy in Male C57BL/6J Mice
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    Combined Targeting of Estrogen Receptor Alpha and Exportin 1 in Metastatic Breast Cancers
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  35. mct.aacrjournals.org mct.aacrjournals.org
    Novel Miniaturized Drug Conjugate Leverages HSP90 Driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors
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  36. www.jbc.org www.jbc.org
    Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet–induced hepatic steatosis and insulin resistance by elevating IL-18 levels
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  37. www.sciencedirect.com www.sciencedirect.com
    PI3K isoform-selective inhibition in neuron-specific PTEN-deficient mice rescues molecular defects and reduces epilepsy-associated phenotypes
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    Augmenting the therapeutic efficacy of adenosine against pancreatic cancer by switching the Akt/p21-dependent senescence to apoptosis
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      DOI: 10.1016/j.ebiom.2019.08.068

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    Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction
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      DOI: 10.1016/j.celrep.2019.07.050

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  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineering exosomes derived from TNF-α preconditioned IPFP-MSCs enhance both yield and therapeutic efficacy for osteoarthritis
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  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mcam stabilizes a luminal progenitor-like breast cancer cell state via Ck2 control and Src/Akt/Stat3 attenuation
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    Endothelial metabolic control of insulin sensitivity through resident macrophages
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    Population Pharmacokinetics, Pharmacodynamics and Safety Properties of Trametinib in Dogs With Cancer: A Phase I Dose Escalating Clinical Trial
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    Acrobatic training prevents learning impairments and astrocyte remodeling in the hippocampus of rats undergoing chronic cerebral hypoperfusion: sex-specific benefits
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    Evaluation of the role of AXL in fusion-positive pediatric rhabdomyosarcoma identifies the small-molecule inhibitor bemcentinib (BGB324) as potent chemosensitizer
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    Akt and AMPK activators rescue hyperexcitability in neurons from patients with bipolar disorder
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    Inhibition of Pim kinases triggers a broad antiviral activity by affecting innate immunity and via the PI3K-Akt-mTOR axis the endolysosomal system
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    Cancer-associated fibroblasts promote enzalutamide resistance and PD-L1 expression in prostate cancer through CCL5-CCR5 paracrine axis
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    Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity
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  132. 52.53.155.43 52.53.155.43
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    Nanodrug-bacteria conjugates-mediated oncogenic collagen depletion enhances immune checkpoint blockade therapy against pancreatic cancer
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    RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation
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  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Inhibition of mGluR5/PI3K-AKT Pathway Alleviates Alzheimer’s Disease-Like Pathology Through the Activation of Autophagy in 5XFAD Mice
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    Ibrutinib-induced pulmonary angiotensin-converting enzyme activation promotes atrial fibrillation in rats
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  165. www.biorxiv.org www.biorxiv.org
    Simulated Microgravity Enhances Adipocyte Maturation and Glucose Uptake via Increased Cortical Actin Remodeling
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    Extracellular-vesicle-packaged S100A11 from osteosarcoma cells mediates lung premetastatic niche formation by recruiting gMDSCs
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