615 Matching Annotations
  1. Apr 2024
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    Central inhibition of HDAC6 re-sensitizes leptin signaling during obesity to induce profound weight loss
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    sciencedirect.com/science/article/pii/S1550413124000536
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    STAT3 couples activated tyrosine kinase signaling to the oncogenic core transcriptional regulatory circuitry of anaplastic large cell lymphoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10983107/
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    Defects of renal tubular homeostasis and cystogenesis in the Pkhd1-knockout
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    ncbi.nlm.nih.gov/pmc/articles/PMC10973142/
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    Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells
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    sciencedirect.com/science/article/pii/S0092867424003039
  6. Mar 2024
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    Human seminal extracellular vesicles enhance endometrial receptivity through leukemia inhibitory factor
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    Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion
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    sciencedirect.com/science/article/pii/S2211124724003309
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    Angiotensin II type-2 receptor signaling facilitates liver injury repair and regeneration via inactivation of Hippo pathway
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    nature.com/articles/s41401-024-01249-0
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    Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders
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    sciencedirect.com/science/article/pii/S2211124724002286
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    Mecp2 knock-out astrocytes affect synaptogenesis by Interleukin 6 dependent mechanisms
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    PBRM1 presents a potential ctDNA marker to monitor response to neoadjuvant chemotherapy in cervical cancer
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    Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice
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    Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon
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    VISTA promotes the metabolism and differentiation of myeloid-derived suppressor cells by STAT3 and polyamine-dependent mechanisms
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    ncbi.nlm.nih.gov/pmc/articles/PMC10851928/
  16. Feb 2024
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    The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes
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    IL-37 dampens immunosuppressive functions of MDSCs via metabolic reprogramming in the tumor microenvironment
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  20. www.biorxiv.org www.biorxiv.org
    A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory target gene expression
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    biorxiv.org/content/10.1101/2024.02.14.580367v1
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    Gut-Brain Axis Interplay via STAT3 pathway: Implications of Helicobacter pylori derived secretome on inflammation and Alzheimer's disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10854367/
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    Osimertinib covalently binds to CD34 and eliminates myeloid leukemia stem/progenitor cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831336/
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    Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M
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    ncbi.nlm.nih.gov/pmc/articles/PMC10829726/
  24. Jan 2024
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    Crosstalk between PARN and EGFR-STAT3 Signaling Facilitates Self-Renewal and Proliferation of Glioblastoma Stem Cells
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    dx.doi.org/10.1158/0008-5472.CAN-22-3965
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    Histone lactylation inhibits RARγ expression in macrophages to promote colorectal tumorigenesis through activation of TRAF6-IL-6-STAT3 signaling
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    Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors
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    sciencedirect.com/science/article/pii/S2666379123006031
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    SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10788290/
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    Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines
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    science.org/doi/10.1126/sciadv.ade1282
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    FK506 bypasses the effect of erythroferrone in cancer cachexia skeletal muscle atrophy
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    Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells
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  33. Dec 2023
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    FLOT2 promotes nasopharyngeal carcinoma progression through suppression of TGF-β pathway via facilitating CD109 expression
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    IL-21-armored B7H3 CAR-iNKT cells exert potent antitumor effects
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    Apoptosis releases hydrogen sulfide to inhibit Th17 cell differentiation
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    Heterogeneity and transcriptional drivers of triple-negative breast cancer
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    BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development
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    Proximity extracellular protein-protein interaction analysis of EGFR using AirID-conjugated fragment of antigen binding
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    Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch
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    The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer
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    Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines
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    ncbi.nlm.nih.gov/pmc/articles/PMC10658995/
  43. Nov 2023
  44. www.sciencedirect.com www.sciencedirect.com
    AGC kinase inhibitors regulate STING signaling through SGK-dependent and SGK-independent mechanisms
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    Hyperleptinemia contributes to antipsychotic drug–associated obesity and metabolic disorders
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    Fibroblast Growth Factor 23 Neutralizing Antibody Ameliorates Abnormal Renal Phosphate Handling in Sickle Cell Disease Mice
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    dx.doi.org/10.1210/endocr/bqad173
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    Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration
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    High fat diet-induced maternal obesity in mice impairs peripartum maternal behaviour
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    onlinelibrary.wiley.com/doi/10.1111/jne.13350
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    A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression
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    Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins
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  51. 52.53.155.43 52.53.155.43
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    Exosomes derived from platelet-rich plasma promote diabetic wound healing via the JAK2/STAT3 pathway
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    Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer
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  54. Oct 2023
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10605716/
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    In vitro generation of mouse morula-like cells
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    Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma
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    Collagen 1-mediated CXCL1 secretion in tumor cells activates fibroblasts to promote radioresistance of esophageal cancer
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    Targeting VCP potentiates immune checkpoint therapy for colorectal cancer
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    Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration
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    STAT3 modulates CD4+ T mitochondrial dynamics and function in aging
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    High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
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    Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1
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    CD9 exacerbates pathological cardiac hypertrophy through regulating GP130/STAT3 signalling pathway
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    Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
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    Inhibition of SOCS3 signaling in the nucleus tractus solitarii and retrotrapezoid nucleus alleviates hypoventilation in diet-induced obese male mice
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  68. Sep 2023
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    Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms
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    ncbi.nlm.nih.gov/pmc/articles/PMC9992133/
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    In vivo modeling of CLL transformation to Richter’s syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities
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  71. Aug 2023
  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Leptin receptor neurons in the dorsomedial hypothalamus input to the circadian feeding network
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    Adrenergic nerves regulate intestinal regeneration through IL-22 signaling from type 3 innate lymphoid cells
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    A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
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    science.org/doi/10.1126/scisignal.ade6737
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    An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver
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    Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors
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    IL-27 mediates immune response of pneumococcal vaccine SPY1 through Th17 and memory CD4+T cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10425906/
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    The miR-17∼92 miRNAs promote plasma cell differentiation by suppressing SOCS3-mediated NIK degradation
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    Reduced smooth muscle-fibroblasts transformation potentially decreases intestinal wound healing and colitis-associated cancer in ageing mice
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    The ATR inhibitor VE-821 increases the sensitivity of gastric cancer cells to cisplatin
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma
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    Hedgehog receptors exert immune-surveillance roles in the epidermis across species
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    Cannabinoid receptor type 1 (CB1R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3
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  86. Jul 2023
  87. www.sciencedirect.com www.sciencedirect.com
    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    Lactate modulates iron metabolism by binding soluble adenylyl cyclase
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    Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia
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    Leptin, but not Estradiol, Signaling in PACAP Neurons Modulates Puberty Onset
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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    GDF15 enhances body weight and adiposity reduction in obese mice by leveraging the leptin pathway
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    STAT3 regulates antiviral immunity by suppressing excessive interferon signaling
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    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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    Interactions between host and intestinal crypt-resided biofilms are controlled by epithelial fucosylation
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    Alpha-tocopherylquinone differentially modulates claudins to enhance intestinal epithelial tight junction barrier via AhR and Nrf2 pathways
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  97. Jun 2023
  98. www.nature.com www.nature.com
    Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation
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