469 Matching Annotations
  1. Dec 2022
  2. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Allicin ameliorates IMQ-induced psoriasis-like skin inflammation via disturbing the interaction of keratinocytes with IL-17A
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    1. scibot 23 Dec 2022
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      DOI: 10.1111/bph.15983

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15983
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    AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance
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    1. scibot 18 Dec 2022
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      DOI: 10.1016/j.celrep.2022.111821

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    sciencedirect.com/science/article/pii/S2211124722017132
  4. journals.lww.com journals.lww.com
    Microglial depletion impairs glial scar formation and... : Neural Regeneration Research
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    1. scibot 06 Dec 2022
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      DOI: 10.4103/1673-5374.357912

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    journals.lww.com/nrronline/Fulltext/2023/06000/Microglial_depletion_impairs_glial_scar_formation.30.aspx
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    Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer
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    1. scibot 02 Dec 2022
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    sciencedirect.com/science/article/pii/S1535610822005529
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Blockage of Lamin-A/C loss diminishes the pro-inflammatory macrophage response
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    1. scibot 02 Dec 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC9708799/
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    Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation
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    1. scibot 01 Dec 2022
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    sciencedirect.com/science/article/pii/S2211124722016199
  8. Nov 2022
  9. www.sciencedirect.com www.sciencedirect.com
    Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis
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    1. scibot 16 Nov 2022
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      DOI: 10.1016/j.neuron.2022.10.028

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    sciencedirect.com/science/article/pii/S0896627322009618
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    STAT3 is activated by CTGF-mediated tumor-stroma cross talk to promote HCC progression.
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    1. scibot 10 Nov 2022
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    sciencedirect.com/science/article/pii/S2352345X22001989
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    Leukemia inhibitory factor is a therapeutic target for renal interstitial fibrosis
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    1. scibot 05 Nov 2022
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    sciencedirect.com/science/article/pii/S2352396422004947
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Niraparib-induced STAT3 inhibition increases its antitumor effects
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    1. scibot 04 Nov 2022
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  13. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deletion of Nox4 enhances remyelination following cuprizone-induced demyelination by increasing phagocytic capacity of microglia and macrophages in mice
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    1. scibot 03 Nov 2022
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    onlinelibrary.wiley.com/doi/10.1002/glia.24292
  14. Oct 2022
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    The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice
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    1. scibot 18 Oct 2022
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    sciencedirect.com/science/article/pii/S1550413122004090
  16. Sep 2022
  17. www.sciencedirect.com www.sciencedirect.com
    Snail maintains the stem/progenitor state of skin epithelial cells and carcinomas through the autocrine effect of matricellular protein Mindin
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    1. scibot 21 Sep 2022
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    sciencedirect.com/science/article/pii/S221112472201227X
  18. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Meprin β expression modulates the interleukin-6 mediated JAK2-STAT3 signaling pathway in ischemia/reperfusion-induced kidney injury
    1
    1. scibot 20 Sep 2022
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      DOI: 10.14814/phy2.15468

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    Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity
    1
    1. scibot 13 Sep 2022
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    sciencedirect.com/science/article/pii/S2666379122002932
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic remodeling by vitamin C potentiates plasma cell differentiation
    1
    1. scibot 09 Sep 2022
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      DOI: 10.7554/eLife.73754

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    ncbi.nlm.nih.gov/pmc/articles/PMC9451539/
  21. Aug 2022
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    ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain
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    1. scibot 31 Aug 2022
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    sciencedirect.com/science/article/pii/S2211124722010865
  23. 52.53.155.43 52.53.155.43
    1960-html.html
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    1. scibot 27 Aug 2022
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    52.53.155.43/c4d56db1e6e5c8b1ff3e886498341985c378d3ad/1960-html.html
  24. aacrjournals.org aacrjournals.org
    Interleukin-27 signaling serves as an immunological checkpoint for innate cytotoxic cells to promote hepatocellular carcinoma
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    1. scibot 27 Aug 2022
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    aacrjournals.org/cancerdiscovery/article/12/8/1960/707258/IL27-Signaling-Serves-as-an-Immunologic-Checkpoint
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation
    1
    1. scibot 26 Aug 2022
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      DOI: 10.1016/j.stem.2022.08.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC9438971/
  26. Jul 2022
  27. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2022 - Li - Maresin 1 intervention Reverses Experimental Pulmonary Arterial Hypertension in mice-html.html
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    1. scibot 29 Jul 2022
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    52.53.155.43/eeb521b7ce9ed18aede2526ed77220c5d9e406f5/British J Pharmacology - 2022 - Li - Maresin 1 intervention Reverses Experimental Pulmonary Arterial Hypertension in mice-html.html
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer
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    1. scibot 12 Jul 2022
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      DOI: 10.3390/cancers14133152

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    ncbi.nlm.nih.gov/pmc/articles/PMC9264918/
  29. Jun 2022
  30. www.sciencedirect.com www.sciencedirect.com
    Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis
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    1. scibot 25 Jun 2022
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      DOI: 10.1016/j.molcel.2022.06.005

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    sciencedirect.com/science/article/pii/S109727652200541X
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    IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells
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    sciencedirect.com/science/article/pii/S1534580722003707
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Humanized Animal Model Predicts Clonal Evolution and Therapeutic Vulnerabilities in Myeloproliferative Neoplasms
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    1. scibot 07 Jun 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC8716669/
  33. academic.oup.com academic.oup.com
    Jumonji domain-containing protein-3 (JMJD3/Kdm6b) is critical for normal ovarian function and female fertility
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      DOI: 10.1210/endocr/bqac047

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    academic.oup.com/endo/article-abstract/163/5/bqac047/6565906
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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    1. scibot 01 Jun 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC9150850/
  35. Apr 2022
  36. www.sciencedirect.com www.sciencedirect.com
    Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques
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      DOI: 10.1016/j.immuni.2022.03.018

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    sciencedirect.com/science/article/pii/S1074761322001418
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    EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
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    sciencedirect.com/science/article/pii/S2589004222004631
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extracellular Nicotinamide Phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4
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    ncbi.nlm.nih.gov/pmc/articles/PMC8990213/
  39. aacrjournals.org aacrjournals.org
    Chk1 Inhibition Potently Blocks STAT3 Tyrosine705 Phosphorylation, DNA-Binding Activity, and Activation of Downstream Targets in Human Multiple Myeloma Cells
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    aacrjournals.org/mcr/article/20/3/456/681666/Chk1-Inhibition-Potently-Blocks-STAT3-Tyrosine705
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    Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer
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  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tenascin-C can Serve as an Indicator for the Immunosuppressive Microenvironment of Diffuse Low-Grade Gliomas
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    ncbi.nlm.nih.gov/pmc/articles/PMC8966496/
  42. Mar 2022
  43. www.sciencedirect.com www.sciencedirect.com
    Protein tyrosine phosphatase receptor δ serves as the orexigenic asprosin receptor
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    sciencedirect.com/science/article/pii/S1550413122000845
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    Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells
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    sciencedirect.com/science/article/pii/S1097276522002076
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    Deletion of STAT3 from Foxd1 cell population protects mice from kidney fibrosis by inhibiting pericytes trans-differentiation and migration
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    sciencedirect.com/science/article/pii/S2211124722002066
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    A nonredundant role for T cell-derived interleukin 22 in antibacterial defense of colonic crypts
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    sciencedirect.com/science/article/pii/S1074761322000838
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    Interleukin-6 mimics insulin-dependent cellular distribution of some cytoskeletal proteins and Glut4 transporter without effect on glucose uptake in 3T3-L1 adipocytes
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      DOI: 10.1007/s00418-022-02091-3

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    Deletion of PTP 1B from Brain Neurons Partly Protects Mice from Diet-Induced Obesity and Minimally Improves Fertility
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    Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer
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  96. www.sciencedirect.com www.sciencedirect.com
    The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3
    1
    1. scibot 30 Jul 2021
      RRID:AB_2491009

      DOI: 10.1016/j.chom.2019.11.012

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    sciencedirect.com/science/article/pii/S1931312819305943
  97. www.sciencedirect.com www.sciencedirect.com
    CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota
    1
    1. scibot 30 Jul 2021
      Phospho-stat3 (Tyr705) rabbit mAb (D3A7)

      DOI: 10.1016/j.celrep.2019.09.003

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    sciencedirect.com/science/article/pii/S2211124719311714
  98. www.nature.com www.nature.com
    Treatment of type 2 diabetes with the designer cytokine IC7Fc
    1
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      pSTAT3 (Y705)

      DOI: 10.1038/s41586-019-1601-9

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  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Curcumin attenuates proangiogenic and proinflammatory factors in human eutopic endometrial stromal cells through the NF‐κB signaling pathway
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      DOI: 10.1002/jcp.27360

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    ncbi.nlm.nih.gov/pmc/articles/PMC6344303/
  100. www.sciencedirect.com www.sciencedirect.com
    Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease
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    1. scibot 30 Jul 2021
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      DOI: 10.1016/j.neuron.2018.10.031

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    sciencedirect.com/science/article/pii/S0896627318309395
  101. www.sciencedirect.com www.sciencedirect.com
    Leptin and insulin do not exert redundant control of metabolic or emotive function via dopamine neurons
    1
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      DOI: 10.1016/j.yhbeh.2018.10.001

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  102. stemcellsjournals.onlinelibrary.wiley.com stemcellsjournals.onlinelibrary.wiley.com
    Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury
    2
    1. scibot 30 Jul 2021
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      DOI: 10.1002/stem.2744

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      DOI: 10.1002/stem.2744

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  103. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Red nucleus interleukin‐1β evokes tactile allodynia through activation of JAK/STAT3 and JNK signaling pathways
    1
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      DOI: 10.1002/jnr.24324

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  104. www.sciencedirect.com www.sciencedirect.com
    Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression
    2
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      RRID:AB_2491009

      DOI: 10.1016/j.celrep.2018.10.063

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  105. academic.oup.com academic.oup.com
    Dopamine Neuron–Restricted Leptin Receptor Signaling Reduces Some Aspects of Food Reward but Exacerbates the Obesity of Leptin Receptor–Deficient Male Mice
    2
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      AB_2491009

      DOI: 10.1210/en.2017-00513

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      RRID:AB_2491009

      DOI: 10.1210/en.2017-00513

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  106. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.immuni.2018.09.004

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  107. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Identification of STAT3 and STAT5 proteins in the rat suprachiasmatic nucleus and the Day/Night difference in astrocytic STAT3 phosphorylation in response to lipopolysaccharide
    1
    1. scibot 27 Jul 2021
      AB_561305

      DOI: 10.1002/jnr.23673

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  108. academic.oup.com academic.oup.com
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      RRID:AB_10140371

      DOI: 10.1210/en.2016-1718

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  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Insulin regulates POMC neuronal plasticity to control glucose metabolism
    1
    1. scibot 27 Jul 2021
      RRID:AB_10694804

      DOI: 10.7554/eLife.38704

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  110. jlb.onlinelibrary.wiley.com jlb.onlinelibrary.wiley.com
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      DOI: 10.1002/JLB.MA1217-495R

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  111. www.sciencedirect.com www.sciencedirect.com
    Modest enhancement of sensory axon regeneration in the sciatic nerve with conditional co-deletion of PTEN and SOCS3 in the dorsal root ganglia of adult mice
    1
    1. scibot 27 Jul 2021
      RRID:AB_561305

      DOI: 10.1016/j.expneurol.2018.02.012

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    sciencedirect.com/science/article/pii/S0014488618300529
  112. academic.oup.com academic.oup.com
    Perinatal Exposure to Low-Dose Bisphenol-A Disrupts the Structural and Functional Development of the Hypothalamic Feeding Circuitry
    1
    1. scibot 27 Jul 2021
      AB_10140371

      DOI: 10.1210/en.2016-1718

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  113. www.sciencedirect.com www.sciencedirect.com
    Crosstalk between different family members: IL27 recapitulates IFNγ responses in HCC cells, but is inhibited by IL6-type cytokines
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      AB_561305

      DOI: 10.1016/j.bbamcr.2016.12.006

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    sciencedirect.com/science/article/pii/S0167488916303317
  114. www.sciencedirect.com www.sciencedirect.com
    Coupling of GPR30 mediated neurogenesis and protection with astroglial Aromatase-STAT3 signaling in rat hippocampus after global cerebral ischemia
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      RRID:AB_2491009

      DOI: 10.1016/j.mce.2021.111394

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    sciencedirect.com/science/article/pii/S0303720721002380
  115. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Spinal interleukin-1β induces mechanical spinal hyperexcitability in rats: interactions and redundancies with TNF and IL-6
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      RRID:AB_2491009

      DOI: 10.1111/jnc.15438

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  116. Jun 2021
  117. www.hindawi.com www.hindawi.com
    Table 2 | Saussureae Radix Attenuates Neuroinflammation in LPS-Stimulated Mouse BV2 Microglia via HO-1/Nrf-2 Induction and Inflammatory Pathway Inhibition
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      AB_2491009

      DOI: 10.1155/2021/6687089

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  118. www.nature.com www.nature.com
    Clobetasol promotes neuromuscular plasticity in mice after motoneuronal loss via sonic hedgehog signaling, immunomodulation and metabolic rebalancing
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      DOI: 10.1038/s41419-021-03907-1

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    nature.com/articles/s41419-021-03907-1
  119. www.frontiersin.org www.frontiersin.org
    Promotion of Bone Lesions Through the Myeloma Integrin α6-Mediated Osteolytic Signaling
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      DOI: 10.3389/fonc.2021.692190

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    frontiersin.org/article/10.3389/fonc.2021.692190/full
  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Canonical NF-κB signaling maintains corneal epithelial integrity and prevents corneal aging via retinoic acid
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      DOI: 10.7554/eLife.67315

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  121. www.sciencedirect.com www.sciencedirect.com
    Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma
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    sciencedirect.com/science/article/pii/S1535610821002683
  122. May 2021
  123. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Loss of interleukin-10 receptor disrupts intestinal epithelial cell proliferation and skews differentiation towards the goblet cell fate
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      9145

      DOI: 10.1096/fj.202002369R

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  124. www.nature.com www.nature.com
    Transcriptomics identifies STAT3 as a key regulator of hippocampal gene expression and anhedonia during withdrawal from chronic alcohol exposure
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      DOI: 10.1038/s41398-021-01421-8

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  125. www.sciencedirect.com www.sciencedirect.com
    PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR
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  126. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      DOI: 10.1111/bph.15435

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  127. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD+
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      DOI: 10.1111/jnc.15367

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  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling
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      DOI: 10.7554/eLife.68348

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    ncbi.nlm.nih.gov/pmc/articles/PMC8118655/
  129. www.sciencedirect.com www.sciencedirect.com
    Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors
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  130. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Binge‐Like Ethanol Drinking Activates ALK Signaling and Increases the Expression of STAT3 Target Genes in the Mouse Hippocampus and Prefrontal Cortex
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      DOI: 10.1111/gbb.12729

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  131. www.sciencedirect.com www.sciencedirect.com
    Integrin-Linked Kinase Mediates Therapeutic Resistance of Quiescent CML Stem Cells to Tyrosine Kinase Inhibitors
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      DOI: 10.1016/j.stem.2020.04.005

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  132. www.sciencedirect.com www.sciencedirect.com
    Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation
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      DOI: 10.1016/j.molcel.2020.04.033

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  133. www.sciencedirect.com www.sciencedirect.com
    Ectosomal PKM2 Promotes HCC by Inducing Macrophage Differentiation and Remodeling the Tumor Microenvironment
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      DOI: 10.1016/j.molcel.2020.05.004

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  134. www.sciencedirect.com www.sciencedirect.com
    Paneth Cell-Derived Lysozyme Defines the Composition of Mucolytic Microbiota and the Inflammatory Tone of the Intestine
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  137. Apr 2021
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    Pharmacoproteomics Identifies Kinase Pathways that Drive the Epithelial-Mesenchymal Transition and Drug Resistance in Hepatocellular Carcinoma
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  141. Mar 2021
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  143. Feb 2021
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    PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity
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    Natural Product Trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer
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    Oncostatin M induces hyperalgesic priming and amplifies signaling of cAMP to ERK by RapGEF2 and PKA
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    Mild Impairment of Mitochondrial OXPHOS Promotes Fatty Acid Utilization in POMC Neurons and Improves Glucose Homeostasis in Obesity
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    Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling
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    Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination
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    Systematic Transcriptional Profiling of Responses to STAT1- and STAT3-Activating Cytokines in Different Cancer Types
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    Leptin receptor neurons in the dorsomedial hypothalamus regulate diurnal patterns of feeding, locomotion, and metabolism
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  162. Jan 2021
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    Transneuronal delivery of hyper-interleukin-6 enables functional recovery after severe spinal cord injury in mice
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    Ablation of STAT3 in Purkinje cells reorganizes cerebellar synaptic plasticity in long-term fear memory network
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  171. Oct 2020
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  177. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    A chalcone derivative, 1m‐6, exhibits atheroprotective effects by increasing cholesterol efflux and reducing inflammation‐induced endothelial dysfunction
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    Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation
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    Leukemogenic Chromatin Alterations Promote AML Leukemia Stem Cells via a KDM4C-ALKBH5-AXL Signaling Axis
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    Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA
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    Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization
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    Differential Roles of the mTOR-STAT3 Signaling in Dermal γδ T Cell Effector Function in Skin Inflammation
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    Deficiency in BDNF/TrkB Neurotrophic Activity Stimulates δ-Secretase by Upregulating C/EBPβ in Alzheimer’s Disease
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    1. scibot 13 Jan 2020
      RRID:AB_2491009

      DOI: 10.1016/j.celrep.2019.06.054

      Resource: (Cell Signaling Technology Cat# 9145, RRID:AB_2491009)

      Curator: @ethanbadger

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      RRID:AB_2491009 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719308277
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    miRNA551b-3p Activates an Oncostatin Signaling Module for the Progression of Triple-Negative Breast Cancer
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    1. scibot 13 Jan 2020
      RRID:AB_2491009

      DOI: 10.1016/j.celrep.2019.11.085

      Resource: (Cell Signaling Technology Cat# 9145, RRID:AB_2491009)

      Curator: @ethanbadger

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      RRID:AB_2491009 RRIDCUR:Validated
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    cell.com/cell-reports/fulltext/S2211-1247(19)31576-1
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    Concomitant Infection of S. mansoni and H. pylori Promotes Promiscuity of Antigen-Experienced Cells and Primes the Liver for a Lower Fibrotic Response
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    1. scibot 13 Jan 2020
      RRID:AB_2491009

      DOI: 10.1016/j.celrep.2019.05.108

      Resource: (Cell Signaling Technology Cat# 9145, RRID:AB_2491009)

      Curator: @ethanbadger

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      RRID:AB_2491009 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719307557