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Sep 2021
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REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps

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Myristoylated alanine-rich C kinase substrate-like protein-1 regulates epithelial sodium channel activity in renal distal convoluted tubule cells

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Full-length isoform transcriptome of the developing human brain provides further insights into autism

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Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy

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Aug 2021
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ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability

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1. scibot 17 Aug 2021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8302662/
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Protein Tyrosine Phosphatase δ mediates the Sema3A-induced cortical basal dendritic arborization through the activation of Fyn tyrosine kinase

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ncbi.nlm.nih.gov/pmc/articles/PMC6705738/
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Functional divergence of Plexin B structural motifs in distinct steps of Drosophila olfactory circuit assembly

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1. scibot 14 Aug 2021
  
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  DOI: 10.7554/eLife.48594
  
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A Drosophila Tumor Suppressor Gene Prevents Tonic TNF Signaling through Receptor N-Glycosylation

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Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism

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Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling

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sciencedirect.com/science/article/pii/S1535610818305269
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  DOI: 10.1038/s41419-018-0871-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6310685/
Jul 2021
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Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

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1. scibot 31 Jul 2021
  
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Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo

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Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer

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Leukocyte receptor tyrosine kinase interacts with secreted midkine to promote survival of migrating neural crest cells

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ncbi.nlm.nih.gov/pmc/articles/PMC6215395/
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Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II

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ncbi.nlm.nih.gov/pmc/articles/PMC6057917/
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cell.com/developmental-cell/abstract/S1534-5807(17)30871-7
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Divergent Connectivity of Homologous Command-like Neurons Mediates Segment-Specific Touch Responses in Drosophila

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lncRNA Sensing of a Viral Suppressor of RNAi Activates Non-canonical Innate Immune Signaling in Drosophila

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  DOI: 10.1016/j.chom.2019.12.006
  
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sciencedirect.com/science/article/pii/S1931312819306353
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Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome

2
1. scibot 27 Jul 2021
  
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sciencedirect.com/science/article/pii/S0002929716304402
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Targeting an anchored phosphatase-deacetylase unit restores renal ciliary homeostasis

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1. scibot 23 Jul 2021
  
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Action potential-coupled Rho GTPase signaling drives presynaptic plasticity

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  DOI: 10.7554/eLife.63756
  
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NANOS2 is a sequence-specific mRNA-binding protein that promotes transcript degradation in spermatogonial stem cells

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Plasmin improves blood–gas barrier function in oedematous lungs by cleaving epithelial sodium channels

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ncbi.nlm.nih.gov/pmc/articles/PMC7280014/
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Mutually repulsive EphA7-EfnA5 organize region-to-region corticopontine projection by inhibiting collateral extension

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Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner

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Optimized protocol for the identification of lipid droplet proteomes using proximity labeling proteomics in cultured human cells

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Differential compartmentalization of BMP4/NOGGIN requires NOGGIN trans-epithelial transport

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Toxoplasma gondii secreted effectors co-opt host repressor complexes to inhibit necroptosis

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Phosphorylation of Collapsin Response Mediator Protein 1 (CRMP1) at Tyrosine 504 residue regulates Semaphorin 3A-induced cortical dendritic growth

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Missense mutations in small muscle protein X-linked ( SMPX ) cause distal myopathy with protein inclusions

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MARCKS-Like Protein-1(MLP-1) regulates ENaC Activity in Renal Distal Convoluted Tubule Cells

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Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold

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The 10q26 Risk Haplotype of Age-Related Macular Degeneration Aggravates Subretinal Inflammation by Impairing Monocyte Elimination

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PIWI proteomics identifies Atari and Pasilla as piRNA biogenesis factors in Aedes mosquitoes

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Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis

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Comprehensive Analysis of G1 Cyclin Docking Motif Sequences that Control CDK Regulatory Potency In Vivo

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Toll receptors remodel epithelia by directing planar-polarized Src and PI3K activity

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ncbi.nlm.nih.gov/pmc/articles/PMC8570296/
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Functional interpretation of ATAD3A variants in neuro-mitochondrial phenotypes

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Integrated genomic analysis reveals key features of long undecoded transcript isoform-based gene repression

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Epigenomic tensor predicts disease subtypes and reveals constrained tumor evolution

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Modeling the complete kinetics of coxsackievirus B3 reveals human determinants of host-cell feedback

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CA10 regulates neurexin heparan sulfate addition via a direct binding in the secretory pathway

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  DOI: 10.15252/embr.202051349
  
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embopress.org/doi/abs/10.15252/embr.202051349
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Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites

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Structural Basis of WLS/Evi-Mediated Wnt Transport and Secretion

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Fatal Perinatal Mitochondrial Cardiac Failure Caused by Recurrent De Novo Duplications in the ATAD3 Locus

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cell.com/med/fulltext/S2666-6340(20)30009-X
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Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2

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Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome

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Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating

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cell.com/cell-reports/abstract/S2211-1247(18)31081-7
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Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis

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cell.com/cell-reports/abstract/S2211-1247(18)31344-5
Jan 2021
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Cross-compartment signal propagation in the mitotic exit network

1
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Two cases of anti-PIT-1 hypophysitis exhibited as a form of paraneoplastic syndrome not associated with thymoma

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academic.oup.com/jes/article/5/3/bvaa194/6056675
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Transcription levels of a noncoding RNA orchestrate opposing regulatory and cell fate outcomes in yeast

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Dec 2020
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Sequential activation of transcriptional repressors promotes progenitor commitment by silencing stem cell identity genes

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Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs

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Spatiotemporal Proteomic Analysis of Stress Granule Disassembly Using APEX Reveals Regulation by SUMOylation and Links to ALS Pathogenesis

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Proximity-based proteomics reveals the thylakoid lumen proteome in the cyanobacterium Synechococcus sp. PCC 7002

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CK2 Inhibits TIMELESS Nuclear Export and Modulates CLOCK Transcriptional Activity to Regulate Circadian Rhythms

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  Mouse monoclonal anti-V5
  
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A Neural Basis for Categorizing Sensory Stimuli to Enhance Decision Accuracy

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isoTarget: A Genetic Method for Analyzing the Functional Diversity of Splicing Isoforms In Vivo

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Proximity labeling in mammalian cells with TurboID and split-TurboID

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Metabolic Reprogramming Induces Germinal Center B Cell Differentiation through Bcl6 Locus Remodeling

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Comparative Connectomics Reveals How Partner Identity, Location, and Activity Specify Synaptic Connectivity in Drosophila

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Sperm-specific COX6B2 enhances oxidative phosphorylation, proliferation, and survival in human lung adenocarcinoma

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A Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions

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CRISPR-Csy4-Mediated Editing of Rotavirus Double-Stranded RNA Genome

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A Thalamic Orphan Receptor Drives Variability in Short-Term Memory

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CRISPR-Csy4-Mediated Editing of Rotavirus Double-Stranded RNA Genome

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Telomerase Repairs Collapsed Replication Forks at Telomeres

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Ingestion of Food Particles Regulates the Mechanosensing Misshapen-Yorkie Pathway in Drosophila Intestinal Growth

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Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms

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Ankyrin Is An Intracellular Tether for TMC Mechanotransduction Channels

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An Optimized Chromatin Immunoprecipitation Protocol for Quantification of Protein-DNA Interactions

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Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish

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Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism

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Lats1/2 Sustain Intestinal Stem Cells and Wnt Activation through TEAD-Dependent and Independent Transcription

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DNAJB6, a Key Factor in Neuronal Sensitivity to Amyloidogenesis

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Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms

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cell.com/developmental-cell/abstract/S1534-5807(18)30240-5
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Pseudo-RNA-Binding Domains Mediate RNA Structure Specificity in Upstream of N-Ras

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Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

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Reprogramming Axial Level Identity to Rescue Neural-Crest-Related Congenital Heart Defects

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S-phase-independent silencing establishment in Saccharomyces cerevisiae

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The role of Rif1 in telomere length regulation is separable from its role in origin firing

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Specialization of the chromatin remodeler RSC to mobilize partially-unwrapped nucleosomes

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Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome

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An Allosteric Interaction Network Promotes Conformation State-Dependent Eviction of the Nas6 Assembly Chaperone from Nascent 26S Proteasomes

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Mechanism of adrenergic Ca V 1.2 stimulation revealed by proximity proteomics

1
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  anti-V5 antibody
  
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The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting

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HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137

1
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  anti-V5
  
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Spt6 is a maintenance factor for centromeric CENP-A

1
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  mouse α V5
  
  DOI: 10.1038/s41467-020-16695-7
  
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Prickle isoforms determine handedness of helical morphogenesis

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The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer

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Gene-Specific Control of tRNA Expression by RNA Polymerase II

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The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer

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Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases

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Human cytomegalovirus interactome analysis identifies degradation hubs, domain associations and viral protein functions

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Context-Dependent Gene Regulation by Homeodomain Transcription Factor Complexes Revealed by Shape-Readout Deficient Proteins

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LRRTMs Organize Synapses through Differential Engagement of Neurexin and PTPσ

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Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements

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Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells

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Antibody Therapy Targeting RAN Proteins Rescues C9 ALS/FTD Phenotypes in C9orf72 Mouse Model

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The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing

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Developmental regulation of an organelle tether coordinates mitochondrial remodeling in meiosis

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Cul4 ubiquitin ligase cofactor DCAF12 promotes neurotransmitter release and homeostatic plasticity

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TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation

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Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation

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Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes

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Direct Gαq Gating Is the Sole Mechanism for TRPM8 Inhibition Caused by Bradykinin Receptor Activation

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PPEF2 Opposes PINK1-Mediated Mitochondrial Quality Control by Dephosphorylating Ubiquitin

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The transcription factor odd-paired regulates temporal identity in transit-amplifying neural progenitors via an incoherent feed-forward loop

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Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing

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Naa10p Inhibits Beige Adipocyte-Mediated Thermogenesis through N-α-acetylation of Pgc1α

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Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis

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PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

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Reconstituting Drosophila Centromere Identity in Human Cells

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Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos

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Determining cellular CTCF and cohesin abundances to constrain 3D genome models

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currentprotocols.onlinelibrary.wiley.com currentprotocols.onlinelibrary.wiley.com

Auxin‐Inducible Degron System for Depletion of Proteins in Saccharomyces cerevisiae

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SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-κB Activation

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Liver-Type Glutaminase GLS2 Is a Druggable Metabolic Node in Luminal-Subtype Breast Cancer

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Atlas of Subcellular RNA Localization Revealed by APEX-Seq

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Leukocyte receptor tyrosine kinase interacts with secreted midkine to promote survival of migrating neural crest cells

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RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity

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Distinct Classes of Chromatin Loops Revealed by Deletion of an RNA-Binding Region in CTCF

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CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells

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Conserved Herpesvirus Protein Kinases Target SAMHD1 to Facilitate Virus Replication

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KIAA0317 regulates pulmonary inflammation through SOCS2 degradation

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MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis

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Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo

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Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition

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Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics

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Oligoadenylate-Synthetase-Family Protein OASL Inhibits Activity of the DNA Sensor cGAS during DNA Virus Infection to Limit Interferon Production

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Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence

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Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens

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Modular Organization and Assembly of SWI/SNF Family Chromatin Remodeling Complexes

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TFAP2 transcription factors are regulators of lipid droplet biogenesis

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Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

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Non-invasive measurement of mRNA decay reveals translation initiation as the major determinant of mRNA stability

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Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation

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Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis

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The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila

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Genome-wide Map of R-Loop-Induced Damage Reveals How a Subset of R-Loops Contributes to Genomic Instability

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Biology and Clinical Implications of the 19q13 Aggressive Prostate Cancer Susceptibility Locus

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Global Proteome Remodeling during ER Stress Involves Hac1-Driven Expression of Long Undecoded Transcript Isoforms

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SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis

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Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α

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Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain

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The SS18-SSX Fusion Oncoprotein Hijacks BAF Complex Targeting and Function to Drive Synovial Sarcoma

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Interrogation of Mammalian Protein Complex Structure, Function, and Membership Using Genome-Scale Fitness Screens

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Phosphorylation-Mediated Clearance of Amyloid-like Assemblies in Meiosis

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A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer

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Inflammation-Modulated Metabolic Reprogramming Is Required for DUOX-Dependent Gut Immunity in Drosophila

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Ari-1 Regulates Myonuclear Organization Together with Parkin and Is Associated with Aortic Aneurysms

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A compartmentalized signaling network mediates crossover control in meiosis

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Directed Evolution to Engineer Monobody for FRET Biosensor Assembly and Imaging at Live-Cell Surface

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Active Protection: Learning-Activated Raf/MAPK Activity Protects Labile Memory from Rac1-Independent Forgetting

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A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes

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Organelle Specific O-Glycosylation Drives MMP14 Activation, Tumor Growth, and Metastasis

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The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A

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Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer

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Multiple conserved cell adhesion protein interactions mediate neural wiring of a sensory circuit in C. elegans.

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Untitled document

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Nov 2017
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Untitled document

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CycD/Cdk4 and Discontinuities in Dpp Signaling Activate TORC1 in the Drosophila Wing Disc

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Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins

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Untitled document

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Phospho-Rasputin Stabilization by Sec16 Is Required for Stress Granule Formation upon Amino Acid Starvation

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Distinct Ventral Pallidal Neural Populations Mediate Separate Symptoms of Depression

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Xenopus laevis M18BP1 Directly Binds Existing CENP-A Nucleosomes to Promote Centromeric Chromatin Assembly

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The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

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Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake

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