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  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Impairment of the glial phagolysosomal system drives prion-like propagation in a Drosophila model of Huntington's disease
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  3. Sep 2024
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    EDC-3 and EDC-4 regulate embryonic mRNA clearance and biomolecular condensate specialization
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    sciencedirect.com/science/article/pii/S221112472401132X
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    The small MAF transcription factor MAFG co-opts MITF to promote melanoma progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11398417/
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    Distinct tumor architectures and microenvironments for the initiation of breast cancer metastasis in the brain
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    sciencedirect.com/science/article/pii/S1535610824003143
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    Multiple direct and indirect roles of the Paf1 complex in transcription elongation, splicing, and histone modifications
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  8. 52.53.155.43 52.53.155.43
    science.adh0037_sm-html.html
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    Aldehydes alter TGF-β signaling and induce obesity and cancer
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    sciencedirect.com/science/article/pii/S2211124724010271
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    Disorder-mediated interactions target proteins to specific condensates
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    sciencedirect.com/science/article/pii/S1097276524006713
  11. Aug 2024
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    Opposing GPCR signaling programs protein intake setpoint in Drosophila
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    sciencedirect.com/science/article/pii/S0092867424008419
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    Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS
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  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TFE3 fusions direct an oncogenic transcriptional program that drives OXPHOS and unveils vulnerabilities in translocation renal cell carcinoma
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    Architecture of native kinetochores revealed by structural studies utilizing a thermophilic yeast
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  16. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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  17. Jul 2024
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Presynaptic Rac1 in the hippocampus selectively regulates working memory
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    Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression
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    sciencedirect.com/science/article/pii/S1097276524005367
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    Gap-junction-mediated bioelectric signaling required for slow muscle development and function in zebrafish
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    Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics
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    Synaptic plasticity in human thalamocortical assembloids
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    ncbi.nlm.nih.gov/pmc/articles/PMC11407288/
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    Astrocytes modulate brain phosphate homeostasis via polarized distribution of phosphate uptake transporter PiT2 and exporter XPR1
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    Molecular and cellular mechanisms of teneurin signaling in synaptic partner matching
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  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Casein kinase 1 family proteins promote Slimb-dependent Expanded degradation
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    1. scibot 11 Jul 2024
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      DOI: 10.7554/eLife.46592

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    ncbi.nlm.nih.gov/pmc/articles/PMC6768662/
  26. Jun 2024
  27. www.sciencedirect.com www.sciencedirect.com
    TRABD modulates mitochondrial homeostasis and tissue integrity
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    sciencedirect.com/science/article/pii/S2211124724006326
  28. May 2024
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    Axonal endoplasmic reticulum tubules control local translation via P180/RRBP1-mediated ribosome interactions
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  30. 52.53.155.43 52.53.155.43
    Non-apoptotic caspase events and Atf3 expression underlie direct neuronal differentiation of adult neural stem cells
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  31. www.science.org www.science.org
    eEF1A2 promotes PTEN-GSK3β-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer
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    Spatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons
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    A conserved site on Ndc80 complex facilitates dynamic recruitment of Mps1 to yeast kinetochores to promote accurate chromosome segregation
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    sciencedirect.com/science/article/pii/S0960982224005281
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    Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants
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  35. www.biorxiv.org www.biorxiv.org
    The deubiquitylating enzyme Fat Facets modulates Fat signalling and regulates tissue growth
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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PDZD8 promotes autophagy at ER-Lysosome contact sites to regulate synaptogenesis
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    Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission
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  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unilateral rNurr1-V5 transgene expression in nigral dopaminergic neurons mitigates bilateral neuropathology and behavioral deficits in parkinsonian rats with α-synucleinopathy
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  39. Apr 2024
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Numb positively regulates Hedgehog signaling at the ciliary pocket
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  41. 52.53.155.43 52.53.155.43
    JNEUROSCI.1256-23.2024.full-html.html
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  42. aacrjournals.org aacrjournals.org
    Adipose triglyceride lipase is a therapeutic target in advanced prostate cancer that promotes metabolic plasticity
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      DOI: 10.1158/0008-5472.CAN-23-0555

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    aacrjournals.org/cancerres/article/84/5/703/734936/Adipose-Triglyceride-Lipase-Is-a-Therapeutic
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Trafficking of Connexin36 (Cx36) in the early secretory pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10996632/
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Innexin hemichannel activation by Microplitis bicoloratus ecSOD monopolymer reduces ROS
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  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ISG12a promotes immunotherapy of HBV-associated hepatocellular carcinoma through blocking TRIM21/AKT/β-Catenin/PD-L1 axis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11000115/
  46. Mar 2024
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Local mitochondrial replication in the periphery of neurons requires the eEF1A1 protein and thetranslation of nuclear-encoded proteins
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    Control of meiotic entry by dual inhibition of a key mitotic transcription factor
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    Complex formation of immunoglobulin superfamily molecules Side-IV and Beat-IIb regulates synaptic specificity
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    Recruitment of BAG2 to DNAJ-PKAc scaffolds promotes cell survival and resistance to drug-induced apoptosis in fibrolamellar carcinoma
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    Proximity proteomic analysis of the NRF family reveals the Parkinson’s disease protein ZNF746/PARIS as a co-complexed repressor of NRF2
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    Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity
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    Single-molecule quantitation of RNA-binding protein occupancy and stoichiometry defines a role for Yra1 (Aly/REF) in nuclear mRNP organization
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    Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria
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    Repression of CENP-A assembly in metaphase requires HJURP phosphorylation and inhibition by M18BP1
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    Effects of heterologous human tau protein expression in yeast models of proteotoxic stress response
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  94. May 2023
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    Neurobeachin controls the asymmetric subcellular distribution of electrical synapse proteins
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    PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence
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    Organism-wide, cell-type-specific secretome mapping of exercise training in mice
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    Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting
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  100. Apr 2023
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    The Transcriptional Regulator Ume6 is a Major Driver of Early Gene Expression during Gametogenesis
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    Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness
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    Boosting BDNF in muscle rescues impaired in vivo axonal transport in a mouse model of DI-CMTC peripheral neuropathy
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  104. Mar 2023
  105. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Ubiquitin-specific Protease USP36 Associates with the Microprocessor Complex and Regulates miRNA Biogenesis by SUMOylating DGCR8
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    Interaction between PI3K and the VDAC2 channel tethers Ras-PI3K-positive endosomes to mitochondria and promotes endosome maturation
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    The conserved histone chaperone Spt6 is strongly required for DNA replication and genome stability
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    Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation
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  109. Feb 2023
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    PIMT regulates Hepatic Gluconeogenesis in Mice
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    Loss of C9orf72 perturbs the Ran-GTPase gradient and nucleocytoplasmic transport, generating compositionally diverse Importin β-1 granules
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    Plasmodium sporozoites require the protein B9 to invade hepatocytes
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    DDR2 coordinates EMT and metabolic reprogramming as a shared effector of FOXQ1 and SNAI1
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  114. Jan 2023
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    A circadian clock translational control mechanism targets specific mRNAs to cytoplasmic messenger ribonucleoprotein granules
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    A novel period mutation implicating nuclear export in temperature compensation of the Drosophila circadian clock
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    Seasonal cues act through the circadian clock and pigment-dispersing factor to control EYES ABSENT and downstream physiological changes
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    Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks
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    Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis
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    Intron retention of an adhesion GPCR generates single transmembrane-helix isoforms to enable 7TM-adhesion GPCR function
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    Proximity biotinylation to define the local environment of the protein kinase A catalytic subunit in adrenal cells
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    Monoallelic CRMP1 gene variants cause neurodevelopmental disorder
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  123. Dec 2022
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    Meiotic nuclear pore complex remodeling provides key insights into nuclear basket organization
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    Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method
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    Bidirectional promoter activity from expression cassettes can drive off-target repression of neighboring gene translation
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    An ER phospholipid hydrolase drives ER-associated mitochondrial constriction for fission and fusion
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  128. Nov 2022
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    Mechanisms governing target search and binding dynamics of hypoxia-inducible factors
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    TEMPO enables sequential genetic labeling and manipulation of vertebrate cell lineages
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    LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus
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    A novel function for the sperm adhesion protein IZUMO1 in cell–cell fusion
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    DDR2 Coordinates EMT and Metabolic Reprogramming as a Shared Effector of FOXQ1 and SNAI1
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    Regulation of mitophagy by the NSL complex underlies genetic risk for Parkinson’s disease at 16q11.2 and MAPT H1 loci
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    ER-mitochondrial contact protein Miga regulates autophagy through Atg14 and Uvrag
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    Multiphase coalescence mediates Hippo pathway activation
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  137. Oct 2022
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    Identification of proteomic landscape of drug-binding proteins in live cells by proximity-dependent target ID
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    Allelic variation in the Arabidopsis TNL CHS3/CSA1 immune receptor pair reveals two functional cell-death regulatory modes
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    In situ cell-type-specific cell-surface proteomic profiling in mice
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    Yeast Mediator facilitates transcription initiation at most promoters via a Tail-independent mechanism
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  142. Sep 2022
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    ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains
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    In vivo characterization of Drosophila golgins reveals redundancy and plasticity of vesicle capture at the Golgi apparatus
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  145. Aug 2022
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    Distinct silencer states generate epigenetic states of heterochromatin
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    The redox cycling of STAT2 maintains innate immune homeostasis
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    Duplex Labeling and Manipulation of Neuronal Proteins Using Sequential CRISPR/Cas9 Gene Editing
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  149. Jul 2022
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    Direct Observation of Compartment-Specific Localization and Dynamics of Voltage-Gated Sodium Channels
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    Mislocalization of protein kinase A drives pathology in Cushing’s syndrome
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    Ubiquitination and deubiquitination of 4E-T regulate neural progenitor cell maintenance and neurogenesis by controlling P-body formation
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    The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex
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  155. Jun 2022
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    Identification of the stress granule transcriptome via RNA-editing in single cells and in vivo
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    Development of an HIV reporter virus that identifies latently infected CD4+ T cells
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    A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency
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  159. May 2022
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    A versatile viral toolkit for functional discovery in the nervous system
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    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
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    Transcription factor Acj6 controls dendrite targeting via a combinatorial cell-surface code
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  163. Apr 2022
  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The non-adrenergic imidazoline-1 receptor protein Nischarin is a key regulator of astrocyte glutamate uptake
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    Single-cell profiling of transcriptome and histone modifications with EpiDamID
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    Melanomas with concurrent BRAF non-p.V600 and NF1 loss-of-function mutations are targetable by BRAF/MEK inhibitor combination therapy
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    The FUS::DDIT3 fusion oncoprotein inhibits BAF complex targeting and activity in myxoid liposarcoma
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    ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function
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  169. Mar 2022
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    PTIP governs NAD+ metabolism by regulating CD38 expression to drive macrophage inflammation
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    Spatial CRISPR genomics identifies regulators of the tumor microenvironment
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    The BTB transcription factors ZBTB11 and ZFP131 maintain pluripotency by repressing pro-differentiation genes
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    PCR-based profiling of transcription factor activity in vivo by a virus-based reporter battery
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    Identification of 14-3-3 proteins, Polo kinase, and RNA-binding protein Pes4 as key regulators of meiotic commitment in budding yeast
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  176. Feb 2022
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    Prickle isoform participation in distinct polarization events in the Drosophila eye
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    Paternal transmission of the Wolbachia CidB toxin underlies cytoplasmic incompatibility
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  179. Jan 2022
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    Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection
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  181. Dec 2021
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    CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism
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    The Lyme disease agent co-opts adiponectin receptor-mediated signaling in its arthropod vector
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  184. Nov 2021
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    Drosophila ßHeavy-Spectrin is required in polarized ensheathing glia that form a diffusion-barrier around the neuropil
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    Programmed cortical ER collapse drives selective ER degradation and inheritance in yeast meiosis
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    Klf5 establishes bi-potential cell fate by dual regulation of ICM and TE specification genes
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    Interplay between protein acetylation and ubiquitination controls MCL1 protein stability
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    AKIRIN2 controls the nuclear import of proteasomes in vertebrates
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    An expansion of the non-coding genome and its regulatory potential underlies vertebrate neuronal diversity
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  191. Oct 2021
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    Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma
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    Temporally distinct post-replicative repair mechanisms fill PRIMPOL-dependent ssDNA gaps in human cells
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    Analysis of meiosis in Pristionchus pacificus reveals plasticity in homolog pairing and synapsis in the nematode lineage
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    An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens
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    REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
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    Myristoylated alanine-rich C kinase substrate-like protein-1 regulates epithelial sodium channel activity in renal distal convoluted tubule cells
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    Regulation of lipid homeostasis by the TBC protein dTBC1D22 via modulation of the small GTPase Rab40 to facilitate lipophagy
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  202. Aug 2021
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    Protein Tyrosine Phosphatase δ mediates the Sema3A-induced cortical basal dendritic arborization through the activation of Fyn tyrosine kinase
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    Functional divergence of Plexin B structural motifs in distinct steps of Drosophila olfactory circuit assembly
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    A Drosophila Tumor Suppressor Gene Prevents Tonic TNF Signaling through Receptor N-Glycosylation
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    Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism
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    Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
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    Comprehensive Genetic Characterization of Mitochondrial Ca2+ Uniporter Components Reveals Their Different Physiological Requirements In Vivo
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    Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer
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    Shutdown of ER-associated degradation pathway rescues functions of mutant iduronate 2-sulfatase linked to mucopolysaccharidosis type II
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    Divergent Connectivity of Homologous Command-like Neurons Mediates Segment-Specific Touch Responses in Drosophila
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    lncRNA Sensing of a Viral Suppressor of RNAi Activates Non-canonical Innate Immune Signaling in Drosophila
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