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Jun 2022
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Dynamic Chromatin States Coupling with Key Transcription Factors in Colitis-Associated Colorectal Cancer

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1. scibot 18 Jun 2022
  
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  DOI: 10.1002/advs.202200536
  
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pmc.ncbi.nlm.nih.gov/articles/PMC9376751/
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A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency

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1. scibot 09 Jun 2022
  
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  DOI: 10.1016/j.celrep.2022.110928
  
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sciencedirect.com/science/article/pii/S2211124722007100
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Jumonji domain-containing protein-3 (JMJD3/Kdm6b) is critical for normal ovarian function and female fertility

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1. scibot 03 Jun 2022
  
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  DOI: 10.1210/endocr/bqac047
  
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academic.oup.com/endo/article-abstract/163/5/bqac047/6565906
May 2022
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Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging

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1. scibot 26 May 2022
  
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  DOI: 10.1016/j.devcel.2022.05.004
  
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sciencedirect.com/science/article/pii/S153458072200332X
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A human breast atlas integrating single-cell proteomics and transcriptomics

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1. scibot 26 May 2022
  
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  DOI: 10.1016/j.devcel.2022.05.003
  
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pubmed.ncbi.nlm.nih.gov/35617956/
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XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation

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1. scibot 25 May 2022
  
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  DOI: 10.1016/j.cell.2022.04.034
  
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sciencedirect.com/science/article/pii/S0092867422005323
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C/EBPδ-induced epigenetic changes control the dynamic gene transcription of S100a8 and S100a9

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1. scibot 24 May 2022
  
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  DOI: 10.7554/eLife.75594
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9122501/
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H3-K27M-mutant nucleosomes interact with MLL1 to shape the glioma epigenetic landscape

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1. scibot 19 May 2022
  
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  DOI: 10.1016/j.celrep.2022.110836
  
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sciencedirect.com/science/article/pii/S221112472200609X
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NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition

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1. scibot 12 May 2022
  
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  DOI: 10.1016/j.molcel.2022.04.015
  
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sciencedirect.com/science/article/pii/S1097276522003264
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KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4

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1. scibot 11 May 2022
  
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  DOI: 10.1016/j.celrep.2022.110788
  
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sciencedirect.com/science/article/pii/S2211124722005551
Apr 2022
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The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function

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1. scibot 22 Apr 2022
  
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  DOI: 10.1016/j.cmet.2022.03.013
  
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sciencedirect.com/science/article/pii/S1550413122001279
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Single-cell proteomics defines the cellular heterogeneity of localized prostate cancer

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1. scibot 21 Apr 2022
  
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  DOI: 10.1016/j.xcrm.2022.100604
  
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sciencedirect.com/science/article/pii/S2666379122001215
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Linkage of methionine addiction, histone lysine hypermethylation, and malignancy

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1. scibot 08 Apr 2022
  
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  DOI: 10.1016/j.isci.2022.104162
  
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sciencedirect.com/science/article/pii/S2589004222004321
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Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma

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1. scibot 07 Apr 2022
  
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  DOI: 10.1016/j.molcel.2022.03.018
  
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sciencedirect.com/science/article/pii/S1097276522002568
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Maintenance of glutamine synthetase expression alleviates endotoxin-induced sepsis via alpha-ketoglutarate-mediated demethylation

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1. scibot 02 Apr 2022
  
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  DOI: 10.1096/fj.202200059R
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202200059R
Mar 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Thymocytes trigger self-antigen-controlling pathways in immature medullary thymic epithelial stages

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1. scibot 03 Mar 2022
  
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  DOI: 10.7554/eLife.69982
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8860447/
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The KRAS-G12D mutation induces Metabolic Vulnerability in B-cell Acute Lymphoblastic Leukemia

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1. scibot 02 Mar 2022
  
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  DOI: 10.1016/j.isci.2022.103881
  
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sciencedirect.com/science/article/pii/S2589004222001511
Feb 2022
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Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity

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1. scibot 23 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110422
  
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sciencedirect.com/science/article/pii/S2211124722001462
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EBF1 nuclear repositioning instructs chromatin refolding to promote therapy resistance in T leukemic cells

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1. scibot 23 Feb 2022
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.molcel.2022.01.015
  
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sciencedirect.com/science/article/pii/S1097276522000582
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The anti-aging protein Klotho affects early postnatal myogenesis by downregulating Jmjd3 and the canonical Wnt pathway

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1. scibot 22 Feb 2022
  
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  RRID:AB_2616029
  
  DOI: 10.1096/fj.202101298R
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202101298R
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Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction

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1. scibot 16 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110390
  
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sciencedirect.com/science/article/pii/S2211124722001115
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Activation-induced chromatin reorganization in neurons depends on HDAC1 activity

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1. scibot 16 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110352
  
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sciencedirect.com/science/article/pii/S2211124722000687
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Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility

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1. scibot 02 Feb 2022
  
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  DOI: 10.1016/j.neuron.2021.12.034
  
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sciencedirect.com/science/article/pii/S0896627321010898
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Gene silencing by EZH2 suppresses TGF-β activity within the decidua to avert pregnancy-adverse wound healing at the maternal-fetal interface

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1. scibot 02 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110329
  
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sciencedirect.com/science/article/pii/S2211124722000456
Jan 2022
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PRC1 sustains the integrity of neural fate in the absence of PRC2 function

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1. scibot 22 Jan 2022
  
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  DOI: 10.7554/eLife.72769
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8765755/
Dec 2021
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Translational and post-translational control of human naïve versus primed pluripotency

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1. scibot 30 Dec 2021
  
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  DOI: 10.1016/j.isci.2021.103645
  
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sciencedirect.com/science/article/pii/S2589004221016151
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TRACE generates fluorescent human reporter cell lines to characterize epigenetic pathways

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1. scibot 28 Dec 2021
  
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  DOI: 10.1016/j.molcel.2021.11.035
  
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sciencedirect.com/science/article/pii/S1097276521010376
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KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma

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1. scibot 18 Dec 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1038/s41467-021-27502-2
  
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nature.com/articles/s41467-021-27502-2
Nov 2021
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CUT&Tag-BS for simultaneous profiling of histone modification and DNA methylation with high efficiency and low cost

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1. scibot 16 Nov 2021
  
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  DOI: 10.1016/j.crmeth.2021.100118
  
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sciencedirect.com/science/article/pii/S266723752100182X
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MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

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1. scibot 12 Nov 2021
  
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  DOI: 10.1016/j.immuni.2021.10.011
  
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sciencedirect.com/science/article/pii/S1074761321004489
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Histone H3.3 K27M and K36M mutations de-repress transposable elements through perturbation of antagonistic chromatin marks

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1. scibot 10 Nov 2021
  
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  DOI: 10.1016/j.molcel.2021.10.008
  
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Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription

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1. scibot 03 Nov 2021
  
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  DOI: 10.1016/j.celrep.2021.109943
  
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sciencedirect.com/science/article/pii/S2211124721014169
Oct 2021
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Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma

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1. scibot 23 Oct 2021
  
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  DOI: 10.1016/j.molcel.2021.10.005
  
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sciencedirect.com/science/article/pii/S1097276521008340
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NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain

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1. scibot 12 Oct 2021
  
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  DOI: 10.1016/j.molcel.2021.09.020
  
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sciencedirect.com/science/article/pii/S1097276521007541
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A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development

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1. scibot 08 Oct 2021
  
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  DOI: 10.1016/j.stem.2021.09.008
  
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sciencedirect.com/science/article/pii/S1934590921003842
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Defining Proximity Proteomics of Histone Modifications by Antibody-mediated Protein A-APEX2 Labeling

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1. scibot 01 Oct 2021
  
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  9733S
  
  DOI: 10.1016/j.gpb.2021.09.003
  
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sciencedirect.com/science/article/pii/S1672022921001820
Sep 2021
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Low folate induces abnormal neuronal maturation and DNA hypomethylation of neuronal differentiation-related genes in cultured mouse neural stem and progenitor cells

1
1. scibot 25 Sep 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.heliyon.2021.e08071
  
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Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance

1
1. scibot 25 Aug 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.celrep.2021.109607
  
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Enhancement of gemcitabine efficacy by K73-03 via epigenetically regulation of miR-421/SPINK1 in gemcitabine resistant pancreatic cancer cells

1
1. scibot 24 Aug 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.phymed.2021.153711
  
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Chromatin and transcription factor profiling in rare stem cell populations using CUT&Tag

1
1. scibot 20 Aug 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.xpro.2021.100751
  
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Quantitative control of noise in mammalian gene expression by dynamic histone regulation

2
1. scibot 18 Aug 2021
  
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  AB_2
  
  DOI: 10.7554/eLife.65654
  
  Resource: (Cell Signaling Technology Cat# 9733, RRID:AB_2616029)
  
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  SciCrunch record: RRID:AB_2616029
  
  Curator comments: Rabbit Anti-Histone H3, Trimethyl (Lys27) Monoclonal Antibody, Unconjugated, Clone C36B11 Cell Signaling Technology Cat# 9733
  
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  RRIDCUR:Unresolved RRID:AB_2616029
2. scibot 17 Aug 2021
  
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  RRID:AB_2616029
  
  DOI: 10.7554/eLife.65654
  
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HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

1
1. scibot 15 Aug 2021
  
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  AB_2616029
  
  DOI: 10.7554/eLife.59654
  
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Untitled document

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1. scibot 11 Aug 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.molcel.2018.08.010
  
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Lymphocyte-Specific Chromatin Accessibility Pre-determines Glucocorticoid Resistance in Acute Lymphoblastic Leukemia

1
1. scibot 09 Aug 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.ccell.2018.11.002
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.ccell.2018.11.015
  
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ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency

1
1. scibot 06 Aug 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.molcel.2021.07.018
  
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Gestational Diabetes Epigenetically Reprograms the Cart Promoter in Fetal Ovary, Causing Subfertility in Adult Life

1
1. scibot 04 Aug 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1210/en.2019-00319
  
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academic.oup.com/endo/article/160/7/1684/5506444
Jul 2021
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Untitled document

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1. scibot 31 Jul 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.ccell.2018.11.014
  
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Untitled document

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1. scibot 29 Jul 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.celrep.2018.11.035
  
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Untitled document

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1. scibot 28 Jul 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.celrep.2018.11.035
  
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Untitled document

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1. scibot 27 Jul 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.cell.2017.04.034
  
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Untitled document

1
1. scibot 27 Jul 2021
  
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  AB_26160629
  
  DOI: 10.1016/j.ydbio.2018.09.014
  
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sciencedirect.com/science/article/pii/S0012160618305153
onlinelibrary.wiley.com onlinelibrary.wiley.com

Multiple polycomb epigenetic regulatory proteins are active in normal and regenerating adult olfactory epithelium

1
1. scibot 27 Jul 2021
  
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  AB_1147656
  
  DOI: 10.1002/lio2.180
  
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  Curator: @evieth
  
  SciCrunch record: RRID:AB_2616029
  
  Curator comments: Cell Signaling Technology Cat# 9733, Rabbit Anti-Histone H3, Trimethyl (Lys27) Monoclonal Antibody, Unconjugated, Clone C36B11
  
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onlinelibrary.wiley.com/doi/full/10.1002/lio2.180
Jun 2021
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BAP1 enhances Polycomb repression by counteracting widespread H2AK119ub1 deposition and chromatin condensation

1
1. scibot 30 Jun 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.molcel.2021.06.020
  
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Correct dosage of X chromosome transcription is controlled by a nuclear pore component

1
1. scibot 16 Jun 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.celrep.2021.109236
  
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sciencedirect.com/science/article/pii/S2211124721005957
May 2021
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Derivation of Intermediate Pluripotent Stem Cells Amenable to Primordial Germ Cell Specification

1
1. scibot 09 May 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.stem.2020.11.003
  
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sciencedirect.com/science/article/pii/S1934590920305415
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Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release

1
1. scibot 08 May 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.molcel.2021.03.008
  
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Opposing Effects of Cohesin and Transcription on CTCF Organization Revealed by Super-resolution Imaging

1
1. scibot 07 May 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.molcel.2020.10.001
  
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H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2

1
1. scibot 07 May 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.molcel.2020.09.028
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7680438/
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Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer

1
1. scibot 07 May 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.molcel.2020.04.027
  
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sciencedirect.com/science/article/pii/S1097276520302690
Apr 2021
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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

1
1. scibot 28 Apr 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.molcel.2021.03.037
  
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sciencedirect.com/science/article/pii/S109727652100232X
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Large-Scale Topological Changes Restrain Malignant Progression in Colorectal Cancer

1
1. scibot 24 Apr 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.cell.2020.07.030
  
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sciencedirect.com/science/article/pii/S0092867420309387
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Metabolic Regulation of the Epigenome Drives Lethal Infantile Ependymoma

1
1. scibot 23 Apr 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.cell.2020.04.047
  
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A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation

1
1. scibot 22 Apr 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.ccell.2021.02.003
  
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  RRIDCUR:Validated RRID:AB_2616029
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sciencedirect.com/science/article/pii/S1535610821001057
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Cholesterol Pathway Inhibition Induces TGF-β Signaling to Promote Basal Differentiation in Pancreatic Cancer

1
1. scibot 22 Apr 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.ccell.2020.08.015
  
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sciencedirect.com/science/article/pii/S1535610820304268
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Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation

1
1. scibot 22 Apr 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.molcel.2021.03.038
  
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sciencedirect.com/science/article/pii/S1097276521002331
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Multi-omic profiling of pituitary thyrotropic cells and progenitors

1
1. scibot 20 Apr 2021
  
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  AB_2616029
  
  DOI: 10.1186/s12915-021-01009-0
  
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link.springer.com/article/10.1186/s12915-021-01009-0
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SETD2 Restricts Prostate Cancer Metastasis by Integrating EZH2 and AMPK Signaling Pathways

1
1. scibot 17 Apr 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.ccell.2020.05.022
  
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SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy

1
1. scibot 17 Apr 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.ccell.2020.04.014
  
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UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability

1
1. scibot 15 Apr 2021
  
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  RRID:AB_2616029
  
  DOI: 10.1016/j.celrep.2021.108966
  
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Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

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The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr

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mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis

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Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

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Embryonic Stem-Cell-Derived Extracellular Vesicles Maintain ESC Stemness by Activating FAK

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Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis

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TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control

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Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants

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Definition of a small core transcriptional circuit regulated by AML1-ETO

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Chromatin dysregulation associated with NSD1 mutation in head and neck squamous cell carcinoma

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Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells

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An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors

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Stage-specific roles of Ezh2 and Retinoic acid signaling ensure calvarial bone lineage commitment.

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Efficient chromatin accessibility mapping in situ by nucleosome-tethered tagmentation

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H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation

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Formation of the CenH3-Deficient Holocentromere in Lepidoptera Avoids Active Chromatin

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ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation

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Metabolic Reprogramming Induces Germinal Center B Cell Differentiation through Bcl6 Locus Remodeling

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Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG

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Bone Morphogenic Proteins Are Immunoregulatory Cytokines Controlling FOXP3+ Treg Cells

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Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response

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Global Regulatory DNA Potentiation by SMARCA4 Propagates to Selective Gene Expression Programs via Domain-Level Remodeling

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Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes

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A Dimeric Structural Scaffold for PRC2-PCL Targeting to CpG Island Chromatin

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Dissecting Murine Muscle Stem Cell Aging through Regeneration Using Integrative Genomic Analysis

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Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

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Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

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EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition

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Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells

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NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma

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A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers

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Aging Suppresses Skin-Derived Circulating SDF1 to Promote Full-Thickness Tissue Regeneration

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Super Elongation Complex as a Targetable Dependency in Diffuse Midline Glioma

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  Tri-Methyl-Histone H3 (Lys27) rabbit mAb
  
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Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming

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  Rabbit monoclonal anti-mouse Tri-methyl-Histone H3 (Lys27) (1:2000 dilution)
  
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Glioma stem-like cells evade interferon suppression through MBD3/NuRD complex–mediated STAT1 downregulation

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Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM

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Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming

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One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages

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A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

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Antagonistic interaction between Ezh2 and Arid1a coordinates root patterning and development via Cdkn2a in mouse molars

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Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements

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EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex

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Quantitative Multiplexed ChIP Reveals Global Alterations that Shape Promoter Bivalency in Ground State Embryonic Stem Cells

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DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation

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An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

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PRC2.1 and PRC2.2 Synergize to Coordinate H3K27 Trimethylation

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Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis

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lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA

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Quantification of Proteins and Histone Marks in Drosophila Embryos Reveals Stoichiometric Relationships Impacting Chromatin Regulation

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Active and Repressed Chromatin Domains Exhibit Distinct Nucleosome Segregation during DNA Replication

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PPEF2 Opposes PINK1-Mediated Mitochondrial Quality Control by Dephosphorylating Ubiquitin

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Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos

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HUMAN TROPHOBLAST DIFFERENTIATION IS ASSOCIATED WITH PROFOUND GENE REGULATORY AND EPIGENETIC CHANGES

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Pioneer Factor-Nucleosome Binding Events during Differentiation Are Motif Encoded

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The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling

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Improved CUT&RUN chromatin profiling tools

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Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B

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Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

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The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

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Untitled document

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Untitled document

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Untitled document

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Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors

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Mutant NPM1 Maintains the Leukemic State through HOX Expression

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Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

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Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency

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EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation

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MicroRNAs Overcome Cell Fate Barrier by Reducing EZH2-Controlled REST Stability during Neuronal Conversion of Human Adult Fibroblasts

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Capturing the Onset of PRC2-Mediated Repressive Domain Formation

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A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer

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Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

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The SS18-SSX Oncoprotein Hijacks KDM2B-PRC1.1 to Drive Synovial Sarcoma

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1. scibot 05 Nov 2018
  
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A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities

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The H3K36me2 Methyltransferase Nsd1 Demarcates PRC2-Mediated H3K27me2 and H3K27me3 Domains in Embryonic Stem Cells

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A Non-canonical BCOR-PRC1.1 Complex Represses Differentiation Programs in Human ESCs

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The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins

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H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas

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Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis

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1. scibot 08 Nov 2017
  
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Gene Resistance to Transcriptional Reprogramming following Nuclear Transfer Is Directly Mediated by Multiple Chromatin-Repressive Pathways

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1. scibot 08 Nov 2017
  
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