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Nov 2022
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Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis

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1. scibot 16 Nov 2022
  
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  DOI: 10.1016/j.neuron.2022.10.028
  
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sciencedirect.com/science/article/pii/S0896627322009618
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Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1

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1. scibot 04 Nov 2022
  
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  DOI: 10.1016/j.isci.2022.105352
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9619380/
Sep 2022
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Activation of cGAS-STING pathway – A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy

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1. scibot 09 Sep 2022
  
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  DOI: 10.1002/jcla.24631
  
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onlinelibrary.wiley.com/doi/10.1002/jcla.24631
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ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP

1
1. scibot 07 Sep 2022
  
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  DOI: 10.1016/j.immuni.2022.08.006
  
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sciencedirect.com/science/article/pii/S1074761322003995
Jul 2022
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Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS

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1. scibot 27 Jul 2022
  
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  DOI: 10.15252/embj.2021109217
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9289529/
Jun 2022
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Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD

1
1. scibot 30 Jun 2022
  
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  DOI: 10.1016/j.devcel.2022.06.003
  
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sciencedirect.com/science/article/pii/S1534580722004129
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cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model

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1. scibot 17 Jun 2022
  
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  DOI: 10.1016/j.isci.2022.104404
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9194172/
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The SETDB1–TRIM28 complex suppresses antitumor immunity

1
1. scibot 07 Jun 2022
  
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  DOI: 10.1158/2326-6066.CIR-21-0754
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8647838/
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LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity

1
1. scibot 03 Jun 2022
  
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  DOI: 10.1016/j.celrep.2022.110880
  
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sciencedirect.com/science/article/pii/S2211124722006556
May 2022
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DDX41 is required for cGAS-STING activation against DNA virus infection

1
1. scibot 26 May 2022
  
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  DOI: 10.1016/j.celrep.2022.110856
  
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sciencedirect.com/science/article/pii/S2211124722006295
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STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program

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1. scibot 26 May 2022
  
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  DOI: 10.1016/j.celrep.2022.110838
  
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sciencedirect.com/science/article/pii/S2211124722006118
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DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production

1
1. scibot 20 May 2022
  
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  DOI: 10.1016/j.molcel.2022.04.030
  
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sciencedirect.com/science/article/pii/S1097276522003938
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WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC

1
1. scibot 19 May 2022
  
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  RRID:AB_2732796
  
  DOI: 10.1016/j.celrep.2022.110814
  
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sciencedirect.com/science/article/pii/S221112472200585X
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Protocol to induce and assess cGAS-STING pathway activation in vitro

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1. scibot 18 May 2022
  
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  DOI: 10.1016/j.xpro.2022.101384
  
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sciencedirect.com/science/article/pii/S2666166722002647
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The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis

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1. scibot 11 May 2022
  
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  DOI: 10.1016/j.immuni.2022.04.006
  
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sciencedirect.com/science/article/pii/S1074761322001777
Feb 2022
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The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation

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1. scibot 04 Feb 2022
  
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  RRID:AB_2732796
  
  DOI: 10.1016/j.molcel.2022.01.008
  
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sciencedirect.com/science/article/pii/S1097276522000089
Jan 2022
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MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells

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1. scibot 26 Jan 2022
  
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  RRID:AB_2732796
  
  DOI: 10.1016/j.ccell.2021.12.009
  
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sciencedirect.com/science/article/pii/S1535610821006620
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Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells

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1. scibot 16 Jan 2022
  
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  DOI: 10.1016/j.celrep.2021.110236
  
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sciencedirect.com/science/article/pii/S2211124721017459
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STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses

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1. scibot 05 Jan 2022
  
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  RRID:AB_2732796
  
  DOI: 10.1016/j.cmet.2021.12.007
  
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sciencedirect.com/science/article/pii/S1550413121006264
Dec 2021
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IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer

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1. scibot 22 Dec 2021
  
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  DOI: 10.1016/j.celrep.2021.110138
  
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sciencedirect.com/science/article/pii/S221112472101634X
Nov 2021
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BPS Publications

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1. scibot 23 Nov 2021
  
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  RRID:AB_2732796
  
  DOI: 10.1111/bph.15673
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15673
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TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis

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1. scibot 10 Nov 2021
  
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  RRID:AB_2732796
  
  DOI: 10.1016/j.celrep.2021.109977
  
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cell.com/cell-reports/fulltext/S2211-1247(21)01456-X
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APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis

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1. scibot 09 Nov 2021
  
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  DOI: 10.1016/j.immuni.2021.10.004
  
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sciencedirect.com/science/article/pii/S1074761321004106
Oct 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CX-5461 Treatment Leads to Cytosolic DNA-Mediated STING Activation in Ovarian Cancer

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1. scibot 28 Oct 2021
  
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  DOI: 10.3390/cancers13205056
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8533980/
Sep 2021
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PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis

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1. scibot 24 Sep 2021
  
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  DOI: 10.1016/j.molcel.2021.08.039
  
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sciencedirect.com/science/article/pii/S1097276521007292
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STING nuclear partners contribute to innate immune signaling responses

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1. scibot 22 Sep 2021
  
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  DOI: 10.1016/j.isci.2021.103055
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8436130/
Aug 2021
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Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity

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1. scibot 28 Aug 2021
  
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  DOI: 10.1016/j.molcel.2021.07.040
  
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sciencedirect.com/science/article/pii/S1097276521006249
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Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy

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1. scibot 16 Aug 2021
  
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  DOI: 10.1016/j.cell.2021.07.020
  
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sciencedirect.com/science/article/pii/S0092867421008795
cancerres.aacrjournals.org cancerres.aacrjournals.org

SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer

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1. scibot 16 Aug 2021
  
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  DOI: 10.1158/0008-5472.CAN-20-3738
  
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cancerres.aacrjournals.org/content/81/12/3215
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Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm

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1. scibot 11 Aug 2021
  
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  DOI: 10.1002/advs.202100779
  
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onlinelibrary.wiley.com/doi/10.1002/advs.202100779
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Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair

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1. scibot 03 Aug 2021
  
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  DOI: 10.1016/j.cmet.2021.07.009
  
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sciencedirect.com/science/article/pii/S1550413121003259
www.ncbi.nlm.nih.govhttp: www.ncbi.nlm.nih.govhttp:

Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

1
1. scibot 01 Aug 2021
  
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  DOI: 10.1016/j.molcel.2018.07.034
  
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ncbi.nlm.nih.govhttp://europepmc.org/articles/PMC6127031/
Jul 2021
www.nature.com www.nature.com

Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C

1
1. scibot 31 Jul 2021
  
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  13647
  
  DOI: 10.1038/s41586-021-03762-2
  
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nature.com/articles/s41586-021-03762-2
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LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

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1. scibot 29 Jul 2021
  
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  RRID:AB_2732796
  
  DOI: 10.1016/j.cell.2018.05.052
  
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  RRID:AB_2732796 RRIDCUR:Unresolved RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S0092867418307153
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Untitled document

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1. scibot 28 Jul 2021
  
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  DOI: 10.1016/j.molcel.2018.07.034
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6127031/
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Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING

1
1. scibot 23 Jul 2021
  
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  DOI: 10.1016/j.celrep.2021.109412
  
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PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity

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  DOI: 10.1016/j.ccell.2021.06.018
  
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Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment.

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DHX15 is required to control RNA virus-induced intestinal inflammation

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C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation

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Translation stress and collided ribosomes are co-activators of cGAS

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Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells

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The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

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BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse

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Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress

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SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function

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LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP

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  DOI: 10.1016/j.molcel.2020.10.021
  
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Mutant p53 suppresses innate immune signaling to promote tumorigenesis

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MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

1
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A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology

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  anti‐STING
  
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DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity

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FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells

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  DOI: 10.1016/j.cell.2020.11.042
  
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Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes

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1. scibot 27 Feb 2021
  
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  DOI: 10.3390/antiox10020334
  
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Disruption of DNA polymerase ζ engages an innate immune response

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  DOI: 10.1016/j.celrep.2021.108775
  
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Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation

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  DOI: 10.1016/j.celrep.2019.03.098
  
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TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS

1
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  DOI: 10.1016/j.cell.2020.09.020
  
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mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

1
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TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells

1
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  DOI: 10.1016/j.celrep.2020.03.056
  
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Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity

1
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Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

1
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Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma

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The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING

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  RRID: AB_2732796
  
  DOI: 10.1016/j.celrep.2018.11.097
  
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cell.com/cell-reports/fulltext/S2211-1247(18)31888-6
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C9orf72 in myeloid cells suppresses STING-induced inflammation

1
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  STING
  
  DOI: 10.1038/s41586-020-2625-x
  
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Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer

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Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury

1
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  DOI: 10.1016/j.celrep.2019.09.050
  
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cell.com/cell-reports/fulltext/S2211-1247(19)31238-0
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IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation

1
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  DOI: 10.1016/j.chom.2019.05.002
  
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The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

1
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  DOI: 10.1016/j.cell.2019.05.035
  
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STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition

1
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  DOI: 10.1016/j.cell.2019.05.036
  
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Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles

1
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  DOI: 10.1016/j.celrep.2019.05.008
  
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CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

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  DOI: 10.1016/j.ccell.2019.11.003
  
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STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production

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  DOI: 10.1016/j.celrep.2019.09.069
  
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Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity

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SLC19A1 Is an Importer of the Immunotransmitter cGAMP

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  DOI: 10.1016/j.molcel.2019.05.006
  
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Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING

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  DOI: 10.1016/j.molcel.2019.02.038
  
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Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages

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NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation

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Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

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Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

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