131 Matching Annotations
  1. Last 7 days
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    Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration
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    1. scibot 19 Apr 2024
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    sciencedirect.com/science/article/pii/S221112472400442X
  3. Mar 2024
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    HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
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    2. scibot 01 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113870

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    sciencedirect.com/science/article/pii/S2211124724001980
  5. Feb 2024
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    The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation
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    1. scibot 16 Feb 2024
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    sciencedirect.com/science/article/pii/S2211124724001207
  7. Jan 2024
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    DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells
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    1. scibot 19 Jan 2024
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      DOI: 10.1016/j.isci.2023.108760

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    sciencedirect.com/science/article/pii/S2589004223028377
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    Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.
    1
    1. scibot 19 Jan 2024
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    sciencedirect.com/science/article/pii/S2589004224000294
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    Interferon-stimulated neutrophils as a predictor of immunotherapy response
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    1. scibot 09 Jan 2024
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    sciencedirect.com/science/article/pii/S1535610823004336
  11. Dec 2023
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    Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
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    1. scibot 16 Dec 2023
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      DOI: 10.1016/j.molcel.2023.11.026

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    sciencedirect.com/science/article/pii/S1097276523009711
  13. Nov 2023
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SIX4 Controls Anti-PD-1 Efficacy by Regulating STING Expression
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    1. scibot 30 Nov 2023
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      DOI: 10.1158/2767-9764.CRC-23-0265

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    ncbi.nlm.nih.gov/pmc/articles/PMC10680432/
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    Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.immuni.2023.11.001

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    sciencedirect.com/science/article/abs/pii/S1074761323004582
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    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113352

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    sciencedirect.com/science/article/pii/S2211124723013645
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
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    1. scibot 03 Nov 2023
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      DOI: 10.1158/1078-0432.CCR-23-0103

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    ncbi.nlm.nih.gov/pmc/articles/PMC10618648/
  18. Oct 2023
  19. www.sciencedirect.com www.sciencedirect.com
    Regulation of STING activity in DNA sensing by ISG15 modification
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    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113277

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    sciencedirect.com/science/article/pii/S2211124723012895
  20. 52.53.155.43 52.53.155.43
    Blocking oligomerization is the most viable strategy to inhibit STING
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    1. scibot 20 Oct 2023
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      DOI: 10.1101/2023.08.11.553045

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    52.53.155.43/b51af3efb3ab194b2ea96b77566b6b4cbbb36c40/2023.08.11.553045v1.full-html.html
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    Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells
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    1. scibot 14 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113180

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    sciencedirect.com/science/article/pii/S2211124723011920
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    Mechanotransduction in response to ECM stiffening impairs cGAS immune signaling in tumor cells
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    1. scibot 13 Oct 2023
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    sciencedirect.com/science/article/pii/S2211124723012251
  23. 52.53.155.43 52.53.155.43
    ccr-23-0103-html.html
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    1. scibot 07 Oct 2023
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  24. Sep 2023
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    Spinal TAOK2 contributes to neuropathic pain via cGAS-STING activation in rats
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    1. scibot 16 Sep 2023
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      DOI: 10.1016/j.isci.2023.107792

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    sciencedirect.com/science/article/pii/S2589004223018692
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    STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells
    2
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      DOI: 10.1016/j.celrep.2023.113108

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    sciencedirect.com/science/article/pii/S2211124723011191
  27. Aug 2023
  28. 52.53.155.43 52.53.155.43
    ccr-23-0103-html.html
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    1. scibot 11 Aug 2023
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  29. Jul 2023
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    STING-IRG1 inhibits liver metastasis of colorectal cancer by regulating the polarization of tumor-associated macrophages
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    1. scibot 29 Jul 2023
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      DOI: 10.1016/j.isci.2023.107376

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    sciencedirect.com/science/article/pii/S2589004223014530
  31. 52.53.155.43 52.53.155.43
    Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
    1
    1. scibot 18 Jul 2023
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    52.53.155.43/e3af5320fa4957e0d04742dece43e2a779968bea/2023.06.01.543220v1.full-html.html
  32. 52.53.155.43 52.53.155.43
    ccr-23-0103-html.html
    1
    1. scibot 08 Jul 2023
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  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Vinorelbine causes a neuropathic pain-like state in mice via STING and MNK1 signaling associated with type I interferon induction.
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10274710/
  34. Jun 2023
  35. www.sciencedirect.com www.sciencedirect.com
    The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity
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    1. scibot 28 Jun 2023
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      DOI: 10.1016/j.immuni.2023.06.002

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    sciencedirect.com/science/article/pii/S1074761323002376
  36. www.sciencedirect.com www.sciencedirect.com
    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
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    1. scibot 02 Jun 2023
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    sciencedirect.com/science/article/pii/S1535610823001733
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    Cancer cell-autonomous cGAS-STING response confers drug resistance
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      DOI: 10.1016/j.chembiol.2023.05.005

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    sciencedirect.com/science/article/pii/S2451945623001411
  38. May 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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    1. scibot 27 May 2023
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      DOI: 10.1016/j.ccell.2023.04.016

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    sciencedirect.com/science/article/pii/S1535610823001423
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    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
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    1. scibot 26 May 2023
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      DOI: 10.1016/j.ccell.2023.04.018

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    sciencedirect.com/science/article/pii/S1535610823001629
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    Human papillomavirus E5 suppresses immunity via inhibition of the immunoproteasome and STING pathway
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    1. scibot 12 May 2023
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      DOI: 10.1016/j.celrep.2023.112508

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    sciencedirect.com/science/article/pii/S2211124723005193
  42. Apr 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Innate immune pathway modulator screen identifies STING pathway activation as a strategy to inhibit multiple families of arbo and respiratory viruses
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      DOI: 10.1016/j.xcrm.2023.101024

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    sciencedirect.com/science/article/pii/S2666379123001349
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    Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING
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    sciencedirect.com/science/article/pii/S2211124723004539
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    The mechanism of STING autoinhibition and activation
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      DOI: 10.1016/j.molcel.2023.03.029

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    sciencedirect.com/science/article/pii/S1097276523002435
  46. www.sciencedirect.com www.sciencedirect.com
    ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer
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      DOI: 10.1016/j.devcel.2023.03.015

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    sciencedirect.com/science/article/pii/S1534580723001314
  47. Mar 2023
  48. www.sciencedirect.com www.sciencedirect.com
    STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion
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      DOI: 10.1016/j.immuni.2023.02.015

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    sciencedirect.com/science/article/pii/S1074761323000894
  49. europepmc.org europepmc.org
    Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING
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    1. scibot 28 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112303

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    europepmc.org/article/med/36952341
  50. www.sciencedirect.com www.sciencedirect.com
    Leaked genomic and mitochondrial DNA contribute to the host response to noroviruses in a STING-dependent manner
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    1. scibot 28 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112179

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    sciencedirect.com/science/article/pii/S2211124723001900
  51. www.sciencedirect.com www.sciencedirect.com
    The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus
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    1. scibot 28 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112306

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    sciencedirect.com/science/article/pii/S2211124723003170
  52. www.sciencedirect.com www.sciencedirect.com
    NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking
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    1. scibot 02 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112185

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    sciencedirect.com/science/article/pii/S2211124723001961
  53. Feb 2023
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preclinical evaluation of tolvaptan and salsalate combination therapy in a Pkd1-mouse model
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  55. Jan 2023
  56. www.sciencedirect.com www.sciencedirect.com
    Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks
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  57. Dec 2022
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    DNA damage repair kinase DNA-PK and cGAS synergize to induce cancer-related inflammation in glioblastoma
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    The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER
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    Structurally distinct PARP7 inhibitors provide new insights into the function of PARP7 in regulating nucleic acid-sensing and IFN-β signaling
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    Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer
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  62. Nov 2022
  63. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    Driving axon regeneration by orchestrating neuronal and non-neuronal innate immune responses via the IFNγ-cGAS-STING axis
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    Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1
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  66. Sep 2022
  67. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Activation of cGAS-STING pathway – A possible cause of myofiber atrophy/necrosis in dermatomyositis and immune-mediated necrotizing myopathy
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    ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP
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  69. Jul 2022
  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS
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  71. Jun 2022
  72. www.sciencedirect.com www.sciencedirect.com
    Replication stress triggered by nucleotide pool imbalance drives DNA damage and cGAS-STING pathway activation in NAFLD
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    cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model
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    The SETDB1–TRIM28 complex suppresses antitumor immunity
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    LL-37 transports immunoreactive cGAMP to activate STING signaling and enhance interferon-mediated host antiviral immunity
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  76. May 2022
  77. www.sciencedirect.com www.sciencedirect.com
    DDX41 is required for cGAS-STING activation against DNA virus infection
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    STING is an intrinsic checkpoint inhibitor that restrains the TH17 cell pathogenic program
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    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
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    WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
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    Protocol to induce and assess cGAS-STING pathway activation in vitro
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    The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis
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  83. Feb 2022
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    The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation
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  85. Jan 2022
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    MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells
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    Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells
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    STING orchestrates the crosstalk between polyunsaturated fatty acid metabolism and inflammatory responses
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  89. Dec 2021
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    IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer
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  91. Nov 2021
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    TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis
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    APOL1 risk variants in individuals of African genetic ancestry drive endothelial cell defects that exacerbate sepsis
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  95. Oct 2021
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CX-5461 Treatment Leads to Cytosolic DNA-Mediated STING Activation in Ovarian Cancer
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  97. Sep 2021
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    PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis
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    STING nuclear partners contribute to innate immune signaling responses
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  100. Aug 2021
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    Induced phase separation of mutant NF2 imprisons the cGAS-STING machinery to abrogate antitumor immunity
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    Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy
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    SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS–STING Activation and Chemotherapeutic Sensitivity in Colon Cancer
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    Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm
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    Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair
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    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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  107. Jul 2021
  108. www.nature.com www.nature.com
    Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C
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  109. www.sciencedirect.com www.sciencedirect.com
    LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade
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  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING
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    PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity
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  113. Jun 2021
  114. clincancerres.aacrjournals.org clincancerres.aacrjournals.org
    Mutations in the IFNγ-JAK-STAT pathway causing resistance to immune checkpoint inhibitors in melanoma increase sensitivity to oncolytic virus treatment.
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    DHX15 is required to control RNA virus-induced intestinal inflammation
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    C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation
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    Translation stress and collided ribosomes are co-activators of cGAS
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  118. May 2021
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    Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells
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    The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake
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    BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse
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    Targeting KDM4A epigenetically activates tumor-cell-intrinsic immunity by inducing DNA replication stress
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    SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function
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    LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP
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  125. Apr 2021
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    Mutant p53 suppresses innate immune signaling to promote tumorigenesis
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    MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway
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    A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology
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      anti‐STING

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  129. Feb 2021
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    DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity
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    FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells
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    sciencedirect.com/science/article/pii/S0092867420316147
  132. www.mdpi.com www.mdpi.com
    Signal Transducer and Activator of Transcription 3 (STAT3) Suppresses STAT1/Interferon Signaling Pathway and Inflammation in Senescent Preadipocytes
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      DOI: 10.3390/antiox10020334

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    Disruption of DNA polymerase ζ engages an innate immune response
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  134. Dec 2020
  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation
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  136. Oct 2020
  137. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS
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  138. Sep 2020
  139. www.sciencedirect.com www.sciencedirect.com
    mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury
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    TBK1 and IKKε Act Redundantly to Mediate STING-Induced NF-κB Responses in Myeloid Cells
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    Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity
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    Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP
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    Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma
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  144. www.cell.com www.cell.com
    The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
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    cell.com/cell-reports/fulltext/S2211-1247(18)31888-6
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    C9orf72 in myeloid cells suppresses STING-induced inflammation
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      STING

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    Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer
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  147. Jan 2020
  148. www.cell.com www.cell.com
    Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury
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    IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation
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    The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death
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    STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
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    Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles
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    CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
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    STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production
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    Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity
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      DOI: 10.1016/j.celrep.2018.11.097

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    SLC19A1 Is an Importer of the Immunotransmitter cGAMP
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      DOI: 10.1016/j.molcel.2019.05.006

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      DOI: 10.1016/j.celrep.2019.03.098

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      DOI: 10.1016/j.celrep.2019.01.105

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      DOI: 10.1016/j.celrep.2018.11.094

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    Interleukin-1β Induces mtDNA Release to Activate Innate Immune Signaling via cGAS-STING
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      DOI: 10.1016/j.molcel.2019.02.038

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  162. Nov 2018
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    Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages
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    NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation
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  165. www.ncbi.nlm.nih.govhttp: www.ncbi.nlm.nih.govhttp:
    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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    Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis
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