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Jun 2023
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Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin

1
1. scibot 23 Jun 2023
  
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  DOI: 10.1016/j.molcel.2023.05.022
  
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sciencedirect.com/science/article/pii/S1097276523003787
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Compromised nonsense-mediated RNA decay results in truncated RNA-binding protein production upon DUX4 expression

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1. scibot 23 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112642
  
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sciencedirect.com/science/article/pii/S2211124723006538
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DNA hypomethylation silences anti-tumor immune genes in early prostate cancer and CTCs

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1. scibot 21 Jun 2023
  
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  DOI: 10.1016/j.cell.2023.05.028
  
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sciencedirect.com/science/article/pii/S0092867423005809
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ARS2 instructs early transcription termination-coupled RNA decay by recruiting ZC3H4 to nascent transcripts

1
1. scibot 21 Jun 2023
  
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  DOI: 10.1016/j.molcel.2023.05.028
  
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sciencedirect.com/science/article/pii/S1097276523003842
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Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas

1
1. scibot 21 Jun 2023
  
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  DOI: 10.1016/j.xcrm.2023.101082
  
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sciencedirect.com/science/article/pii/S266637912300201X
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SAM-Competitive EZH2-Inhibitors Induce Platinum Resistance by EZH2-Independent Induction of ABC-Transporters

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1. scibot 08 Jun 2023
  
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  DOI: 10.3390/cancers15113043
  
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mdpi.com/2072-6694/15/11/3043
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Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer

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1. scibot 01 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112533
  
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sciencedirect.com/science/article/pii/S2211124723005442
May 2023
52.53.155.43 52.53.155.43

Global identification of direct SWI/SNF targets reveals compensation by EP400

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1. scibot 26 May 2023
  
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  DOI: 10.1101/2023.03.07.531379
  
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52.53.155.43/1f9bfe96276133d800deede23a60dc1d07ed8bc3/2023.03.07.531379v1.full-html.html
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Epigenetic reprogramming of imprinting at meiosis

1
1. scibot 25 May 2023
  
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  DOI: 10.1101/2023.05.17.541143
  
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biorxiv.org/content/10.1101/2023.05.17.541143v1
academic.oup.com academic.oup.com

Extension of the DNAJB2a isoform in a dominant neuromyopathy family

1
1. scibot 25 May 2023
  
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  DOI: 10.1093/hmg/ddad058
  
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academic.oup.com/hmg/article/32/21/3029/7127670
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

Integrative transcriptomics and cell systems analyses reveal protective pathways controlled by Igfbp-3 in anthracycline-induced cardiotoxicity

1
1. scibot 24 May 2023
  
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  DOI: 10.1096/fj.202201885RR
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202201885RR
52.53.155.43 52.53.155.43

BMP4 triggers regulatory circuits specifying the cardiac mesoderm lineage

1
1. scibot 19 May 2023
  
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  DOI: 10.1242/dev.201450
  
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52.53.155.43/dd2974174e67d65ed3a779c744ae7b3f60cd7f18/RRID11-html.html
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Airway dysbiosis accelerates lung function decline in chronic obstructive pulmonary disease

1
1. scibot 19 May 2023
  
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  DOI: 10.1016/j.chom.2023.04.018
  
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sciencedirect.com/science/article/pii/S1931312823001671
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The mitochondrial intermembrane space protein mitofissin drives mitochondrial fission required for mitophagy

1
1. scibot 17 May 2023
  
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  DOI: 10.1016/j.molcel.2023.04.022
  
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sciencedirect.com/science/article/pii/S1097276523003167
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Methionine consumption by cancer cells drives a progressive upregulation of PD-1 expression in CD4 T cells

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1. scibot 06 May 2023
  
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  DOI: 10.1038/s41467-023-38316-9
  
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nature.com/articles/s41467-023-38316-9
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Phase separation of HRLP regulates flowering time in Arabidopsis

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1. scibot 05 May 2023
  
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  DOI: 10.1126/sciadv.abn5488
  
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science.org/doi/10.1126/sciadv.abn5488
Apr 2023
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A hyper-quiescent chromatin state formed during aging is reversed by regeneration

1
1. scibot 29 Apr 2023
  
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  DOI: 10.1016/j.molcel.2023.04.005
  
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sciencedirect.com/science/article/pii/S1097276523002496
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NSD1 deposits histone H3 lysine 36 dimethylation to pattern non-CG DNA methylation in neurons

1
1. scibot 26 Apr 2023
  
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  RRID:AB_302613
  
  DOI: 10.1016/j.molcel.2023.04.001
  
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sciencedirect.com/science/article/pii/S1097276523002459
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Reduced histone gene copy number disrupts Drosophila Polycomb function

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1. scibot 20 Apr 2023
  
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  DOI: 10.1101/2023.03.28.534544
  
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biorxiv.org/content/10.1101/2023.03.28.534544v1
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Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair

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1. scibot 14 Apr 2023
  
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  DOI: 10.1016/j.molcel.2023.03.021
  
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sciencedirect.com/science/article/pii/S1097276523002113
52.53.155.43 52.53.155.43

Release of Histone H3K4-reading transcription factors from chromosomes in mitosis is independent of adjacent H3 phosphorylation

1
1. scibot 13 Apr 2023
  
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  DOI: 10.1101/2023.02.28.530230
  
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52.53.155.43/21d7e0de21d77b609c83e3b4525fe6d90ea7288a/2023.02.28.530230v1.full-html.html
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PRC2.1- and PRC2.2-specific accessory proteins drive recruitment of different forms of canonical PRC1

1
1. scibot 08 Apr 2023
  
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  DOI: 10.1016/j.molcel.2023.03.018
  
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sciencedirect.com/science/article/pii/S1097276523002083
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Sodium ion influx regulates liquidity of biomolecular condensates in hyperosmotic stress response

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1. scibot 06 Apr 2023
  
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  DOI: 10.1016/j.celrep.2023.112315
  
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sciencedirect.com/science/article/pii/S2211124723003261
Mar 2023
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TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy

1
1. scibot 22 Mar 2023
  
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  DOI: 10.1016/j.jbc.2023.104621
  
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sciencedirect.com/science/article/pii/S0021925823002636
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Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration

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1. scibot 17 Mar 2023
  
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  DOI: 10.1016/j.cell.2023.02.023
  
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sciencedirect.com/science/article/pii/S0092867423001666
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A central chaperone-like role for 14-3-3 proteins in human cells

1
1. scibot 17 Mar 2023
  
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  DOI: 10.1016/j.molcel.2023.02.018
  
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sciencedirect.com/science/article/pii/S1097276523001211
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Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1

1
1. scibot 11 Mar 2023
  
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  DOI: 10.1016/j.cmet.2023.02.004
  
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sciencedirect.com/science/article/pii/S1550413123000402
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dodecaploid Xenopus longipes provides insight into the emergence of size scaling relationships during development

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1. scibot 11 Mar 2023
  
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  DOI: 10.1016/j.cub.2023.02.021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10115129/
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Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity

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1. scibot 10 Mar 2023
  
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  DOI: 10.1016/j.cmet.2023.02.013
  
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sciencedirect.com/science/article/pii/S1550413123000499
www.biorxiv.org www.biorxiv.org

Exposure to high-sugar diet induces transgenerational changes in sweet sensitivity and feeding behavior via H3K27me3 reprogramming

1
1. scibot 08 Mar 2023
  
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  DOI: 10.1101/2023.01.15.524137
  
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biorxiv.org/content/10.1101/2023.01.15.524137v1
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JMJ28 guides sequence-specific targeting of ATX1/2-containing COMPASS-like complex in Arabidopsis

1
1. scibot 03 Mar 2023
  
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  DOI: 10.1016/j.celrep.2023.112163
  
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sciencedirect.com/science/article/pii/S2211124723001742
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Histone bivalency regulates the timing of cerebellar granule cell development

1
1. scibot 03 Mar 2023
  
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  DOI: 10.1101/2023.02.02.526881
  
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biorxiv.org/content/10.1101/2023.02.02.526881v1
Feb 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5

1
1. scibot 23 Feb 2023
  
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  DOI: 10.7554/eLife.79013
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9943068/
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Multiple ubiquitin E3 ligase genes antagonistically regulate chloroplast-associated protein degradation

1
1. scibot 23 Feb 2023
  
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  DOI: 10.1016/j.cub.2023.01.060
  
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sciencedirect.com/science/article/pii/S096098222300129X
link.springer.com link.springer.com

Isolating Mitochondria, Mitoplasts, and mtDNA from Cultured Mammalian Cells

1
1. scibot 23 Feb 2023
  
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  RRID:AB_302613
  
  DOI: 10.1007/978-1-0716-2922-2_2
  
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link.springer.com/protocol/10.1007/978-1-0716-2922-2_2
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Pro-Regenerative Environment Triggers Premalignant to Malignant Transformation of Senescent Hepatocytes

1
1. scibot 11 Feb 2023
  
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  DOI: 10.1158/0008-5472.CAN-22-1477
  
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Genome-wide epigenetic and mRNA-expression profiling followed by CRISPR/Cas9-mediated gene-disruptions corroborate the MIR141/MIR200C-ZEB1/ZEB2-FGFR1 axis in acquired EMT-associated EGFR TKI-resistance in NSCLC cells

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Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification

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Recycling of modified H2A-H2B provides short-term memory of chromatin states

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RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1

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GEN1 promotes common fragile site expression

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Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance

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BRPF1 bridges H3K4me3 and H3K23ac in human ESCs and is essential to pluripotency

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Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control

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RNA mis-splicing drives viral mimicry response after DNMTi therapy in SETD2-mutant kidney cancer

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MDC1 maintains active elongation complexes of RNA polymerase II

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Loss of epigenetic information as a cause of mammalian aging

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Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

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SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B cell lymphomagenesis

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Developmental phenomics suggests that H3K4 monomethylation confers multi-level phenotypic robustness

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Hypoxia induces transgenerational epigenetic inheritance of small RNAs

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Chromatin-associated YTHDC1 coordinates heat-induced reprogramming of gene expression

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Cystatin B deficiency results in sustained histone H3 tail cleavage in postnatal mouse brain mediated by increased chromatin-associated cathepsin L activity

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NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors

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NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors

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Excessive proteostasis contributes to pathology in fragile X syndrome

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PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing

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Profiling lariat intermediates reveals genetic determinants of early and late co-transcriptional splicing

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LncRNA nuclear-enriched abundant transcript 1 aggravates cerebral ischemia/reperfusion injury through activating early growth response-1/RNA binding motif protein 25 axis

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Pan-claudin family interactome analysis reveals shared and specific interactions

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Loss of the Ash2l subunit of histone H3K4 methyltransferase complexes promotes chromatin compaction at promoters

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Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci

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The long noncoding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

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The long noncoding RNA mimi scaffolds neuronal granules to maintain nervous system maturity

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A surface-receptor-coupled G protein regulates plant immunity through nuclear protein kinases

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Sox9 mediates Autophagy-dependent vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis

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p300/CBP sustains Polycomb silencing by non-enzymatic functions

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Regulation of KDM5C stability and enhancer reprogramming in breast cancer

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Chromatin jets define the properties of cohesin-driven in vivo loop extrusion

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A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation

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Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease

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SMN controls neuromuscular junction integrity through U7 snRNP

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Heterologous reporter expression in the planarian Schmidtea mediterranea through somatic mRNA transfection

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Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin remodelers

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Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages

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The Il6 -39kb enhancer containing clustered GATA2- and PU.1- binding sites is essential for Il6 expression in murine mast cells

1
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Polycomb-mediated repression of paternal chromosomes maintains haploid dosage in diploid embryos of Marchantia

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AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer

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RAD51 protects human cells from transcription-replication conflicts

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Molecular conflicts disrupting centromere maintenance contribute to Xenopus hybrid inviability

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Discovery of compounds that reactivate p53 mutants in vitro and in vivo

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mTORC1 is required for epigenetic silencing during β-cell functional maturation

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Broad-spectrum chemicals block ROS detoxification to prevent plant fungal invasion

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A non-transcriptional function of Yap regulates the DNA replication program in Xenopus laevis

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Acetylation of p62 regulates base excision repair through interaction with APE1

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Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells

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Induction of senescence upon loss of the Ash2l core subunit of H3K4 methyltransferase complexes

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Phase separation of HRLP regulates flowering time in Arabidopsis

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Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction

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Jun 2022
52.53.155.43 52.53.155.43

cd-21-1514-html.html

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  DOI: 10.1158/2159-8290.CD-21-1514
  
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Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia

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Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells

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MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines

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Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes

1
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Analysis of estrogen-regulated enhancer RNAs identifies a functional motif required for enhancer assembly and gene expression

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A rice protein modulates endoplasmic reticulum homeostasis and coordinates with a transcription factor to initiate blast disease resistance

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A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency

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Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators

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JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation

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Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

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May 2022
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Alcohol induced increases in sperm Histone H3 lysine 4 trimethylation correlate with increased placental CTCF occupancy and altered developmental programming

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Xist-mediated silencing requires additive functions of SPEN and Polycomb together with differentiation-dependent recruitment of SmcHD1

1
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Twist2-driven chromatin remodeling governs the postnatal maturation of dermal fibroblasts

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Single-cell analysis of human testis aging and correlation with elevated body mass index

1
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Apr 2022
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H3K4 methylation by SETD1A/BOD1L facilitates RIF1-dependent NHEJ

1
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CDYL1-dependent decrease in lysine crotonylation at DNA double-strand break sites functionally uncouples transcriptional silencing and repair

1
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Microtubules promote the non-cell autonomous action of microRNAs by inhibiting their cytoplasmic loading onto ARGONAUTE1 in Arabidopsis

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  DOI: 10.1016/j.devcel.2022.03.015
  
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Heat-induced SIRT1-mediated H4K16ac deacetylation impairs resection and SMARCAD1 recruitment to double strand breaks

2
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CTCF functions as an insulator for somatic genes and a chromatin remodeler for pluripotency genes during reprogramming

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  DOI: 10.1016/j.celrep.2022.110626
  
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PGC1α/β EXPRESSION PREDICTS THERAPEUTIC RESPONSE TO OXIDATIVE PHOSPHORYLATION INHIBITION IN OVARIAN CANCER

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  DOI: 10.1158/0008-5472.CAN-21-1223
  
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aacrjournals.org/cancerres/article/82/7/1423/694053/PGC1-Expression-Predicts-Therapeutic-Response-to
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The TFIIH complex is required to establish and maintain mitotic chromosome structure

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Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression

1
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  DOI: 10.1016/j.molcel.2022.03.004
  
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Histone deacetylation regulates nucleotide excision repair through an interaction with the XPC protein

1
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  DOI: 10.1016/j.isci.2022.104040
  
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Liquid-to-solid phase transition of oskar ribonucleoprotein granules is essential for their function in Drosophila embryonic development

1
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  DOI: 10.1016/j.cell.2022.02.022
  
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Neddylation is essential for β-catenin degradation in Wnt signaling pathway

1
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FBXO47 is essential for preventing the synaptonemal complex from premature disassembly in mouse male meiosis

1
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  DOI: 10.1016/j.isci.2022.104008
  
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Distinct and diverse chromatin proteomes of ageing mouse organs reveal protein signatures that correlate with physiological functions

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A trio of ubiquitin ligases sequentially drives ubiquitylation and autophagic degradation of dysfunctional yeast proteasomes

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Dynamic control of chromatin-associated m6A methylation regulates nascent RNA synthesis

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An Inducible CRISPR/Cas9 Screen Identifies DTX2 as a Transcriptional Regulator of Human Telomerase

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  DOI: 10.1016/j.isci.2022.103813
  
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dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region

1
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  AB_1791
  
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Feb 2022
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Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes

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  DOI: 10.7554/eLife.70714
  
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Ketogenic diet and chemotherapy combine to disrupt pancreatic cancer metabolism and growth

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  DOI: 10.1016/j.medj.2021.12.008
  
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E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression

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  DOI: 10.1016/j.molcel.2022.01.002
  
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Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing

1
1. scibot 26 Jan 2022
  
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  DOI: 10.1016/j.molcel.2021.12.023
  
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cell.com/molecular-cell/fulltext/S1097-2765(21)01085-6
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Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation

1
1. scibot 22 Jan 2022
  
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  DOI: 10.7554/eLife.72867
  
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Histone acetyltransferase NAA40 modulates acetyl-CoA levels and lipid synthesis

1
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  AB_302613
  
  DOI: 10.1186/s12915-021-01225-8
  
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Chromatin alterations during the epididymal maturation of mouse sperm refine the paternally inherited epigenome

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  RRID:AB_302613
  
  DOI: 10.1186/s13072-021-00433-4
  
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link.springer.com/article/10.1186/s13072-021-00433-4
Dec 2021
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EMSY inhibits homologous recombination repair and the interferon response, promoting lung cancer immune evasion

1
1. scibot 28 Dec 2021
  
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  DOI: 10.1016/j.cell.2021.12.005
  
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IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer

1
1. scibot 22 Dec 2021
  
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  DOI: 10.1016/j.celrep.2021.110138
  
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Potent macrocycle inhibitors of the human SAGA deubiquitinating module

1
1. scibot 22 Dec 2021
  
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  DOI: 10.1016/j.chembiol.2021.12.004
  
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www-sciencedirect-com.proxy.library.vcu.edu/science/article/pii/S2451945621005183
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Evolution of a histone variant involved in compartmental regulation of NAD metabolism

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  DOI: 10.1038/s41594-021-00692-5
  
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nature.com/articles/s41594-021-00692-5
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Pharmacological targeting of Sam68 functions in colorectal cancer stem cells

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  DOI: 10.1016/j.isci.2021.103442
  
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MYC assembles and stimulates topoisomerases 1 and 2 in a “topoisome”

1
1. scibot 10 Dec 2021
  
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  RRID:AB_302613
  
  DOI: 10.1016/j.molcel.2021.11.016
  
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cell.com/molecular-cell/fulltext/S1097-2765(21)00996-5
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The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability

1
1. scibot 09 Dec 2021
  
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  RRID:AB_302613
  
  DOI: 10.1016/j.celrep.2021.110080
  
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Methods to separate nuclear soluble fractions reflecting localizations in living cells

1
1. scibot 08 Dec 2021
  
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  DOI: 10.1016/j.isci.2021.103503
  
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SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity

1
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  DOI: 10.1016/j.molcel.2021.11.011
  
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Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts

1
1. scibot 01 Dec 2021
  
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  DOI: 10.7554/eLife.67952
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8626089/
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Ago1 controls myogenic differentiation by regulating eRNA-mediated CBP-guided epigenome reprogramming

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  DOI: 10.1016/j.celrep.2021.110066
  
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sciencedirect.com/science/article/pii/S2211124721015527
Nov 2021
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MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts

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1. scibot 30 Nov 2021
  
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  DOI: 10.1016/j.molcel.2021.11.002
  
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Transcription-wide mapping of dihydrouridine reveals that mRNA dihydrouridylation is required for meiotic chromosome segregation

1
1. scibot 19 Nov 2021
  
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  DOI: 10.1016/j.molcel.2021.11.003
  
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Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1

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Acetyl-CoA derived from hepatic mitochondrial fatty acid β-oxidation aggravates inflammation by enhancing p65 acetylation

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DDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks

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A role for SMARCB1 in synovial sarcomagenesis reveals that SS18-SSX induces canonical BAF destruction

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Glut1 expression in tumor-associated neutrophils promotes lung cancer growth and resistance to radiotherapy

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Identification of the sex-determining factor in the liverwort Marchantia polymorpha reveals unique evolution of sex chromosomes in a haploid system

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A complex of BRCA2 and PP2A-B56 is required for DNA repair by homologous recombination

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The BORDER family of negative transcription elongation factors regulates flowering time in Arabidopsis

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A viral histone-like protein exploits antagonism between linker histones and HMGB proteins to obstruct the cell cycle

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Gene bookmarking by the heat shock transcription factor programs the insulin-like signaling pathway

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NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain

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PIWI-mediated control of tissue-specific transposons is essential for somatic cell differentiation

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H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity

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A hydride transfer complex reprograms NAD metabolism and bypasses senescence

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DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation

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The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress

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Independent transcriptomic and proteomic regulation by type I and II protein arginine methyltransferases

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Hybrid protein assembly-histone modification mechanism for PRC2-based epigenetic switching and memory

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Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns

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Linker histone H1.8 inhibits chromatin binding of condensins and DNA topoisomerase II to tune chromosome length and individualization

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Reshaping of the androgen-driven chromatin landscape in normal prostate cells by early cancer drivers and effect on therapeutic sensitivity

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UV-induced reduction in Polycomb repression promotes epidermal pigmentation

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Mutant U2AF1-induced alternative splicing of H2afy (macroH2A1) regulates B-lymphopoiesis in mice

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Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration

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Fatty acids impact sarcomere integrity through myristoylation and ER homeostasis

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HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness

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Feedback repression of PPARα signaling by Let-7 microRNA

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Epigenetic Dysregulation Induces Translocation of Histone H3 into Cytoplasm

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miR-1 coordinately regulates lysosomal v-ATPase and biogenesis to impact proteotoxicity and muscle function during aging

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DNA Damage Signaling-Induced Cancer Cell Reprogramming as a Driver of Tumor Relapse

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UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway

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KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance

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The Splicing Factor hnRNP M Is a Critical Regulator of Innate Immune Gene Expression in Macrophages

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