663 Matching Annotations
  1. Last 7 days
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    Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation
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    1. scibot 24 Apr 2024
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      DOI: 10.1038/s41594-024-01294-7

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    link.springer.com/article/10.1038/s41594-024-01294-7
  3. Apr 2024
  4. www.sciencedirect.com www.sciencedirect.com
    H2AK119ub1 differentially fine-tunes gene expression by modulating canonical PRC1- and H1-dependent chromatin compaction
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    1. scibot 11 Apr 2024
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      DOI: 10.1016/j.molcel.2024.02.017

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    sciencedirect.com/science/article/pii/S1097276524001369
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    An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains
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    1. scibot 10 Apr 2024
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      DOI: 10.1016/j.molcel.2024.03.015

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    sciencedirect.com/science/article/pii/S1097276524002259
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    EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells
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    1. scibot 10 Apr 2024
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      DOI: 10.1007/s00018-024-05209-z

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    link.springer.com/article/10.1007/s00018-024-05209-z
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    A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation
    1
    1. scibot 09 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114024

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    sciencedirect.com/science/article/pii/S2211124724003528
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    Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer
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    1. scibot 05 Apr 2024
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      DOI: 10.1016/j.ccell.2024.03.005

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    sciencedirect.com/science/article/pii/S1535610824000904
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    A senescence restriction point acting on chromatin integrates oncogenic signals
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    1. scibot 04 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114044

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    sciencedirect.com/science/article/pii/S2211124724003723
  10. dx.doi.org dx.doi.org
    Wnt16 Promotes Vascular Smooth Muscle Contractile Phenotype and Function via Taz(Wwtr1) Activation in Male LDLR-/- Mice
    1
    1. scibot 04 Apr 2024
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      DOI: 10.1210/endocr/bqad192

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    dx.doi.org/10.1210/endocr/bqad192
  11. Mar 2024
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
    2
    1. scibot 08 Mar 2024
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    2. scibot 08 Mar 2024
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      DOI: 10.1016/j.molcel.2024.02.010

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    sciencedirect.com/science/article/pii/S1097276524001291
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    ApoE maintains neuronal integrity via miRNA and H3K27me3-mediated repression.
    2
    1. scibot 07 Mar 2024
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      DOI: 10.1016/j.isci.2024.109231

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    2. scibot 06 Mar 2024
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      DOI: 10.1016/j.isci.2024.109231

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    sciencedirect.com/science/article/pii/S2589004224004528
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    MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors
    2
    1. scibot 07 Mar 2024
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      DOI: 10.1016/j.isci.2024.109188

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    2. scibot 06 Mar 2024
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      DOI: 10.1016/j.isci.2024.109188

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    sciencedirect.com/science/article/pii/S2589004224004097
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    Alternative splicing decouples local from global PRC2 activity
    1
    1. scibot 06 Mar 2024
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      DOI: 10.1016/j.molcel.2024.02.011

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    sciencedirect.com/science/article/pii/S1097276524001308
  16. Feb 2024
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCID2 dysregulates transcription and viral RNA processing to promote HIV-1 latency
    1
    1. scibot 28 Feb 2024
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      DOI: 10.1016/j.isci.2024.109152

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    ncbi.nlm.nih.gov/pmc/articles/PMC10879814/
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    Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
    1
    1. scibot 23 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113845

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    sciencedirect.com/science/article/pii/S2211124724001736
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    Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons
    1
    1. scibot 23 Feb 2024
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      DOI: 10.1016/j.neuron.2024.01.023

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    sciencedirect.com/science/article/pii/S0896627324000497
  20. 52.53.155.43 52.53.155.43
    53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication
    1
    1. scibot 22 Feb 2024
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      DOI: 10.1101/2023.09.27.559698

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    52.53.155.43/9b07aa3872d935df1f2ff4d73fc96f76996bcf22/2023.09.27.559698v1.full-html.html
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas
    1
    1. scibot 15 Feb 2024
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      DOI: 10.1158/2767-9764.CRC-23-0399

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    ncbi.nlm.nih.gov/pmc/articles/PMC10863487/
  22. www.biorxiv.org www.biorxiv.org
    Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation
    1
    1. scibot 15 Feb 2024
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      DOI: 10.1101/2023.12.20.572718

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    biorxiv.org/content/10.1101/2023.12.20.572718v1
  23. 52.53.155.43 52.53.155.43
    bvae029-html.html
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    1. scibot 15 Feb 2024
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      DOI: 10.1210/jendso/bvae029

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    52.53.155.43/91f4741c570f637c33beb2463bb95c19a65c82ea/bvae029-html.html
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    SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability
    1
    1. scibot 13 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113778

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    sciencedirect.com/science/article/pii/S2211124724001062
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    Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells
    1
    1. scibot 09 Feb 2024
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      DOI: 10.1016/j.cels.2024.01.001

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    sciencedirect.com/science/article/pii/S240547122400022X
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    DExH-box helicase 9 modulates hippocampal synapses and regulates neuropathic pain
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      DOI: 10.1016/j.isci.2024.109016

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    sciencedirect.com/science/article/pii/S2589004224002372
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    Histone methylation readers MRG1/2 interact with PIF4 to promote thermomorphogenesis in Arabidopsis
    1
    1. scibot 06 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113726

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    sciencedirect.com/science/article/pii/S2211124724000548
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    n-3 polyunsaturated fatty acids delay intervertebral disc degeneration by inhibiting nuclear receptor coactivator 4-mediated iron overload
    1
    1. scibot 03 Feb 2024
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      DOI: 10.1016/j.isci.2023.108721

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    ncbi.nlm.nih.gov/pmc/articles/PMC10830877/
  29. www.sciencedirect.com www.sciencedirect.com
    H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells
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    1. scibot 02 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113707

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    sciencedirect.com/science/article/pii/S2211124724000354
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sirt6 regulates proliferation of neural precursor cells and cortical neurogenesis in mice
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      DOI: 10.1016/j.isci.2023.108706

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    ncbi.nlm.nih.gov/pmc/articles/PMC10823065/
  31. Jan 2024
  32. www.sciencedirect.com www.sciencedirect.com
    PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression
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    1. scibot 19 Jan 2024
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      DOI: 10.1016/j.devcel.2023.12.015

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    sciencedirect.com/science/article/pii/S1534580723006962
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    Discrete prefrontal neuronal circuits determine repeated stress-induced behavioral phenotypes in male mice
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      DOI: 10.1016/j.neuron.2023.12.004

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    sciencedirect.com/science/article/pii/S0896627323009340
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    Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression
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    1. scibot 11 Jan 2024
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      DOI: 10.1016/j.celrep.2023.113575

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    sciencedirect.com/science/article/pii/S2211124723015875
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    Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation
    1
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      DOI: 10.1016/j.cmet.2023.12.010

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    sciencedirect.com/science/article/pii/S1550413123004618
  36. Dec 2023
  37. www.sciencedirect.com www.sciencedirect.com
    TOR inactivation triggers heterochromatin formation in rDNA during glucose starvation
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      DOI: 10.1016/j.celrep.2023.113320

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    sciencedirect.com/science/article/pii/S2211124723013323
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    53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication
    1
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      DOI: 10.1016/j.celrep.2023.113412

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    sciencedirect.com/science/article/pii/S2211124723014249
  39. Nov 2023
  40. www.sciencedirect.com www.sciencedirect.com
    Manipulating the 3D organization of the largest synthetic yeast chromosome
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      DOI: 10.1016/j.molcel.2023.10.015

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    sciencedirect.com/science/article/pii/S1097276523008523
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    Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.cell.2023.09.025

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    sciencedirect.com/science/article/pii/S0092867423010796
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    Age-related decline in spermatogenic activity accompanied with endothelial cell senescence in male mice
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      DOI: 10.1016/j.isci.2023.108456

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    sciencedirect.com/science/article/pii/S2589004223025336
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    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113484

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    sciencedirect.com/science/article/pii/S2211124723014961
  44. 52.53.155.43 52.53.155.43
    Progesterone activates histone lactylation-Hif1α-glycolysis feedback loop to promote decidualization
    2
    1. scibot 18 Nov 2023
      AB_302613

      DOI: 10.1210/endocr/bqad169

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      DOI: 10.1210/endocr/bqad169

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    52.53.155.43/a32f66b9b11d3fe5e0af257f387c02b0aece4ce8/bqad169 (2)-html.html
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    RNA polymerase II dynamics and mRNA stability feedback scale mRNA amounts with cell size
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      DOI: 10.1016/j.cell.2023.10.012

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    Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains
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    Smith–Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling
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    Release of Histone H3K4-reading transcription factors from chromosomes in mitosis is independent of adjacent H3 phosphorylation
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    RBFOX2 regulated EYA3 isoforms partner with SIX4 or ZBTB1 to control transcription during myogenesis
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    The proteomic landscape of synaptic diversity across brain regions and cell types
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    The ubiquitin conjugase Rad6 mediates ribosome pausing during oxidative stress
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    Global identification of SWI/SNF targets reveals compensation by EP400
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    m6A demethylase FTO stabilizes LINK-A to exert oncogenic roles via MCM3-mediated cell-cycle progression and HIF-1α activation
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  54. Oct 2023
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    Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells
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    MircroRNA-92b as a Negative Regulator of the TGF-β Signaling by Targeting the Type I Receptor
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    A Haspin-ARHGAP11A axis regulates epithelial morphogenesis through Rho-ROCK dependent modulation of LIMK1-Cofilin
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    Splicing quality control mediated by DHX15 and its G-patch activator SUGP1
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    Exposure to high-sugar diet induces transgenerational changes in sweet sensitivity and feeding behavior via H3K27me3 reprogramming
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    ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms
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    15-keto-PGE2 Alleviates Nonalcoholic Steatohepatitis through its Covalent Modification of NF-κB Factors
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    ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct
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    Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth
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  64. Sep 2023
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein
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    Histone bivalency regulates the timing of cerebellar granule cell development
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    A distinct circular DNA profile intersects with proteome changes in the genotoxic stress-related hSOD1G93A model of ALS
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    Protocol to study the role of a human nuclear m6A RNA reader on chromatin-associated RNA targets
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    The SMC5/6 complex compacts and silences unintegrated HIV-1 DNA and is antagonized by Vpr
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    Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8
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    Chromatin remodeling of histone H3 variants by DDM1 underlies epigenetic inheritance of DNA methylation
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    Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A
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    Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis
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    High-throughput functional characterization of combinations of transcriptional activators and repressors
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    DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype
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    Histone variants shape chromatin states in Arabidopsis
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    Heterogeneous non-canonical nucleosomes predominate in yeast cells in situ
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  79. Jul 2023
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    Histone H1 protects telomeric repeats from H3K27me3 invasion in Arabidopsis
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    Thymine DNA glycosylase regulates cell-cycle-driven p53 transcriptional control in pluripotent cells
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    Pharmacological HDAC inhibition impairs pancreatic β-cell function through an epigenome-wide reprogramming
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    Widespread dysregulation of mRNA splicing implicates RNA processing in the development and progression of Huntington's disease
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    Nucleocytoplasmic mRNA redistribution accompanies RNA binding protein mislocalization in ALS motor neurons and is restored by VCP ATPase inhibition
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    Upregulation of EphA4 deteriorate brain damage by shifting microglia M1-polarization via NF-κB signaling after focal cerebral ischemia in rats
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    SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck
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    Reduced histone gene copy number disrupts Drosophila Polycomb function
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    Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin
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    Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas
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    Release of Histone H3K4-reading transcription factors from chromosomes in mitosis is independent of adjacent H3 phosphorylation
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    Dodecaploid Xenopus longipes provides insight into the emergence of size scaling relationships during development
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    Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
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    Exposure to high-sugar diet induces transgenerational changes in sweet sensitivity and feeding behavior via H3K27me3 reprogramming
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    JMJ28 guides sequence-specific targeting of ATX1/2-containing COMPASS-like complex in Arabidopsis
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    Histone bivalency regulates the timing of cerebellar granule cell development
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  136. Feb 2023
  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5
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    Multiple ubiquitin E3 ligase genes antagonistically regulate chloroplast-associated protein degradation
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    Isolating Mitochondria, Mitoplasts, and mtDNA from Cultured Mammalian Cells
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    A Pro-Regenerative Environment Triggers Premalignant to Malignant Transformation of Senescent Hepatocytes
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    Genome-wide epigenetic and mRNA-expression profiling followed by CRISPR/Cas9-mediated gene-disruptions corroborate the MIR141/MIR200C-ZEB1/ZEB2-FGFR1 axis in acquired EMT-associated EGFR TKI-resistance in NSCLC cells
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    Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification
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    Recycling of modified H2A-H2B provides short-term memory of chromatin states
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    RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1
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    GEN1 promotes common fragile site expression
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    Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance
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    BRPF1 bridges H3K4me3 and H3K23ac in human ESCs and is essential to pluripotency
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    Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control
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    RNA mis-splicing drives viral mimicry response after DNMTi therapy in SETD2-mutant kidney cancer
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    MDC1 maintains active elongation complexes of RNA polymerase II
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    Loss of epigenetic information as a cause of mammalian aging
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    Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
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    SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B cell lymphomagenesis
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  156. www.sciencedirect.com www.sciencedirect.com
    Developmental phenomics suggests that H3K4 monomethylation confers multi-level phenotypic robustness
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    Hypoxia induces transgenerational epigenetic inheritance of small RNAs
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    Chromatin-associated YTHDC1 coordinates heat-induced reprogramming of gene expression
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    Cystatin B deficiency results in sustained histone H3 tail cleavage in postnatal mouse brain mediated by increased chromatin-associated cathepsin L activity
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    NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors
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  161. www.science.org www.science.org
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    Excessive proteostasis contributes to pathology in fragile X syndrome
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    PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing
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    Profiling lariat intermediates reveals genetic determinants of early and late co-transcriptional splicing
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    LncRNA nuclear-enriched abundant transcript 1 aggravates cerebral ischemia/reperfusion injury through activating early growth response-1/RNA binding motif protein 25 axis
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    Pan-claudin family interactome analysis reveals shared and specific interactions
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    Loss of the Ash2l subunit of histone H3K4 methyltransferase complexes promotes chromatin compaction at promoters
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    Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci
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  170. Oct 2022
  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The long noncoding RNA mimi scaffolds neuronal granules to maintain nervous system maturity
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  172. www.science.org www.science.org
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    A surface-receptor-coupled G protein regulates plant immunity through nuclear protein kinases
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    Sox9 mediates Autophagy-dependent vascular smooth muscle cell phenotypic modulation and transplant arteriosclerosis
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    p300/CBP sustains Polycomb silencing by non-enzymatic functions
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    Chromatin jets define the properties of cohesin-driven in vivo loop extrusion
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    A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation
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    The Il6 -39kb enhancer containing clustered GATA2- and PU.1- binding sites is essential for Il6 expression in murine mast cells
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    Inhibition of DYRK1A, via histone modification, promotes cardiomyocyte cell cycle activation and cardiac repair after myocardial infarction
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    Clioquinol as an inhibitor of JmjC-histone demethylase exhibits common and unique histone methylome and transcriptome between clioquinol and hypoxia
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    Analysis of estrogen-regulated enhancer RNAs identifies a functional motif required for enhancer assembly and gene expression
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    Breaking boundaries: Pan BETi disrupt 3D chromatin structure, BD2-selective BETi are strictly epigenetic transcriptional regulators
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    Alcohol induced increases in sperm Histone H3 lysine 4 trimethylation correlate with increased placental CTCF occupancy and altered developmental programming
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    Xist-mediated silencing requires additive functions of SPEN and Polycomb together with differentiation-dependent recruitment of SmcHD1
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    Twist2-driven chromatin remodeling governs the postnatal maturation of dermal fibroblasts
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