831 Matching Annotations
  1. Aug 2024
  2. www.sciencedirect.com www.sciencedirect.com
    MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation
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    sciencedirect.com/science/article/pii/S2211124724010337
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8+ T cell exhaustion and anti-PD-1 resistance
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    ncbi.nlm.nih.gov/pmc/articles/PMC11384939/
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    Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes and peripheral T cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11333044/
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    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    cell.com/cell/fulltext/S0092-8674(20)30163-X
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    Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy
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    cell.com/cell-reports/abstract/S2211-1247(24)00902-1
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    Disc Large Homolog 1 Is Critical for Early T Cell Receptor Micro Cluster Formation and Activation in Human T Cells
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    mdpi.com/2076-393X/9/12/1446/htm
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    Linking Hypothermia and Altered Metabolism with TrkB Activation
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    pubs.acs.org/doi/full/10.1021/acschemneuro.3c00350
  9. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Purinergic receptor P2Y6 contributes to 1‐methyl‐4‐phenylpyridinium‐induced oxidative stress and cell death in neuronal SH‐SY5Y cells
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    onlinelibrary.wiley.com/doi/10.1002/jnr.24119/full
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    Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function
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    onlinelibrary.wiley.com/doi/10.1111/jnc.13038/full
  11. Jul 2024
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
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    ncbi.nlm.nih.gov/pmc/articles/PMC11284272/
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    Apocynin Prevents Cigarette Smoke-Induced Anxiety-Like Behavior and Preserves Microglial Profiles in Male Mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC11274253/
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    Impact of Interleukin-6 Activation and Arthritis on Epidermal Growth Factor Receptor (EGFR) Activation in Sensory Neurons and the Spinal Cord
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    mdpi.com/1422-0067/25/13/7168
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    Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling
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    sciencedirect.com/science/article/pii/S2666379124003720
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    Arrestin-3-assisted activation of JNK3 mediates dopaminergic behavioral sensitization
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    G protein–coupled receptor endocytosis generates spatiotemporal bias in β-arrestin signaling
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    science.org/doi/10.1126/scisignal.adi0934
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    wang-et-al-2024-lilrb1-hla-g-axis-defines-a-checkpoint-driving-natural-killer-cell-exhaustion-in-tuberculosis-html.html
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    LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis
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    embopress.org/doi/10.1038/s44321-024-00106-1
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    Cenicriviroc Suppresses and Reverses Steatohepatitis by Regulating Macrophage Infiltration and M2 Polarization in Mice
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    dx.doi.org/10.1210/endocr/bqae069
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    Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC11293342/
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    A methodology to globally assess ectodomain shedding using soluble fractions from the mouse brain
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    ncbi.nlm.nih.gov/pmc/articles/PMC11219901/
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    Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11223027/
  24. Jun 2024
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    Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target
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  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evaluation of the role of AXL in fusion-positive pediatric rhabdomyosarcoma identifies the small-molecule inhibitor bemcentinib (BGB324) as potent chemosensitizer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11148551/
  27. May 2024
  28. www.mdpi.com www.mdpi.com
    Lysophosphatidic Acid Stimulates Mitogenic Activity and Signaling in Human Neuroblastoma Cells through a Crosstalk with Anaplastic Lymphoma Kinase
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  29. 52.53.155.43 52.53.155.43
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    Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC
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    The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation
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    The Human Intermediate Prolactin Receptor I-tail Contributes Breast Oncogenesis by Targeting Ras/MAPK Pathway
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    dx.doi.org/10.1210/endocr/bqae039
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    Ganoderma lucidum extract attenuates corticotropin-releasing hormone induced cellular senescence in human hair follicle cells
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    Contrasting consequences of podocyte IGF1R inhibition
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    Comprehensive proteogenomic characterization of rare kidney tumors
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  39. Apr 2024
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
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    Adipocyte PI3K links adipostasis with baseline insulin secretion at fasting through an adipoincretin effect
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    Selective vulnerability of the ventral hippocampus-prelimbic cortex axis parvalbumin interneuron network underlies learning deficits of fragile X mice
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  43. 52.53.155.43 52.53.155.43
    The regulation of enteric neuron connectivity by Semaphorin 5A is affected by the autism-associated S956G missense mutation
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    SWI/SNF complex-mediated chromatin remodelling in Candida glabrata promotes immune evasion
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    Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1
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    β-cell insulin resistance plays a causal role in fat-induced β-cell dysfunction in vitro and in vivo
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    dx.doi.org/10.1210/endocr/bqae044
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    Zona Glomerulosa–Derived Klotho Modulates Aldosterone Synthase Expression in Young Female Mice
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    dx.doi.org/10.1210/endocr/bqae040
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    A senescence restriction point acting on chromatin integrates oncogenic signals
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  49. Mar 2024
  50. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Extracellular signal‐regulated kinases 2 (Erk2) and Erk5 in the central nervous system differentially contribute to central sensitization in male mice
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    onlinelibrary.wiley.com/doi/10.1002/jnr.24827
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    S-nitrosylation-triggered unfolded protein response maintains hematopoietic progenitors in Drosophila
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    IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating β1-integrin via FAK and MRTF/SRF
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    sciencedirect.com/science/article/pii/S2211124724003176
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    Dietary protein restriction regulates skeletal muscle fiber metabolic characteristics associated with the FGF21-ERK1/2 pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10915561/
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    Bactericidal/permeability-increasing protein instructs dendritic cells to elicit Th22 cell response
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    sciencedirect.com/science/article/pii/S2211124724002572
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    Targeting up-regulated cIAP2 in SOX10-deficient drug tolerant melanoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10527992/
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    Liver-derived plasminogen mediates muscle stem cell expansion during caloric restriction through the plasminogen receptor Plg-RKT
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    Structure-based design of non-hypertrophic apelin receptor modulator
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  58. Feb 2024
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    Microglia-Endothelial Cross-Talk Mediating Retinal Vascular Dysfunction through Remodeling Inflammatory Microenvironment in Diabetic Retinopathy
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    The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes
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    Trans-omic analysis reveals opposite metabolic dysregulation between feeding and fasting in liver associated with obesity
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    SPOCK2 modulates neuropathic pain by interacting with MT1-MMP to regulate astrocytic MMP-2 activation in rats with chronic constriction injury
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    link.springer.com/article/10.1186/s12974-024-03051-5
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    Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer
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    RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation
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    Identification of an H-Ras nanocluster disrupting peptide
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    An improved PDE6D inhibitor combines with Sildenafil to synergistically inhibit KRAS mutant cancer cell growth
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    Axon-derived PACSIN1 binds to the Schwann cell survival receptor, LRP1, and transactivates TrkC to promote gliatrophic activities
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    Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
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    Disruption of MerTK increases the efficacy of checkpoint inhibitor by enhancing ferroptosis and immune response in hepatocellular carcinoma
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    mTOR regulates mineralocorticoid receptor transcriptional activity by ULK1- dependent and independent mechanisms
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    Lumbricus Extract Prevents LPS-Induced Inflammatory Activation of BV2 Microglia and Glutamate-Induced Hippocampal HT22 Cell Death by Suppressing MAPK/NF-κB/NLRP3 Signaling and Oxidative Stress
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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10851855/
  73. www.biorxiv.org www.biorxiv.org
    HDAC10 blockade upregulates SPARC expression thereby repressing melanoma cell growth and BRAF inhibitor resistance
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    biorxiv.org/content/10.1101/2023.12.05.570182v1
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    Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function
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    elifesciences.org/articles/89176
  75. Jan 2024
  76. www.sciencedirect.com www.sciencedirect.com
    Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity
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    SORCS2 activity in pancreatic α-cells safeguards insulin granule formation and release from glucose-stressed β-cells
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    MIF modulates p38/ERK phosphorylation via MKP-1 induction in sarcoidosis
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    Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk
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  81. Dec 2023
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    MEK-inhibitors decrease Nfix in muscular dystrophy but induce unexpected calcifications, partially rescued with Cyanidin diet
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    An essential signaling cascade for avian auditory hair cell regeneration
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    Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk
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    Autophagy supports PDGFRA-dependent brain tumor development by enhancing oncogenic signaling
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    B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling
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  87. Nov 2023
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    Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers
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    The proteomic landscape of synaptic diversity across brain regions and cell types
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    Targeting intracellular oncoproteins with dimeric IgA promotes expulsion from the cytoplasm and immune-mediated control of epithelial cancers
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    Insulin receptor loss impairs mammary tumorigenesis in mice
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  93. Oct 2023
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    High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma
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    RhoA balances microglial reactivity and survival during neuroinflammation
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