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  1. Sep 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Aged fibroblast-derived extracellular vesicles promote angiogenesis in melanoma
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    1. scibot 12 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010726
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
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    1. scibot 05 Sep 2024
      RRID:AB_331646

      DOI: 10.1158/2767-9764.CRC-24-0020

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    ncbi.nlm.nih.gov/pmc/articles/PMC11370239/
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    A bispecific antibody targeting EGFR and AXL delays resistance to osimertinib
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    sciencedirect.com/science/article/pii/S2666379124004245
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    Loss of p53 and SMAD4 induces adenosquamous subtype pancreatic cancer in the absence of an oncogenic KRAS mutation
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    sciencedirect.com/science/article/pii/S2666379124004324
  6. Aug 2024
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    Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8+ T cell exhaustion and anti-PD-1 resistance
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    sciencedirect.com/science/article/pii/S2666379124004075
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    Reiterated Male-to-Female Violence Disrupts Hippocampal Estrogen Receptor β Expression, Prompting Anxiety-Like Behavior
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    sciencedirect.com/science/article/pii/S2589004224018108
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    Defective endomembrane dynamics in Rab27a deficiency impairs nucleic acid sensing and cytokine secretion in immune cells
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    Ubiquitination and degradation of plant helper NLR by the Ralstonia solanacearum effector RipV2 overcome tomato bacterial wilt resistance
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    sciencedirect.com/science/article/pii/S2211124724009355
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    Hepatic BMAL1 and HIF1α regulate a time-dependent hypoxic response and prevent hepatopulmonary-like syndrome
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    sciencedirect.com/science/article/pii/S1550413124002742
  12. www.cell.com www.cell.com
    Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy
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    cell.com/cell-reports/abstract/S2211-1247(24)00902-1
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    In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma
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  14. academic.oup.com academic.oup.com
    Exploring visceral and subcutaneous adipose tissue secretomes in human obesity: implications for metabolic disease
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    academic.oup.com/endo/article-abstract/163/11/bqac140/6678177
  15. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Regulation of synaptic MAPK/ERK phosphorylation in the rat striatum and medial prefrontal cortex by dopamine and muscarinic acetylcholine receptors
    1
    1. scibot 02 Aug 2024
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      DOI: 10.1002/jnr.23622

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    onlinelibrary.wiley.com/doi/10.1002/jnr.23622/full
  16. www.mdpi.com www.mdpi.com
    Disc Large Homolog 1 Is Critical for Early T Cell Receptor Micro Cluster Formation and Activation in Human T Cells
    1
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      DOI: 10.3390/vaccines9121446

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  17. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Purinergic receptor P2Y6 contributes to 1‐methyl‐4‐phenylpyridinium‐induced oxidative stress and cell death in neuronal SH‐SY5Y cells
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    1. scibot 02 Aug 2024
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      DOI: 10.1002/jnr.24119

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  18. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Protein kinase A directly phosphorylates metabotropic glutamate receptor 5 to modulate its function
    1
    1. scibot 02 Aug 2024
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  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    E2F1-associated purine synthesis pathway is a major component of the MET-DNA damage response network
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11288008/
  20. Jul 2024
  21. www.sciencedirect.com www.sciencedirect.com
    A Comprehensive Protocol for Efficient Differentiation of Human NPCs into Electrically Competent Neurons
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    sciencedirect.com/science/article/pii/S0165027024001705
  22. www.sciencedirect.com www.sciencedirect.com
    Human MC4R variants affect endocytosis, trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation
    1
    1. scibot 26 Jul 2024
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      DOI: 10.1016/j.celrep.2021.108862

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    sciencedirect.com/science/article/pii/S2211124721001765
  23. www.sciencedirect.com www.sciencedirect.com
    TERT activation targets DNA methylation and multiple aging hallmarks
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    sciencedirect.com/science/article/pii/S0092867424005920
  24. www.cell.com www.cell.com
    Monitoring melanoma patients on treatment reveals a distinct macrophage population driving targeted therapy resistance
    1
    1. scibot 23 Jul 2024
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    cell.com/cell-reports-medicine/fulltext/S2666-3791(24)00315-X
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    A transient transcriptional activation governs unpolarized-to-polarized morphogenesis during embryo implantation
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    sciencedirect.com/science/article/pii/S1097276524004830
  26. www.science.org www.science.org
    In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss
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    1. scibot 18 Jul 2024
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      DOI: 10.1126/sciadv.adk2299

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  27. dx.doi.org dx.doi.org
    Cenicriviroc Suppresses and Reverses Steatohepatitis by Regulating Macrophage Infiltration and M2 Polarization in Mice
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    1. scibot 18 Jul 2024
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      DOI: 10.1210/endocr/bqae069

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    dx.doi.org/10.1210/endocr/bqae069
  28. link.springer.com link.springer.com
    Direct GPCR-EGFR interaction enables synergistic membrane-to-nucleus information transfer
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      DOI: 10.1007/s00018-024-05281-5

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  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling
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  30. Jun 2024
  31. www.cell.com www.cell.com
    Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies
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    cell.com/iscience/abstract/S2589-0042(24)01293-8
  32. www.science.org www.science.org
    In silico transcriptome screens identify epidermal growth factor receptor inhibitors as therapeutics for noise-induced hearing loss
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  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multiomic ALS signatures highlight subclusters and sex differences suggesting the MAPK pathway as therapeutic target
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      DOI: 10.1038/s41467-024-49196-y

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  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Evaluation of the role of AXL in fusion-positive pediatric rhabdomyosarcoma identifies the small-molecule inhibitor bemcentinib (BGB324) as potent chemosensitizer
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    Accelerated drug-resistant variant discovery with an enhanced, scalable mutagenic base editor platform
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  36. May 2024
  37. www.sciencedirect.com www.sciencedirect.com
    A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death
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  38. 52.53.155.43 52.53.155.43
    mct-23-0285-html.html
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  39. www.sciencedirect.com www.sciencedirect.com
    Integrative molecular and spatial analysis reveals evolutionary dynamics and tumor-immune interplay of in situ and invasive acral melanoma
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  40. www.cell.com www.cell.com
    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
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    cell.com/cell-reports/fulltext/S2211-1247(24)00530-8
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ganoderma lucidum extract attenuates corticotropin-releasing hormone induced cellular senescence in human hair follicle cells
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  42. www.sciencedirect.com www.sciencedirect.com
    Nurr1 overexpression in the primary motor cortex alleviates motor dysfunction induced by intracerebral hemorrhage in the striatum in mice
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      DOI: 10.1016/j.neurot.2024.e00370

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  43. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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      DOI: 10.1111/bph.16391

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16391
  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma
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      DOI: 10.1158/1078-0432.CCR-22-2854

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    ncbi.nlm.nih.gov/pmc/articles/PMC11060649/
  45. Apr 2024
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HDAC10 inhibition represses melanoma cell growth and BRAF inhibitor resistance via upregulating SPARC expression
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    Context-dependent roles for ubiquitous mitochondrial creatine kinase CKMT1 in breast cancer progression
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    Acquired NF2 mutation confers resistance to TRK inhibition in an ex vivo LMNA::NTRK1-rearranged soft-tissue sarcoma cell model
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    The regulation of enteric neuron connectivity by Semaphorin 5A is affected by the autism-associated S956G missense mutation
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    Pharmacological inhibition of RAS overcomes FLT3 inhibitor resistance in FLT3-ITD+ AML through AP-1 and RUNX1
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    Zona Glomerulosa–Derived Klotho Modulates Aldosterone Synthase Expression in Young Female Mice
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    Systematic Omics Analysis Identifies CCR6 as a Therapeutic Target to Overcome Cancer Resistance to EGFR Inhibitors
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    Extracellular signal‐regulated kinases 2 (Erk2) and Erk5 in the central nervous system differentially contribute to central sensitization in male mice
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    Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L
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    Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
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    l-Methionine potentiates anticancer activity of Sorafenib by epigenetically altering DUSP3/ERK pathway in hepatocellular carcinoma
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    Axon-derived PACSIN1 binds to the Schwann cell survival receptor, LRP1, and transactivates TrkC to promote gliatrophic activities
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    Membrane-associated NRPM proteins are novel suppressors of stomatal production in Arabidopsis
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    Functional Heterogeneity in MET Pathway Activation in PDX Models of Osimertinib Resistant EGFR-Driven Lung Cancer
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    MIF modulates p38/ERK phosphorylation via MKP-1 induction in sarcoidosis
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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHTOP Alleviates Cerebral Ischemia/Reperfusion-Induced Injury by Regulating RNA Alternative Splicing
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    MEK-inhibitors decrease Nfix in muscular dystrophy but induce unexpected calcifications, partially rescued with Cyanidin diet
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    A desmosomal cadherin controls multipotent hair follicle stem cell quiescence and orchestrates regeneration through adhesion signaling
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    B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling
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    Econazole selectively induces cell death in NF1-homozygous mutant tumor cells
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    The Na/K-ATPase α1/Src Signaling Axis Regulates Mitochondrial Metabolic Function and Redox Signaling in Human iPSC-Derived Cardiomyocytes
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    ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
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  97. Nov 2023
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    Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration
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    Allosteric SHP2 inhibition increases apoptotic dependency on BCL2 and synergizes with venetoclax in FLT3- and KIT-mutant AML
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    ASCL1-ERK1/2 Axis: ASCL1 restrains ERK1/2 via the dual specificity phosphatase DUSP6 to promote survival of a subset of neuroendocrine lung cancers
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    MAPK-ERK-CREB signaling pathway upregulates Nav1.6 in oxaliplatin-induced neuropathic pain in the rat
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    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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  123. Jul 2023
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    Banana MKK1 modulates fruit ripening via the MKK1-MPK6-3/11-4-bZIP21 module
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    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
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    T lymphocytes expressing the switchable chimeric Fc receptor CD64 exhibit augmented persistence and antitumor activity
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  133. Jun 2023
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    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
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    Excess pancreatic elastase alters acinar-β cell communication by impairing the mechano-signaling and the PAR2 pathways
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  148. May 2023
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    Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System
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    Statins enhances antitumor effect of oxaliplatin in KRAS-mutated colorectal cancer cells and inhibits oxaliplatin-induced neuropathy
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    N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kα inhibition in breast cancer
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    Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System
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    Sulforaphane attenuates cancer cell-induced atrophy of C2C12 myotubes
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    Sulforaphane attenuates cancer cell-induced atrophy of C2C12 myotubes
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    Interaction between PI3K and the VDAC2 channel tethers Ras-PI3K-positive endosomes to mitochondria and promotes endosome maturation
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    Bone marrow Adipoq-lineage progenitors are a major cellular source of M-CSF that dominates bone marrow macrophage development, osteoclastogenesis, and bone mass
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    Cav1.3 L-type Ca2+ channel-activated CaMKII/ERK2 pathway in the ventral tegmental area is required for cocaine conditioned place preference
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