742 Matching Annotations
  1. Feb 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831936/
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    Gut-liver axis calibrates intestinal stem cell fitness
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    sciencedirect.com/science/article/pii/S0092867424000035
  4. Jan 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling
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    ncbi.nlm.nih.gov/pmc/articles/PMC10798567/
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    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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    nature.com/articles/s41388-024-02947-z
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning
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    ncbi.nlm.nih.gov/pmc/articles/PMC10800076/
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    O6-Methylguanine DNA Methyltransferase Regulates β-glucan-induced Trained Immunity of Macrophages via Farnesoid X Receptor and AMPK
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    ncbi.nlm.nih.gov/pmc/articles/PMC10792243/
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TNIK drives Castration-Resistant Prostate Cancer via phosphorylating EGFR
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    ncbi.nlm.nih.gov/pmc/articles/PMC10788198/
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    CHTOP Alleviates Cerebral Ischemia/Reperfusion-Induced Injury by Regulating RNA Alternative Splicing
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    ncbi.nlm.nih.gov/pmc/articles/PMC10770728/
  11. Dec 2023
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Casein kinase-2 inhibition promotes retinal ganglion cell survival after acute intraocular pressure elevation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10749609/
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    A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas
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    Econazole selectively induces cell death in NF1-homozygous mutant tumor cells
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    sciencedirect.com/science/article/pii/S2666379123005037
  15. bmccancer.biomedcentral.com bmccancer.biomedcentral.com
    pERK-mediated IL8 secretion can enhance the migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells
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    bmccancer.biomedcentral.com/articles/10.1186/s12885-021-09025-7
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    ALK inhibitors increase ALK expression and sensitize neuroblastoma cells to ALK.CAR-T cells
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    sciencedirect.com/science/article/pii/S1535610823003951
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  18. Nov 2023
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC10675918/
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    Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer
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    sciencedirect.com/science/article/pii/S2589004223024768
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    The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability
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    sciencedirect.com/science/article/pii/S2211124723013864
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    Blockade of CCR5 suppresses paclitaxel-induced peripheral neuropathic pain caused by increased deoxycholic acid
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    A combinatorial therapeutic approach to enhance FLT3-ITD AML treatment
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    Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration
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    HOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway by regulating MSK1 and PPP2R2B
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    Repositioning of Montelukast to inhibit proliferation of mutated KRAS pancreatic cancer through a novel mechanism that interfere the binding between KRAS and GTP/GDP
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    ANKRD49 promotes the metastasis of NSCLC via activating JNK-ATF2/c-Jun-MMP-2/9 axis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10644579/
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    Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk
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    Exploring the role of SWI/SNF complex subunit BAF60c in lipid metabolism and inflammation in fish
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    Targeting cuproptosis by zinc pyrithione in triple-negative breast cancer
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  31. Oct 2023
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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    Skull progenitor cell-driven meningeal lymphatic restoration improves neurocognitive functions in craniosynostosis
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    Protocol for auxin-inducible depletion of the RNA-binding protein PTBP1 in mouse embryonic stem cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10594634/
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    MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling
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    Peroxisomal ERK mediates Akh/glucagon action and glycemic control
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    Inhibition of a lower potency target drives the anticancer activity of a clinical p38 inhibitor
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    Activation of the JNK/COX-2/HIF-1α axis promotes M1 macrophage via glycolytic shift in HIV-1 infection
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  39. aiche.onlinelibrary.wiley.com aiche.onlinelibrary.wiley.com
    Mechanochemical coupling of MGF mediates periodontal regeneration
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    aiche.onlinelibrary.wiley.com/doi/10.1002/btm2.10603
  40. www.cell.com www.cell.com
    Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling
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    cell.com/iscience/abstract/S2589-0042(23)02017-5
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    Irisin reduces amyloid-β by inducing the release of neprilysin from astrocytes following downregulation of ERK-STAT3 signaling
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    Methylation of KRAS by SETD7 promotes KRAS degradation in non-small cell lung cancer
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ONC201/TIC10 enhances durability of mTOR inhibitor everolimus in metastatic ER+ breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10541180/
  45. 52.53.155.43 52.53.155.43
    Metformin Improves the Prerequisites for FGF21 Signaling in Patients with Type 2 Diabetes
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    Tyrosine hydroxylase phosphorylation is under the control of serine 40
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.15963
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    ERK1-mediated immunomodulation of mesenchymal stem cells ameliorates inflammatory disorders
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    Neutrophil extracellular traps enhance S. aureus skin colonization by oxidative stress induction and downregulation of epidermal barrier genes
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  49. Sep 2023
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    MAPK-ERK-CREB signaling pathway upregulates Nav1.6 in oxaliplatin-induced neuropathic pain in the rat
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    Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis
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    sciencedirect.com/science/article/pii/S1934590923002473
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    URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease.
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    ncbi.nlm.nih.gov/pmc/articles/PMC10483053/
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    CGK733 alleviates ovariectomy-induced bone loss through blocking RANKL-mediated Ca2+ oscillations and NF-κB/MAPK signaling pathways
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The MORC2 p.S87L mutation reduces proliferation of pluripotent stem cells derived from a patient with the spinal muscular atrophy-like phenotype by inhibiting proliferation-related signaling pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC10479865/
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucose Transporter-2 Regulation of Male versus Female Hypothalamic Astrocyte MAPK Expression and Activation: Impact of Glucose
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    ncbi.nlm.nih.gov/pmc/articles/PMC10361449/
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    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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    sciencedirect.com/science/article/pii/S2211124723010811
  57. Aug 2023
  58. www.sciencedirect.com www.sciencedirect.com
    Apical extrusion prevents apoptosis from activating an acute inflammatory program in epithelia
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  59. 52.53.155.43 52.53.155.43
    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
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  60. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    Tumoral P2Y2 receptor modulates tumor growth and host anti-tumor immune responses in a syngeneic murine model of oral cancer
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    link.springer.com/article/10.1007/s11302-023-09960-z
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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    ncbi.nlm.nih.gov/pmc/articles/PMC10407955/
  63. 52.53.155.43 52.53.155.43
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery of a pyrrole-pyridinimidazole derivative as novel SIRT6 inhibitor for sensitizing pancreatic cancer to gemcitabine
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    ncbi.nlm.nih.gov/pmc/articles/PMC10403574/
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    Targeting CD36 determines nicotine derivative NNK-induced lung adenocarcinoma carcinogenesis
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    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
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  67. Jul 2023
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unique vulnerability of RAC1-mutant melanoma to combined inhibition of CDK9 and immune checkpoints
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    ncbi.nlm.nih.gov/pmc/articles/PMC10327161/
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    Activation of GPR44 decreases severity of myeloid leukemia via specific targeting of leukemia initiating stem cells
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    PARP2 downregulation in T cells ameliorates lipopolysaccharide-induced inflammation of the large intestine
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    ncbi.nlm.nih.gov/pmc/articles/PMC10347374/
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    Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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    Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling
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    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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  75. Jun 2023
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    TOPK mediates immune evasion of Renal Cell Carcinoma via upregulating the expression of PD-L1
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    SHP2 participates in decidualization by activating ERK to maintain normal nuclear localization of progesterone receptor
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    ncbi.nlm.nih.gov/pmc/articles/PMC10304905/
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    The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity
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    Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway
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    Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design
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    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
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    How aberrant N-glycosylation can alter protein functionality and ligand binding: An atomistic view
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    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer
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    USP10 regulates ZEB1 ubiquitination and protein stability to inhibit ZEB1-mediated colorectal cancer metastasis
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    A Drosophila model of diabetic neuropathy reveals a role of proteasome activity in the glia
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    N6-methyl-2′-deoxyadenosine promotes self-renewal of BFU-E progenitor in erythropoiesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10239700/
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    IRAK1 inhibition blocks the HIV-1 RNA mediated pro-inflammatory cytokine response from microglia
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    microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001858
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    New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation
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    Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters
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    RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition
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