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  1. Jun 2023
  2. www.nature.com www.nature.com
    Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters
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    1. scibot 08 Jun 2023
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      DOI: 10.1038/s41467-023-38512-7

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    nature.com/articles/s41467-023-38512-7
  3. aacrjournals.org aacrjournals.org
    RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition
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    1. scibot 03 Jun 2023
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      DOI: 10.1158/0008-5472.CAN-22-1549

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    aacrjournals.org/cancerres/article/83/9/1490/726058/RBM10-Loss-Promotes-EGFR-Driven-Lung-Cancer-and
  4. www.cell.com www.cell.com
    Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis
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    1. scibot 03 Jun 2023
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      DOI: 10.1016/j.chom.2023.05.007

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    cell.com/cell-host-microbe/fulltext/S1931-3128(23)00200-7
  5. academic.oup.com academic.oup.com
    Casein kinase 1α regulates testosterone synthesis and testis development in adult mice
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    1. scibot 02 Jun 2023
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      DOI: 10.1210/endocr/bqad042

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    academic.oup.com/endo/article/164/5/bqad042/7079750
  6. academic.oup.com academic.oup.com
    Cadmium-induced Sertoli cell injury through p38-MAPK and related signaling proteins – a study by RNA sequencing
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    1. scibot 02 Jun 2023
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      DOI: 10.1210/endocr/bqad045

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    academic.oup.com/endo/article/164/6/bqad045/7079002
  7. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 01 Jun 2023
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      DOI: 10.1111/bph.16080

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16080
  8. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Targeting formyl peptide receptor 1 by anteiso-C13-surfactin for neutrophil-dominant acute respiratory distress syndrome
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    1. scibot 01 Jun 2023
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      DOI: 10.1111/bph.16073

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16073
  9. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 01 Jun 2023
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      DOI: 10.1111/bph.16069

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16069
  10. May 2023
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced arthritis in mice
    1
    1. scibot 27 May 2023
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      DOI: 10.3389/fimmu.2023.1182278

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    ncbi.nlm.nih.gov/pmc/articles/PMC10208528/
  12. www.sciencedirect.com www.sciencedirect.com
    Microenvironmental control of hematopoietic stem cell fate via CXCL8 and protein kinase C
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    1. scibot 25 May 2023
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      DOI: 10.1016/j.celrep.2023.112528

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    sciencedirect.com/science/article/pii/S2211124723005399
  13. www.sciencedirect.com www.sciencedirect.com
    Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma
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    1. scibot 20 May 2023
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    sciencedirect.com/science/article/pii/S0006295223002034
  14. www.sciencedirect.com www.sciencedirect.com
    Heat promotes melanogenesis by increasing the paracrine effects in keratinocytes via the TRPV3/Ca2+/Hh signaling pathway
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    1. scibot 14 May 2023
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      DOI: 10.1016/j.isci.2023.106749

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    sciencedirect.com/science/article/pii/S258900422300826X
  15. www.sciencedirect.com www.sciencedirect.com
    Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials
    1
    1. scibot 13 May 2023
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    sciencedirect.com/science/article/pii/S2589004223007721
  16. journals.aai.org journals.aai.org
    cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway
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    1. scibot 13 May 2023
      RRID:AB_390779

      DOI: 10.4049/jimmunol.2200351

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    journals.aai.org/jimmunol/article/210/8/1098/263495/cGAS-Mediates-Inflammation-by-Polarizing
  17. www.sciencedirect.com www.sciencedirect.com
    VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection
    1
    1. scibot 12 May 2023
      RRID:AB_390779

      DOI: 10.1016/j.celrep.2023.112489

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    sciencedirect.com/science/article/pii/S2211124723005004
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overexpression of mitogen-activated protein kinase... : Neural Regeneration Research
    1
    1. scibot 06 May 2023
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      DOI: 10.4103/1673-5374.363836

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    ncbi.nlm.nih.gov/pmc/articles/PMC10154501/
  19. aacrjournals.org aacrjournals.org
    RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition
    1
    1. scibot 05 May 2023
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      DOI: 10.1158/1078-0432.CCR-21-4291

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    aacrjournals.org/clincancerres/article/28/14/3091/706867/RASGRF1-Fusions-Activate-Oncogenic-RAS-Signaling
  20. academic.oup.com academic.oup.com
    Mechanisms of estradiol-induced EGF-like factor expression and oocyte maturation via G protein-coupled estrogen receptor
    1
    1. scibot 05 May 2023
      RRID:AB_390779

      DOI: 10.1210/endocr/bqaa190

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    academic.oup.com/endo/article/161/12/bqaa190/5929646
  21. www.sciencedirect.com www.sciencedirect.com
    Cross-activation of FGF, NODAL, and WNT pathways constrains BMP-signaling-mediated induction of the totipotent state in mouse embryonic stem cells
    1
    1. scibot 03 May 2023
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      DOI: 10.1016/j.celrep.2023.112438

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    sciencedirect.com/science/article/pii/S2211124723004497
  22. Apr 2023
  23. www.sciencedirect.com www.sciencedirect.com
    Regulation of sertoli cell function by planar cell polarity (PCP) protein Fjx1
    1
    1. scibot 29 Apr 2023
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      DOI: 10.1016/j.mce.2023.111936

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    sciencedirect.com/science/article/pii/S0303720723000874
  24. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Amphiregulin blockade decreases the levodopa-induced dyskinesia in a 6-hydroxydopamine Parkinson's disease mouse model
    1
    1. scibot 29 Apr 2023
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      DOI: 10.1111/cns.14229

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    onlinelibrary.wiley.com/doi/10.1111/cns.14229
  25. www.biorxiv.org www.biorxiv.org
    ANKRD49 promotes the metastasis of NCI-H1299 and NCI-H1703 cells via activating JNK-ATF2/c-Jun-MMP-2/9 axis
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    1. scibot 28 Apr 2023
      RRID:AB_390779

      DOI: 10.1101/2023.03.22.533821

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    biorxiv.org/content/10.1101/2023.03.22.533821v1
  26. www.sciencedirect.com www.sciencedirect.com
    IGFBP3 induced by the TGF-β/EGFRvIII transactivation contributes to the malignant phenotype of glioblastoma
    1
    1. scibot 27 Apr 2023
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      DOI: 10.1016/j.isci.2023.106639

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    sciencedirect.com/science/article/pii/S2589004223007162
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MEK Inhibition Synergizes with TYK2 Inhibitors in NF1-Associated Malignant Peripheral Nerve Sheath Tumors
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    1. scibot 21 Apr 2023
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      DOI: 10.1158/1078-0432.CCR-22-3722

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    ncbi.nlm.nih.gov/pmc/articles/PMC10102849/
  28. www.nature.com www.nature.com
    Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer
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    1. scibot 18 Apr 2023
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      DOI: 10.1038/s41416-023-02264-4

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    nature.com/articles/s41416-023-02264-4
  29. www.embopress.org www.embopress.org
    RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
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    1. scibot 18 Apr 2023
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      DOI: 10.15252/emmm.202217078

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    embopress.org/doi/10.15252/emmm.202217078
  30. www.sciencedirect.com www.sciencedirect.com
    Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
    1
    1. scibot 15 Apr 2023
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      DOI: 10.1016/j.celrep.2023.112377

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    sciencedirect.com/science/article/pii/S2211124723003881
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model
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    1. scibot 09 Apr 2023
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      DOI: 10.1016/j.isci.2023.106375

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    ncbi.nlm.nih.gov/pmc/articles/PMC10074152/
  32. onlinelibrary.wiley.com onlinelibrary.wiley.com
    ERK Inhibition Promotes Engraftment of Allografts by Reprogramming T-Cell Metabolism
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      DOI: 10.1002/advs.202206768

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    onlinelibrary.wiley.com/doi/10.1002/advs.202206768
  33. www.sciencedirect.com www.sciencedirect.com
    Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer
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      DOI: 10.1016/j.celrep.2023.112324

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    sciencedirect.com/science/article/pii/S2211124723003352
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone H3 phospho-regulation by KimH3 in both interphase and mitosis
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      DOI: 10.1016/j.isci.2023.106372

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    ncbi.nlm.nih.gov/pmc/articles/PMC10066537/
  35. Mar 2023
  36. www.ijbs.com www.ijbs.com
    IFNγ blockade in capillary leak site improves tumour chemotherapy by inhibiting lactate-induced endocytosis of vascular endothelial-cadherins
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      DOI: 10.7150/ijbs.78248

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    ijbs.com/v19p1490.htm
  37. www.sciencedirect.com www.sciencedirect.com
    Epithelial cells activate fibroblasts to promote esophageal cancer development
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    sciencedirect.com/science/article/pii/S1535610823000491
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo
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      DOI: 10.1371/journal.pone.0281063

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    ncbi.nlm.nih.gov/pmc/articles/PMC10035898/
  39. 52.53.155.43 52.53.155.43
    Sulforaphane attenuates cancer cell-induced atrophy of C2C12 myotubes
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      DOI: 10.1152/ajpcell.00025.2022

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    52.53.155.43/481178bc3fb55978002914f915f545e61972c754/ajpcell.00025.2022-html.html
  40. journals.physiology.org journals.physiology.org
    Sulforaphane attenuates cancer cell-induced atrophy of C2C12 myotubes
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    journals.physiology.org/doi/10.1152/ajpcell.00025.2022
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical Function of DPP4 Promotes Cognitive Impairment through ERp29-associated Mitochondrial Calcium Overload in Diabetes
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      DOI: 10.1016/j.isci.2023.106271

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    ncbi.nlm.nih.gov/pmc/articles/PMC10014273/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metformin Prevents Endothelial Oxidative Stress and Microvascular Insulin Resistance during Obesity Development in Male Rats
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      DOI: 10.1152/ajpendo.00240.2021

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    ncbi.nlm.nih.gov/pmc/articles/PMC8897003/
  43. www.sciencedirect.com www.sciencedirect.com
    Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
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    sciencedirect.com/science/article/pii/S1535610823000326
  44. www.sciencedirect.com www.sciencedirect.com
    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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      DOI: 10.1016/j.celrep.2023.112188

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    sciencedirect.com/science/article/pii/S2211124723001997
  45. Feb 2023
  46. www.sciencedirect.com www.sciencedirect.com
    CAR-T cells targeting HLA-G as potent therapeutic strategy for EGFR mutated and overexpressed oral cancer
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    Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models
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    Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator
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    Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation
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    Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease
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    Siponimod exerts neuroprotective effects on the retina and... : Neural Regeneration Research
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    Capicua suppresses YAP1 to limit tumorigenesis and maintain drug sensitivity in human cancer
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    Enteric VIP-producing neurons maintain gut microbiota homeostasis through regulating epithelium fucosylation
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    cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells
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    STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization
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    Tripartite Motif 38 Attenuates Cardiac Fibrosis after Myocardial Infarction by Suppressing TAK1 Activation via TAB2/3 Degradation
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    Ras Inhibitor Lonafarnib Rescues Structural and Functional Impairments of Synapses of Aβ1-42 Mice via α7nAChR-Dependent BDNF Upregulation
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    Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as an AMPK substrate regulating skeletal muscle function
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    A RET::GRB2 fusion in pheochromocytoma defies the classic paradigm of RET oncogenic fusions
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    Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer
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    A novel germline deletion of p.C630 in RET causes MTC and promotes cell proliferation and sensitivity to pralsetinib
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    Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis
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    Progesterone limits the tumor-promoting effects of the beta-subunit of human chorionic gonadotropin via non-nuclear receptors
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    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
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    SM22α-lineage niche cells regulate intramembranous bone regeneration via PDGFRβ-triggered hydrogen sulfide production
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    Dysfunction of Inflammatory Pathways and Their Relationship With Psychological Factors in Adult Female Patients With Eating Disorders
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  136. Apr 2022
  137. www.sciencedirect.com www.sciencedirect.com
    Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis
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  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
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  139. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Atractylenolide III ameliorates spinal cord injury in rats by modulating microglial/macrophage polarization
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  140. Mar 2022
  141. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The PTN-PTPRZ signal activates the AFAP1L2-dependent PI3K-AKT pathway for oligodendrocyte differentiation: Targeted inactivation of PTPRZ activity in mice
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  142. www.sciencedirect.com www.sciencedirect.com
    Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells
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  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis
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  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deprogramming metabolism in pancreatic cancer with a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist
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  145. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cytidine Deaminase APOBEC3A Regulates PD-L1 Expression in Cancer Cells in a JNK/c-JUN-dependent Manner
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  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combination of Resminostat with Ruxolitinib Exerts Antitumor Effects in the Chick Embryo Chorioallantoic Membrane Model for Cutaneous T Cell Lymphoma
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  147. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Cancer-associated fibroblasts at the unfavorable desmoplastic stroma promote colorectal cancer aggressiveness: potential role of ADAM9
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    Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state
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  149. Feb 2022
  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Supplementing Soy-Based Diet with Creatine in Rats: Implications for Cardiac Cell Signaling and Response to Doxorubicin
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  151. www.embopress.org www.embopress.org
    Identification of treatment-induced vulnerabilities in pancreatic cancer patients using functional model systems
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    Contribution of ferroptosis and GPX4’s dual functions to osteoarthritis progression
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  153. Jan 2022
  154. link.springer.com link.springer.com
    miR-155 activates the NLRP3 inflammasome by regulating the MEK/ERK/NF-κB pathway in carotid atherosclerotic plaques in ApoE−/− mice
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  155. academic.oup.com academic.oup.com
    Regulation of mouse primordial follicle formation by signaling through the PI3K pathway
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  156. www.sciencedirect.com www.sciencedirect.com
    MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells
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  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c)
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  158. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Triple targeting of breast tumors driven by hormonal receptors and HER2
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  159. www.sciencedirect.com www.sciencedirect.com
    Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis
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  160. Dec 2021
  161. link.springer.com link.springer.com
    Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway
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  162. www.nature.com www.nature.com
    GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure
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  163. www.sciencedirect.com www.sciencedirect.com
    Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity
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  164. www.nature.com www.nature.com
    Pharmacologically controlling protein-protein interactions through epichaperomes for therapeutic vulnerability in cancer
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  165. Nov 2021
  166. 52.53.155.43 52.53.155.43
    ajpheart.00125.2021-html.html
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  167. www.sciencedirect.com www.sciencedirect.com
    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
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  168. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Non-canonical protease-activated receptor 1 regulates lymphatic differentiation in zebrafish
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    Single-cell transcriptomics reveals opposing roles of Shp2 in Myc-driven liver tumor cells and microenvironment
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dietary nitrate supplementation prevents radiotherapy-induced xerostomia
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  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tpl2 contributes to IL-1β-induced IL-8 expression via ERK1/2 activation in canine dermal fibroblasts
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  173. link.springer.com link.springer.com
    Carbon dioxide inhibits COVID-19-type proinflammatory responses through extracellular signal-regulated kinases 1 and 2, novel carbon dioxide sensors
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  174. www.sciencedirect.com www.sciencedirect.com
    GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12
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  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy
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  176. www.sciencedirect.com www.sciencedirect.com
    Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors
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    Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action
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  178. link.springer.com link.springer.com
    Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex
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  179. Oct 2021
  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-Inflammatory and Antimicrobial Volatile Oils: Fennel and Cumin Inhibit Neutrophilic Inflammation via Regulating Calcium and MAPKs
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  181. www.sciencedirect.com www.sciencedirect.com
    Adenosine deaminase 2 produced by infiltrative monocytes promotes liver fibrosis in nonalcoholic fatty liver disease
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  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bletinib ameliorates neutrophilic inflammation and lung injury by inhibiting Src family kinase phosphorylation and activity
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    Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
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    Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
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    The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling
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    Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis
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    CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance
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    Cytohesin-2 mediates group I metabotropic glutamate receptor-dependent mechanical allodynia through the activation of ADP ribosylation factor 6 in the spinal cord
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    Mitogen‐activated protein kinase signaling mediates opioid‐induced presynaptic NMDA receptor activation and analgesic tolerance
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    Stimulus evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization
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    High‐intensity treadmill running impairs cognitive behavior and hippocampal synaptic plasticity of rats via activation of inflammatory response
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    CRISPR/Cas9-Mediated Knock-Out of KrasG12D Mutated Pancreatic Cancer Cell Lines
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    An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma
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      Rabbit mAb anti-p44/42 MAPK (Total Erk1/2)

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    O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity
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    ANGPTL2 Promotes Inflammation via Integrin α5β1 in Chondrocytes - Mami Takano, Naoto Hirose, Chikako Sumi, Makoto Yanoshita, Sayuri Nishiyama, Azusa Onishi, Yuki Asakawa, Kotaro Tanimoto,
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      anti–total ERK1/2

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