401 Matching Annotations
  1. Aug 2021
  2. www.sciencedirect.com www.sciencedirect.com
    Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn’s disease
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    1. scibot 07 Aug 2021
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      DOI: 10.1016/j.immuni.2021.07.004

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    sciencedirect.com/science/article/pii/S1074761321002909
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.1016/j.celrep.2018.09.045

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    ncbi.nlm.nih.gov/pmc/articles/PMC6338448/
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    Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines
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      DOI: 10.1016/j.molcel.2017.02.003

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    sciencedirect.com/science/article/pii/S1097276517300953
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pharmacological induction of heat shock proteins ameliorates toxicity of mutant PKCγ in spinocerebellar ataxia type 14
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      DOI: 10.1074/jbc.RA118.002913

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    ncbi.nlm.nih.gov/pmc/articles/PMC6153279/
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    O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity
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      DOI: 10.1016/j.chom.2018.11.001

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    sciencedirect.com/science/article/pii/S1931312818305584
  7. www.cell.com www.cell.com
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    cell.com/molecular-cell/abstract/S1097-2765(17)30095-3
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.7554/eLife.40045

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    ncbi.nlm.nih.gov/pmc/articles/PMC6202052/
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    Orchestration of Processing Body Dynamics and mRNA Decay in Arabidopsis Immunity
    1
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      DOI: 10.1016/j.celrep.2019.07.054

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    sciencedirect.com/science/article/pii/S2211124719309581
  10. Jul 2021
  11. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.celrep.2019.03.071

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    sciencedirect.com/science/article/pii/S2211124719304012
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    sciencedirect.com/science/article/pii/S1550413118306831
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ABCC9 -related Intellectual disability Myopathy Syndrome is a K ATP channelopathy with loss-of-function mutations in ABCC9
    1
    1. scibot 30 Jul 2021
      Anti-Flag M2-HRP-conjugate

      DOI: 10.1038/s41467-019-12428-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC6773855/
  14. journals.plos.org journals.plos.org
    Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase
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    1. scibot 30 Jul 2021
      Anti-Flag M2 monoclonal antibody peroxidase conjugate

      DOI: 10.1371/journal.pone.0218500

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    journals.plos.org/plosone/article
  15. wellcomeopenresearch.org wellcomeopenresearch.org
    Pathogenic <i>FAM83G</i> palmoplantar keratoderma mutations inhibit the PAWS1:CK1α association and attenuate Wnt signalling.
    1
    1. scibot 30 Jul 2021
      monoclonal mouse anti-FLAG M2-HRP

      DOI: 10.12688/wellcomeopenres.15403.1

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    wellcomeopenresearch.org/articles/4-133
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    Activity of the SPCA1 Calcium Pump Couples Sphingomyelin Synthesis to Sorting of Secretory Proteins in the Trans-Golgi Network
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    1. scibot 30 Jul 2021
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      DOI: 10.1016/j.devcel.2018.10.012

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    sciencedirect.com/science/article/pii/S1534580718308335
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    1. scibot 29 Jul 2021
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      DOI: 10.1016/j.molcel.2018.08.042

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    ncbi.nlm.nih.gov/pmc/articles/PMC6242708/
  18. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Proline-arginine poly-dipeptide encoded by the C9orf72 repeat expansion inhibits adenosine deaminase acting on RNA
    1
    1. scibot 29 Jul 2021
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      DOI: 10.1111/jnc.15445

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15445
  19. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Phosphorylation-Dependent control of arc protein by TNIK
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    1. scibot 29 Jul 2021
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      DOI: 10.1111/jnc.15440

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15440
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      DOI: 10.7554/eLife.34334

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      DOI: 10.7554/eLife.34334

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    ncbi.nlm.nih.gov/pmc/articles/PMC5837557/
  21. elifesciences.org elifesciences.org
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      DOI: 10.7554/eLife.34334

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      DOI: 10.7554/eLife.34334

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    elifesciences.org/articles/34334
  22. academic.oup.com academic.oup.com
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    1. scibot 28 Jul 2021
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      DOI: 10.1210/en.2016-1807

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    academic.oup.com/endo/article/158/7/2319/3746606
  23. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    1. scibot 27 Jul 2021
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      DOI: 10.1111/mmi.14143

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    onlinelibrary.wiley.com/doi/full/10.1111/mmi.14143
  24. www.sciencedirect.com www.sciencedirect.com
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      DOI: 10.1016/j.chom.2018.11.007

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    sciencedirect.com/science/article/pii/S1931312818305894
  25. www.sciencedirect.com www.sciencedirect.com
    EHD1 impairs decidualization by regulating the Wnt4/β-catenin signaling pathway in recurrent implantation failure
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    1. scibot 27 Jul 2021
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      DOI: 10.1016/j.ebiom.2019.10.018

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    sciencedirect.com/science/article/pii/S2352396419306814
  26. www.sciencedirect.com www.sciencedirect.com
    Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation
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    1. scibot 23 Jul 2021
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      DOI: 10.1016/j.immuni.2021.06.014

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    sciencedirect.com/science/article/pii/S1074761321002582
  27. Jun 2021
  28. www.sciencedirect.com www.sciencedirect.com
    Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing
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      DOI: 10.1016/j.cell.2021.05.019

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    sciencedirect.com/science/article/pii/S0092867421006498
  29. www.sciencedirect.com www.sciencedirect.com
    Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity
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      DOI: 10.1016/j.cell.2021.05.021

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    sciencedirect.com/science/article/pii/S0092867421006516
  30. May 2021
  31. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin
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    1. scibot 29 May 2021
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      DOI: 10.1096/fj.202002385RR

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202002385RR
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression
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    1. scibot 28 May 2021
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      DOI: 10.7554/eLife.67409

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    ncbi.nlm.nih.gov/pmc/articles/PMC8143796/
  33. www.sciencedirect.com www.sciencedirect.com
    The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding
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    1. scibot 26 May 2021
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      DOI: 10.1016/j.celrep.2021.109184

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    sciencedirect.com/science/article/pii/S2211124721005295
  34. www.sciencedirect.com www.sciencedirect.com
    Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions
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      DOI: 10.1016/j.cell.2021.04.036

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    sciencedirect.com/science/article/pii/S0092867421005717
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2
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      DOI: 10.1016/j.chembiol.2021.04.020

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    ncbi.nlm.nih.gov/pmc/articles/PMC8075810/
  36. wellcomeopenresearch.org wellcomeopenresearch.org
    SpEDIT: A fast and efficient CRISPR/Cas9 method for fission yeast
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      DOI: 10.12688/wellcomeopenres.16405.1

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    wellcomeopenresearch.org/articles/5-274
  37. www.sciencedirect.com www.sciencedirect.com
    WNK1 is an assembly factor for the human ER membrane protein complex
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    sciencedirect.com/science/article/pii/S109727652100318X
  38. www.sciencedirect.com www.sciencedirect.com
    SENP3 senses oxidative stress to facilitate STING-dependent dendritic cell antitumor function
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      DOI: 10.1016/j.molcel.2020.12.024

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    sciencedirect.com/science/article/pii/S109727652030945X
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    A Prion-like Domain in Transcription Factor EBF1 Promotes Phase Separation and Enables B Cell Programming of Progenitor Chromatin
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      DOI: 10.1016/j.immuni.2020.10.009

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    sciencedirect.com/science/article/pii/S1074761320304507
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    Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains
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    sciencedirect.com/science/article/pii/S1097276521003178
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    HectD1 controls hematopoietic stem cell regeneration by coordinating ribosome assembly and protein synthesis
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      DOI: 10.1016/j.stem.2021.02.008

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    sciencedirect.com/science/article/pii/S1934590921000588
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    Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane
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      DOI: 10.1016/j.molcel.2021.02.025

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    sciencedirect.com/science/article/pii/S1097276521001350
  43. Apr 2021
  44. www.sciencedirect.com www.sciencedirect.com
    Signatures of antagonistic pleiotropy in a bacterial flagellin epitope
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      DOI: 10.1016/j.chom.2021.02.008

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    sciencedirect.com/science/article/pii/S1931312821000871
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    A complex immune response to flagellin epitope variation in commensal communities
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    sciencedirect.com/science/article/pii/S1931312821000858
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    Periplasmic expression of SpyTagged antibody fragments enables rapid modular antibody assembly
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      DOI: 10.1016/j.chembiol.2021.01.011

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    Hypomorph Mutation-Directed Small-Molecule Protein-Protein Interaction Inducers to Restore Mutant SMAD4-Suppressed TGF-β Signaling
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    Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia
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      Rabbit anti-FLAG, HRP conjugate clone M2

      DOI: 10.1016/j.cell.2020.07.011

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    Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria
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    Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate
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    Protease-mediated processing of Argonaute proteins controls small RNA association
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      Mouse Monoclonal anti-FLAG HRP

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    The connectome of neural crest enhancers reveals regulatory features of signaling systems
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  53. Mar 2021
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    Sarbecovirus ORF6 proteins hamper the induction of interferon signaling
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    Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy
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    The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses
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    Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine
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    BLM has Contrary Effects on Repeat-Mediated Deletions, based on the Distance of DNA DSBs to a Repeat and Repeat Divergence
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  59. Feb 2021
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    Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1
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    CRTC1/MAML2 directs a PGC-1α-IGF-1 circuit that confers vulnerability to PPARγ inhibition
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    The ubiquitin ligase Ariadne-1 regulates neurotransmitter release via ubiquitination of NSF
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      mouse monoclonal anti-FLAG M2 HRP

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    Structure of the catalytic core of the Integrator complex
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  64. Jan 2021
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    Impact of WIN site inhibitor on the WDR5 interactome
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    MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1
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    Quality-Control Mechanism for Telomerase RNA Folding in the Cell
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  68. Dec 2020
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    Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs
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    The Nucleosome Remodeling and Deacetylase Complex Has an Asymmetric, Dynamic, and Modular Architecture
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  71. Nov 2020
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    Casein kinase 1G2 suppresses necroptosis-promoted testis aging by inhibiting receptor-interacting kinase 3
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    Modulation of Ago2 Loading by Cyclophilin 40 Endows a Unique Repertoire of Functional miRNAs during Sperm Maturation in Drosophila
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    GIP receptor suppresses PAC1 receptor‐mediated neuronal differentiation via formation of a receptor heterocomplex
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      anti‐Flag

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  75. Sep 2020
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    Crystal Structure of β-Arrestin 2 in Complex with CXCR7 Phosphopeptide
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    Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome
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    Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins
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    Dynamic Regulation of Mitochondrial Import by the Ubiquitin System
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    Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing
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    High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models
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    Cep97 Is Required for Centriole Structural Integrity and Cilia Formation in Drosophila
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    Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation
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    EDF1 coordinates cellular responses to ribosome collisions
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    Site-Specific Incorporation of Two ncAAs for Two-Color Bioorthogonal Labeling and Crosslinking of Proteins on Live Mammalian Cells
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    Modulation of circRNA Metabolism by m6A Modification
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    AirID, a novel proximity biotinylation enzyme, for analysis of protein–protein interactions
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    The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function
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    Amplification of a broad transcriptional program by a common factor triggers the meiotic cell cycle in mice
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    Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2
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    Structural Insights of Transcriptionally Active, Full-Length Androgen Receptor Coactivator Complexes
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    Cryo-EM Structure of the Fork Protection Complex Bound to CMG at a Replication Fork
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    BLM has Contrary Effects on Repeat-Mediated Deletions, based on the Distance of DNA DSBs to a Repeat and Repeat Divergence
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    DUX-miR-344-ZMYM2-Mediated Activation of MERVL LTRs Induces a Totipotent 2C-like State
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    Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34
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    Phenformin Inhibits Hedgehog-Dependent Tumor Growth through a Complex I-Independent Redox/Corepressor Module
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    The ZGRF1 Helicase Promotes Recombinational Repair of Replication-Blocking DNA Damage in Human Cells
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    iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
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    An advanced cell cycle tag toolbox reveals principles underlying temporal control of structure-selective nucleases
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    TBC1D5-Catalyzed Cycling of Rab7 Is Required for Retromer-Mediated Human Papillomavirus Trafficking during Virus Entry
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    A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy
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    C1QBP Promotes Homologous Recombination by Stabilizing MRE11 and Controlling the Assembly and Activation of MRE11/RAD50/NBS1 Complex
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    Rad52 Restrains Resection at DNA Double-Strand Break Ends in Yeast
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    ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection
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    Vaccinia Virus Ankyrin-Repeat/F-Box Protein Targets Interferon-Induced IFITs for Proteasomal Degradation
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    PI31 Is an Adaptor Protein for Proteasome Transport in Axons and Required for Synaptic Development
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    Conformational Sensors and Domain Swapping Reveal Structural and Functional Differences between β-Arrestin Isoforms
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    STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production
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    Development of Photocrosslinking Probes Based on Huwentoxin-IV to Map the Site of Interaction on Nav1.7
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    Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells
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    Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15
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    Inflammasome Regulates Hematopoiesis through Cleavage of the Master Erythroid Transcription Factor GATA1
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    Native Chromatin Proteomics Reveals a Role for Specific Nucleoporins in Heterochromatin Organization and Maintenance
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    Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection
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    Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface
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    53BP1 Supports Immunoglobulin Class Switch Recombination Independently of Its DNA Double-Strand Break End Protection Function
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    O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3
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    ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97
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    Perturbation-Based Proteomic Correlation Profiling as a Target Deconvolution Methodology
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    Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex
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    Elongation/Termination Factor Exchange Mediated by PP1 Phosphatase Orchestrates Transcription Termination
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    Metformin reverses early cortical network dysfunction and behavior changes in Huntington’s disease
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    POLE3-POLE4 Is a Histone H3-H4 Chaperone that Maintains Chromatin Integrity during DNA Replication
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    Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications
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    A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases
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    Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment
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    High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies
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    Regulated Crossing-Over Requires Inactivation of Yen1/GEN1 Resolvase during Meiotic Prophase I
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    Assembly of the WHIP-TRIM14-PPP6C Mitochondrial Complex Promotes RIG-I-Mediated Antiviral Signaling
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    A Tyrosine Phosphorylation Cycle Regulates Fungal Activation of a Plant Receptor Ser/Thr Kinase
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    MLKL Requires the Inositol Phosphate Code to Execute Necroptosis
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    An Intermediate Pluripotent State Controlled by MicroRNAs Is Required for the Naive-to-Primed Stem Cell Transition
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    ZNFX-1 Functions within Perinuclear Nuage to Balance Epigenetic Signals
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  180. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    ncbi.nlm.nih.gov/pmc/articles/PMC5745086/
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    UVR8 Interacts with BES1 and BIM1 to Regulate Transcription and Photomorphogenesis in Arabidopsis
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    Transcriptional Regulation of the Warburg Effect in Cancer by SIX1
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  183. www.jneurosci.org www.jneurosci.org
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  184. www.sciencedirect.com www.sciencedirect.com
    Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability
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  185. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Repression of Adipose Tissue Fibrosis through a PRDM16-GTF2IRD1 Complex Improves Systemic Glucose Homeostasis
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  187. europepmc.org europepmc.org
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  188. europepmc.org europepmc.org
    Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth.
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  189. europepmc.org europepmc.org
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  190. www.sciencedirect.com www.sciencedirect.com
    A Bacterial Type III Effector Targets the Master Regulator of Salicylic Acid Signaling, NPR1, to Subvert Plant Immunity
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  191. wellcomeopenresearch.org wellcomeopenresearch.org
    Perturbation of PALB2 function by the T413S mutation found in small cell lung cancer
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      Curator: @patriciaelyse_

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  192. europepmc.org europepmc.org
    A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants
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  193. Nov 2017
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    Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells
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    A Potent Germline-like Human Monoclonal Antibody Targets a pH-Sensitive Epitope on H7N9 Influenza Hemagglutinin
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  196. www.sciencedirect.com www.sciencedirect.com
    The Kinetochore Receptor for the Cohesin Loading Complex
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  197. www.sciencedirect.com www.sciencedirect.com
    Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor
    1
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      A8592

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  198. www.sciencedirect.com www.sciencedirect.com
    A Split-Abl Kinase for Direct Activation in Cells
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    RAN Translation Regulated by Muscleblind Proteins in Myotonic Dystrophy Type 2
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  200. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Hierarchical organisation and genetically separable subfamilies of PSD95 postsynaptic supercomplexes
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      Curator: @patriciaelyse_

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    onlinelibrary.wiley.com/doi/10.1111/jnc.14056/full
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    Heterogeneity of Stop Codon Readthrough in Single Bacterial Cells and Implications for Population Fitness
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  202. elifesciences.org elifesciences.org
    Impact of nucleic acid and methylated H3K9 binding activities of Suv39h1 on its heterochromatin assembly
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    elifesciences.org/articles/25317
  203. academic.oup.com academic.oup.com
    Tac1 Signaling Is Required for Sexual Maturation and Responsiveness of GnRH Neurons to Kisspeptin in the Male Mouse
    1
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      Curator: @chewbeccax

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  204. www.sciencedirect.com www.sciencedirect.com
    Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases
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      Curator: @Zeljana_Babic

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    In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-Linked Chain Specificity of the Proteasome
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      AB_439702

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  206. www.sciencedirect.com www.sciencedirect.com
    The RNA Exosome Syncs IAV-RNAPII Transcription to Promote Viral Ribogenesis and Infectivity
    1
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      Curator: @kaitlinsung

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  207. elifesciences.org elifesciences.org
    SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation
    1
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      AB_439702

      Curator: @gabimpine

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    elifesciences.org/content/6/e25158
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    Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines
    1
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      Curator: @chewbeccax

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    Mitochondrial Ca2+ Uniporter Is a Mitochondrial Luminal Redox Sensor that Augments MCU Channel Activity
    1
    1. scibot 08 Nov 2017
      Monoclonal ANTI-FLAG M2-peroxidase (HRP) antibody produced in mouse

      Curator: @kaitlinsung

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    LIN41 Post-transcriptionally Silences mRNAs by Two Distinct and Position-Dependent Mechanisms
    1
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      AB_439702

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    sciencedirect.com/science/article/pii/S1097276516308486
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    Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair
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  212. elifesciences.org elifesciences.org
    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling
    1
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