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  1. Last 7 days
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    Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair
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  3. Nov 2024
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Substrate specificity and protein stability drive the divergence of plant-specific DNA methyltransferases
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    pmc.ncbi.nlm.nih.gov/articles/PMC11540031/
  5. Oct 2024
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    Hormone-mediated disassembly and inactivation of a plant E3 ubiquitin ligase complex
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    sciencedirect.com/science/article/pii/S2211124724011537
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    Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon
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    RNA degradation triggered by decapping is largely independent of initial deadenylation
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    Pervasive mislocalization of pathogenic coding variants underlying human disorders
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  10. Sep 2024
  11. www.pnas.org www.pnas.org
    An AAGAB-to-CCDC32 handover mechanism controls the assembly of the AP2 adaptor complex
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    The Receptor Kinases BAK1/SERK4 Regulate Ca2+ Channel-Mediated Cellular Homeostasis for Cell Death Containment
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    Rewiring protein binding specificity in paralogous DRG/DFRP complexes
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    Optimized in vivo multispectral bioluminescent imaging of tumor biology using engineered BRET reporters
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  15. Aug 2024
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    Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression
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    Ubiquitin-specific peptidase 22 controls integrin-dependent cancer cell stemness and metastasis
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    The ribosomal protein L22 binds the MDM4 pre-mRNA and promotes exon skipping to activate p53 upon nucleolar stress
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    Beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy
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    The fork protection complex promotes parental histone recycling and epigenetic memory
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    Activation of the helper NRC4 immune receptor forms a hexameric resistosome
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    Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases
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    cell.com/molecular-cell/fulltext/S1097-2765(20)30889-3
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    Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling
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    Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor
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  25. Jul 2024
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A CPF-like phosphatase module links transcription termination to chromatin silencing
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    Arabidopsis COP1 suppresses root hair development by targeting type I ACS proteins for ubiquitination and degradation
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    Structural insights into ligand recognition, selectivity, and activation of bombesin receptor subtype-3
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    cell.com/cell-reports/abstract/S2211-1247(24)00840-4
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    Waves of regulated protein expression and phosphorylation rewire the proteome to drive gametogenesis in budding yeast
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    Proteomic analysis reveals a PLK1-dependent G2/M degradation program and a role for AKAP2 in coordinating the mitotic cytoskeleton
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    Deubiquitylase OTUD3 regulates integrated stress response to suppress progression and sorafenib resistance of liver cancer
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  32. Jun 2024
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    eIF4F complex dynamics are important for the activation of the integrated stress response
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    The ribotoxic stress response drives UV-mediated cell death
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  35. May 2024
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    Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng
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    RNA quality control factors nucleate Clr4/SUV39H and trigger constitutive heterochromatin assembly
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    An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins
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    N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation
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  40. Apr 2024
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    Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor
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    A critical suppression feedback loop determines soybean photoperiod sensitivity
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    Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21
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    A highly optimized human in vitro translation system
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  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NLRP3 Cys126 palmitoylation by ZDHHC7 promotes inflammasome activation
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    A receptor required for chitin perception facilitates arbuscular mycorrhizal associations and distinguishes root symbiosis from immunity
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    sciencedirect.com/science/article/pii/S0960982224003129
  47. Mar 2024
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity
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  49. 52.53.155.43 52.53.155.43
    NLRP6 induces RIP1 kinase-dependent necroptosis via TAK1-mediated p38MAPK/MK2 phosphorylation in S. Typhimurium infection
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    52.53.155.43/edc059b1f8d2daaa9b02a6bfc9253e0bab800af6/1-s2.0-S2589004224005601-main-html.html
  50. Feb 2024
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Myeloid/natural killer (NK) cell precursor acute leukemia as a distinct leukemia type
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    Mitochondrial-encoded complex I impairment induces a targetable dependency on aerobic fermentation in Hürthle cell carcinoma of the thyroid
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    DGK5β-derived phosphatidic acid regulates ROS production in plant immunity by stabilizing NADPH oxidase
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    Cytotoxin-mediated silk gland organ dysfunction diverts resources to enhance silkworm fecundity by potentiating nutrient-sensing IIS/TOR pathways
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    Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function
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    BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair
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    Dual phosphorylation of DGK5-mediated PA burst regulates ROS in plant immunity
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    Myeloid/natural killer (NK) cell precursor acute leukemia as a distinct leukemia type
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    Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signaling pathway
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    The FANCI/FANCD2 complex links DNA damage response to R-loop regulation through SRSF1-mediated mRNA export
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    The RNA helicase Dbp10 coordinates assembly factor association with PTC maturation during ribosome biogenesis
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    Snapshot of the cannabinoid receptor 1-arrestin complex unravels the biased signaling mechanism
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    Proximity extracellular protein-protein interaction analysis of EGFR using AirID-conjugated fragment of antigen binding
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    m6A-Mediated Biogenesis of circDDIT4 Inhibits Prostate Cancer Progression by Sequestrating ELAVL1/HuR
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    Protocol for the production and purification of an i-Motif-specific nanobody
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    Dual stop codon suppression in mammalian cells with genomically integrated genetic code expansion machinery
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    Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation
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    The plant immune receptor SNC1 monitors helper NLRs targeted by a bacterial effector
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  72. Oct 2023
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    Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors
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    Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression
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    Crucial roles of the BRCA1-BARD1 E3 ubiquitin ligase activity in homology-directed DNA repair
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  76. Sep 2023
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    Antagonism among DUX family members evolved from an ancestral toxic single homeodomain protein
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    Targeting MCL-1 triggers DNA damage and an anti-proliferative response independent from apoptosis induction
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    Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
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    Inducible mismatch repair streamlines forward genetic approaches to target identification of cytotoxic small molecules
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    Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3
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    C1orf112 teams up with FIGNL1 to facilitate RAD51 filament disassembly and DNA interstrand cross-link repair
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  84. Jul 2023
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    Mechanism of orphan subunit recognition during assembly quality control
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    Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens
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    Complexes of vertebrate TMC1/2 and CIB2/3 proteins form hair-cell mechanotransduction cation channels
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    Systematic analysis of the molecular and biophysical properties of key DNA damage response factors
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    Generation of host-directed and virus-specific antivirals using targeted protein degradation promoted by small molecules and viral RNA mimics
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    Dynamic mapping of proteome trafficking within and between living cells by TransitID
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    Convergence of multiple RNA-silencing pathways on GW182/TNRC6
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    Pathogen protein modularity enables elaborate mimicry of a host phosphatase
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    Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function
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    ROTACs leverage signaling-incompetent R-spondin for targeted protein degradation
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    Acetate controls endothelial-to-mesenchymal transition
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    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    Mechanism of ribosome-associated mRNA degradation during tubulin autoregulation
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    The Transmembrane Protein TM4SF3 Interacts with AR and AR-V7 and is Recruited to AR Target Genes
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    A key GPCR phosphorylation motif discovered in arrestin2⋅CCR5 phosphopeptide complexes
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    Structural snapshots uncover a key phosphorylation motif in GPCRs driving β-arrestin activation
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    Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment
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    The integrated LIM-peptidase domain of the CSA1-CHS3/DAR4 paired immune receptor detects changes in DA1 peptidase inhibitors in Arabidopsis
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    Concurrent remodelling of nucleolar 60S subunit precursors by the Rea1 ATPase and Spb4 RNA helicase
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  107. Apr 2023
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    Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling
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    The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia
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    SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions
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    HHL1 and SOQ1 synergistically regulate non-photochemical quenching in Arabidopsis
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    Negative allosteric modulation of the glucagon receptor by RAMP2
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    TRIM28 represses renal cell carcinoma cell proliferation by inhibiting TFE3/KDM6A-regulated autophagy
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    Dual roles for CND1 in maintenance of nuclear and chloroplast genome stability in plants
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    Molecular and cellular basis of praziquantel action in the cardiovascular system
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    A central chaperone-like role for 14-3-3 proteins in human cells
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    Two Hippo signaling modules orchestrate liver size and tumorigenesis
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    A combinatorial approach to uncover an additional Integrator subunit
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    A pair of readers of bivalent chromatin mediate formation of Polycomb-based “memory of cold” in plants
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    A non-hallucinogenic LSD analog with therapeutic potential for mood disorders
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    Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome
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    Regulation of cargo exocytosis by a Reps1-Ralbp1-RalA module
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  125. Feb 2023
  126. journals.physiology.org journals.physiology.org
    Molecular and cellular basis of praziquantel action in the cardiovascular system
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    Conservation of the PBL-RBOH immune module in land plants
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    Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production
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    Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria
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    An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation
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  131. Jan 2023
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    C. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH-1
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    Structures of the entire human opioid receptor family
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    Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic Europe
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    Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging
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  136. Dec 2022
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    The Golgi-resident protein ACBD3 concentrates STING at ER-Golgi contact sites to drive export from the ER
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    Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP
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    PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation
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    Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL
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    Energy sensor AMPK gamma regulates translation via phosphatase PPP6C independent of AMPK alpha
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    Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway
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    Spatial Definition of the Human Progesterone Receptor-B Transcriptional Complex
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    Multiphase coalescence mediates Hippo pathway activation
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  146. Oct 2022
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    A critical developmental window for ELAV/Hu-dependent mRNA signatures at the onset of neuronal differentiation
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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The long noncoding RNA mimi scaffolds neuronal granules to maintain nervous system maturity
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    ATP13A1 prevents ERAD of folding-competent mislocalized and misoriented proteins
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    The long noncoding RNA mimi scaffolds neuronal granules to maintain nervous system maturity
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    Alternative somatic and germline gene-regulatory strategies during starvation-induced developmental arrest
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    Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival
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  153. Sep 2022
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    A methylbenzimidazole derivative regulates mammalian circadian rhythms by targeting Cryptochrome proteins
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    Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C isozymes are involved in mGlu5a receptor internalization
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    Target protein localization and its impact on PROTAC-mediated degradation
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    A family of C. elegans VASA homologs control Argonaute pathway specificity and promote transgenerational silencing
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  158. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Applying the auxin-based degron system for the inducible, reversible and complete protein degradation in Komagataella phaffii
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  159. Aug 2022
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    Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers
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    Mutated KLF4(K409Q) in meningioma binds STRs and activates FGF3 gene expression
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    TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation
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    Potent and broad neutralization of SARS-CoV-2 variants of concern (VOCs) including omicron sub-lineages BA.1 and BA.2 by biparatopic human VH domains
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    Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation
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  165. Jul 2022
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    Varicella‐Zoster virus ORF9 is an antagonist of the DNA sensor cGAS
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    Fine-tuned KDM1A alternative splicing regulates human cardiomyogenesis through an enzymatic-independent mechanism
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  168. Jun 2022
  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Phytophthora Effector Suppresses Trans-Kingdom RNAi to Promote Disease Susceptibility
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  170. www.nature.com www.nature.com
    BCL-2 isoform β promotes angiogenesis by TRiC-mediated upregulation of VEGF-A in lymphoma
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    GPCRs steer Gi and Gs selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors
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    UBP12 and UBP13 deubiquitinases destabilize the CRY2 blue light receptor to regulate Arabidopsis growth
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    Oncogenic ZMYND11-MBTD1 fusion protein anchors the NuA4/TIP60 histone acetyltransferase complex to the coding region of active genes
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  174. www.nature.com www.nature.com
    Furin extracellularly cleaves secreted PTENα/β to generate C-terminal fragment with a tumor-suppressive role
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  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional Analysis of the Candida albicans Kinome Reveals Hrr25 as a Regulator of Antifungal Susceptibility
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    Drosophila CLASP regulates microtubule orientation and dendrite pruning by suppressing Par-1 kinase
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    MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression
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    Rab39 and its effector UACA regulate basolateral exosome release from polarized epithelial cells
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    Mediator recruits the cohesin loader Scc2 to RNA Pol II-transcribed genes and promotes sister chromatid cohesion
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    Cross-species incompatibility between a DNA satellite and the Drosophila Spartan homolog poisons germline genome integrity
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  181. May 2022
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    A plant immune protein enables broad antitumor response by rescuing microRNA deficiency
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    UPF1 promotes rapid degradation of m6A-containing RNAs
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    Oxygen level regulates N-terminal translation elongation of selected proteins through deoxyhypusine hydroxylation
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  185. www.cell.com www.cell.com
    Systematic discovery of mutation-directed neo-protein-protein interactions in cancer
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  186. Apr 2022
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    WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy
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    The Arabidopsis F-box protein FBW2 targets AGO1 for degradation to prevent spurious loading of illegitimate small RNA
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  189. Mar 2022
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    Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody
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  191. www.nature.com www.nature.com
    RUFY3 and RUFY4 are ARL8 effectors that promote coupling of endolysosomes to dynein-dynactin
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  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Orally active bivalent VHH construct prevents proliferation of F4+ enterotoxigenic Escherichia coli in weaned piglets
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    The PAF1 complex promotes 3′ processing of pervasive transcripts
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    CRM1-spike-mediated nuclear export of hepatitis B virus encapsidated viral RNA
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    RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1
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    Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease
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  197. Feb 2022
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    Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death
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    Zic5 stabilizes Gli3 via a non-transcriptional mechanism during retinal development
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  200. Jan 2022
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    Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression
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    Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses
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    Identification and functional characterization of transcriptional activators in human cells
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  204. Dec 2021
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    Kel1 is a phosphorylation-regulated noise suppressor of the pheromone signaling pathway
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    Circular RNA ZNF609/CKAP5 mRNA interaction regulates microtubule dynamics and tumorigenicity
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    Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2
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    NLRP3 cages revealed by full-length mouse NLRP3 structure control pathway activation
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    A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling
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  210. Nov 2021
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    An epigenetic mechanism underlying chromosome 17p deletion-driven tumorigenesis
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    The fission yeast FLCN/FNIP complex augments TORC1 repression or activation in response to amino acid (AA) availability
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    AtpΘ is an inhibitor of F0F1 ATP synthase to arrest ATP hydrolysis during low-energy conditions in cyanobacteria
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  214. Oct 2021
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    Peli1 facilitates NLRP3 inflammasome activation by mediating ASC ubiquitination
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    An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity
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    TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease
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    Promyelocytic leukemia protein targets MK2 to promote cytotoxicity
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    Proteome-wide mapping of short-lived proteins in human cells
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    Gravin-associated kinase signaling networks coordinate γ-tubulin organization at mitotic spindle poles
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  221. Sep 2021
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    Noncanonical mono(ADP-ribosyl)ation of zinc finger SZF proteins counteracts ubiquitination for protein homeostasis in plant immunity
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    A polysaccharide deacetylase enhances bacterial adhesion in high-ionic-strength environments
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    Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors
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    DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation
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    Translational control of polyamine metabolism by CNBP is required for Drosophila locomotor function
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    Shigella ubiquitin ligase IpaH7.8 targets gasdermin D for degradation to prevent pyroptosis and enable infection
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    Stabilization of Motin family proteins in NF2-deficient cells prevents full activation of YAP/TAZ and rapid tumorigenesis
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    NANOS2 suppresses the cell cycle by repressing mTORC1 activators in embryonic male germ cells
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    Tracing the evolutionary history of Ca2+-signaling modulation by human Bcl-2: Insights from the Capsaspora owczarzaki IP3 receptor ortholog
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    A loss-of-function variant in SUV39H2 identified in autism-spectrum disorder causes altered H3K9 trimethylation and dysregulation of protocadherin β-cluster genes in the developing brain
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    ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation
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    A composite DNA element that functions as a maintainer required for epigenetic inheritance of heterochromatin
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    Overlapping Role of SCYL1 and SCYL3 in Maintaining Motor Neuron Viability
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