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Sep 2023
52.53.155.43 52.53.155.43

PPP1R3A inhibits Osteogenesis and Negatively Regulates Intracellular Calcium Levels in Calcific Tendinopathy

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1. scibot 29 Sep 2023
  
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  DOI: 10.1016/j.isci.2023.107784
  
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52.53.155.43/76614f024b889d9d72cc0422cf3e1a84c4b4f247/PIIS2589004223018618-html.html
52.53.155.43 52.53.155.43

Molecular Oncology - 2023 - Horie-html.html

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1. scibot 22 Sep 2023
  
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  DOI: 10.1002/1878-0261.13524
  
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  DOI: 10.1002/1878-0261.13524
  
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52.53.155.43/b5e8e877c627d157950951119edc64db79086ad6/Molecular Oncology - 2023 - Horie-html.html
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MATR3 is an endogenous inhibitor of DUX4 in FSHD muscular dystrophy

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1. scibot 14 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113120
  
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sciencedirect.com/science/article/pii/S2211124723011324
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Mammalian autophagosomes form from finger-like phagophores

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  DOI: 10.1016/j.devcel.2023.08.016
  
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sciencedirect.com/science/article/pii/S1534580723004100
Aug 2023
www.biorxiv.org www.biorxiv.org

Acylation of MLKL impacts its function in necroptosis

1
1. scibot 28 Aug 2023
  
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  DOI: 10.1101/2023.08.19.553906
  
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biorxiv.org/content/10.1101/2023.08.19.553906v1
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Loss-of-function cancer-associated mutations in the EIF4G2 non-canonical translation initiation factor

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1. scibot 28 Aug 2023
  
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  DOI: 10.1101/2023.08.22.554280
  
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biorxiv.org/content/10.1101/2023.08.22.554280v2
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ZXDC Enhances Cervical Cancer Metastasis Through IGF2BP3-Mediated Activation of RhoA/ROCK Signaling

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1. scibot 26 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107447
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10433122/
52.53.155.43 52.53.155.43

Capture and Inactivation of Viral Particles from Bioaerosols by Electrostatic Precipitation.

1
1. scibot 18 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107567
  
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52.53.155.43/da2c8b5aeb2f7218f03e820c3ca94e85c25a03ad/PIIS2589004223016449-html.html
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Catalytic and non-catalytic mechanisms of histone H4 lysine 20 methyltransferase SUV420H1

1
1. scibot 18 Aug 2023
  
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  DOI: 10.1016/j.molcel.2023.07.020
  
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sciencedirect.com/science/article/abs/pii/S1097276523005646
52.53.155.43 52.53.155.43

Molecular and clonal evolution in vivo reveal a common pathway of distant relapse gliomas

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1. scibot 12 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107528
  
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52.53.155.43/7a8c6a26be7c0ab8d087dcd799997f08730bdcd3/PIIS258900422301605X-html.html
52.53.155.43 52.53.155.43

Preterm birth and detection of common respiratory pathogens among pediatric pneumonia

1
1. scibot 04 Aug 2023
  
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  DOI: 10.1016/j.isci.2023.107488
  
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52.53.155.43/9a7f06b10cedd217d3505011f808b38b0a543e19/PIIS2589004223015651-html.html
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Tryptophan metabolism promotes immune evasion in human pancreatic β cells

1
1. scibot 03 Aug 2023
  
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  DOI: 10.1016/j.ebiom.2023.104740
  
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sciencedirect.com/science/article/pii/S2352396423003055
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DPPA3-HIF1α axis controls colorectal cancer chemoresistance by imposing a slow cell-cycle phenotype

1
1. scibot 03 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112927
  
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sciencedirect.com/science/article/pii/S2211124723009385
Jul 2023
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Identification of IQCH as a calmodulin-associated protein required for sperm motility in humans

1
1. scibot 27 Jul 2023
  
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  RRID:AB_477593
  
  DOI: 10.1016/j.isci.2023.107354
  
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sciencedirect.com/science/article/pii/S2589004223014311
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White adipose tissue undergoes browning during preweaning period in association with microbiota formation in mice

1
1. scibot 25 Jul 2023
  
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  DOI: 10.1016/j.isci.2023.107239
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10362363/
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Protocol for automated multivariate quantitative-image-based cytometry analysis by fluorescence microscopy of asynchronous adherent cells

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1. scibot 22 Jul 2023
  
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  DOI: 10.1016/j.xpro.2023.102446
  
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sciencedirect.com/science/article/pii/S2666166723004136
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Specific prostaglandins are produced in the migratory cells and the surrounding substrate to promote Drosophila border cell migration

1
1. scibot 18 Jul 2023
  
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  AB_477593
  
  DOI: 10.1101/2023.06.23.546291
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10327004/
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Development of small fluorescent probes for the analysis of autophagy kinetics

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1. scibot 15 Jul 2023
  
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  DOI: 10.1016/j.isci.2023.107218
  
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sciencedirect.com/science/article/pii/S2589004223012956
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Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling

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1. scibot 14 Jul 2023
  
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  DOI: 10.1016/j.ccell.2023.06.007
  
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sciencedirect.com/science/article/pii/S1535610823002179
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Centrosome amplification fine tunes tubulin acetylation to differentially control intracellular organization

2
1. scibot 08 Jul 2023
  
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  DOI: 10.15252/embj.2022112812
  
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2. scibot 08 Jul 2023
  
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  DOI: 10.15252/embj.2022112812
  
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embopress.org/doi/full/10.15252/embj.2022112812
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Single-cell dissection of Merkel cell carcinoma heterogeneity unveils transcriptomic plasticity and therapeutic vulnerabilities

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1. scibot 08 Jul 2023
  
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  DOI: 10.1016/j.xcrm.2023.101101
  
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sciencedirect.com/science/article/pii/S2666379123002203
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The kinesin Kif21b regulates radial migration of cortical projection neurons through a non-canonical function on actin cytoskeleton

1
1. scibot 07 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112744
  
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sciencedirect.com/science/article/pii/S2211124723007556
Jun 2023
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KaryoCreate: A CRISPR-based technology to study chromosome-specific aneuploidy by targeting human centromeres

1
1. scibot 30 Jun 2023
  
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  DOI: 10.1016/j.cell.2023.03.029
  
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sciencedirect.com/science/article/abs/pii/S0092867423003264
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Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts

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1. scibot 29 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.107113
  
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Integrated regulation of tubulin tyrosination and microtubule stability by human α-tubulin isotypes

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1. scibot 23 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112653
  
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sciencedirect.com/science/article/pii/S2211124723006642
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Reconstitution of muscle cell microtubule organization in vitro

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1. scibot 21 Jun 2023
  
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  DOI: 10.1002/cm.21710
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9329249/
www.nature.com www.nature.com

Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid

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1. scibot 17 Jun 2023
  
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  DOI: 10.1038/s41467-023-39151-8
  
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nature.com/articles/s41467-023-39151-8
52.53.155.43 52.53.155.43

Activity modulation of the Escherichia coli F1FO ATP synthase by a designed antimicrobial peptide via cardiolipin sequestering.

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1. scibot 16 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.107004
  
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52.53.155.43/89e213679aa9521d91d9c0570ab64f700fb2fcae/1-s2.0-S2589004223010817-main-html.html
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KIF4 regulates neuronal morphology and seizure susceptibility via the PARP1 signaling pathway

1
1. scibot 10 Jun 2023
  
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  DOI: 10.1083/jcb.202208108
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9735414/
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Centromere/kinetochore is assembled through CENP-C oligomerization

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1. scibot 09 Jun 2023
  
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  DOI: 10.1016/j.molcel.2023.05.023
  
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sciencedirect.com/science/article/pii/S1097276523003799
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Sox9 regulates melanocytic fate decision of adult hair follicle stem cells

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1. scibot 02 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.106919
  
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sciencedirect.com/science/article/pii/S2589004223009963
May 2023
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A Wnt-induced lncRNA-DGCR5 splicing switch drives tumor-promoting inflammation in esophageal squamous cell carcinoma

1
1. scibot 25 May 2023
  
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  DOI: 10.1016/j.celrep.2023.112542
  
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sciencedirect.com/science/article/pii/S2211124723005533
academic.oup.com academic.oup.com

Miniature RNAs are embedded in an exceptionally protein-rich mitoribosome via an elaborate assembly pathway

1
1. scibot 20 May 2023
  
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  DOI: 10.1093/nar/gkad422
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkad422/7173778
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Protein quality control machinery supports primary ciliogenesis by eliminating GDP-bound Rab8-family GTPases

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1. scibot 13 May 2023
  
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  DOI: 10.1016/j.isci.2023.106652
  
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sciencedirect.com/science/article/pii/S2589004223007290
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A conditional strategy for cell-type-specific labeling of endogenous excitatory synapses in Drosophila

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The Cytoskeletal Protein Zyxin Inhibits Retinoic Acid Signaling by Destabilizing the Maternal mRNA of the RXRγ Nuclear Receptor

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Transcriptional repression by FoxM1 suppresses tumor differentiation and promotes metastasis of breast cancer

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BUB-1-bound PLK-1 directs CDC-20 kinetochore recruitment to ensure timely embryonic mitoses

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ClC-3 regulates the excitability of nociceptive neurons and is involved in inflammatory processes within the spinal sensory pathway

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Fanconi anemia-associated chromosomal radial formation is dependent on POLθ-mediated alternative end joining

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Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness

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INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model

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Asparagine starvation suppresses histone demethylation through iron depletion

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The meiotic LINC complex component KASH5 is an activating adaptor for cytoplasmic dynein

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Incomplete Elongation of Ultra-long-chain Polyunsaturated Acyl-CoAs by the Fatty Acid Elongase ELOVL4 in Spinocerebellar Ataxia Type 34

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Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance

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A single-copy knockin translating ribosome immunoprecipitation toolkit for tissue-specific profiling of actively translated mRNAs in C. elegans

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NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes

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FAM193A is a positive regulator of p53 activity

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Harnessing transcriptionally driven chromosomal instability adaptation to target therapy-refractory lethal prostate cancer

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Apolipoprotein E4 inhibits γ-secretase activity via binding to the γ-secretase complex

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Association between cumulative lipoprotein(a) exposure and adverse cardiovascular outcomes in patients with prediabetes or diabetes

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The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5

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Prostaglandins limit nuclear actin to control nucleolar function during oogenesis

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NRF3 activates mTORC1 arginine-dependently for cancer cell viability

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Phase separation of an actin nucleator by junctional microtubules regulates epithelial function

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Microtubule-associated proteins MAP7 and MAP7D1 promote DNA double-strand break repair in the G1 cell cycle phase

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Low affinity CTCF binding drives transcriptional regulation whereas high affinity binding encompasses architectural functions

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Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression

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MANF regulates neuronal survival and UPR through its ER-located receptor IRE1α

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CAMSAP2 localizes to the Golgi in islet β-cells and facilitates Golgi-ER trafficking

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Drosophila Toll-9 is induced by aging and neurodegeneration to modulate stress signaling and its deficiency exacerbates tau-mediated neurodegeneration

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Genetic screens reveal new targetable vulnerabilities in BAP1-deficient mesothelioma

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GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylation

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Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance

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Synthetic Essentiality of Tryptophan 2,3-dioxygenase 2 in APC-Mutated Colorectal Cancer

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Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation

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The SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant

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The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation

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The oncogenic JAG1 intracellular domain is a transcriptional cofactor that acts in concert with DDX17/SMAD3/TGIF2

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PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation

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Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide)

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Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response

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Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer

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Toll-like receptor 2 orchestrates a tumor suppressor response in non-small cell lung cancer

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Combinatorial and antagonistic effects of tubulin glutamylation and glycylation on katanin microtubule severing

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Metabolic regulation by p53 prevents R-loop-associated genomic instability

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Alcohol self-administration and nicotine withdrawal alter biomarkers of stress and inflammation and prefrontal cortex changes in Gβ subunits

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BCAT1 redox function maintains mitotic fidelity

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Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex

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Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors

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Regulation of Claspin by the p38 stress-activated protein kinase protects cells from DNA damage

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STAG2 promotes the myelination transcriptional program in oligodendrocytes

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Structural basis for Gemin5 decamer-mediated mRNA binding

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RAD51 protects human cells from transcription-replication conflicts

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Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression

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Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2

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Experimentally induced hyperglycemia in prepubertal phase impairs oocyte quality and functionality in adult mice

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CHIKV infection reprograms codon optimality to favor viral RNA translation by altering the tRNA epitranscriptome

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EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression

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mTORC1 is required for epigenetic silencing during β-cell functional maturation

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Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity

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Direct chemical reprogramming of human cord blood erythroblasts to induced megakaryocytes that produce platelets

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Differentiated glioma cell-derived fibromodulin activates integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth

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Cannabinoid CB1 receptor gene inactivation in oligodendrocyte precursors disrupts oligodendrogenesis and myelination in mice

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Contribution of septins to human platelet structure and function

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Jun 2022
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cd-21-0680-html.html

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Protective roles of MITOL against myocardial senescence and ischemic injury partly via Drp1 regulation

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Single-cell transcriptional regulation and genetic evolution of neuroendocrine prostate cancer

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52.53.155.43 52.53.155.43

Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation

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Drosophila CLASP regulates microtubule orientation and dendrite pruning by suppressing Par-1 kinase

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γ-secretase promotes Drosophila postsynaptic development through the cleavage of a Wnt receptor

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Defining reference ranges for serum anti-Müllerian hormone (AMH) on a large cohort of normozoospermic adult men

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May 2022
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An RNA-immunoprecipitation protocol to identify RNAs associated with RNA-binding proteins in cytoplasmic and nuclear Drosophila head fractions

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AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma

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Molecules and fossils tell distinct yet complementary stories of mammal diversification

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Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis

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Translational Strategies for Repotrectinib in Neuroblastoma

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Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling

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High Intratumoral Dihydrotestosterone is Associated with Antiandrogen Resistance in VCaP Prostate Cancer Xenografts in Castrated Mice

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Inducible degradation of dosage compensation protein DPY-27 facilitates isolation of Caenorhabditis elegans males for molecular and biochemical analyses

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Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways

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Genetic instability from a single S phase after whole-genome duplication

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GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway

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Functional Assessment of Calcium-Sensing Receptor Variants Confirms Familial Hypocalciuric Hypercalcaemia

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The TFIIH complex is required to establish and maintain mitotic chromosome structure

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CENP-B-mediated DNA loops regulate activity and stability of human centromeres

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Cortical reorganization of the glutamate synapse in the activity-based anorexia rat model: impact on cognition

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Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria

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Estrogen alpha receptor inactivation in two sisters: different phenotypic severities for the same pathogenic variant

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AP-4-mediated axonal transport controls endocannabinoid production in neurons

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Recruitment of DNA to tumor-derived microvesicles

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Activity-dependent PI4P synthesis by PI4KIIIα regulates long-term synaptic potentiation

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BET protein inhibition in macrophages enhances dorsal root ganglion neurite outgrowth in female mice

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The Intrinsic Blue Light Responses of Avian Müller Glial Cells Imply Calcium Release from Internal Stores

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Non-centrosomal microtubules at kinetochores promote rapid chromosome biorientation during mitosis in human cells

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Growth hormone-induced STAT5B regulates Star gene expression through a cooperation with cJUN in mouse MA-10 Leydig cells

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Purification of functional Plasmodium falciparum tubulin allows for the identification of parasite-specific microtubule inhibitors

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SURF4-induced tubular ERGIC selectively expedites ER-to-Golgi transport

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Compartmentalized control of Cdk1 drives mitotic spindle assembly

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Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis

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Seipin localizes at endoplasmic-reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes

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Coordinated post-transcriptional control of oncogene-induced senescence by UNR/CSDE1

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The Alzheimer susceptibility gene BIN1 induces isoform-dependent neurotoxicity through early endosome defects

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Assessing kinetics and recruitment of DNA repair factors using high content screens

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Disrupted expression of mitochondrial NCLX sensitizes neuroglial networks to excitotoxic stimuli and renders synaptic activity toxic

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Targeted search for scaling genes reveals matrix metalloproteinase 3 as a scaler of the dorsal-ventral pattern in Xenopus laevis embryos

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TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules

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Methods to separate nuclear soluble fractions reflecting localizations in living cells

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Developmental defects in Huntington’s disease show that axonal growth and microtubule reorganization require NUMA1

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Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction

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Loss of sister kinetochore co-orientation and peri-centromeric cohesin protection after meiosis I depends on cleavage of centromeric REC8

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Polarized Dishevelled dissolution and reassembly drives embryonic axis specification in sea star oocytes

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Gene replacement strategies validate the use of functional tags on centromeric chromatin and invalidate an essential role for CENP-AK124ub

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Myogenin controls via AKAP6 non-centrosomal microtubule-organizing center formation at the nuclear envelope

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NRF3 upregulates gene expression in SREBP2-dependent mevalonate pathway with cholesterol uptake and lipogenesis inhibition

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Trophectoderm cell failure leads to peri-implantation lethality in Trpm7-deficient mouse embryos

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Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription

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Complex species and strain ecology of the vaginal microbiome from pregnancy to postpartum and association with preterm birth

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Neuronal XRN1 is required for maintenance of whole-body metabolic homeostasis

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The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment

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Gravin-associated kinase signaling networks coordinate γ-tubulin organization at mitotic spindle poles

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Vitamin B12 impacts amyloid beta-induced proteotoxicity by regulating the methionine/S-adenosylmethionine cycle

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Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins

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Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion

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Efficient Generation of Multi-gene Knockout Cell Lines and Patient-derived Xenografts Using Multi-colored Lenti-CRISPR-Cas9

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Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion

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Overexpression of α-synuclein inhibits mitochondrial Ca2+ trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75–IP3R interaction

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Linker histone H1.8 inhibits chromatin binding of condensins and DNA topoisomerase II to tune chromosome length and individualization

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Viral targeting of glioblastoma stem cells with patient-specific genetic and post-translational p53 deregulations

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Selective dephosphorylation by PP2A-B55 directs the meiosis I-meiosis II transition in oocytes

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Androgen signaling connects short isoform production to breakpoint formation at Ewing sarcoma breakpoint region 1

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Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis

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Cytohesin-2 mediates group I metabotropic glutamate receptor-dependent mechanical allodynia through the activation of ADP ribosylation factor 6 in the spinal cord

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Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

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Quantitative live-cell imaging and computational modeling shed new light on endogenous WNT/CTNNB1 signaling dynamics

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Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility

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Protein Tyrosine Phosphatase δ mediates the Sema3A-induced cortical basal dendritic arborization through the activation of Fyn tyrosine kinase

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A fluorescent reporter assay of differential gene expression response to insulin in hepatocytes

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Mice lacking EFA6C/Psd2, a guanine nucleotide exchange factor for Arf6, exhibit lower Purkinje cell synaptic density but normal cerebellar motor functions

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Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion

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Cas4 nucleases define the PAM, length, and orientation of DNA fragments integrated at CRISPR loci

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