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Aug 2025
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BIN1 expression in the presynaptic compartment leads to isoform-specific synaptotoxicity

1
1. scibot 19 Aug 2025
  
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  DOI: 10.1101/2025.08.11.669624
  
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biorxiv.org/content/10.1101/2025.08.11.669624v1
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ER-phagy and proteostasis defects prime pancreatic epithelial state changes in KRAS-mediated oncogenesis

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  DOI: 10.1016/j.devcel.2025.07.016
  
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sciencedirect.com/science/article/pii/S1534580725004733
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Beta-hydroxybutyrate (BHB) elicits concentration-dependent anti-inflammatory effects on microglial cells which are reversible by blocking its monocarboxylate (MCT) importer

1
1. scibot 14 Aug 2025
  
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  DOI: 10.3389/fragi.2025.1628835
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12339548/
52.53.155.43 52.53.155.43

2025.08.06.668996v1.full-html.html

1
1. scibot 13 Aug 2025
  
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  AB_477593
  
  DOI: 10.1101/2025.08.06.668996
  
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52.53.155.43/9762f0542a12c1b879bb3817e6abf20525e5b06e/2025.08.06.668996v1.full-html.html
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FEBS Press

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1. scibot 05 Aug 2025
  
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  DOI: 10.1002/1878-0261.70089
  
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febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70089
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19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism

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1. scibot 01 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116041
  
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cell.com/cell-reports/abstract/S2211-1247(25)00812-5
Jul 2025
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Cohesin-mediated stabilization of the CCAN complex at kinetochores in mitosis

1
1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.cub.2025.07.011
  
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Mitotic slippage causes nuclear instability in polyploid cells

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1. scibot 25 Jul 2025
  
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  DOI: 10.1101/2025.07.21.665898
  
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biorxiv.org/content/10.1101/2025.07.21.665898v1
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19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism

2
1. scibot 24 Jul 2025
  
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  AB_477593
  
  DOI: 10.1016/j.celrep.2025.116041
  
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2. scibot 24 Jul 2025
  
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  RRID:_AB_477593
  
  DOI: 10.1016/j.celrep.2025.116041
  
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cell.com/cell-reports/abstract/S2211-1247(25)00812-5
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Rapid active zone remodeling consolidates presynaptic potentiation

1
1. scibot 17 Jul 2025
  
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  DOI: 10.1038/s41467-019-08977-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC6403334/
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A Rac-specific competitive inhibitor of guanine nucleotide binding reduces metastasis in triple-negative breast cancer

1
1. scibot 09 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102233
  
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sciencedirect.com/science/article/pii/S2666379125003064
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JAG modulates sepal flatness by regulating cell growth direction, interacts with AS2, and is antagonized by TCP24

1
1. scibot 09 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115950
  
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sciencedirect.com/science/article/pii/S2211124725007211
Jun 2025
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The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells

1
1. scibot 28 Jun 2025
  
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  RRID:AB_477593
  
  DOI: 10.1016/j.molcel.2025.06.002
  
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52.53.155.43 52.53.155.43

ENEURO.0149-16.2017.full-html.html

1
1. scibot 26 Jun 2025
  
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  RRID:AB_477593
  
  DOI: 10.1523/eneuro.0149-16.2017
  
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52.53.155.43/15d555d90ef5c3ac2c5d7b24efa8a9a51c9e436b/ENEURO.0149-16.2017.full-html.html
52.53.155.43 52.53.155.43

1-s2.0-S2589004225011423-main-html.html

2
1. scibot 17 Jun 2025
  
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  AB_477593
  
  DOI: 10.1016/j.isci.2025.112881
  
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2. scibot 14 Jun 2025
  
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  AB_477593
  
  DOI: 10.1016/j.isci.2025.112881
  
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52.53.155.43/31a2db85ed1e4e88cfb392023b2c28eccb7c9f0f/1-s2.0-S2589004225011423-main-html.html
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance

1
1. scibot 14 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.04.006
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12240685/
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 12 Jun 2025
  
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  AB_477593
  
  DOI: 10.1016/j.isci.2025.112839
  
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52.53.155.43/24cfa21e3df3dd566f1ede382780eae43e37666e/PDF-html.html
52.53.155.43 52.53.155.43

1-s2.0-S2589004225010892-main-html.html

1
1. scibot 12 Jun 2025
  
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  AB_477593
  
  DOI: 10.1016/j.isci.2025.112828
  
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52.53.155.43/83221e4dcd7570a72fe06345124094261125dc77/1-s2.0-S2589004225010892-main-html.html
onlinelibrary.wiley.com onlinelibrary.wiley.com

Disruption of Retriever Function Impacts Retrograde Trafficking From Endosomes

1
1. scibot 11 Jun 2025
  
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  DOI: 10.1002/cbin.70037
  
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onlinelibrary.wiley.com/doi/10.1002/cbin.70037
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Off-pore Nup98 condensates mobilize heterochromatic breaks and exclude Rad51

1
1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.05.012
  
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cell.com/molecular-cell/abstract/S1097-2765(25)00446-0
May 2025
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A novel SUN1-ALLAN complex coordinates segregation of the bipartite MTOC across the nuclear envelope during rapid closed mitosis in Plasmodium berghei

1
1. scibot 29 May 2025
  
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  DOI: 10.7554/eLife.106537
  
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elifesciences.org/articles/106537
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Inhibition of IRE1α Alleviates Renal Fibrosis and Downregulates M1 Macrophage Activation via the p38 MAPK Pathway

1
1. scibot 29 May 2025
  
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  RRID:AB_477593
  
  DOI: 10.1111/imm.13949
  
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onlinelibrary.wiley.com/doi/10.1111/imm.13949
52.53.155.43 52.53.155.43

1-s2.0-S2589004225009861-main-html.html

1
1. scibot 29 May 2025
  
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  AB_477593
  
  DOI: 10.1016/j.isci.2025.112725
  
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52.53.155.43/97492e98a3e2c7c22333d1580c0d702048c9778e/1-s2.0-S2589004225009861-main-html.html
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Disrupted endosomal trafficking of the Vangl-Celsr polarity complex underlies congenital anomalies in Xenopus trachea-esophageal morphogenesis

1
1. scibot 29 May 2025
  
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  DOI: 10.1016/j.devcel.2025.04.026
  
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sciencedirect.com/science/article/pii/S1534580725002862
52.53.155.43 52.53.155.43

1-s2.0-S2589004225009514-main-html.html

1
1. scibot 20 May 2025
  
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  AB_477593
  
  DOI: 10.1016/j.isci.2025.112690
  
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52.53.155.43/a159f4d3f38a51441ad0ab778452f917ec713d81/1-s2.0-S2589004225009514-main-html.html
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Development of SOCS1 mimetics as novel approach to harmonize inflammation, oxidative stress, and fibrogenesis in metabolic dysfunction-associated steatotic liver disease

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1. scibot 18 May 2025
  
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  DOI: 10.1016/j.redox.2025.103670
  
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sciencedirect.com/science/article/pii/S2213231725001831
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1-s2.0-S2589004225009149-main-html.html

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  AB_477593
  
  DOI: 10.1016/j.isci.2025.112653
  
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EFA6A, a Guanine Nucleotide Exchange Factor for Arf6, Regulates Developmental Stage-Dependent Spine Morphogenesis, Synaptic Plasticity, and Long-Term Memory in the Hippocampus

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1. scibot 16 May 2025
  
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  DOI: 10.1007/s12035-025-05009-x
  
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link.springer.com/article/10.1007/s12035-025-05009-x
52.53.155.43 52.53.155.43

1-s2.0-S2589004225009022-main-html.html

1
1. scibot 16 May 2025
  
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  AB_477593
  
  DOI: 10.1002/andp.202200250
  
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52.53.155.43/a4f46ad0b3ca20bd284f188e907c4d0f4b768ad4/1-s2.0-S2589004225009022-main-html.html
Apr 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225007643-main-html.html

1
1. scibot 24 Apr 2025
  
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  AB_477593
  
  DOI: 10.5281/zenodo.15166960
  
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52.53.155.43/d78169c1728eead68a394b7884e99a86e9c562a2/1-s2.0-S2589004225007643-main-html.html
52.53.155.43 52.53.155.43

1-s2.0-S2589004225007242-main-html.html

1
1. scibot 19 Apr 2025
  
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  AB_477593
  
  DOI: 10.1016/j.isci.2025.112463
  
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52.53.155.43/1e499d8ab8d9a427694f44a944f8d59472ed5797/1-s2.0-S2589004225007242-main-html.html
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

Targeting MLL1/WDR5-Mediated Epigenetic Regulation Mitigates Peritoneal Fibrosis by Reducing p16INK4a

1
1. scibot 17 Apr 2025
  
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  DOI: 10.1096/fj.202402382R
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202402382R
52.53.155.43 52.53.155.43

1-s2.0-S2589004225006972-main-html.html

1
1. scibot 17 Apr 2025
  
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  RRID:AB_477593
  
  DOI: 10.1016/j.isci.2025.112436
  
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1-s2.0-S2589004225006819-main-html.html

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Spatially Restricted Regulation of Spätzle/Toll Signaling during Cell Competition

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Quiescent cell re-entry is limited by macroautophagy-induced lysosomal damage

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RAF1 kinase contributes to autophagic lysosome reformation

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CD3xHER2 bsAb-Mediated Activation of Resting T-cells at HER2 Positive Tumor Clusters Is Sufficient to Trigger Bystander Eradication of Distant HER2 Negative Clusters Through IFNγ and TNFα

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Lysosome positioning affects NLRP3 inflammasome activation

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Ischemic preconditioning attenuates ischemia/reperfusion-induced acute kidney injury dependent on mitochondrial protease CLPP

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Versatile roles of annexin A4 in clear cell renal cell carcinoma: Impact on membrane repair, transcriptional signatures, and composition of the tumor microenvironment

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Mar 2025
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science.adh0037_sm-html.html

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Forebrain Eml1 depletion reveals early centrosomal dysfunction causing subcortical heterotopia

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GEF-H1 drives breast cancer cells to tumor progression

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The non-catalytic ε DNA polymerase subunit is an NPF motif recognition protein

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Glucose modulates IRF6 transcription factor dimerization to enable epidermal differentiation

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Net zero in power and industry – creating or destroying value and jobs?

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1-s2.0-S258900422500416X-main (1)-html.html

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EPAS1 induction drives myocardial degeneration in desmoplakin-cardiomyopathy

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Mitofusin-Dependent ER Stress Triggers Glial Dysfunction and Nervous System Degeneration in a Drosophila Model of Friedreich’s Ataxia

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Septin 3 regulates memory and L-LTP-dependent extension of endoplasmic reticulum into spines

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Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence

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1-s2.0-S2589004225003347-main (1)-html.html

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A ‘torn bag mechanism’ of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes)

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Novel Pannexin 1 isoform is increased in cancer

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1-s2.0-S2589004225001968-main (1)-html.html

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1-s2.0-S2589004225001956-main-html.html

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Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination

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Centromeric chromatin clearings demarcate the site of kinetochore formation

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1-s2.0-S2589004225001282-main-html.html

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TanGIBLE: A selective probe for evaluating hydrophobicity-exposed defective proteins in live cells

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1-s2.0-S2589004225000483-main-html.html

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1-s2.0-S2589004225000306-main-html.html

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1-s2.0-S2589004225000124-main-html.html

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Mechanistic basis of temperature adaptation in microtubule dynamics across frog species

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1
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Role of immature choroid plexus in the pathology of model mice and human iPSC-derived organoids with autism spectrum disorder

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The histone H3.3 K27M mutation suppresses Ser31phosphorylation and mitotic fidelity, which can directly drive gliomagenesis

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Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state

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1
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Temperature perception by ER UPR promotes preventive innate immunity and longevity

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Molecular details and phospho-regulation of the CENP-T-Mis12 complex interaction during mitosis in DT40 cells

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1
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The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

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Modulation of SNARE-dependent exocytosis in astrocytes improves neuropathology in Huntington's disease

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CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2

1
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Systematic screens for fertility genes essential for malaria parasite transmission reveal conserved aspects of sex in a divergent eukaryote

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Insulin Mediates Lipopolysaccharide-Induced Inflammatory Responses and Oxidative Stress in BV2 Microglia

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Evolutionarily conserved behavioral plasticity enables context-dependent mating in C. elegans

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SOX10 mediates glioblastoma cell-state plasticity

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A benzarone derivative inhibits EYA to suppress tumor growth in SHH medulloblastoma

1
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Activation of the NLRP1B inflammasome by caspase-8

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Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation

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Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System

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Unlocking the Secrets of Adipose Tissue: How an Obesity-Associated Secretome Promotes Osteoblast Dedifferentiation via TGF-β1 Signaling, Paving the Path to an Adipogenic Phenotype

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IGFBP7 is upregulated in islets from T2D donors and reduces insulin secretion

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TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson’s Disease

1
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Developmental Cytoplasmic-to-Nuclear Translocation of RNA-Binding Protein HuR Is Required for Adult Neurogenesis

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CTENO64 Is Required for Coordinated Paddling of Ciliary Comb Plate in Ctenophores

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Metastatic Tumor Cells Exploit Their Adhesion Repertoire to Counteract Shear Forces during Intravascular Arrest

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Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic gene reactivation

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Intrinsic Molecular Proton Sensitivity Underlies GPR4 Effects on Retrotrapezoid Nucleus Neuronal Activation and CO2-Stimulated Breathing

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science.adh0037_sm-html.html

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Anti-Hebbian plasticity in the motor cortex promotes defensive freezing

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Gemcitabine therapeutically disrupts essential SIRT1-mediated p53 repression in atypical teratoid/rhabdoid tumors

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The cell cycle controls spindle architecture in Arabidopsis by activating the augmin pathway

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Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins

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Caenorhabditis elegans SEL-5/AAK1 regulates cell migration and cell outgrowth independently of its kinase activity

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  DOI: 10.7554/eLife.91054
  
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CD3-engaging bispecific antibodies trigger a paracrine regulated wave of T-cell recruitment for effective tumor killing

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  DOI: 10.1038/s42003-024-06682-9
  
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An Arabidopsis Kinesin-14D motor is associated with midzone microtubules for spindle morphogenesis

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The genomic basis of temporal niche evolution in a diurnal rodent

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A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development

1
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HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability

1
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Septins promote macrophage pyroptosis by regulating gasdermin D cleavage and ninjurin-1-mediated plasma membrane rupture

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Hepatic BMAL1 and HIF1α regulate a time-dependent hypoxic response and prevent hepatopulmonary-like syndrome

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The FXR1 network acts as a signaling scaffold for actomyosin remodeling

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SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation

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Alcohol self-administration and nicotine withdrawal alter biomarkers of stress and inflammation and prefrontal cortex changes in Gβ subunits

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RIPK1 Promotes Energy Sensing by the mTORC1 Pathway

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Untitled document

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The carbocyanine dye DiD labels in vitro and in vivo neural stem cells of the subventricular zone as well as myelinated structures following in vivo injection in the lateral ventricle

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Morphology, innervation, and peripheral sensory cells of the siphon of aplysia californica

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Connexin50 couples axon terminals of mouse horizontal cells by homotypic gap junctions

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Intracellular tau fragment droplets serve as seeds for tau fibrils

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Dynamic regulation of alternative polyadenylation by PQBP1 during neurogenesis

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The germline coordinates mitokine signaling

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PP2A-B55 phosphatase counteracts Ki-67-dependent chromosome individualization during mitosis

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PIIS2589004224017000-html.html

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High-Throughput Discovery and Characterization of Viral Transcriptional Effectors in Human Cells

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STAT3 drives the expression of ACSL4 in acute kidney injury

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Impaired Tryptophan Metabolism by Type 2 Inflammation in Epithelium Worsening Asthma

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elife-92755-v2-html.html

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Embryos from Prepubertal Hyperglycemic Female Mice Respond Differentially to Oxygen Tension In Vitro

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The evolutionarily ancient FOXA transcription factors shape the murine gut microbiome via control of epithelial glycosylation

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The C-terminal disordered loop domain of Apc8 unlocks APC/C mitotic activation

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Aurora-A condensation mediated by BuGZ aids its mitotic centrosome functions

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EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells

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Ablation of Atp5if1 impairs metabolic reprogramming and proliferation of T lymphocytes and compromises mouse survival

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Peripheral immunophenotyping reveals lymphocyte stimulation in healthy women living with hereditary breast and ovarian cancer syndrome

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Enzymatic depletion of circulating glutamine is immunosuppressive in cancers

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Apr 2024
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Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia

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Sequence and chromatin features guide DNA double-strand break resection initiation

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PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response

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EPB41L5 controls podocyte extracellular matrix assembly by adhesome-dependent force transmission

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Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia

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A validation strategy to assess the role of phase separation as a determinant of macromolecular localization

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TSPYL2 induces renal ischemia-reperfusion injury through SREBP-2/ACMSD signaling

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Microtubule-associated protein MAP7 promotes tubulin posttranslational modifications and cargo transport to enable osmotic adaptation

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Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency

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Initiation of a ZAKα-dependent ribotoxic stress response by the innate immunity endoribonuclease RNase L

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Non-random spatial organization of telomere varies during the cell cycle and requires LAP2 and BAF

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The deubiquitinase Otud7b suppresses cone photoreceptor degeneration in mouse models of retinal degenerative diseases

1
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Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin

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Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons

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Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness

3
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YOLOX-DG Robotic Detection Systems for Large-Scale Underwater Concrete Structures

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LC3-dependent extracellular vesicles (LDEVs) promote M-MDSC accumulation and immunosuppression in colorectal cancer.

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Transcriptome Regulation by PARP13 in Basal and Antiviral States in Human Cells

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RTF2 controls replication repriming and ribonucleotide excision at the replisome

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Substrate-bound and soluble domains of tenascin-C regulate differentiation, proliferation and migration of neural stem and progenitor cells

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Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model

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Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology

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Complex formation of immunoglobulin superfamily molecules Side-IV and Beat-IIb regulates synaptic specificity

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Mouse oocytes sequester aggregated proteins in degradative super-organelles

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SLC25A51 decouples the mitochondrial NAD+/NADH ratio to control proliferation of AML cells

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C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line

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RNF4 prevents genomic instability caused by chronic DNA under-replication

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Protocol for gene knockdown using siRNA in primary cultured neonatal murine microglia

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SIN3A histone deacetylase action counteracts MUS81 to promote stalled fork stability

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Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates

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EHD2 regulates plasma membrane integrity and downstream insulin receptor signalling events

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  DOI: 10.1091/mbc.E23-03-0078
  
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Two-step evolution of HIV-1 budding system leading to pandemic in the human population

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A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells

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Specific prostaglandins are produced in the migratory cells and the surrounding substrate to promote Drosophila border cell migration

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Jan 2024
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Retroelement decay by the exonuclease XRN1 is a viral mimicry dependency in cancer

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BRCA2 promotes genomic integrity and therapy resistance primarily through its role in homology-directed repair

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Maintaining Toll signaling in Drosophila brain is required to sustain autophagy for dopamine neuron survival

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EHD2 regulates plasma membrane integrity and downstream insulin receptor signaling events

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The autophagy protein Atg9 functions in glia and contributes to parkinsonian symptoms in a Drosophila model of Parkinson’s disease

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Loss-of-function cancer-linked mutations in the EIF4G2 non-canonical translation initiation factor

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A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs

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FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination

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Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1

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S-SCAM is essential for synapse formation

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Sbp2l contributes to oligodendrocyte maturation through translational control in Tcf7l2 signaling

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A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during aging and in Alzheimer’s disease

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Repression of CENP-A assembly in metaphase requires HJURP phosphorylation and inhibition by M18BP1

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Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria

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Choroid plexuses carry nodal-like cilia that undergo axoneme regression from early adult stage

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Loss of EIF4G2 Mediates Aggressiveness in Distinct Human Endometrial Cancer Subpopulations with Poorer Survival Outcome in Patients

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CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression

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Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method

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Abl2 repairs microtubules and phase separates with tubulin to promote microtubule nucleation

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Chimpanzees show the capacity to communicate about concomitant daily life events.

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Neurosurgical Robots in China: state of the art and future prospect

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ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct

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Differential roles of cyclooxygenase enzymes in the regulation of murine juvenile undifferentiated spermatogonia

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PPP1R3A inhibits Osteogenesis and Negatively Regulates Intracellular Calcium Levels in Calcific Tendinopathy

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