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Jun 2022
onlinelibrary.wiley.com onlinelibrary.wiley.com

Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion

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1. scibot 17 Jun 2022
  
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  DOI: 10.1111/jnc.15622
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15622
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Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

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1. scibot 17 Jun 2022
  
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  DOI: 10.1016/j.isci.2022.104519
  
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sciencedirect.com/science/article/pii/S2589004222007908
May 2022
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Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception

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1. scibot 26 May 2022
  
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  DOI: 10.1016/j.devcel.2022.05.001
  
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sciencedirect.com/science/article/pii/S153458072200329X
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DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism

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1. scibot 25 May 2022
  
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  DOI: 10.1016/j.devcel.2022.04.020
  
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sciencedirect.com/science/article/pii/S1534580722003069
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Nde1 is required for heterochromatin compaction and stability in neocortical neurons

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1. scibot 19 May 2022
  
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  DOI: 10.1016/j.isci.2022.104354
  
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sciencedirect.com/science/article/pii/S2589004222006253
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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis

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1. scibot 19 May 2022
  
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  DOI: 10.1016/j.devcel.2022.04.018
  
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sciencedirect.com/science/article/pii/S1534580722002866
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The oocyte spindle midzone pauses Cdk1 inactivation during fertilization to enable male pronuclear formation and embryo development

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1. scibot 13 May 2022
  
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  DOI: 10.1016/j.celrep.2022.110789
  
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sciencedirect.com/science/article/pii/S2211124722005563
Apr 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A superior loading control for the cellular thermal shift assay

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1. scibot 29 Apr 2022
  
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  DOI: 10.1038/s41598-022-10653-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9035151/
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Rab33b-exocyst interaction mediates localized secretion for focal adhesion turnover and cell migration

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1. scibot 28 Apr 2022
  
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  DOI: 10.1016/j.isci.2022.104250
  
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sciencedirect.com/science/article/pii/S258900422200520X
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Reduction of Nuak1 decreases tau and reverses phenotypes in a tauopathy mouse model

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1. scibot 22 Apr 2022
  
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  DOI: 10.1016/j.neuron.2016.09.022
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5745060/
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Lockdown, a selective small-molecule inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion

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1. scibot 21 Apr 2022
  
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  DOI: 10.1016/j.chembiol.2022.03.011
  
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sciencedirect.com/science/article/pii/S2451945622001283
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Vinculin controls endothelial cell junction dynamics during vascular lumen formation

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1. scibot 14 Apr 2022
  
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  DOI: 10.1016/j.celrep.2022.110658
  
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sciencedirect.com/science/article/pii/S2211124722004107
academic.oup.com academic.oup.com

Adipose Mitochondrial Complex I Deficiency Modulates Inflammation and Glucose Homeostasis in a Sex-Dependent Manner

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1. scibot 13 Apr 2022
  
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  DOI: 10.1210/endocr/bqac018
  
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academic.oup.com/endo/article/163/4/bqac018/6529386
Mar 2022
onlinelibrary.wiley.com onlinelibrary.wiley.com

Mechanical regulation of oligodendrocyte morphology and maturation by the mechanosensor p130Cas

1
1. scibot 31 Mar 2022
  
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  DOI: 10.1111/jnc.14657
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.14657
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Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression

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1. scibot 31 Mar 2022
  
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  DOI: 10.1016/j.molcel.2022.03.004
  
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sciencedirect.com/science/article/pii/S1097276522002131
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Novel cellular mechanism that mediates the collecting duct formation during postnatal renal development

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1. scibot 26 Mar 2022
  
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  DOI: 10.1002/jcp.28016
  
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onlinelibrary.wiley.com/doi/10.1002/jcp.28016
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Cardiomyocyte substructure reverts to an immature phenotype during heart failure

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1. scibot 26 Mar 2022
  
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  RRID:AB_477629
  
  DOI: 10.1113/JP277273
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/JP277273
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer

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1. scibot 17 Mar 2022
  
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  DOI: 10.1158/0008-5472.CAN-20-0125
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8916161/
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Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier

1
1. scibot 16 Mar 2022
  
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  DOI: 10.1016/j.neuron.2022.02.017
  
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sciencedirect.com/science/article/pii/S0896627322001842
elifesciences.org elifesciences.org

Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

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1. scibot 11 Mar 2022
  
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  DOI: 10.7554/eLife.73150
  
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elifesciences.org/articles/73150
onlinelibrary.wiley.com onlinelibrary.wiley.com

Crosstalk between ERK and MRTF-A signaling regulates TGFβ1-induced epithelial-mesenchymal transition

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1. scibot 05 Mar 2022
  
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  DOI: 10.1002/jcp.30705
  
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onlinelibrary.wiley.com/doi/10.1002/jcp.30705
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Proteome-centric cross-omics characterization and integrated network analyses of triple-negative breast cancer

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1. scibot 02 Mar 2022
  
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  DOI: 10.1016/j.celrep.2022.110460
  
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sciencedirect.com/science/article/pii/S2211124722001875
Feb 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma

1
1. scibot 16 Feb 2022
  
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  DOI: 10.1158/0008-5472.CAN-21-1677
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7611539/
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5-FU blocks shuttling of HuR mediated by PKCδ in gastric cancer cells

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1. scibot 04 Feb 2022
  
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  RRID:AB_477629
  
  DOI: 10.21037/tcr-20-2129
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8798337/
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Heat shock induces premature transcript termination and reconfigures the human transcriptome

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1. scibot 04 Feb 2022
  
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  DOI: 10.1016/j.molcel.2022.01.007
  
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sciencedirect.com/science/article/pii/S1097276522000077
Jan 2022
onlinelibrary.wiley.com onlinelibrary.wiley.com

Genomic variants reducing expression of two endocytic receptors in 46,XY differences of sex development

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1. scibot 27 Jan 2022
  
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  DOI: 10.1002/humu.24325
  
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onlinelibrary.wiley.com/doi/10.1002/humu.24325
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WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity

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1. scibot 19 Jan 2022
  
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  DOI: 10.1016/j.celrep.2021.110261
  
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sciencedirect.com/science/article/pii/S2211124721017733
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GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis

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1. scibot 13 Jan 2022
  
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  DOI: 10.1016/j.cell.2021.12.024
  
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sciencedirect.com/science/article/pii/S0092867421014872
physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com

Platelet rich plasma affects gap junctional features in myofibroblasts in vitro via Vascular Endothelial Growth Factor (VEGF)-A/VEGF receptor

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1. scibot 06 Jan 2022
  
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  RRID:AB_477629
  
  DOI: 10.1113/EP090052
  
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physoc.onlinelibrary.wiley.com/doi/10.1113/EP090052
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance

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1. scibot 05 Jan 2022
  
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  DOI: 10.1126/sciadv.abl4988
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8673768/
Dec 2021
www.science.org www.science.org

Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance

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1. scibot 31 Dec 2021
  
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  DOI: 10.1126/sciadv.abl4988
  
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science.org/doi/abs/10.1126/sciadv.abl4988
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Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1

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1. scibot 15 Dec 2021
  
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  DOI: 10.1016/j.celrep.2021.110104
  
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sciencedirect.com/science/article/pii/S2211124721015989
faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com

Galectin-9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin-dependent manner

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1. scibot 02 Dec 2021
  
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  DOI: 10.1096/fj.202100832R
  
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faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202100832R
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CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment

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1. scibot 01 Dec 2021
  
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  DOI: 10.1016/j.celrep.2021.110060
  
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sciencedirect.com/science/article/pii/S2211124721015461
Nov 2021
www.cell.com www.cell.com

MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts

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1. scibot 30 Nov 2021
  
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  DOI: 10.1016/j.molcel.2021.11.002
  
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cell.com/molecular-cell/fulltext/S1097-2765(21)00952-7
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A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization

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1. scibot 18 Nov 2021
  
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  DOI: 10.1016/j.molcel.2021.10.017
  
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Developmental defects in Huntington’s disease show that axonal growth and microtubule reorganization require NUMA1

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  DOI: 10.1016/j.neuron.2021.10.033
  
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AKIRIN2 controls the nuclear import of proteasomes in vertebrates

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  DOI: 10.1038/s41586-021-04035-8
  
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USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma

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  DOI: 10.7554/eLife.71596
  
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Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis

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Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape

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Protocol for the assessment of mTOR activity in mouse primary hepatocytes

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Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues

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A viral histone-like protein exploits antagonism between linker histones and HMGB proteins to obstruct the cell cycle

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Biosensors based on peptide exposure show single molecule conformations in live cells

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Proteome-wide mapping of short-lived proteins in human cells

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Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice

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SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling

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Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion

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REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps

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The Amot/integrin protein complex transmits mechanical forces required for vascular expansion

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NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1

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CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance

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SCAF4 and SCAF8, mRNA Anti-Terminator Proteins

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  DOI: 10.1016/j.cell.2019.04.038
  
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Untitled document

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The P2X7 Receptor Stimulates IL-6 Release from Pancreatic Stellate Cells and Tocilizumab Prevents Activation of STAT3 in Pancreatic Cancer Cells

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Molecular basis for substrate recruitment to the PRMT5 methylosome

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Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy

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ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma

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Neural Deletion of Glucose Transporter Isoform 3 Creates Distinct Postnatal and Adult Neurobehavioral Phenotypes

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  DOI: 10.1523/JNEUROSCI.0503-18.2018
  
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Structural Basis of Paxillin Recruitment by Kindlin-2 in Regulating Cell Adhesion

1
1. scibot 30 Jul 2021
  
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  Monoclonal Anti-Vinculin antibody produced in mouse
  
  DOI: 10.1016/j.str.2019.09.006
  
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Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity

1
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  Mouse polyclonal anti Vinculin
  
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The heat shock protein amplifier arimoclomol improves refolding, maturation and lysosomal activity of glucocerebrosidase

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CRISPR-induced RASGAP deficiencies in colorectal cancer organoids reveal that only loss of NF1 promotes resistance to EGFR inhibition

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  DOI: 10.18632/oncotarget.26677
  
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De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma

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  DOI: 10.1016/j.stem.2019.01.003
  
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Untitled document

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  DOI: 10.1016/j.celrep.2018.11.099
  
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Transcription-mediated supercoiling regulates genome folding and loop formation

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FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates

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  V9131
  
  DOI: 10.1038/s41598-021-92408-4
  
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Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination

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Identification of a class of non-conventional ER-stress-response-derived immunogenic peptides

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Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis

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Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition

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Translation stress and collided ribosomes are co-activators of cGAS

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Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function

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Loss of Ambra1 promotes melanoma growth and invasion

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The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake

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AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation

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Hydrogel Network Dynamics Regulate Vascular Morphogenesis

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Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin

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Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension

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  DOI: 10.1016/j.stem.2020.11.002
  
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A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis

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Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters

1
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The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules

1
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  DOI: 10.1016/j.molcel.2020.05.017
  
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Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells

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  DOI: 10.1016/j.devcel.2021.02.020
  
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Pancreatic Cancer Cells Require the Transcription Factor MYRF to Maintain ER Homeostasis

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Defects in translation-dependent quality control pathways lead to convergent molecular and neurodevelopmental pathology

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  DOI: 10.7554/eLife.66904
  
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Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis

1
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Tyrosine Phosphorylation of the Myosin Regulatory Light Chain Controls Non-muscle Myosin II Assembly and Function in Migrating Cells

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Mitochondria Define Intestinal Stem Cell Differentiation Downstream of a FOXO/Notch Axis

1
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Coordinate regulation of the senescent state by selective autophagy

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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

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Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression

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Functional interrogation of DNA damage response variants with base editing screens

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Reduced Thiamine Availability and Hyperglycemia Impair Thiamine Transport in Renal Glomerular Cells through Modulation of Thiamine Transporter 2

1
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A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology

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  mouse anti‐vinculin
  
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Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling

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  DOI: 10.1038/s41556-021-00654-5
  
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Protocol for analysis of integrin-mediated cell adhesion of lateral plate mesoderm cells isolated from zebrafish embryos

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  DOI: 10.1016/j.xpro.2021.100428
  
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Mar 2021
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TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation

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  DOI: 10.7554/eLife.62873
  
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MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage

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Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer

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  DOI: 10.1016/j.cell.2020.12.031
  
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Mesoscale Modeling and Single-Nucleosome Tracking Reveal Remodeling of Clutch Folding and Dynamics in Stem Cell Differentiation

1
1. scibot 28 Feb 2021
  
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  DOI: 10.1016/j.celrep.2020.108614
  
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Translation in amino-acid-poor environments is limited by tRNAGln charging

1
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  DOI: 10.7554/eLife.62307
  
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Loss of the Extracellular Matrix Molecule Tenascin-C Leads to Absence of Reactive Gliosis and Promotes Anti-inflammatory Cytokine Expression in an Autoimmune Glaucoma Mouse Model

1
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Efficiency of the four proteasome subtypes to degrade ubiquitinated or oxidized proteins

1
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Generation of stress fibers through myosin-driven reorganization of the actin cortex

1
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Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration

1
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The ER-embedded UBE2J1/RNF26 ubiquitylation complex exerts spatiotemporal control over the endolysosomal pathway

1
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Increased demand for NAD+ relative to ATP drives aerobic glycolysis

1
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The ubiquitin ligase RFWD3 is required for translesion DNA synthesis

1
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Neutrophil infiltration regulates clock-gene expression to organize daily hepatic metabolism

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MASTL promotes cell contractility and motility through kinase-independent signaling

1
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  DOI: 10.1083/jcb.201906204
  
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BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in Mitosis

1
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elifesciences.org elifesciences.org

GTPBP1 resolves paused ribosomes to maintain neuronal homeostasis

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Coxsackievirus B Type 4 Infection in β Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing

1
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Gene therapy with secreted acid alpha-glucosidase rescues Pompe disease in a novel mouse model with early-onset spinal cord and respiratory defects

1
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Sep 2020
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Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas

1
1. scibot 30 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.108196
  
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Telophase correction refines division orientation in stratified epithelia

1
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  DOI: 10.7554/eLife.49249
  
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Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness

1
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Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons

1
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Evidence That STK19 Is Not an NRAS-dependent Melanoma Driver

1
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Melanoblast transcriptome analysis reveals pathways promoting melanoma metastasis

1
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Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

1
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PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin

2
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2. scibot 07 Sep 2020
  
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Regulation of the RNAPII Pool Is Integral to the DNA Damage Response

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FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function

1
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Doublecortin like kinase 1 regulates α-Synuclein levels and toxicity

1
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  DOI: 10.1523/JNEUROSCI.1076-19.2019
  
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Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense-Mediated Decay as Modifiers of ALS/FTD C9orf72 Toxicity

1
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Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription

1
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Sensing Actin Dynamics through Adherens Junctions

1
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  DOI: 10.1016/j.celrep.2020.01.106
  
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onlinelibrary.wiley.com onlinelibrary.wiley.com

Next‐generation sequencing reveals a novel role of lysine‐specific demethylase 1 in adhesion of rhabdomyosarcoma cells

1
1. scibot 04 Sep 2020
  
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  mouse anti‐Vinculin
  
  DOI: 10.1002/ijc.32806
  
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onlinelibrary.wiley.com/doi/10.1002/ijc.32806
clincancerres.aacrjournals.org clincancerres.aacrjournals.org

RABL6A is an essential driver of MPNSTs that negatively regulates the RB1 pathway and sensitizes tumor cells to CDK4/6 inhibitors

1
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  vinculin
  
  DOI: 10.1158/1078-0432.CCR-19-2706
  
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clincancerres.aacrjournals.org/content/26/12/2997
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The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks

1
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  DOI: 10.1016/j.celrep.2019.12.067
  
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ATR expands embryonic stem cell fate potential in response to replication stress

1
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  DOI: 10.7554/eLife.54756
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7067586/
Jan 2020
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Suppression of p16 Induces mTORC1-Mediated Nucleotide Metabolic Reprogramming

1
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Murine maternal dietary restriction affects neural Humanin expression and cellular profile

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Talin-mediated force transmission and talin rod domain unfolding independently regulate adhesion signaling

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The SUMO Isopeptidase SENP6 Functions as a Rheostat of Chromatin Residency in Genome Maintenance and Chromosome Dynamics

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Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling

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PAK4 Kinase Activity Plays a Crucial Role in the Podosome Ring of Myeloid Cells

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Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation

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Neurexophilin4 is a selectively expressed α-neurexin ligand that modulates specific cerebellar synapses and motor functions

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A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

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Circulating blood cellular glucose transporters – Surrogate biomarkers for neonatal hypoxic ischemic encephalopathy assessed by novel scoring systems

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The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes

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Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

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Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability

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Shortening the Half-Life of Cas9 Maintains Its Gene Editing Ability and Reduces Neuronal Toxicity

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MYC status as a determinant of synergistic response to Olaparib and Palbociclib in ovarian cancer

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Modulation of DNA Repair Systems in Blind Cavefish during Evolution in Constant Darkness

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Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody

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Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

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Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

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A Systematic p53 Mutation Library Links Differential Functional Impact to Cancer Mutation Pattern and Evolutionary Conservation

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An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential

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Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns

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c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling

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Untitled document

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ATXN1-CIC Complex Is the Primary Driver of Cerebellar Pathology in Spinocerebellar Ataxia Type 1 through a Gain-of-Function Mechanism

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Untitled document

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Untitled document

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Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions

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Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions

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mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis

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As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid

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Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers

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Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth.

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Nov 2017
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Carbon Black Nanoparticles Inhibit Aromatase Expression and Estradiol Secretion in Human Granulosa Cells Through the ERK1/2 Pathway

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Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

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Calpain-Mediated Proteolysis of Talin and FAK Regulates Adhesion Dynamics Necessary for Axon Guidance

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The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling

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Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules

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Crosstalk between CLCb/Dyn1-Mediated Adaptive Clathrin-Mediated Endocytosis and Epidermal Growth Factor Receptor Signaling Increases Metastasis

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Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores

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Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores

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Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model

1
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