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    Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages
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    sciencedirect.com/science/article/pii/S1074761324001419
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    A validation strategy to assess the role of phase separation as a determinant of macromolecular localization
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  4. Apr 2024
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    Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates
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    Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator
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    ncbi.nlm.nih.gov/pmc/articles/PMC10983002/
  7. Mar 2024
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    Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1535610824000795
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    First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure
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    A surge in cytoplasmic viscosity triggers nuclear remodeling required for Dux silencing and pre-implantation embryo development
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    INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors
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    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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    SARS-CoV-2 targets ribosomal RNA biogenesis
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    sciencedirect.com/science/article/pii/S2211124724002195
  14. Feb 2024
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    Selective DNA-PK inhibition enhances chemotherapy and ionizing radiation activity in soft-tissue sarcomas
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    aacrjournals.org/clincancerres/article/30/3/629/733549/Selective-DNA-PK-Inhibition-Enhances-Chemotherapy
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    YAP mediates apoptosis through failed integrin adhesion reinforcement
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    sciencedirect.com/science/article/pii/S2211124724001396
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    Cell-type-specific expression of tRNAs in the brain regulates cellular homeostasis
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    PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
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    RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling
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    The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation
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    Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo
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    Annexin A2 modulates phospholipid membrane composition upstream of Arp2 to control angiogenic sprout initiation
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    PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
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    Targeting BET proteins downregulates miR-33a to promote synergy with PIM inhibitors in CMML
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    β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
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    SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
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  28. Jan 2024
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    IP3RPEP6, a novel peptide inhibitor of IP3 receptor channels that does not affect connexin-43 hemichannels
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      DOI: 10.1111/apha.14086

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    Epigenetic regulator RNF20 underlies temporal hierarchy of gene expression to regulate postnatal cardiomyocyte polarization
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    MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
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    RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling
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    PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression
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    Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants
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    Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres
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    Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma
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    Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate
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  38. Dec 2023
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    Phosphoprotein dynamics of interacting T cells and tumor cells by HySic
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    sciencedirect.com/science/article/pii/S2211124723016108
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    MEK-inhibitors decrease Nfix in muscular dystrophy but induce unexpected calcifications, partially rescued with Cyanidin diet
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    Ethanol induces replication fork stalling and membrane stress in immortalized laryngeal cells
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    Peripheral 5-HT/HTR6 axis is responsible for obesity-associated hypertension
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    Cell stretching activates an ATM mechano-transduction pathway that remodels cytoskeleton and chromatin
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    Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines
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      DOI: 10.1158/0008-5472.CAN-22-2316

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  45. Nov 2023
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    Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1
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    Dual agonistic and antagonistic roles of ZC3H18 provide for co-activation of distinct nuclear RNA decay pathways
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  70. Jun 2023
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    Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2
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    MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma
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    AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
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    Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p.G23V
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    Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V
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    Identifying constitutive and context-specific molecular-tension-sensitive protein recruitment within focal adhesions
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    Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
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    Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer
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    Triap1 upregulation promotes escape from mitotic-slippage-induced G1 arrest
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      DOI: 10.1016/j.celrep.2023.112215

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  94. www.sciencedirect.com www.sciencedirect.com
    Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut
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      RRID:AB_477

      DOI: 10.1016/j.immuni.2023.02.018

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  95. www.sciencedirect.com www.sciencedirect.com
    Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
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    sciencedirect.com/science/article/pii/S1550413123000499
  96. Feb 2023
  97. www.sciencedirect.com www.sciencedirect.com
    Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers
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      DOI: 10.1016/j.isci.2023.106090

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  98. www.sciencedirect.com www.sciencedirect.com
    An adverse tumor-protective effect of IDO1 inhibition
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  99. www.sciencedirect.com www.sciencedirect.com
    CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance
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      DOI: 10.1016/j.ccell.2023.01.007

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  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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      DOI: 10.1016/j.celrep.2023.112076

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  101. Jan 2023
  102. www.sciencedirect.com www.sciencedirect.com
    MDC1 maintains active elongation complexes of RNA polymerase II
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  103. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
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      DOI: 10.1158/2159-8290.CD-22-0489

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  104. www.sciencedirect.com www.sciencedirect.com
    Evolutionarily conserved regulators of tau identify targets for new therapies
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      DOI: 10.1016/j.neuron.2022.12.012

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  105. Dec 2022
  106. www.mdpi.com www.mdpi.com
    Concentration Dependent Effect of Quaternary Amines on the Adhesion of U251-MG Cells
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      DOI: 10.3390/gels8120827

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  107. Nov 2022
  108. www.sciencedirect.com www.sciencedirect.com
    Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer
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  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection
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      DOI: 10.1084/jem.20220837

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  110. Oct 2022
  111. www.science.org www.science.org
    Ketogenic diet uncovers differential metabolic plasticity of brain cells
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      DOI: 10.1126/sciadv.abo7639

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  112. www.sciencedirect.com www.sciencedirect.com
    Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy
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    A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1
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  114. Sep 2022
  115. www.embopress.org www.embopress.org
    Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
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      DOI: 10.15252/embr.202154136

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  116. www.sciencedirect.com www.sciencedirect.com
    Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
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      DOI: 10.1016/j.ccell.2022.08.016

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  117. www.sciencedirect.com www.sciencedirect.com
    Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
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      DOI: 10.1016/j.celrep.2022.111396

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  118. www.sciencedirect.com www.sciencedirect.com
    Filopodial adhesive force in discrete nodes revealed by integrin molecular tension imaging
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      DOI: 10.1016/j.cub.2022.08.040

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  119. www.sciencedirect.com www.sciencedirect.com
    Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation
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      DOI: 10.1016/j.molcel.2022.08.012

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    sciencedirect.com/science/article/pii/S1097276522007973
  120. Aug 2022
  121. www.science.org www.science.org
    Functional and biological heterogeneity of KRASQ61 mutations
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      DOI: 10.1126/scisignal.abn2694

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  122. www.sciencedirect.com www.sciencedirect.com
    De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
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    sciencedirect.com/science/article/pii/S1535610822003245
  123. Jul 2022
  124. www.sciencedirect.com www.sciencedirect.com
    Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover
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      DOI: 10.1016/j.devcel.2022.06.011

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  125. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aberrant expression and subcellular localization of ECT2 drives colorectal cancer progression and growth
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      DOI: 10.1158/0008-5472.CAN-20-4218

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  126. Jun 2022
  127. www.sciencedirect.com www.sciencedirect.com
    An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
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    Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis
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  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2
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      DOI: 10.3389/fcell.2022.886527

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  130. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion
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      DOI: 10.1111/jnc.15622

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  131. www.sciencedirect.com www.sciencedirect.com
    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
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  132. May 2022
  133. www.sciencedirect.com www.sciencedirect.com
    Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception
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  134. www.sciencedirect.com www.sciencedirect.com
    DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism
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    Nde1 is required for heterochromatin compaction and stability in neocortical neurons
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  136. www.sciencedirect.com www.sciencedirect.com
    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
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    The oocyte spindle midzone pauses Cdk1 inactivation during fertilization to enable male pronuclear formation and embryo development
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  138. Apr 2022
  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A superior loading control for the cellular thermal shift assay
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      DOI: 10.1038/s41598-022-10653-7

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  140. www.sciencedirect.com www.sciencedirect.com
    Rab33b-exocyst interaction mediates localized secretion for focal adhesion turnover and cell migration
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  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reduction of Nuak1 decreases tau and reverses phenotypes in a tauopathy mouse model
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      DOI: 10.1016/j.neuron.2016.09.022

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  142. www.sciencedirect.com www.sciencedirect.com
    Lockdown, a selective small-molecule inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion
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    Vinculin controls endothelial cell junction dynamics during vascular lumen formation
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      DOI: 10.1016/j.celrep.2022.110658

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  144. academic.oup.com academic.oup.com
    Adipose Mitochondrial Complex I Deficiency Modulates Inflammation and Glucose Homeostasis in a Sex-Dependent Manner
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      DOI: 10.1210/endocr/bqac018

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  145. Mar 2022
  146. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Mechanical regulation of oligodendrocyte morphology and maturation by the mechanosensor p130Cas
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      DOI: 10.1111/jnc.14657

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  147. www.sciencedirect.com www.sciencedirect.com
    Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression
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    Novel cellular mechanism that mediates the collecting duct formation during postnatal renal development
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  149. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Cardiomyocyte substructure reverts to an immature phenotype during heart failure
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  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
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    Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier
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    Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness
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  153. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Crosstalk between ERK and MRTF-A signaling regulates TGFβ1-induced epithelial-mesenchymal transition
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    Proteome-centric cross-omics characterization and integrated network analyses of triple-negative breast cancer
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  155. Feb 2022
  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma
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  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    5-FU blocks shuttling of HuR mediated by PKCδ in gastric cancer cells
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  158. www.sciencedirect.com www.sciencedirect.com
    Heat shock induces premature transcript termination and reconfigures the human transcriptome
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  159. Jan 2022
  160. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Genomic variants reducing expression of two endocytic receptors in 46,XY differences of sex development
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    WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity
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    GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis
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  163. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Platelet rich plasma affects gap junctional features in myofibroblasts in vitro via Vascular Endothelial Growth Factor (VEGF)-A/VEGF receptor
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  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance
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  165. Dec 2021
  166. www.science.org www.science.org
    Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance
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  167. www.sciencedirect.com www.sciencedirect.com
    Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1
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    Galectin-9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin-dependent manner
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      DOI: 10.1096/fj.202100832R

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  169. www.sciencedirect.com www.sciencedirect.com
    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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  170. Nov 2021
  171. www.cell.com www.cell.com
    MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts
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    A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
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    Developmental defects in Huntington’s disease show that axonal growth and microtubule reorganization require NUMA1
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  174. www.nature.com www.nature.com
    AKIRIN2 controls the nuclear import of proteasomes in vertebrates
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  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma
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  176. www.sciencedirect.com www.sciencedirect.com
    Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis
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    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
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    Protocol for the assessment of mTOR activity in mouse primary hepatocytes
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  179. Oct 2021
  180. www.sciencedirect.com www.sciencedirect.com
    Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues
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    A viral histone-like protein exploits antagonism between linker histones and HMGB proteins to obstruct the cell cycle
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    Biosensors based on peptide exposure show single molecule conformations in live cells
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    Proteome-wide mapping of short-lived proteins in human cells
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    Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
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    SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling
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  186. Sep 2021
  187. www.sciencedirect.com www.sciencedirect.com
    Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion
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    REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
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  189. Aug 2021
  190. www.sciencedirect.com www.sciencedirect.com
    The Amot/integrin protein complex transmits mechanical forces required for vascular expansion
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  191. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1
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    CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance
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  193. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SCAF4 and SCAF8, mRNA Anti-Terminator Proteins
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  194. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  195. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  198. www.mdpi.com www.mdpi.com
    The P2X7 Receptor Stimulates IL-6 Release from Pancreatic Stellate Cells and Tocilizumab Prevents Activation of STAT3 in Pancreatic Cancer Cells
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  199. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    Molecular basis for substrate recruitment to the PRMT5 methylosome
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    Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy
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    ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma
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  205. Jul 2021
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    Neural Deletion of Glucose Transporter Isoform 3 Creates Distinct Postnatal and Adult Neurobehavioral Phenotypes
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    Structural Basis of Paxillin Recruitment by Kindlin-2 in Regulating Cell Adhesion
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      Monoclonal Anti-Vinculin antibody produced in mouse

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    Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity
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      Mouse polyclonal anti Vinculin

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  210. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The heat shock protein amplifier arimoclomol improves refolding, maturation and lysosomal activity of glucocerebrosidase
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    CRISPR-induced RASGAP deficiencies in colorectal cancer organoids reveal that only loss of NF1 promotes resistance to EGFR inhibition
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    De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma
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  214. www.cell.com www.cell.com
    Transcription-mediated supercoiling regulates genome folding and loop formation
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    FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates
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    Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination
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    Identification of a class of non-conventional ER-stress-response-derived immunogenic peptides
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    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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    Translation stress and collided ribosomes are co-activators of cGAS
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    Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function
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  223. May 2021
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    Loss of Ambra1 promotes melanoma growth and invasion
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    The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake
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    AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation
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    Hydrogel Network Dynamics Regulate Vascular Morphogenesis
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    Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension
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    A comprehensive phenotypic CRISPR-Cas9 screen of the ubiquitin pathway uncovers roles of ubiquitin ligases in mitosis
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    Ubiquitylation of MYC couples transcription elongation with double-strand break repair at active promoters
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    The Nuclear SUMO-Targeted Ubiquitin Quality Control Network Regulates the Dynamics of Cytoplasmic Stress Granules
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    Mechanical instability of adherens junctions overrides intrinsic quiescence of hair follicle stem cells
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