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Epigenetic modulation of BARD1 to enhance anti-VEGF therapy

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1. scibot 04 Sep 2025
  
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  DOI: 10.1016/j.xcrm.2025.102329
  
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sciencedirect.com/science/article/pii/S2666379125004021
Aug 2025
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Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer

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1. scibot 27 Aug 2025
  
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  DOI: 10.1016/j.devcel.2025.07.023
  
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SOX4-ZIP14-zinc metabolism mediates oncogenesis and suppresses T cell immunity in nasopharyngeal carcinoma

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1. scibot 19 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102300
  
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cell.com/cell-reports-medicine/abstract/S2666-3791(25)00373-8
Jul 2025
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Nitrogen metabolism profiling reveals cell state-specific pyrimidine synthesis pathway choice

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1. scibot 30 Jul 2025
  
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  DOI: 10.1101/2025.07.23.666448
  
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biorxiv.org/content/10.1101/2025.07.23.666448v1
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Cancer immunology data engine reveals secreted AOAH as a potential immunotherapy

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  DOI: 10.1016/j.cell.2025.07.004
  
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sciencedirect.com/science/article/pii/S0092867425007937
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Loss of Predicted Cell Adhesion Molecule MPZL3 Promotes EMT in Ovarian Cancer

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  DOI: 10.1158/2767-9764.CRC-24-0591
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12277487/
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An in vivo screen identifies NAT10 as a master regulator of brain metastasis

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1. scibot 25 Jul 2025
  
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  DOI: 10.1126/sciadv.ads6021
  
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HIF-independent oxygen sensing via KDM6A regulates ferroptosis

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.molcel.2025.07.001
  
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β-catenin functions as a molecular adapter for disordered cBAF interactions

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1. scibot 22 Jul 2025
  
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  DOI: 10.1016/j.molcel.2025.06.026
  
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A mechanistic basis of fast myofiber vulnerability to neuromuscular diseases

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1. scibot 09 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115959
  
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sciencedirect.com/science/article/pii/S2211124725007302
Jun 2025
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1-s2.0-S2589004225012349-main-html.html

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1. scibot 25 Jun 2025
  
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  DOI: 10.1016/j.isci.2025.112973
  
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52.53.155.43/10837dffa25b0941ec8baff34deb4bca4e90e942/1-s2.0-S2589004225012349-main-html.html
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Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes

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1. scibot 24 Jun 2025
  
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  DOI: 10.1038/s41418-025-01532-5
  
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nature.com/articles/s41418-025-01532-5
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Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

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1. scibot 18 Jun 2025
  
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  DOI: 10.1101/2025.05.17.654676
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12139833/
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The immunoproteasome disturbs neuronal metabolism and drives neurodegeneration in multiple sclerosis

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1. scibot 18 Jun 2025
  
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  DOI: 10.1016/j.cell.2025.05.029
  
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CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance

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1. scibot 14 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.04.006
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12240685/
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DPP8/9 processing of human AK2 unmasks an IAP binding motif

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1. scibot 13 Jun 2025
  
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  DOI: 10.1038/s44319-025-00455-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12152192/
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RNA shielding of P65 is required to potentiate oncogenic inflammation in TET2 mutated clonal hematopoiesis

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1. scibot 11 Jun 2025
  
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  DOI: 10.1158/2159-8290.CD-24-0093
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11611684/
May 2025
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IMPDH inhibition induces DNA replication stress and ATR sensitivity in Merkel cell carcinoma

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.isci.2025.112567
  
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sciencedirect.com/science/article/pii/S2589004225008284
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1. scibot 20 May 2025
  
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  DOI: 10.1101/2025.04.30.651453
  
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52.53.155.43/dd3c8f74e9cdc1e420d33be7f8443dfa69ebea7a/PDF-html.html
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Mechanobiological mechanism of cyclic stretch-induced cell columnarization

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115662
  
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sciencedirect.com/science/article/pii/S2211124725004334
Apr 2025
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Downregulation of rRNA synthesis by BCL-2 induces chemoresistance in diffuse large B cell lymphoma

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1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.isci.2025.112333
  
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Alpha-Synuclein Phosphomimetic Y39E and S129D Knock-In Mice Show Cytosolic Alpha-Synuclein Localization without Developing Neurodegeneration or Motor Deficits

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1. scibot 19 Apr 2025
  
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  DOI: 10.1523/ENEURO.0357-24.2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11998964/
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PPARγ-dependent remodeling of translational machinery in adipose progenitors is impaired in obesity

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1. scibot 18 Apr 2025
  
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  DOI: 10.1016/j.celrep.2024.114945
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12002411/
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1. scibot 10 Apr 2025
  
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  DOI: 10.1158/1541-7786.mcr-24-0957
  
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52.53.155.43/009f5d6e39c430064ce0b832cf798a7e9caafb80/PDF-html.html
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  DOI: 10.1523/eneuro.0357-24.2025
  
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52.53.155.43/6343470ab662b00750e766dae62c29226c242386/PDF-html.html
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Genetically encoded reporters of actin filament organization in living cells and tissues

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1. scibot 03 Apr 2025
  
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  DOI: 10.1016/j.cell.2025.03.003
  
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Mar 2025
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TDP-43 seeding induces cytoplasmic aggregation heterogeneity and nuclear loss of function of TDP-43

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.neuron.2025.03.004
  
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An in vivo screen identifies NAT10 as a master regulator of brain metastasis

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1. scibot 28 Mar 2025
  
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  DOI: 10.1126/sciadv.ads6021
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11939035/
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Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth

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  DOI: 10.1016/j.celrep.2025.115470
  
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Distinctive CD8+ T cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells

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  DOI: 10.1016/j.celrep.2025.115413
  
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Dependence on Mdm2 for Mdm4 inhibition of p53 activity

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1. scibot 13 Mar 2025
  
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  DOI: 10.1016/j.canlet.2025.217622
  
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sciencedirect.com/science/article/pii/S0304383525001867
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Luminescent sensing of conformational integrin activation in living cells

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1. scibot 01 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115319
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11861568/
Feb 2025
52.53.155.43 52.53.155.43

1-s2.0-S258900422500327X-main (1)-html.html

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1. scibot 25 Feb 2025
  
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  DOI: 10.1016/j.isci.2025.112067
  
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52.53.155.43/3cbb3584cae961877f8ec4cdabce6ca1f7e3aaf6/1-s2.0-S258900422500327X-main (1)-html.html
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Canonical and non-canonical PRC1 differentially contribute to regulation of neural stem cell fate

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1. scibot 15 Feb 2025
  
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  DOI: 10.26508/lsa.202403006
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11814486/
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Vimentin intermediate filaments coordinate actin stress fibers and podosomes to determine the extracellular matrix degradation by macrophages

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1. scibot 14 Feb 2025
  
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  DOI: 10.1016/j.devcel.2025.01.016
  
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sciencedirect.com/science/article/pii/S153458072500036X
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Lactate controls cancer stemness and plasticity through epigenetic regulation

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1. scibot 14 Feb 2025
  
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  DOI: 10.1016/j.cmet.2025.01.002
  
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GDF-15 predicts epithelioid hemangioendothelioma aggressiveness and is down-regulated by sirolimus through ATF4/ATF5 suppression

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USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation

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G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration

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Cytoplasmic mRNA decay controlling inflammatory gene expression is determined by pre-mRNA fate decision

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Coordination of Focal Adhesion Nanoarchitecture and Dynamics in Mechanosensing for Cardiomyoblast Differentiation

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Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis

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  DOI: 10.7554/eLife.95842
  
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Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state

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  DOI: 10.1038/s41418-024-01439-7
  
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Acute MeCP2 loss in adult mice reveals transcriptional and chromatin changes that precede neurological dysfunction and inform pathogenesis

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CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription

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Identification of suitable target/E3 ligase pairs for PROTAC development using a rapamycin-induced proximity assay (RiPA)

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STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair

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Autophagy-dependent splicing control directs translation toward inflammation during senescence

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Redundant pathways for removal of defective RNA polymerase II complexes at a promoter-proximal pause checkpoint

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A multivalent adaptor mechanism drives the nuclear import of proteasomes

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A functional connection between the Microprocessor and a variant NEXT complex

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Protocol for validating liquid-liquid phase separation as a driver of membraneless organelle assembly in vitro and in human cells

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RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation

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Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application

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Sep 2024
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Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels

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  DOI: 10.1093/hmg/ddae135
  
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Saturation mutagenesis-reinforced functional assays for disease-related genes

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Androgens Suppress Corticosteroid Binding Globulin in Male Mice, Affecting the Endocrine Stress Response

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  DOI: 10.1210/endocr/bqae119
  
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Cancer cell stiffening via CoQ10 and UBIAD1 regulates ECM signaling and ferroptosis in breast cancer

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Dynamic remodeling of Septin structures fine-tunes myogenic differentiation

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MYC Induces Oncogenic Stress through RNA Decay and Ribonucleotide Catabolism in Breast Cancer

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PlexinB1 Inactivation Reprograms Immune Cells in the Tumor Microenvironment, Inhibiting Breast Cancer Growth and Metastatic Dissemination

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Aldehydes alter TGF-β signaling and induce obesity and cancer

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Aug 2024
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Inhibition of bromodomain and extra-terminal proteins targets constitutively active NFκB and STAT signaling in lymphoma and influences the expression of the antiapoptotic proteins BCL2A1 and c-MYC

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Association with TFIIIC limits MYCN localisation in hubs of active promoters and chromatin accumulation of non-phosphorylated RNA polymerase II

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RAD51 protects abasic sites to prevent replication fork breakage

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RPL22 is a tumor suppressor in MSI-high cancers and a splicing regulator of MDM4

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Protocol for establishing inducible CRISPRd system for blocking transcription factor-binding sites in human pluripotent stem cells

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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

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  DOI: 10.1126/science.adk0775
  
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Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer

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A molecular pathway for cancer cachexia-induced muscle atrophy revealed at single-nucleus resolution

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Phosphorylation of H3-Thr3 by Haspin Is Required for Primary Cilia Regulation

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  DOI: 10.3390/ijms22147753
  
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Untitled document

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  DOI: 10.1038/s41419-017-0201-6
  
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Retinal pigment epithelial integrity is compromised in the developing albino mouse retina

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  DOI: 10.1002/cne.24025
  
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ATAD1 prevents clogging of TOM and damage caused by un-imported mitochondrial proteins

1
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Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer

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Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers

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  DOI: 10.1126/science.adk0775
  
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Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer

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PP2A-B55 phosphatase counteracts Ki-67-dependent chromosome individualization during mitosis

1
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Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

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Acetyl-NPKY of Integrin-beta 1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity.

1
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STING orchestrates the neuronal inflammatory stress response in multiple sclerosis

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Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation

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The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress

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Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer

1
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  DOI: 10.1158/0008-5472.CAN-23-0519
  
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IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy

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Targeting MCL1-driven anti-apoptotic pathways overcomes blast progression after hypomethylating agent failure in chronic myelomonocytic leukemia

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  DOI: 10.1016/j.xcrm.2024.101585
  
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A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1

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The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex

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Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB

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Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages

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A validation strategy to assess the role of phase separation as a determinant of macromolecular localization

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Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates

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Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator

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  DOI: 10.1021/acs.jmedchem.3c02245
  
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Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer

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First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure

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A surge in cytoplasmic viscosity triggers nuclear remodeling required for Dux silencing and pre-implantation embryo development

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INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors

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  DOI: 10.1158/2159-8290.CD-23-0954
  
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RTF2 controls replication repriming and ribonucleotide excision at the replisome

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SARS-CoV-2 targets ribosomal RNA biogenesis

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Feb 2024
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cd-23-0954-html.html

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Selective DNA-PK inhibition enhances chemotherapy and ionizing radiation activity in soft-tissue sarcomas

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YAP mediates apoptosis through failed integrin adhesion reinforcement

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Cell-type-specific expression of tRNAs in the brain regulates cellular homeostasis

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  DOI: 10.1016/j.neuron.2024.01.028
  
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PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma

1
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  RRID:AB_477629
  
  DOI: 10.1038/s41467-024-45760-8
  
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RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling

1
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  RRID AB_477629
  
  DOI: 10.1126/scisignal.adg5289
  
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The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation

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  DOI: 10.1016/j.celrep.2024.113792
  
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Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo

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  DOI: 10.1126/sciadv.adk1835
  
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Annexin A2 modulates phospholipid membrane composition upstream of Arp2 to control angiogenic sprout initiation

1
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  DOI: 10.1096/fj.202201088R
  
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PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression

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  DOI: 10.1016/j.cmet.2024.01.006
  
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Targeting BET proteins downregulates miR-33a to promote synergy with PIM inhibitors in CMML

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  DOI: 10.1158/1078-0432.CCR-22-3929
  
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β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models

1
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  DOI: 10.1016/j.biopha.2024.116217
  
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SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion

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  DOI: 10.1016/j.cell.2024.01.008
  
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Jan 2024
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IP3RPEP6, a novel peptide inhibitor of IP3 receptor channels that does not affect connexin-43 hemichannels

1
1. scibot 26 Jan 2024
  
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  RRID:AB_477629
  
  DOI: 10.1111/apha.14086
  
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Epigenetic regulator RNF20 underlies temporal hierarchy of gene expression to regulate postnatal cardiomyocyte polarization

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  DOI: 10.1016/j.celrep.2023.113416
  
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MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension

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  DOI: 10.1126/sciadv.adk6524
  
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RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling

1
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  RRID:AB_477629
  
  DOI: 10.1126/scisignal.adg5289
  
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PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression

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  DOI: 10.1016/j.devcel.2023.12.015
  
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Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants

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  DOI: 10.1158/0008-5472.CAN-22-3464
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10524763/
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Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres

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  RRID:AB_477629
  
  DOI: 10.1016/j.isci.2023.108655
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10783591/
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Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma

1
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  DOI: 10.1016/j.molcel.2023.12.010
  
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Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate

1
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  RRID:AB_477629
  
  DOI: 10.1016/j.molcel.2023.12.007
  
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Dec 2023
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Phosphoprotein dynamics of interacting T cells and tumor cells by HySic

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  RRID:AB_477629
  
  DOI: 10.1016/j.celrep.2023.113598
  
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MEK-inhibitors decrease Nfix in muscular dystrophy but induce unexpected calcifications, partially rescued with Cyanidin diet

1
1. scibot 22 Dec 2023
  
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  RRID:AB_477629
  
  DOI: 10.1016/j.isci.2023.108696
  
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Ethanol induces replication fork stalling and membrane stress in immortalized laryngeal cells

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  RRID:AB_477629
  
  DOI: 10.1016/j.isci.2023.108564
  
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Peripheral 5-HT/HTR6 axis is responsible for obesity-associated hypertension

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  RRID:AB_477629
  
  DOI: 10.1016/j.bbamcr.2023.119651
  
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Cell stretching activates an ATM mechano-transduction pathway that remodels cytoskeleton and chromatin

1
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  DOI: 10.1016/j.celrep.2023.113555
  
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Hypoxia potentiates the inflammatory fibroblast phenotype promoted by pancreatic cancer cell-derived cytokines

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  DOI: 10.1158/0008-5472.CAN-22-2316
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10658995/
Nov 2023
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Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies

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  DOI: 10.1016/j.ccell.2023.11.001
  
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Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1

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  RRID:AB_477629
  
  DOI: 10.1016/j.xcrm.2023.101282
  
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Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence

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  DOI: 10.1016/j.celrep.2023.113381
  
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Oct 2023
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Lactate activates the mitochondrial electron transport chain independently of its metabolism

1
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  DOI: 10.1016/j.molcel.2023.09.034
  
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β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4

1
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  RRID:AB_477629
  
  DOI: 10.1016/j.celrep.2023.113322
  
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Dual agonistic and antagonistic roles of ZC3H18 provide for co-activation of distinct nuclear RNA decay pathways

1
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  DOI: 10.1016/j.celrep.2023.113325
  
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CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression

1
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  DOI: 10.1016/j.cmet.2023.09.012
  
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cell.com/cell-metabolism/fulltext/S1550-4131(23)00368-6
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A Haspin-ARHGAP11A axis regulates epithelial morphogenesis through Rho-ROCK dependent modulation of LIMK1-Cofilin

1
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  DOI: 10.1016/j.isci.2023.108011
  
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Linear ubiquitination at damaged lysosomes induces local NF-κB activation and controls cell survival

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  DOI: 10.1101/2023.10.06.560832
  
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biorxiv.org/content/10.1101/2023.10.06.560832v1
Sep 2023
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CD44 correlates with longevity and enhances basal ATF6 activity and ER stress resistance

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  DOI: 10.1016/j.celrep.2023.113130
  
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Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation

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  DOI: 10.1016/j.celrep.2023.113079
  
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cell.com/cell-reports/fulltext/S2211-1247(23)01090-2
Aug 2023
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GSK3 and lamellipodin balance lamellipodial protrusions and focal adhesion maturation in mouse neural crest migration

1
1. scibot 27 Aug 2023
  
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Coalescent RNA-localizing and transcriptional activities of SAM68 modulate adhesion and subendothelial basement membrane assembly

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  DOI: 10.7554/eLife.85165
  
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CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis

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Coexisting cancer stem cells with heterogeneous gene amplifications, transcriptional profiles, and malignancy are isolated from single glioblastomas

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Thymine DNA glycosylase regulates cell-cycle-driven p53 transcriptional control in pluripotent cells

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Regulation of VKORC1L1 is critical for p53-mediated tumor suppression through vitamin K metabolism

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The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2

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Sphingosine 1-phosphate elicits a ROS-mediated proinflammatory response in human endometrial stromal cells via ERK5 activation

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  DOI: 10.1096/fj.202300323R
  
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IFITM1 inhibits trophoblast invasion and is induced in placentas associated with IFN-mediated pregnancy diseases

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Jun 2023
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can-22-3464-html.html

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  DOI: 10.1158/0008-5472.can-22-3464
  
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Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2

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MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma

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Oncogenic IDH mutations increase heterochromatin-related replication stress without impacting homologous recombination

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(R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers

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Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity

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Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones

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May 2023
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AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells

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Metamorphic proteins at the basis of human autophagy initiation and lipid transfer

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Ubiquitin-independent proteasomal degradation driven by C-degron pathways

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Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease

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  DOI: 10.1038/s41467-023-38165-6
  
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Adherens junctions stimulate and spatially guide integrin activation and extracellular matrix deposition

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RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition

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Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p.G23V

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Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V

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A tissue injury sensing and repair pathway distinct from host pathogen defense

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Identifying constitutive and context-specific molecular-tension-sensitive protein recruitment within focal adhesions

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Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy

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  DOI: 10.1038/s41467-023-37617-3
  
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Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

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Mar 2023
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Triap1 upregulation promotes escape from mitotic-slippage-induced G1 arrest

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Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut

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Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity

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Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers

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An adverse tumor-protective effect of IDO1 inhibition

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CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance

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CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication

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Jan 2023
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MDC1 maintains active elongation complexes of RNA polymerase II

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  DOI: 10.1016/j.celrep.2022.111979
  
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Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers

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  DOI: 10.1158/2159-8290.CD-22-0489
  
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Evolutionarily conserved regulators of tau identify targets for new therapies

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  DOI: 10.1016/j.neuron.2022.12.012
  
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Concentration Dependent Effect of Quaternary Amines on the Adhesion of U251-MG Cells

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  DOI: 10.3390/gels8120827
  
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Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer

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  DOI: 10.1016/j.xcrm.2022.100815
  
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P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

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  DOI: 10.1084/jem.20220837
  
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Oct 2022
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Ketogenic diet uncovers differential metabolic plasticity of brain cells

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  DOI: 10.1126/sciadv.abo7639
  
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  DOI: 10.1126/sciadv.abo7639
  
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Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy

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  DOI: 10.1016/j.cmet.2022.09.021
  
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A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1

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  DOI: 10.1016/j.celrep.2022.111475
  
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Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair

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  DOI: 10.15252/embr.202154136
  
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Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses

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Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors

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Filopodial adhesive force in discrete nodes revealed by integrin molecular tension imaging

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  DOI: 10.1016/j.cub.2022.08.040
  
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Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation

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  DOI: 10.1016/j.molcel.2022.08.012
  
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Aug 2022
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Functional and biological heterogeneity of KRASQ61 mutations

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  DOI: 10.1126/scisignal.abn2694
  
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De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma

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Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover

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  DOI: 10.1016/j.devcel.2022.06.011
  
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Aberrant expression and subcellular localization of ECT2 drives colorectal cancer progression and growth

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  DOI: 10.1158/0008-5472.CAN-20-4218
  
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Jun 2022
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An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma

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  DOI: 10.1016/j.molcel.2022.06.003
  
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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis

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Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2

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