318 Matching Annotations
  1. Jun 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acetyl-NPKY of Integrin-beta 1 binds KINDLIN2 to control endothelial cell proliferation and junctional integrity.
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    1. scibot 30 Jun 2024
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      DOI: 10.1016/j.isci.2024.110129

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    ncbi.nlm.nih.gov/pmc/articles/PMC11187247/
  3. www.sciencedirect.com www.sciencedirect.com
    STING orchestrates the neuronal inflammatory stress response in multiple sclerosis
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    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.cell.2024.05.031

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    sciencedirect.com/science/article/pii/S0092867424005762
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    Sustained generation of neurons destined for neocortex with oxidative metabolic upregulation upon filamin abrogation
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    1. scibot 21 Jun 2024
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    sciencedirect.com/science/article/pii/S258900422401424X
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    The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress
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    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.isci.2024.110196

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    sciencedirect.com/science/article/pii/S2589004224014214
  6. aacrjournals.org aacrjournals.org
    Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
    1
    1. scibot 07 Jun 2024
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      DOI: 10.1158/0008-5472.CAN-23-0519

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    aacrjournals.org/cancerres/article/84/11/1834/745520/Obesogenic-High-Fat-Diet-and-MYC-Cooperate-to
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IRX4204 Induces Senescence and Cell Death in HER2-positive Breast Cancer and Synergizes with Anti-HER2 Therapy
    1
    1. scibot 07 Jun 2024
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      DOI: 10.1158/1078-0432.CCR-23-3839

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    ncbi.nlm.nih.gov/pmc/articles/PMC11145169/
  8. May 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Targeting MCL1-driven anti-apoptotic pathways overcomes blast progression after hypomethylating agent failure in chronic myelomonocytic leukemia
    1
    1. scibot 23 May 2024
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      DOI: 10.1016/j.xcrm.2024.101585

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    sciencedirect.com/science/article/pii/S2666379124002775
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    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
    1
    1. scibot 08 May 2024
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    sciencedirect.com/science/article/pii/S1550413124001359
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    The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex
    1
    1. scibot 07 May 2024
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      DOI: 10.1016/j.molcel.2024.04.007

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    sciencedirect.com/science/article/pii/S1097276524002855
  12. Apr 2024
  13. www.sciencedirect.com www.sciencedirect.com
    Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-κB
    1
    1. scibot 26 Apr 2024
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      DOI: 10.1016/j.cell.2024.03.022

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    sciencedirect.com/science/article/pii/S0092867424003131
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    Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages
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    1. scibot 18 Apr 2024
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      DOI: 10.1016/j.immuni.2024.03.020

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    sciencedirect.com/science/article/pii/S1074761324001419
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    A validation strategy to assess the role of phase separation as a determinant of macromolecular localization
    1
    1. scibot 16 Apr 2024
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    sciencedirect.com/science/article/pii/S1097276524002673
  16. www.sciencedirect.com www.sciencedirect.com
    Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates
    2
    1. scibot 09 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114064

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      DOI: 10.1016/j.celrep.2024.114064

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    sciencedirect.com/science/article/pii/S2211124724003929
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator
    1
    1. scibot 03 Apr 2024
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      DOI: 10.1021/acs.jmedchem.3c02245

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    ncbi.nlm.nih.gov/pmc/articles/PMC10983002/
  18. Mar 2024
  19. www.sciencedirect.com www.sciencedirect.com
    Mapping functional to morphological variation reveals the basis of regional extracellular matrix subversion and nerve invasion in pancreatic cancer
    2
    1. scibot 22 Mar 2024
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      DOI: 10.1016/j.ccell.2024.02.017

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      DOI: 10.1016/j.ccell.2024.02.017

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    sciencedirect.com/science/article/pii/S1535610824000795
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    First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure
    1
    1. scibot 19 Mar 2024
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      DOI: 10.1016/j.cell.2024.02.023

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    sciencedirect.com/science/article/pii/S0092867424002253
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    A surge in cytoplasmic viscosity triggers nuclear remodeling required for Dux silencing and pre-implantation embryo development
    1
    1. scibot 14 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113917

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    sciencedirect.com/science/article/pii/S2211124724002456
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    INX-315, a selective CDK2 inhibitor, induces cell cycle arrest and senescence in solid tumors
    1
    1. scibot 06 Mar 2024
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      DOI: 10.1158/2159-8290.CD-23-0954

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    ncbi.nlm.nih.gov/pmc/articles/PMC10905675/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
    1
    1. scibot 06 Mar 2024
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      DOI: 10.1038/s41467-024-45947-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC10908796/
  24. www.sciencedirect.com www.sciencedirect.com
    SARS-CoV-2 targets ribosomal RNA biogenesis
    1
    1. scibot 05 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113891

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    sciencedirect.com/science/article/pii/S2211124724002195
  25. Feb 2024
  26. 52.53.155.43 52.53.155.43
    cd-23-0954-html.html
    1
    1. scibot 27 Feb 2024
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      DOI: 10.1158/2159-8290.cd-23-0954

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    52.53.155.43/aaf525c30ae01b53e260240fad732783dfb4bbac/cd-23-0954-html.html
  27. aacrjournals.org aacrjournals.org
    Selective DNA-PK inhibition enhances chemotherapy and ionizing radiation activity in soft-tissue sarcomas
    1
    1. scibot 23 Feb 2024
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      DOI: 10.1158/1078-0432.CCR-23-1531

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    aacrjournals.org/clincancerres/article/30/3/629/733549/Selective-DNA-PK-Inhibition-Enhances-Chemotherapy
  28. www.sciencedirect.com www.sciencedirect.com
    YAP mediates apoptosis through failed integrin adhesion reinforcement
    2
    1. scibot 23 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113811

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      DOI: 10.1016/j.celrep.2024.113811

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    sciencedirect.com/science/article/pii/S2211124724001396
  29. www.cell.com www.cell.com
    Cell-type-specific expression of tRNAs in the brain regulates cellular homeostasis
    1
    1. scibot 21 Feb 2024
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      DOI: 10.1016/j.neuron.2024.01.028

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    cell.com/neuron/fulltext/S0896-6273(24)00054-0
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma
    1
    1. scibot 21 Feb 2024
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      DOI: 10.1038/s41467-024-45760-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC10873513/
  31. www.science.org www.science.org
    RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling
    1
    1. scibot 16 Feb 2024
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      DOI: 10.1126/scisignal.adg5289

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    science.org/doi/10.1126/scisignal.adg5289
  32. www.sciencedirect.com www.sciencedirect.com
    The HIF transcription network exerts innate antiviral activity in neurons and limits brain inflammation
    1
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      DOI: 10.1016/j.celrep.2024.113792

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    sciencedirect.com/science/article/pii/S2211124724001207
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutant p53 protects triple-negative breast adenocarcinomas from ferroptosis in vivo
    1
    1. scibot 15 Feb 2024
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      DOI: 10.1126/sciadv.adk1835

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    ncbi.nlm.nih.gov/pmc/articles/PMC10866549/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Annexin A2 modulates phospholipid membrane composition upstream of Arp2 to control angiogenic sprout initiation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10586062/
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    PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression
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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting BET proteins downregulates miR-33a to promote synergy with PIM inhibitors in CMML
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      DOI: 10.1158/1078-0432.CCR-22-3929

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    ncbi.nlm.nih.gov/pmc/articles/PMC10524644/
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    β1 integrin mediates unresponsiveness to PI3Kα inhibition for radiochemosensitization of 3D HNSCC models
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    sciencedirect.com/science/article/pii/S0753332224000982
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    SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion
    1
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      DOI: 10.1016/j.cell.2024.01.008

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    sciencedirect.com/science/article/pii/S0092867424000102
  39. Jan 2024
  40. onlinelibrary.wiley.com onlinelibrary.wiley.com
    IP3RPEP6, a novel peptide inhibitor of IP3 receptor channels that does not affect connexin-43 hemichannels
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      DOI: 10.1111/apha.14086

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    onlinelibrary.wiley.com/doi/10.1111/apha.14086
  41. www.cell.com www.cell.com
    Epigenetic regulator RNF20 underlies temporal hierarchy of gene expression to regulate postnatal cardiomyocyte polarization
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      DOI: 10.1016/j.celrep.2023.113416

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    cell.com/cell-reports/abstract/S2211-1247(23)01428-6
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension
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      DOI: 10.1126/sciadv.adk6524

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    ncbi.nlm.nih.gov/pmc/articles/PMC10798563/
  43. www.science.org www.science.org
    RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling
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    science.org/doi/10.1126/scisignal.adg5289
  44. www.sciencedirect.com www.sciencedirect.com
    PCGF6 controls murine Tuft cell differentiation via H3K9me2 modification independently of Polycomb repression
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      DOI: 10.1016/j.devcel.2023.12.015

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    Unique transcriptional profiles underlie osteosarcomagenesis driven by different p53 mutants
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    Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres
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    Kinome-wide siRNA screen identifies a DCLK2-TBK1 oncogenic signaling axis in clear cell renal cell carcinoma
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    MEK-inhibitors decrease Nfix in muscular dystrophy but induce unexpected calcifications, partially rescued with Cyanidin diet
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    Ethanol induces replication fork stalling and membrane stress in immortalized laryngeal cells
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    Peripheral 5-HT/HTR6 axis is responsible for obesity-associated hypertension
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    Cell stretching activates an ATM mechano-transduction pathway that remodels cytoskeleton and chromatin
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    Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies
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    Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1
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    Lactate activates the mitochondrial electron transport chain independently of its metabolism
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    Dual agonistic and antagonistic roles of ZC3H18 provide for co-activation of distinct nuclear RNA decay pathways
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    CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression
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    A Haspin-ARHGAP11A axis regulates epithelial morphogenesis through Rho-ROCK dependent modulation of LIMK1-Cofilin
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    MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma
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    AKT activation because of PTEN loss upregulates xCT via GSK3β/NRF2, leading to inhibition of ferroptosis in PTEN-mutant tumor cells
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      DOI: 10.1016/j.molcel.2023.04.023

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  93. www.nature.com www.nature.com
    Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease
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      DOI: 10.1038/s41467-023-38165-6

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  94. www.sciencedirect.com www.sciencedirect.com
    Adherens junctions stimulate and spatially guide integrin activation and extracellular matrix deposition
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      DOI: 10.1016/j.celrep.2022.111091

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  95. aacrjournals.org aacrjournals.org
    RASGRF1 Fusions Activate Oncogenic RAS Signaling and Confer Sensitivity to MEK Inhibition
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      DOI: 10.1158/1078-0432.CCR-21-4291

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  96. www.sciencedirect.com www.sciencedirect.com
    Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p.G23V
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      DOI: 10.1016/j.scr.2023.103108

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  97. Apr 2023
  98. www.sciencedirect.com www.sciencedirect.com
    Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V
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  99. www.sciencedirect.com www.sciencedirect.com
    A tissue injury sensing and repair pathway distinct from host pathogen defense
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  100. www.sciencedirect.com www.sciencedirect.com
    Identifying constitutive and context-specific molecular-tension-sensitive protein recruitment within focal adhesions
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  101. www.nature.com www.nature.com
    Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy
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      DOI: 10.1038/s41467-023-37617-3

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  102. www.sciencedirect.com www.sciencedirect.com
    Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer
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  103. Mar 2023
  104. www.sciencedirect.com www.sciencedirect.com
    Triap1 upregulation promotes escape from mitotic-slippage-induced G1 arrest
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    Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut
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      DOI: 10.1016/j.immuni.2023.02.018

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  106. www.sciencedirect.com www.sciencedirect.com
    Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
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    sciencedirect.com/science/article/pii/S1550413123000499
  107. Feb 2023
  108. www.sciencedirect.com www.sciencedirect.com
    Actin crosslinking by α-actinin averts viscous dissipation of myosin force transmission in stress fibers
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  109. www.sciencedirect.com www.sciencedirect.com
    An adverse tumor-protective effect of IDO1 inhibition
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  110. www.sciencedirect.com www.sciencedirect.com
    CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance
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  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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      DOI: 10.1016/j.celrep.2023.112076

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  112. Jan 2023
  113. www.sciencedirect.com www.sciencedirect.com
    MDC1 maintains active elongation complexes of RNA polymerase II
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  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human Papillomavirus 42 Drives Digital Papillary Adenocarcinoma and Elicits a Germ Cell–like Program Conserved in HPV-Positive Cancers
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      DOI: 10.1158/2159-8290.CD-22-0489

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  115. www.sciencedirect.com www.sciencedirect.com
    Evolutionarily conserved regulators of tau identify targets for new therapies
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      DOI: 10.1016/j.neuron.2022.12.012

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    sciencedirect.com/science/article/pii/S0896627322010856
  116. Dec 2022
  117. www.mdpi.com www.mdpi.com
    Concentration Dependent Effect of Quaternary Amines on the Adhesion of U251-MG Cells
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      DOI: 10.3390/gels8120827

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  118. Nov 2022
  119. www.sciencedirect.com www.sciencedirect.com
    Extensive preclinical validation of combined RMC-4550 and LY3214996 supports clinical investigation for KRAS mutant pancreatic cancer
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      DOI: 10.1016/j.xcrm.2022.100815

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  120. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection
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      DOI: 10.1084/jem.20220837

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  121. Oct 2022
  122. www.science.org www.science.org
    Ketogenic diet uncovers differential metabolic plasticity of brain cells
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      DOI: 10.1126/sciadv.abo7639

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  123. www.sciencedirect.com www.sciencedirect.com
    Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy
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    A mechanical G2 checkpoint controls epithelial cell division through E-cadherin-mediated regulation of Wee1-Cdk1
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  125. Sep 2022
  126. www.embopress.org www.embopress.org
    Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair
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      DOI: 10.15252/embr.202154136

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    Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
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    Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
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    Filopodial adhesive force in discrete nodes revealed by integrin molecular tension imaging
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      DOI: 10.1016/j.cub.2022.08.040

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    Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation
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  131. Aug 2022
  132. www.science.org www.science.org
    Functional and biological heterogeneity of KRASQ61 mutations
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      DOI: 10.1126/scisignal.abn2694

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  133. www.sciencedirect.com www.sciencedirect.com
    De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma
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  134. Jul 2022
  135. www.sciencedirect.com www.sciencedirect.com
    Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover
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  136. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aberrant expression and subcellular localization of ECT2 drives colorectal cancer progression and growth
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  137. Jun 2022
  138. www.sciencedirect.com www.sciencedirect.com
    An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma
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    Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis
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  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Brevican, Neurocan, Tenascin-C, and Tenascin-R Act as Important Regulators of the Interplay Between Perineuronal Nets, Synaptic Integrity, Inhibitory Interneurons, and Otx2
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      DOI: 10.3389/fcell.2022.886527

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  141. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Protein interactome and cell-type expression analyses reveal that cytoplasmic FMR1-interacting protein 1 (CYFIP1), but not CYFIP2, associates with astrocytic focal adhesion
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      DOI: 10.1111/jnc.15622

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  142. www.sciencedirect.com www.sciencedirect.com
    Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration
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      DOI: 10.1016/j.isci.2022.104519

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  143. May 2022
  144. www.sciencedirect.com www.sciencedirect.com
    Guidance by followers ensures long-range coordination of cell migration through α-catenin mechanoperception
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    DRP1 levels determine the apoptotic threshold during embryonic differentiation through a mitophagy-dependent mechanism
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    Nde1 is required for heterochromatin compaction and stability in neocortical neurons
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    Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis
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    The oocyte spindle midzone pauses Cdk1 inactivation during fertilization to enable male pronuclear formation and embryo development
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    sciencedirect.com/science/article/pii/S2211124722005563
  149. Apr 2022
  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A superior loading control for the cellular thermal shift assay
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      DOI: 10.1038/s41598-022-10653-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC9035151/
  151. www.sciencedirect.com www.sciencedirect.com
    Rab33b-exocyst interaction mediates localized secretion for focal adhesion turnover and cell migration
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  152. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Reduction of Nuak1 decreases tau and reverses phenotypes in a tauopathy mouse model
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    ncbi.nlm.nih.gov/pmc/articles/PMC5745060/
  153. www.sciencedirect.com www.sciencedirect.com
    Lockdown, a selective small-molecule inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion
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    sciencedirect.com/science/article/pii/S2451945622001283
  154. www.sciencedirect.com www.sciencedirect.com
    Vinculin controls endothelial cell junction dynamics during vascular lumen formation
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  155. academic.oup.com academic.oup.com
    Adipose Mitochondrial Complex I Deficiency Modulates Inflammation and Glucose Homeostasis in a Sex-Dependent Manner
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      DOI: 10.1210/endocr/bqac018

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  156. Mar 2022
  157. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Mechanical regulation of oligodendrocyte morphology and maturation by the mechanosensor p130Cas
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    Chromatin modifier HUSH co-operates with RNA decay factor NEXT to restrict transposable element expression
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  159. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Novel cellular mechanism that mediates the collecting duct formation during postnatal renal development
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  160. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Cardiomyocyte substructure reverts to an immature phenotype during heart failure
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      DOI: 10.1113/JP277273

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    A Division of Labor between YAP and TAZ in Non–Small Cell Lung Cancer
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    Pericyte-to-endothelial cell signaling via vitronectin-integrin regulates blood-CNS barrier
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      DOI: 10.1016/j.neuron.2022.02.017

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  163. elifesciences.org elifesciences.org
    Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness
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  164. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Crosstalk between ERK and MRTF-A signaling regulates TGFβ1-induced epithelial-mesenchymal transition
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    Proteome-centric cross-omics characterization and integrated network analyses of triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S2211124722001875
  166. Feb 2022
  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MYC and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma
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      DOI: 10.1158/0008-5472.CAN-21-1677

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  168. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    5-FU blocks shuttling of HuR mediated by PKCδ in gastric cancer cells
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  169. www.sciencedirect.com www.sciencedirect.com
    Heat shock induces premature transcript termination and reconfigures the human transcriptome
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    sciencedirect.com/science/article/pii/S1097276522000077
  170. Jan 2022
  171. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Genomic variants reducing expression of two endocytic receptors in 46,XY differences of sex development
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      DOI: 10.1002/humu.24325

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    WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity
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    GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis
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      DOI: 10.1016/j.cell.2021.12.024

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    Platelet rich plasma affects gap junctional features in myofibroblasts in vitro via Vascular Endothelial Growth Factor (VEGF)-A/VEGF receptor
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  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance
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      DOI: 10.1126/sciadv.abl4988

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  176. Dec 2021
  177. www.science.org www.science.org
    Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance
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  178. www.sciencedirect.com www.sciencedirect.com
    Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1
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    Galectin-9 mediates neutrophil capture and adhesion in a CD44 and β2 integrin-dependent manner
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      DOI: 10.1096/fj.202100832R

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  180. www.sciencedirect.com www.sciencedirect.com
    CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment
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  181. Nov 2021
  182. www.cell.com www.cell.com
    MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts
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    A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization
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    Developmental defects in Huntington’s disease show that axonal growth and microtubule reorganization require NUMA1
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  185. www.nature.com www.nature.com
    AKIRIN2 controls the nuclear import of proteasomes in vertebrates
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  186. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma
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    Spiny mice activate unique transcriptional programs after severe kidney injury regenerating organ function without fibrosis
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    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
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    Protocol for the assessment of mTOR activity in mouse primary hepatocytes
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  190. Oct 2021
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    Mitophagy antagonism by ZIKV reveals Ajuba as a regulator of PINK1 signaling, PKR-dependent inflammation, and viral invasion of tissues
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      DOI: 10.1016/j.celrep.2021.109888

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    A viral histone-like protein exploits antagonism between linker histones and HMGB proteins to obstruct the cell cycle
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    Biosensors based on peptide exposure show single molecule conformations in live cells
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      DOI: 10.1016/j.cell.2021.09.026

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    Proteome-wide mapping of short-lived proteins in human cells
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    Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice
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    SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling
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  197. Sep 2021
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    Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion
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    REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps
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  200. Aug 2021
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    The Amot/integrin protein complex transmits mechanical forces required for vascular expansion
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    NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1
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    CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance
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  204. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SCAF4 and SCAF8, mRNA Anti-Terminator Proteins
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    ncbi.nlm.nih.gov/pmc/articles/PMC6579486/
  205. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    sciencedirect.com/science/article/pii/S2211124718320163
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  209. www.mdpi.com www.mdpi.com
    The P2X7 Receptor Stimulates IL-6 Release from Pancreatic Stellate Cells and Tocilizumab Prevents Activation of STAT3 in Pancreatic Cancer Cells
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  210. onlinelibrary.wiley.com onlinelibrary.wiley.com
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    onlinelibrary.wiley.com/doi/full/10.1002/cne.24025
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    Molecular basis for substrate recruitment to the PRMT5 methylosome
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    Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy
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    ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma
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  216. Jul 2021
  217. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neural Deletion of Glucose Transporter Isoform 3 Creates Distinct Postnatal and Adult Neurobehavioral Phenotypes
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    Structural Basis of Paxillin Recruitment by Kindlin-2 in Regulating Cell Adhesion
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      Monoclonal Anti-Vinculin antibody produced in mouse

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    Intranasal Targeting of Hypothalamic PTP1B and TCPTP Reinstates Leptin and Insulin Sensitivity and Promotes Weight Loss in Obesity
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      Mouse polyclonal anti Vinculin

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  221. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The heat shock protein amplifier arimoclomol improves refolding, maturation and lysosomal activity of glucocerebrosidase
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  222. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-induced RASGAP deficiencies in colorectal cancer organoids reveal that only loss of NF1 promotes resistance to EGFR inhibition
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      DOI: 10.18632/oncotarget.26677

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    De Novo PITX1 Expression Controls Bi-Stable Transcriptional Circuits to Govern Self-Renewal and Differentiation in Squamous Cell Carcinoma
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      DOI: 10.1016/j.stem.2019.01.003

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  224. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  225. www.cell.com www.cell.com
    Transcription-mediated supercoiling regulates genome folding and loop formation
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  226. www.nature.com www.nature.com
    FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates
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      DOI: 10.1038/s41598-021-92408-4

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    Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination
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    Identification of a class of non-conventional ER-stress-response-derived immunogenic peptides
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    Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis
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  230. Jun 2021
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    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
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    Translation stress and collided ribosomes are co-activators of cGAS
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    Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function
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