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Apr 2021
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Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells

1
1. scibot 30 Apr 2021
  
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  DOI: 10.1016/j.cmet.2020.10.022
  
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A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes

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1. scibot 29 Apr 2021
  
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  DOI: 10.1016/j.cmet.2020.08.007
  
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sciencedirect.com/science/article/pii/S1550413120304204
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Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer

1
1. scibot 27 Apr 2021
  
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  Rabbit anti-phospho-4EBP1-T37/46
  
  DOI: 10.1016/j.chembiol.2020.06.011
  
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sciencedirect.com/science/article/pii/S2451945620302348
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Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer

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1. scibot 24 Apr 2021
  
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  DOI: 10.1016/j.cell.2020.10.016
  
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sciencedirect.com/science/article/pii/S0092867420313222
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The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine

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1. scibot 22 Apr 2021
  
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  DOI: 10.1016/j.cmet.2021.03.025
  
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sciencedirect.com/science/article/pii/S1550413121001662
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β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells

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1. scibot 08 Apr 2021
  
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  DOI: 10.1016/j.cub.2021.01.081
  
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cell.com/current-biology/abstract/S0960-9822(21)00146-9
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Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila

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1. scibot 02 Apr 2021
  
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  DOI: 10.7554/eLife.58565
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8007214/
Mar 2021
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Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila

1
1. scibot 24 Mar 2021
  
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  DOI: 10.1016/j.celrep.2021.108875
  
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sciencedirect.com/science/article/pii/S2211124721001893
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An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence

1
1. scibot 01 Mar 2021
  
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  DOI: 10.1016/j.ccell.2020.12.002
  
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sciencedirect.com/science/article/pii/S1535610820306097
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Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

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1. scibot 01 Mar 2021
  
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  DOI: 10.1016/j.cell.2020.11.018
  
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sciencedirect.com/science/article/pii/S009286742031535X
Feb 2021
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Metabolic conditioning of CD8 + effector T cells for adoptive cell therapy

1
1. scibot 26 Feb 2021
  
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  anti-phospho-4E-BP1Thr37/45
  
  DOI: 10.1038/s42255-020-0256-z
  
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nature.com/articles/s42255-020-0256-z
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 24 Feb 2021
  
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  DOI: 10.1111/bph.14882
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14882
Oct 2020
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Interferon-λ Enhances the Differentiation of Naive B Cells into Plasmablasts via the mTORC1 Pathway

1
1. scibot 08 Oct 2020
  
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  DOI: 10.1016/j.celrep.2020.108211
  
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sciencedirect.com/science/article/pii/S2211124720312006
Sep 2020
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Metabolic Control over mTOR-Dependent Diapause-like State

1
1. scibot 26 Sep 2020
  
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  DOI: 10.1016/j.devcel.2019.12.018
  
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sciencedirect.com/science/article/pii/S1534580719310676
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Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis

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1. scibot 25 Sep 2020
  
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  DOI: 10.1016/j.devcel.2020.02.015
  
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sciencedirect.com/science/article/pii/S1534580720301428
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Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy

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1. scibot 23 Sep 2020
  
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  DOI: 10.1016/j.immuni.2020.07.011
  
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sciencedirect.com/science/article/pii/S1074761320303186
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Dietary Adaptation of Microbiota in Drosophila Requires NF-κB-Dependent Control of the Translational Regulator 4E-BP

1
1. scibot 15 Sep 2020
  
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  RRID:AB_560835
  
  DOI: 10.1016/j.celrep.2020.107736
  
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sciencedirect.com/science/article/pii/S2211124720307166
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EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis

1
1. scibot 13 Sep 2020
  
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  RRID:AB_560835
  
  DOI: 10.1016/j.celrep.2019.12.086
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7357864/
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Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms

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1. scibot 12 Sep 2020
  
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  DOI: 10.1016/j.stem.2019.12.006
  
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sciencedirect.com/science/article/pii/S1934590919305247
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The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition

1
1. scibot 11 Sep 2020
  
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  DOI: 10.7554/eLife.52714
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7224698/
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Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome

1
1. scibot 09 Sep 2020
  
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  RRID:AB_560835
  
  DOI: 10.1016/j.celrep.2020.02.107
  
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sciencedirect.com/science/article/pii/S2211124720302886
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mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex

1
1. scibot 09 Sep 2020
  
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  DOI: 10.7554/eLife.58737
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7467727/
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The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis

1
1. scibot 07 Sep 2020
  
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  RRID:AB_560835
  
  DOI: 10.7554/eLife.57381
  
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elifesciences.org/articles/57381
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Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR

1
1. scibot 05 Sep 2020
  
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  AB_560835
  
  DOI: 10.1016/j.celrep.2020.107571
  
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sciencedirect.com/science/article/pii/S2211124720305209
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Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1

1
1. scibot 04 Sep 2020
  
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  phosphor‐4E‐BP1
  
  DOI: 10.15252/embr.201949898
  
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embopress.org/doi/abs/10.15252/embr.201949898
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Environmental arginine controls multinuclear giant cell metabolism and formation

1
1. scibot 03 Sep 2020
  
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  p-4EBP1 Thr37/46
  
  DOI: 10.1038/s41467-020-14285-1
  
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  Curator: @evieth
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6976629/
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Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells

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1. scibot 03 Sep 2020
  
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  DOI: 10.1126/sciadv.aaz6699
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7299619/
Jan 2020
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Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses

1
1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.immuni.2019.06.007
  
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sciencedirect.com/science/article/pii/S1074761319302778
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Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.chembiol.2019.05.009
  
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sciencedirect.com/science/article/pii/S2451945619301783
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Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity

1
1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cmet.2019.07.010
  
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sciencedirect.com/science/article/pii/S1550413119303833
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Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension

1
1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.08.084
  
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sciencedirect.com/science/article/pii/S2211124719311465
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p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

1
1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.07.027
  
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sciencedirect.com/science/article/pii/S2211124719309246
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Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome

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1. scibot 13 Jan 2020
  
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  RRID:AB_560835
  
  DOI: 10.1016/j.celrep.2019.10.038
  
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sciencedirect.com/science/article/pii/S221112471931352X
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NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

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  DOI: 10.1016/j.celrep.2019.06.085
  
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Mechanical loading stimulates hypertrophy in tissue‐engineered skeletal muscle: Molecular and phenotypic responses

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Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb

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Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy

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mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux

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Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs

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Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells

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The GATOR complex regulates an essential response to meiotic double-stranded breaks in Drosophila

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Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer

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Tumor Heterogeneity Underlies Differential Cisplatin Sensitivity in Mouse Models of Small-Cell Lung Cancer

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Lysosome Positioning Influences mTORC2 and AKT Signaling

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p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors

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Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer

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New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis

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MicroRNA-29 enhances autophagy and cleanses exogenous mutant αB-crystallin in retinal pigment epithelial cells

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Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC

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TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy

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The Lineage-Defining Transcription Factors SOX2 and NKX2-1 Determine Lung Cancer Cell Fate and Shape the Tumor Immune Microenvironment

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Protein Kinase C Epsilon Deletion in Adipose Tissue, but Not in Liver, Improves Glucose Tolerance

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mTOR Regulates Phase Separation of PGL Granules to Modulate Their Autophagic Degradation

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Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool

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Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

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mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance

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Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy

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Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor

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mTORC1-Mediated Inhibition of 4EBP1 Is Essential for Hedgehog Signaling-Driven Translation and Medulloblastoma

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Sensing and Transmitting Intracellular Amino Acid Signals through Reversible Lysine Aminoacylations

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mTORC1 Inactivation Promotes Colitis-Induced Colorectal Cancer but Protects from APC Loss-Dependent Tumorigenesis

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The Kinase mTORC1 Promotes the Generation and Suppressive Function of Follicular Regulatory T Cells

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mTOR Inhibition Restores Amino Acid Balance in Cells Dependent on Catabolism of Extracellular Protein

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PTEN Loss Increases the Connectivity of Fast Synaptic Motifs and Functional Connectivity in a Developing Hippocampal Network

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Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system

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Prosapip1-Dependent Synaptic Adaptations in the Nucleus Accumbens Drive Alcohol Intake, Seeking, and Reward

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A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice

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Clock Regulation of Metabolites Reveals Coupling between Transcription and Metabolism

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TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease

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Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase

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LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

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mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT

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Time-Resolved Proteomics Extends Ribosome Profiling-Based Measurements of Protein Synthesis Dynamics

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An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice

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SF-1 expression in the hypothalamus is required for beneficial metabolic effects of exercise

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Dynamics of mTORC1 activation in response to amino acids

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L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity

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Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery

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Untitled document

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Systematic analysis of BRAFV600E melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis

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