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    The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice
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  3. Apr 2024
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    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
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  6. Mar 2024
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    Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness
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    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
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    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
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  10. Feb 2024
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    Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury
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    Cytotoxin-mediated silk gland organ dysfunction diverts resources to enhance silkworm fecundity by potentiating nutrient-sensing IIS/TOR pathways
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    CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway
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    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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  15. Jan 2024
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    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
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  17. Dec 2023
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    An oncogenic phenoscape of colonic stem cell polarization
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    Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses
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    Lysosomal dynamics regulate mammalian cortical neurogenesis
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  21. Nov 2023
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    Tsc2 coordinates neuroprogenitor differentiation
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    CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
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  24. Oct 2023
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    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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  28. Sep 2023
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    Sphingosine Kinase 1 is Involved in Triglyceride Breakdown by Maintaining Lysosomal Integrity in Brown Adipocytes
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    Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells
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    WNK1 is required during male pachynema to sustain fertility.
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  32. Aug 2023
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    Fast drosophila enterocyte regrowth after infection involves a reverse metabolic flux driven by an amino acid transporter
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    Short-term PI3K inhibition prevents breast cancer in preclinical models
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    Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression
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  36. Jul 2023
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    Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
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    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
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    Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells
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    N-myc mediated translation control is a therapeutic vulnerability in medulloblastoma
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  41. Jun 2023
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    A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy
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    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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  44. May 2023
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    PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway
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    ATROPHIC REMODELING OF THE HEART DURING VITAMIN D DEFICIENCY AND INSUFFICIENCY IN A RAT MODEL
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    sciencedirect.com/science/article/pii/S0955286323001158
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    eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance
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    cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway
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    journals.aai.org/jimmunol/article/210/8/1098/263495/cGAS-Mediates-Inflammation-by-Polarizing
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    LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation
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    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    Interferon-λ Enhances the Differentiation of Naive B Cells into Plasmablasts via the mTORC1 Pathway
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    Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis
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    Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy
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    Dietary Adaptation of Microbiota in Drosophila Requires NF-κB-Dependent Control of the Translational Regulator 4E-BP
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    EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis
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    Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
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    The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition
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    Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome
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    Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
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    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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    Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
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    Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity
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    Calorie-Restriction-Induced Insulin Sensitivity Is Mediated by Adipose mTORC2 and Not Required for Lifespan Extension
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    p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas
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    Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome
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    NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression
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    Mechanical loading stimulates hypertrophy in tissue‐engineered skeletal muscle: Molecular and phenotypic responses
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    Amino Acids License Kinase mTORC1 Activity and Treg Cell Function via Small G Proteins Rag and Rheb
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    Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy
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    mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux
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    Lipid Deprivation Induces a Stable, Naive-to-Primed Intermediate State of Pluripotency in Human PSCs
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    Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells
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    The GATOR complex regulates an essential response to meiotic double-stranded breaks in Drosophila
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    Functional Redundancy between β1 and β3 Integrin in Activating the IR/Akt/mTORC1 Signaling Axis to Promote ErbB2-Driven Breast Cancer
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    Tumor Heterogeneity Underlies Differential Cisplatin Sensitivity in Mouse Models of Small-Cell Lung Cancer
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    Lysosome Positioning Influences mTORC2 and AKT Signaling
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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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    Increased Serine and One-Carbon Pathway Metabolism by PKCλ/ι Deficiency Promotes Neuroendocrine Prostate Cancer
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