297 Matching Annotations
  1. Aug 2025
  2. www.sciencedirect.com www.sciencedirect.com
    Targeting the MYC oncogene with a selective bi-steric mTORC1 inhibitor elicits tumor regression in MYC-driven cancers
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    sciencedirect.com/science/article/pii/S2451945625002272
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    Multi-dimensional metabolomic remodeling under diverse muscle atrophic stimuli in vivo
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    sciencedirect.com/science/article/pii/S221112472500868X
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    Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size
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    biorxiv.org/content/10.1101/2025.07.23.666188v1
  5. Jul 2025
  6. www.science.org www.science.org
    Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling
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    science.org/doi/10.1126/science.adm9805
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    A bitopic mTORC inhibitor reverses phenotypes in a tuberous sclerosis complex model
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    link.springer.com/article/10.1038/s41598-025-08345-z
  8. Jun 2025
  9. www.nature.com www.nature.com
    Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes
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    nature.com/articles/s41418-025-01532-5
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Delayed forebrain excitatory and inhibitory neurogenesis in STRADA-related megalencephaly via mTOR hyperactivity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12132401/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147910/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting the Glucose–Insulin Link in Head and Neck Squamous Cell Carcinoma Induces Cytotoxic Oxidative Stress and Inhibits Cancer Growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC12141995/
  13. May 2025
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147910/
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    Lymphatic endothelial mTORC1 instructs metabolic and developmental signaling during lymphangiogenesis
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    sciencedirect.com/science/article/pii/S1534580725002503
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    Beta cells intrinsically sense and limit their secretory activity via mTORC1-RhoA signaling
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    sciencedirect.com/science/article/pii/S2211124725004188
  17. Apr 2025
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Time Release Ion Matrix Regenerates Dystrophic Skeletal Muscle
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    pmc.ncbi.nlm.nih.gov/articles/PMC11957216/
  19. Mar 2025
  20. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Hippocampal Inhibitory Interneuron-Specific DREADDs Treatment Alters mTORC1-4E-BP Signaling and Impairs Memory Formation
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    onlinelibrary.wiley.com/doi/10.1111/jnc.70048
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    Cytotoxic Autophagy: A Novel Treatment Paradigm against Breast Cancer Using Oleanolic Acid and Ursolic Acid
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    mdpi.com/2072-6694/16/19/3367
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A highland-adaptation variant near MCUR1 reduces its transcription and attenuates erythrogenesis in Tibetans
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    pmc.ncbi.nlm.nih.gov/articles/PMC11960549/
  23. Feb 2025
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 activity and aggravates liver tumorigenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11832924/
  25. www.nature.com www.nature.com
    PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors
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    nature.com/articles/s41593-024-01865-3
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP5 stabilizes YTHDF1 to control cancer immune surveillance through mTORC1-mediated phosphorylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC11791202/
  27. www.nature.com www.nature.com
    The coagulation and tumor system are directly linked through the proteolysis and activation of epidermal growth factor receptor by thrombin
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    nature.com/articles/s41388-025-03296-1
  28. Jan 2025
  29. www.nature.com www.nature.com
    Nutrient-sensing alteration leads to age-associated distortion of intestinal stem cell differentiating direction
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    nature.com/articles/s41467-024-53675-7
  30. www.sciencedirect.com www.sciencedirect.com
    Non-cell-autonomous regulation of mTORC2 by Hedgehog signaling maintains lipid homeostasis
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    sciencedirect.com/science/article/pii/S2211124724015420
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    JAK inhibition decreases the autoimmune burden in Down syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC11687933/
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    Bone marrow mesenchymal stromal cells support translation in refractory acute myeloid leukemia
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  33. Dec 2024
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Impact of a Ketogenic Diet on Late-Stage Pancreatic Carcinogenesis in Mice: Efficacy and Safety Studies
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    pmc.ncbi.nlm.nih.gov/articles/PMC11597385/
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    A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor
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  36. 52.53.155.43 52.53.155.43
    1-s2.0-S2352345X24001905-main-html.html
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  37. Nov 2024
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11493941/
  39. Sep 2024
  40. dx.doi.org dx.doi.org
    Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels
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    dx.doi.org/10.1093/hmg/ddae135
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    Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States
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  42. aacrjournals.org aacrjournals.org
    Activating mTOR mutations are detrimental in nutrient-poor conditions
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    aacrjournals.org/cancerres/article/82/18/3263/709030/Activating-mTOR-Mutations-Are-Detrimental-in
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
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    ncbi.nlm.nih.gov/pmc/articles/PMC11370239/
  44. Aug 2024
  45. www.sciencedirect.com www.sciencedirect.com
    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
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  46. journals.physiology.org journals.physiology.org
    mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology
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    journals.physiology.org/doi/full/10.1152/ajpcell.00385.2020
  47. pubs.acs.org pubs.acs.org
    Himalaquinones A–G, Angucyclinone-Derived Metabolites Produced by the Himalayan Isolate Streptomyces sp. PU-MM59
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    pubs.acs.org/doi/10.1021/acs.jnatprod.1c00192
  48. www.cell.com www.cell.com
    RIPK1 Promotes Energy Sensing by the mTORC1 Pathway
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    cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    E2F1-associated purine synthesis pathway is a major component of the MET-DNA damage response network
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    ncbi.nlm.nih.gov/pmc/articles/PMC11288008/
  50. Jul 2024
  51. www.sciencedirect.com www.sciencedirect.com
    Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila
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    sciencedirect.com/science/article/pii/S2211124721001893
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
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    ncbi.nlm.nih.gov/pmc/articles/PMC11284272/
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    Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells
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    sciencedirect.com/science/article/pii/S1934590924002534
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging
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    ncbi.nlm.nih.gov/pmc/articles/PMC11262205/
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    Multi-step regulation of microRNA expression and secretion into small extracellular vesicles by insulin
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    sciencedirect.com/science/article/pii/S2211124724008209
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis
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    ncbi.nlm.nih.gov/pmc/articles/PMC7357864/
  57. www.biorxiv.org www.biorxiv.org
    Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor
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    biorxiv.org/content/10.1101/2024.06.11.598518v2
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC11199525/
  59. Jun 2024
  60. www.sciencedirect.com www.sciencedirect.com
    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
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    sciencedirect.com/science/article/pii/S1550413124001918
  61. May 2024
  62. www.biorxiv.org www.biorxiv.org
    Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells
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    biorxiv.org/content/10.1101/2024.05.13.593567v1
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    Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance
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    sciencedirect.com/science/article/pii/S1074761324002292
  64. www.sciencedirect.com www.sciencedirect.com
    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
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    sciencedirect.com/science/article/pii/S1550413124001359
  65. Apr 2024
  66. www.sciencedirect.com www.sciencedirect.com
    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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    sciencedirect.com/science/article/pii/S2211124724004777
  67. www.cell.com www.cell.com
    The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice
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    cell.com/cell-host-microbe/fulltext/S1931-3128(24)00112-4
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    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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    sciencedirect.com/science/article/pii/S2352396424001348
  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
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    ncbi.nlm.nih.gov/pmc/articles/PMC10998866/
  70. Mar 2024
  71. www.sciencedirect.com www.sciencedirect.com
    Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness
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    sciencedirect.com/science/article/pii/S1535610824000606
  72. www.sciencedirect.com www.sciencedirect.com
    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
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    sciencedirect.com/science/article/pii/S2211124724002638
  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
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    ncbi.nlm.nih.gov/pmc/articles/PMC10920058/
  74. Feb 2024
  75. www.sciencedirect.com www.sciencedirect.com
    Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury
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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cytotoxin-mediated silk gland organ dysfunction diverts resources to enhance silkworm fecundity by potentiating nutrient-sensing IIS/TOR pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC10830876/
  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831937/
  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
  79. Jan 2024
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
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    pmc.ncbi.nlm.nih.gov/articles/PMC10839450/
  81. Dec 2023
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    An oncogenic phenoscape of colonic stem cell polarization
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    Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses
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    Lysosomal dynamics regulate mammalian cortical neurogenesis
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    sciencedirect.com/science/article/pii/S1534580723006196
  85. Nov 2023
  86. www.sciencedirect.com www.sciencedirect.com
    Tsc2 coordinates neuroprogenitor differentiation
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    sciencedirect.com/science/article/pii/S2589004223025191
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    CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
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  88. Oct 2023
  89. www.embopress.org www.embopress.org
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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    embopress.org/doi/10.15252/embr.202356815
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    s41586-023-06657-6_reference-html.html
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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    sciencedirect.com/science/article/pii/S2211124723012147
  92. Sep 2023
  93. www.sciencedirect.com www.sciencedirect.com
    Sphingosine Kinase 1 is Involved in Triglyceride Breakdown by Maintaining Lysosomal Integrity in Brown Adipocytes
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    sciencedirect.com/science/article/pii/S0022227523001232
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    Lysosomal cyst(e)ine storage potentiates tolerance to oxidative stress in cancer cells
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    WNK1 is required during male pachynema to sustain fertility.
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    sciencedirect.com/science/article/pii/S2589004223016930
  96. Aug 2023
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fast drosophila enterocyte regrowth after infection involves a reverse metabolic flux driven by an amino acid transporter
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    ncbi.nlm.nih.gov/pmc/articles/PMC10448536/
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Short-term PI3K inhibition prevents breast cancer in preclinical models
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    ncbi.nlm.nih.gov/pmc/articles/PMC9905287/
  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10405072/
  100. Jul 2023
  101. www.sciencedirect.com www.sciencedirect.com
    Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
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    sciencedirect.com/science/article/pii/S2589004223012087
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    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
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    sciencedirect.com/science/article/pii/S2211124723007751
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    Transcriptional metabolic reprogramming implements meiotic fate decision in mouse testicular germ cells
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-myc mediated translation control is a therapeutic vulnerability in medulloblastoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC9812901/
  105. Jun 2023
  106. www.embopress.org www.embopress.org
    A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy
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    embopress.org/doi/full/10.15252/emmm.202216951
  107. www.sciencedirect.com www.sciencedirect.com
    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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    sciencedirect.com/science/article/pii/S2211124723006435
  108. May 2023
  109. www.sciencedirect.com www.sciencedirect.com
    PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway
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    sciencedirect.com/science/article/pii/S2211124723005302
  110. www.sciencedirect.com www.sciencedirect.com
    ATROPHIC REMODELING OF THE HEART DURING VITAMIN D DEFICIENCY AND INSUFFICIENCY IN A RAT MODEL
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    sciencedirect.com/science/article/pii/S0955286323001158
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    eIF4E phosphorylation recruits β-catenin to mRNA cap and promotes Wnt pathway translation in dentate gyrus LTP maintenance
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    sciencedirect.com/science/article/pii/S2589004223007265
  112. journals.aai.org journals.aai.org
    cGAS Mediates Inflammation by Polarizing Macrophages to M1 Phenotype via the mTORC1 Pathway
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