267 Matching Annotations
  1. Nov 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Everolimus alleviates CD4+ T cell inflammation by regulating autophagy and cellular redox homeostasis
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      DOI: 10.1007/s11357-024-01187-z

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    pmc.ncbi.nlm.nih.gov/articles/PMC11493941/
  3. Sep 2024
  4. dx.doi.org dx.doi.org
    Modeling antisense oligonucleotide therapy in MECP2 duplication syndrome human iPSC-derived neurons reveals gene expression programs responsive to MeCP2 levels
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      DOI: 10.1093/hmg/ddae135

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    dx.doi.org/10.1093/hmg/ddae135
  5. www.sciencedirect.com www.sciencedirect.com
    Molecular Transducers of Human Skeletal Muscle Remodeling under Different Loading States
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    1. scibot 25 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124720309657
  6. aacrjournals.org aacrjournals.org
    Activating mTOR mutations are detrimental in nutrient-poor conditions
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    1. scibot 12 Sep 2024
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      DOI: 10.1158/0008-5472.CAN-22-0121

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    aacrjournals.org/cancerres/article/82/18/3263/709030/Activating-mTOR-Mutations-Are-Detrimental-in
  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts
    1
    1. scibot 05 Sep 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11370239/
  8. Aug 2024
  9. www.sciencedirect.com www.sciencedirect.com
    Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions
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    sciencedirect.com/science/article/pii/S2211124724010143
  10. journals.physiology.org journals.physiology.org
    mTORC1/2 signaling is downregulated by amino acid-free culture of mouse preimplantation embryos and is only partially restored by amino acid readdition | American Journal of Physiology-Cell Physiology
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      DOI: 10.1152/ajpcell.00385.2020

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    journals.physiology.org/doi/full/10.1152/ajpcell.00385.2020
  11. pubs.acs.org pubs.acs.org
    Himalaquinones A–G, Angucyclinone-Derived Metabolites Produced by the Himalayan Isolate Streptomyces sp. PU-MM59
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      DOI: 10.1021/acs.jnatprod.1c00192

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    pubs.acs.org/doi/10.1021/acs.jnatprod.1c00192
  12. www.cell.com www.cell.com
    RIPK1 Promotes Energy Sensing by the mTORC1 Pathway
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      4E-BP1 phospho-Thr37/46

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    cell.com/molecular-cell/fulltext/S1097-2765(20)30786-3
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    E2F1-associated purine synthesis pathway is a major component of the MET-DNA damage response network
    1
    1. scibot 01 Aug 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11288008/
  14. Jul 2024
  15. www.sciencedirect.com www.sciencedirect.com
    Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila
    1
    1. scibot 31 Jul 2024
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    sciencedirect.com/science/article/pii/S2211124721001893
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Kinome-Wide Synthetic Lethal CRISPR/Cas9 Screen Reveals That mTOR Inhibition Prevents Adaptive Resistance to CDK4/CDK6 Blockade in HNSCC
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    1. scibot 31 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11284272/
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    Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells
    1
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    sciencedirect.com/science/article/pii/S1934590924002534
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TP53INP2-dependent activation of muscle autophagy ameliorates sarcopenia and promotes healthy aging
    1
    1. scibot 25 Jul 2024
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      DOI: 10.1080/15548627.2024.2333717

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  19. www.sciencedirect.com www.sciencedirect.com
    Multi-step regulation of microRNA expression and secretion into small extracellular vesicles by insulin
    1
    1. scibot 16 Jul 2024
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    sciencedirect.com/science/article/pii/S2211124724008209
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis
    1
    1. scibot 16 Jul 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC7357864/
  21. www.biorxiv.org www.biorxiv.org
    Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor
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    1. scibot 04 Jul 2024
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      DOI: 10.1101/2024.06.11.598518

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    biorxiv.org/content/10.1101/2024.06.11.598518v2
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells
    1
    1. scibot 03 Jul 2024
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      DOI: 10.3389/fonc.2024.1394653

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    ncbi.nlm.nih.gov/pmc/articles/PMC11199525/
  23. Jun 2024
  24. www.sciencedirect.com www.sciencedirect.com
    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
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    1. scibot 21 Jun 2024
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      DOI: 10.1016/j.cmet.2024.05.015

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    sciencedirect.com/science/article/pii/S1550413124001918
  25. May 2024
  26. www.biorxiv.org www.biorxiv.org
    Auranofin and reactive oxygen species inhibit protein synthesis and regulate the level of the PLK1 protein in Ewing sarcoma cells
    1
    1. scibot 23 May 2024
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      DOI: 10.1101/2024.05.13.593567

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    biorxiv.org/content/10.1101/2024.05.13.593567v1
  27. www.sciencedirect.com www.sciencedirect.com
    Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance
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    1. scibot 21 May 2024
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      DOI: 10.1016/j.immuni.2024.04.024

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    sciencedirect.com/science/article/pii/S1074761324002292
  28. www.sciencedirect.com www.sciencedirect.com
    A 5:2 intermittent fasting regimen ameliorates NASH and fibrosis and blunts HCC development via hepatic PPARα and PCK1
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    sciencedirect.com/science/article/pii/S1550413124001359
  29. Apr 2024
  30. www.sciencedirect.com www.sciencedirect.com
    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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    1. scibot 30 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114149

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    sciencedirect.com/science/article/pii/S2211124724004777
  31. www.cell.com www.cell.com
    The complete Kaposi sarcoma-associated herpesvirus genome induces early-onset, metastatic angiosarcoma in transgenic mice
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      Cell Signaling TechnologiesCat#2855

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    cell.com/cell-host-microbe/fulltext/S1931-3128(24)00112-4
  32. www.sciencedirect.com www.sciencedirect.com
    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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    sciencedirect.com/science/article/pii/S2352396424001348
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagy inhibitor NSC185058 suppresses mTORC1-mediated protein anabolism in cultured skeletal muscle
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    ncbi.nlm.nih.gov/pmc/articles/PMC10998866/
  34. Mar 2024
  35. www.sciencedirect.com www.sciencedirect.com
    Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness
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    sciencedirect.com/science/article/pii/S1535610824000606
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    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
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    sciencedirect.com/science/article/pii/S2211124724002638
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast‐twitch muscle in rats
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    ncbi.nlm.nih.gov/pmc/articles/PMC10920058/
  38. Feb 2024
  39. www.sciencedirect.com www.sciencedirect.com
    Region-specific cellular and molecular basis of liver regeneration after acute pericentral injury
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    sciencedirect.com/science/article/pii/S1934590924000432
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cytotoxin-mediated silk gland organ dysfunction diverts resources to enhance silkworm fecundity by potentiating nutrient-sensing IIS/TOR pathways
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    ncbi.nlm.nih.gov/pmc/articles/PMC10830876/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC10831937/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modeling uncovers p21-driven drug resistance and prioritizes therapies for PIK3CA-mutant breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10810864/
  43. Jan 2024
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
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    pmc.ncbi.nlm.nih.gov/articles/PMC10839450/
  45. Dec 2023
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    An oncogenic phenoscape of colonic stem cell polarization
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    sciencedirect.com/science/article/pii/S0092867423012217
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    Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses
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    Lysosomal dynamics regulate mammalian cortical neurogenesis
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    CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline
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    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
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    CDKL5 deficiency in adult glutamatergic neurons alters synaptic activity and causes spontaneous seizures via TrkB signaling
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    Sphingosine Kinase 1 is Involved in Triglyceride Breakdown by Maintaining Lysosomal Integrity in Brown Adipocytes
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    Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
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    Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic “integrated stress response”
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    PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway
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    Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19
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    TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
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    TRIM28 secures skeletal stem cell fate during skeletogenesis by silencing neural gene expression and repressing GREM1/AKT/mTOR signaling axis
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    The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model
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    TM6SF2/PNPLA3/MBOAT7 Loss-of-Function Genetic Variants Impact on NAFLD Development and Progression Both in Patients and in In Vitro Models
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    Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
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    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    Resistance to Epigenetic-Targeted Therapy Engenders Tumor Cell Vulnerabilities Associated with Enhancer Remodeling
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    Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation
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    ERBB3 overexpression due to miR-205 inactivation confers sensitivity to FGF, metabolic activation, and liability to ERBB3 targeting in glioblastoma
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  185. Jul 2021
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    Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder
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    Gut-microbiota-targeted diets modulate human immune status
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  193. Jun 2021
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    OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin
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    Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms
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  196. May 2021
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    Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK
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    Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function
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  206. Apr 2021
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    Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector Treg Cells
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    A Cell-Autonomous Signature of Dysregulated Protein Phosphorylation Underlies Muscle Insulin Resistance in Type 2 Diabetes
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    Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer
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    The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
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    β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells
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  214. Mar 2021
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    Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila
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    An Embryonic Diapause-like Adaptation with Suppressed Myc Activity Enables Tumor Treatment Persistence
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    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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  218. Feb 2021
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      anti-phospho-4E-BP1Thr37/45

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  220. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  221. Oct 2020
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    Interferon-λ Enhances the Differentiation of Naive B Cells into Plasmablasts via the mTORC1 Pathway
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  223. Sep 2020
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    Metabolic Control over mTOR-Dependent Diapause-like State
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    Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis
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    Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy
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    Dietary Adaptation of Microbiota in Drosophila Requires NF-κB-Dependent Control of the Translational Regulator 4E-BP
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    EGFR Signaling Stimulates Autophagy to Regulate Stem Cell Maintenance and Lipid Homeostasis in the Drosophila Testis
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    Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms
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    Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR
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    Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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      phosphor‐4E‐BP1

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    Environmental arginine controls multinuclear giant cell metabolism and formation
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      p-4EBP1 Thr37/46

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  238. Jan 2020
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    Slc6a8-Mediated Creatine Uptake and Accumulation Reprogram Macrophage Polarization via Regulating Cytokine Responses
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    Discovery of Small-Molecule Selective mTORC1 Inhibitors via Direct Inhibition of Glucose Transporters
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    Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity
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