637 Matching Annotations
  1. Mar 2023
  2. 52.53.155.43 52.53.155.43
    943-html.html
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    1. scibot 16 Mar 2023
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      DOI: 10.1158/1078-0432.CCR-22-1763

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  3. www.sciencedirect.com www.sciencedirect.com
    S-acylation stabilizes ligand-induced receptor kinase complex formation during plant pattern-triggered immune signaling
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    1. scibot 16 Mar 2023
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      DOI: 10.1016/j.cub.2023.02.065

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    sciencedirect.com/science/article/pii/S0960982223002385
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    Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation
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    1. scibot 11 Mar 2023
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      DOI: 10.1016/j.isci.2023.106294

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    sciencedirect.com/science/article/pii/S2589004223003711
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    Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB
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    1. scibot 10 Mar 2023
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      DOI: 10.1016/j.chembiol.2023.02.008

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    sciencedirect.com/science/article/pii/S2451945623000570
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    Inhibition of monoamine oxidase-a increases respiration in isolated mouse cortical mitochondria
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    1. scibot 02 Mar 2023
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      DOI: 10.1016/j.expneurol.2023.114356

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    sciencedirect.com/science/article/pii/S0014488623000407
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    Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state
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    1. scibot 02 Mar 2023
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      DOI: 10.1016/j.celrep.2023.112169

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    sciencedirect.com/science/article/pii/S2211124723001808
  8. Feb 2023
  9. aacrjournals.org aacrjournals.org
    Bone metastasis initiation is coupled with bone remodeling through osteogenic differentiation of NG2+ cells
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    1. scibot 18 Feb 2023
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      DOI: 10.1158/2159-8290.CD-22-0220

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    aacrjournals.org/cancerdiscovery/article/13/2/474/716294/Bone-Metastasis-Initiation-Is-Coupled-with-Bone
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    Increased alcohol dehydrogenase 1 activity promotes longevity
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    1. scibot 18 Feb 2023
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      DOI: 10.1016/j.cub.2023.01.059

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    sciencedirect.com/science/article/pii/S0960982223001288
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    Inducing primary brainstem gliomas in genetically engineered mice using RCAS/TVA retroviruses and Cre/loxP recombination
    1
    1. scibot 17 Feb 2023
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      DOI: 10.1016/j.xpro.2023.102094

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    sciencedirect.com/science/article/pii/S2666166723000527
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    Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation
    1
    1. scibot 11 Feb 2023
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    sciencedirect.com/science/article/pii/S2451945623000302
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    Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture
    1
    1. scibot 10 Feb 2023
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      DOI: 10.1016/j.isci.2023.106073

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    sciencedirect.com/science/article/pii/S2589004223001505
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    Peroxiredoxin 2 is required for the redox mediated adaptation to exercise
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    1. scibot 10 Feb 2023
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      DOI: 10.1016/j.redox.2023.102631

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    sciencedirect.com/science/article/pii/S2213231723000320
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    Recycling of modified H2A-H2B provides short-term memory of chromatin states
    1
    1. scibot 09 Feb 2023
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      DOI: 10.1016/j.cell.2023.01.007

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    sciencedirect.com/science/article/pii/S0092867423000077
  16. www.sciencedirect.com www.sciencedirect.com
    Thyroid hormones regulate Zfp423 expression in regionally distinct adipose depots through direct and cell-autonomous action
    1
    1. scibot 09 Feb 2023
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      DOI: 10.1016/j.celrep.2023.112088

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    sciencedirect.com/science/article/pii/S2211124723000992
  17. www.nature.com www.nature.com
    The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
    1
    1. scibot 04 Feb 2023
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      DOI: 10.1038/s41467-023-36058-2

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    nature.com/articles/s41467-023-36058-2
  18. www.sciencedirect.com www.sciencedirect.com
    IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment
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    1. scibot 03 Feb 2023
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      DOI: 10.1016/j.ccell.2023.01.003

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    sciencedirect.com/science/article/pii/S153561082300003X
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fibroblast growth factor-21 improves insulin action in nonlactating ewes
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    1. scibot 02 Feb 2023
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      DOI: 10.1152/ajpregu.00259.2021

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    ncbi.nlm.nih.gov/pmc/articles/PMC8816633/
  20. Jan 2023
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform
    1
    1. scibot 25 Jan 2023
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      DOI: 10.1016/j.isci.2023.105944

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    ncbi.nlm.nih.gov/pmc/articles/PMC9822553/
  22. link.springer.com link.springer.com
    CNTNAP2 Protein Is Degraded by the Ubiquitin–Proteasome System and the Macroautophagy-Lysosome Pathway
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    1. scibot 21 Jan 2023
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      DOI: 10.1007/s12035-023-03227-9

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    link.springer.com/article/10.1007/s12035-023-03227-9
  23. www.biorxiv.org www.biorxiv.org
    Intron retention of an adhesion GPCR generates single transmembrane-helix isoforms to enable 7TM-adhesion GPCR function
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    1. scibot 20 Jan 2023
      RRID: AB_621843

      DOI: 10.1101/2023.01.11.521585

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    biorxiv.org/content/10.1101/2023.01.11.521585v1
  24. www.sciencedirect.com www.sciencedirect.com
    An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes
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    1. scibot 19 Jan 2023
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      DOI: 10.1016/j.cell.2022.12.025

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    sciencedirect.com/science/article/pii/S0092867422015380
  25. www.sciencedirect.com www.sciencedirect.com
    Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticles
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    1. scibot 19 Jan 2023
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      DOI: 10.1016/j.xcrm.2022.100899

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    sciencedirect.com/science/article/pii/S2666379122004785
  26. www.sciencedirect.com www.sciencedirect.com
    Zinc-finger protein Zpr1 is a bespoke chaperone essential for eEF1A biogenesis
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    1. scibot 12 Jan 2023
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      DOI: 10.1016/j.molcel.2022.12.012

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    sciencedirect.com/science/article/pii/S1097276522011698
  27. 52.53.155.43 52.53.155.43
    SSRN-id4221334-html.html
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    1. scibot 06 Jan 2023
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      DOI: 10.2139/ssrn.4221334

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    52.53.155.43/2daa560a2b97e54a9bac815ccf8a22777d2d1280/SSRN-id4221334-html.html
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits
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    1. scibot 06 Jan 2023
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      DOI: 10.1016/j.isci.2022.105732

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    ncbi.nlm.nih.gov/pmc/articles/PMC9800269/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Diverse effector and regulatory functions of fibro/adipogenic progenitors during skeletal muscle fibrosis in muscular dystrophy
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    1. scibot 06 Jan 2023
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      DOI: 10.1016/j.isci.2022.105775

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    ncbi.nlm.nih.gov/pmc/articles/PMC9804115/
  30. Dec 2022
  31. www.sciencedirect.com www.sciencedirect.com
    Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer
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    1. scibot 17 Dec 2022
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      DOI: 10.1016/j.ccell.2022.11.016

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    sciencedirect.com/science/article/pii/S1535610822005633
  32. www.sciencedirect.com www.sciencedirect.com
    Epidermal stratification requires retromer-mediated desmoglein-1 recycling
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    1. scibot 11 Dec 2022
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      DOI: 10.1016/j.devcel.2022.11.010

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    sciencedirect.com/science/article/pii/S1534580722008103
  33. www.sciencedirect.com www.sciencedirect.com
    Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT
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    1. scibot 11 Dec 2022
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      DOI: 10.1016/j.cell.2022.11.014

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    sciencedirect.com/science/article/pii/S009286742201457X
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cocaine sensitizes the CD4+ T cells for HIV infection by co-stimulating NFAT and AP-1
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    1. scibot 09 Dec 2022
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      DOI: 10.1016/j.isci.2022.105651

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    ncbi.nlm.nih.gov/pmc/articles/PMC9722482/
  35. www.sciencedirect.com www.sciencedirect.com
    Adaptor protein MyD88 confers the susceptibility to stress via amplifying immune danger signals
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    1. scibot 08 Dec 2022
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      DOI: 10.1016/j.bbi.2022.12.007

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    sciencedirect.com/science/article/pii/S0889159122004652
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A RADAR method to measure DNA topoisomerase covalent complexes
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    1. scibot 08 Dec 2022
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      DOI: 10.1016/bs.mie.2022.03.036

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    ncbi.nlm.nih.gov/pmc/articles/PMC9722332/
  37. 52.53.155.43 52.53.155.43
    cd-22-0220-html.html
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      DOI: 10.1158/2159-8290.cd-22-0220

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    52.53.155.43/b725a3c3e409b5ecfb6e439733821b69db1577f5/cd-22-0220-html.html
  38. aacrjournals.org aacrjournals.org
    BAF complex maintains glioma stem cells in pediatric H3K27M-glioma
    1
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      DOI: 10.1158/2159-8290.CD-21-1491

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    aacrjournals.org/cancerdiscovery/article/12/12/2880/711164/BAF-Complex-Maintains-Glioma-Stem-Cells-in
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DOT1L inhibition does not modify the sensitivity of cutaneous T cell lymphoma to pan-HDAC inhibitors in vitro
    1
    1. scibot 02 Dec 2022
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      DOI: 10.3389/fgene.2022.1032958

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    ncbi.nlm.nih.gov/pmc/articles/PMC9681147/
  40. Nov 2022
  41. www.sciencedirect.com www.sciencedirect.com
    MYC regulates a pan-cancer network of co-expressed oncogenic splicing factors
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    1. scibot 23 Nov 2022
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      DOI: 10.1016/j.celrep.2022.111704

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    sciencedirect.com/science/article/pii/S2211124722015789
  42. academic.oup.com academic.oup.com
    Estrogen Receptor Beta 1: A Potential Therapeutic Target for Female Triple Negative Breast Cancer
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    1. scibot 18 Nov 2022
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      DOI: 10.1210/endocr/bqac172

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    academic.oup.com/endo/article/163/12/bqac172/6762323
  43. www.sciencedirect.com www.sciencedirect.com
    TES-1/Tes and ZYX-1/Zyxin protect junctional actin networks under tension during epidermal morphogenesis in the C. elegans embryo
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    1. scibot 17 Nov 2022
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      DOI: 10.1016/j.cub.2022.10.045

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    sciencedirect.com/science/article/pii/S0960982222016931
  44. www.sciencedirect.com www.sciencedirect.com
    Hippocampal parvalbumin interneurons play a critical role in memory development
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      DOI: 10.1016/j.celrep.2022.111643

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  91. Apr 2022
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    Resurrected Rubisco suggests uniform carbon isotope signatures over geologic time
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    miRNA/mRNA co-profiling identifies the miR-200 family as a central regulator of SMC quiescence
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    A presynaptic phosphosignaling hub for lasting homeostatic plasticity
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    The lipophilic cyclic peptide cyclosporin A induces aggregation of gel-forming mucins
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    Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function
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    The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
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    An optimized protocol to analyze membrane protein degradation in yeast using quantitative western blot and flow cytometry
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    mDKN-01, a Novel Anti-DKK1 mAb, Enhances Innate Immune Responses in the Tumor Microenvironment
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    Structure of SNX9 SH3 in complex with a viral ligand reveals the molecular basis of its unique specificity for alanine-containing class I SH3 motifs
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    ADAM17 regulates p75NTR–mediated fibrinolysis and nerve remyelination
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  102. Mar 2022
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    The TFIIH complex is required to establish and maintain mitotic chromosome structure
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    Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
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    Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria
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    Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense
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    Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization
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    Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness
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    Contribution of cyclooxygenase-1-dependent prostacyclin synthesis to bradykinin-induced dermal extravasation
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    Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning
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    Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass
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    Recurrent evolution of an inhibitor of ESCRT-dependent virus budding and LINE-1 retrotransposition in primates
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    An Inducible CRISPR/Cas9 Screen Identifies DTX2 as a Transcriptional Regulator of Human Telomerase
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    Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
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    Renal Klotho and inorganic phosphate are extrinsic factors that antagonistically regulate hematopoietic stem cell maintenance
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    C-type natriuretic peptide-induced PKA activation promotes endochondral bone formation in hypertrophic chondrocytes
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    CRAF dimerization with ARAF regulates KRAS-driven tumor growth
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    Heat shock induces premature transcript termination and reconfigures the human transcriptome
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    Mechanical phenotyping reveals unique biomechanical responses in retinoic acid-resistant acute promyelocytic leukemia
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  122. Jan 2022
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    Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection
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    Maternal exercise intergenerationally drives muscle-based thermogenesis via activation of apelin-AMPK signaling
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    Circadian Transcription Factor NPAS2 and the NAD+-Dependent Deacetylase SIRT1 Interact in the Mouse Nucleus Accumbens and Regulate Reward
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    R-type voltage-gated Ca2+ channels mediate A-type K+ current regulation of synaptic input in hippocampal dendrites
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    PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma
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    Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
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    Apolipoprotein E derived from CD11c+ cells ameliorates atherosclerosis
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    GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors
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    Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models
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  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional independence of endogenous μ- and δ-opioid receptors co-expressed in cholinergic interneurons
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    Discovery of small-molecule positive allosteric modulators of Parkin E3 ligase
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    16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis
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  137. Dec 2021
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    The Fibronectin–ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells
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    Evolution of a histone variant involved in compartmental regulation of NAD metabolism
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    Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells
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    Rescue of α-synuclein aggregation in Parkinson’s patient neurons by synergistic enhancement of ER proteostasis and protein trafficking
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    Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1γ-Dependent Mechanism
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    Balancing of mitochondrial translation through METTL8-mediated m3C modification of mitochondrial tRNAs
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    A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy
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    MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function
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    The hepatic compensatory response to elevated systemic sulfide promotes diabetes
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    A role for SMARCB1 in synovial sarcomagenesis reveals that SS18-SSX induces canonical BAF destruction
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    DNAJB6b-enriched small extracellular vesicles decrease polyglutamine aggregation in in vitro and in vivo models of Huntington disease
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    Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation
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    Adenosine deaminase 2 produced by infiltrative monocytes promotes liver fibrosis in nonalcoholic fatty liver disease
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    Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy
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    Mechanistic Insights into COVID-19 by Global Analysis of the SARS-CoV-2 3CLpro Substrate Degradome
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    H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity
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    Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns
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    An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens
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    A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes
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    Dynamic bi-directional phosphorylation events associated with the reciprocal regulation of synapses during homeostatic up- and down-scaling
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      IRDye 800CW Goat Anti-Rabbit IgG, Conjugated Antibody

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    W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34
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      DOI: 10.1007/s12035-021-02439-1

      Resource: (LI-COR Biosciences Cat# 926-32211, RRID:AB_621843)

      Curator: @scibot

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    link.springer.com/article/10.1007/s12035-021-02439-1
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    Protocol for nuclear export signal characterization of cGAS in mammalian cells
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    1. scibot 07 Jul 2021
      RRID:AB_621843

      DOI: 10.1016/j.xpro.2021.100649

      Resource: (LI-COR Biosciences Cat# 926-32211, RRID:AB_621843)

      Curator: @scibot

      SciCrunch record: RRID:AB_621843

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      RRID:AB_621843
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    sciencedirect.com/science/article/pii/S2666166721003567