456 Matching Annotations
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    Profound synthetic lethality between SMARCAL1 and FANCM
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    sciencedirect.com/science/article/pii/S1097276524008566
  3. Nov 2024
  4. www.biorxiv.org www.biorxiv.org
    Loss of mitochondrial enzyme GPT2 leads to reprogramming of synaptic glutamate metabolism
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      DOI: 10.1101/2024.11.06.622291

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    biorxiv.org/content/10.1101/2024.11.06.622291v1
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses
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    pmc.ncbi.nlm.nih.gov/articles/PMC11535224/
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    Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development
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  7. 52.53.155.43 52.53.155.43
    can-24-0529-html.html
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  8. Oct 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VPS13B is localized at the interface between Golgi cisternae and is a functional partner of FAM177A1
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      DOI: 10.1083/jcb.202311189

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    ncbi.nlm.nih.gov/pmc/articles/PMC11451052/
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    Pharmacologic inhibition of eIF4A blocks NRF2 synthesis to prevent osteosarcoma metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11443218/
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    Dysregulation of miRNA expression and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids
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    nature.com/articles/s41380-024-02761-9
  12. Sep 2024
  13. www.biorxiv.org www.biorxiv.org
    Zika virus NS3 drives the assembly of a viroplasm-like structure
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    biorxiv.org/content/10.1101/2024.09.16.613201v1
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    Type-II kinase inhibitors that target Parkinson’s Disease-associated LRRK2
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    Troriluzole rescues glutamatergic deficits, amyloid and tau pathology, and synaptic and memory impairments in 3xTg-AD mice
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      DOI: 10.1111/jnc.16215

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16215
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    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10187264/
  17. www.sciencedirect.com www.sciencedirect.com
    Skeletal muscle heme oxygenase-1 activity regulates aerobic capacity
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    sciencedirect.com/science/article/pii/S2211124721003326
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    Positive allosteric modulation of type 1 cannabinoid receptors reduces spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg
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      DOI: 10.1016/j.neuropharm.2021.108553

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    sciencedirect.com/science/article/pii/S0028390821001076
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    Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating
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    sciencedirect.com/science/article/pii/S2211124720311906
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    Scleral HIF-1α is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis
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    sciencedirect.com/science/article/pii/S235239642030253X
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    Identification of a Master Regulator of Differentiation in Toxoplasma
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      DOI: 10.1016/j.cell.2019.12.013

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    MED12 and CDK8/19 modulate androgen receptor activity and enzalutamide response in prostate cancer
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      DOI: 10.1210/endocr/bqae114

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    ncbi.nlm.nih.gov/pmc/articles/PMC11398899/
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    Antibacterial action, proteolytic immunity, and in vivo activity of a Vibrio cholerae microcin
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    sciencedirect.com/science/article/pii/S1931312824003196
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    TGF-β and RAS jointly unmask primed enhancers to drive metastasis
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    Pooled endogenous protein tagging and recruitment for systematic profiling of protein function
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    sciencedirect.com/science/article/pii/S2666979X24002623
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    Proteome-scale characterisation of motif-based interactome rewiring by disease mutations
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    Oxidative stress induces release of mitochondrial DNA into the extracellular space in human placental villous trophoblast BeWo cells
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  28. Aug 2024
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The TGFβ type I receptor kinase inhibitor vactosertib in combination with pomalidomide in relapsed/refractory multiple myeloma: a phase 1b trial
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    Patient-derived tumor organoids mimic treatment-induced DNA damage response in glioblastoma
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    sciencedirect.com/science/article/pii/S2589004224018297
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    Maelstrom Represses Canonical Polymerase II Transcription within Bi-Directional piRNA Clusters in Drosophila melanogaster
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    The divergent effects of G3BP orthologs on human stress granule assembly imply a centric role for the core protein interaction network
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    sciencedirect.com/science/article/pii/S2211124724009677
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    Dual effect of N-terminal deletion of cardiac myosin essential light chain in mitigating cardiomyopathy
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    sciencedirect.com/science/article/pii/S2589004224018169
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    Redox heterogeneity in mouse embryonic stem cells individualizes cell fate decisions
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    The cullin Rtt101 promotes ubiquitin-dependent DNA−protein crosslink repair across the cell cycle
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      DOI: 10.1093/nar/gkae658

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  36. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Spatial patterning of excitatory and inhibitory neuropil territories during spinal circuit development
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    onlinelibrary.wiley.com/doi/10.1002/cne.24152/full
  37. www.sciencedirect.com www.sciencedirect.com
    The V-ATPase/ATG16L1 axis is controlled by the V1H subunit
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  38. Jul 2024
  39. www.sciencedirect.com www.sciencedirect.com
    Leveraging a self-cleaving peptide for tailored control in proximity labeling proteomics
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      DOI: 10.1016/j.crmeth.2024.100818

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    sciencedirect.com/science/article/pii/S2667237524001838
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    Observing isolated synaptic vesicle association and fusion ex vivo
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  41. www.cell.com www.cell.com
    Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle
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    cell.com/molecular-cell/fulltext/S1097-2765(24)00511-2
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    Polymerization of ZBTB transcription factors regulates chromatin occupancy
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  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Robust GRK2/3/6-dependent desensitization of oxytocin receptor in neurons
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    ncbi.nlm.nih.gov/pmc/articles/PMC11179071/
  44. Jun 2024
  45. www.cell.com www.cell.com
    Moderate-intensity aerobic exercise training improves CD8+ tumor-infiltrating lymphocytes effector function by reducing mitochondrial loss.
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    Capturing acyl–enzyme intermediates with genetically encoded 2,3-diaminopropionic acid for hydrolase substrate identification
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    HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity
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    The TERT Promoter is Polycomb-Repressed in Neuroblastoma Cells with Long Telomeres
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    DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks
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    Inhibition of NLRP3 inflammasome alleviates cognitive deficits in a mouse model of anti-NMDAR encephalitis induced by active immunization
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    De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
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    Truncated protein isoforms generate diversity of protein localization and function in yeast
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      D. Secondary antibodies

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  56. www.sciencedirect.com www.sciencedirect.com
    Epithelial aPKC deficiency leads to stem cell loss preceding metaplasia in colorectal cancer initiation
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    Everolimus exerts anticancer effects through inhibiting the interaction of matrix metalloproteinase-7 with syndecan-2 in colon cancer cells
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  58. www.sciencedirect.com www.sciencedirect.com
    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
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    Direct interrogation of context-dependent GPCR activity with a universal biosensor platform
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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intersectin1 promotes clathrin-mediated endocytosis by organizing and stabilizing endocytic protein interaction networks
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    ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum
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  62. 52.53.155.43 52.53.155.43
    Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development
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  63. 52.53.155.43 52.53.155.43
    Defining a small-molecule stimulator of the human Hsp70-disaggregase system with selectivity for DnaJB proteins
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  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Combined CDK4/6 and ERK1/2 inhibition enhances anti-tumor activity in NF1-associated plexiform neurofibroma
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  65. Apr 2024
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    Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia
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    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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  69. 52.53.155.43 52.53.155.43
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    An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains
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    RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
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    A dual role of the conserved PEX19 helix in safeguarding peroxisomal membrane proteins
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    Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling
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  74. Mar 2024
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    Molecular determinants and signaling effects of PKA RIα phase separation
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    Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression
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    Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
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    HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
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  80. Feb 2024
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    AURKA enhances the glycolysis and development of ovarian endometriosis through ERβ
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    Identification of an H-Ras nanocluster disrupting peptide
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  83. link.springer.com link.springer.com
    UFM1 E3 ligase promotes recycling of 60S ribosomal subunits from the ER
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  84. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pyruvate dehydrogenase kinase 2 knockdown restores the ability of amyotrophic lateral sclerosis-linked SOD1G93A rat astrocytes to support motor neuron survival by increasing mitochondrial respiration
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    Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis
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    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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    DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells
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    Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
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    METTL17 is an Fe-S cluster checkpoint for mitochondrial translation
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  91. Dec 2023
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    Calmodulin regulates protease versus co-chaperone activity of a metacaspase
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    Solid-to-liquid phase transition in the dissolution of cytosolic misfolded-protein aggregates
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    Manipulating the 3D organization of the largest synthetic yeast chromosome
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    Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
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    Distinct disease mutations in DNMT3A result in a spectrum of behavioral, epigenetic, and transcriptional deficits
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    Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest
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    Imbalanced glucocorticoid and mineralocorticoid stress hormone receptor function has sex-dependent and independent regulatory effects in the mouse hippocampus
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    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
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    Impact of Mutations Defining SARS-CoV-2 Omicron Subvariants BA.2.12.1 and BA.4/5 on Spike Function and Neutralization
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    Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice
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    In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
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    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
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  105. Oct 2023
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    Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2
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    Sequential activation of E2F via Rb degradation and c-Myc drives resistance to CDK4/6 inhibitors in breast cancer
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    The Effects of Chronic Unpredictable Mild Stress and Semi-Pure Diets on the Brain, Gut and Adrenal Medulla in C57BL6 Mice
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    Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse
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    N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes
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    Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases
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    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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    Fiber deprivation and microbiome-borne curli shift gut bacterial populations and accelerate disease in a mouse model of Parkinson’s disease
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  114. Sep 2023
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    Essential role of the amino-terminal region of Drosha for the Microprocessor function
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    A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer
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  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cortical Brain Injury Causes Retrograde Degeneration of Afferent Basal Forebrain Cholinergic Neurons via the p75NTR
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  118. Aug 2023
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    Combating pan-coronavirus infection by indomethacin through simultaneously inhibiting viral replication and inflammatory response
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    Long-term safety and dose escalation of intracerebroventricular CLN5 gene therapy in sheep supports clinical translation for CLN5 Batten disease
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    The Achromobacter type 3 secretion system drives pyroptosis and immunopathology via independent activation of NLRC4 and NLRP3 inflammasomes
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    RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation
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    Cu(ATSM) Increases P-Glycoprotein Expression and Function at the Blood-Brain Barrier in C57BL6/J Mice
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    A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms
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  126. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of the novel FOXP3-dependent Treg cell transcription factor MEOX1 by high-dimensional analysis of human CD4+ T cells
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  127. Jul 2023
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    CCDC176 stabilizes microtubule doublets 1 and 9 to ensure proper sperm movement
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    Proximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome
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    The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling
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    The C-terminus of Sudan ebolavirus VP40 contains a functionally important CXnC motif, a target for redox modifications
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  132. Jun 2023
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    Sex-Dependent Effects of Chronic Restraint Stress on Mood-Related Behaviours and Neurochemistry in Mice
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    Clonal evolution in tyrosine kinase inhibitor-resistance: lessons from in vitro-models
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    SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex
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    SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas
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    PTBP1 enforces ATR-CHK1 signalling determining the potency of CDC7 inhibitors
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    Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification
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    The intrinsically disordered region of coronins fine-tunes oligomerization and actin polymerization
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    Tumor cell-intrinsic and tumor microenvironmental conditions co-determine signaling by the glycoimmune checkpoint receptor Siglec-7
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  141. May 2023
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    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    Human gasdermin D and MLKL disrupt mitochondria, endocytic traffic and TORC1 signalling in budding yeast
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    Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions
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    Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length
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    Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.
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    Ubx5-Cdc48 assists the protease Wss1 at DNA-protein crosslink sites in yeast
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    Vaccination with a bacterial peptide conjugated to SARS-CoV-2 receptor-binding domain accelerates immunity and protects against COVID-19
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  149. Apr 2023
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    Salmonella invasion of a cell is self-limiting due to effector-driven activation of N-WASP
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    Vascular cells improve functionality of human cardiac organoids
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    Generation of left ventricle-like cardiomyocytes with improved structural, functional, and metabolic maturity from human pluripotent stem cells
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    Proteomic discovery of chemical probes that perturb protein complexes in human cells
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    Human APOBEC3B promotes tumor heterogeneity in vivo including signature mutations and metastases
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    UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS
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  157. Mar 2023
  158. www.sciencedirect.com www.sciencedirect.com
    The conserved histone chaperone Spt6 is strongly required for DNA replication and genome stability
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    S-acylation stabilizes ligand-induced receptor kinase complex formation during plant pattern-triggered immune signaling
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    Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation
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    Dual IKZF2 and CK1α degrader targets acute myeloid leukemia cells
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    Linoleic acid improves PIEZO2 dysfunction in a mouse model of Angelman Syndrome
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    Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state
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    Epigenetic function during heroin self-administration controls future relapse-associated behavior in a cell type-specific manner
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  165. Feb 2023
  166. aacrjournals.org aacrjournals.org
    Bone metastasis initiation is coupled with bone remodeling through osteogenic differentiation of NG2+ cells
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  167. www.sciencedirect.com www.sciencedirect.com
    Increased alcohol dehydrogenase 1 activity promotes longevity
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    Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture
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    Regulation of DNA damage response by trimeric G-proteins
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    IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment
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  171. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fibroblast growth factor-21 improves insulin action in nonlactating ewes
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  172. Jan 2023
  173. www.biorxiv.org www.biorxiv.org
    Intron retention of an adhesion GPCR generates single transmembrane-helix isoforms to enable 7TM-adhesion GPCR function
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    An E3 ligase network engages GCN1 to promote the degradation of translation factors on stalled ribosomes
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    Carbonic anhydrases in development: morphological observations and gene expression profiling in sea urchin embryos exposed to acetazolamide
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  176. 52.53.155.43 52.53.155.43
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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits
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  178. Dec 2022
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    Bidirectional promoter activity from expression cassettes can drive off-target repression of neighboring gene translation
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    Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer
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    A minimal construct of nuclear-import receptor Karyopherin-β2 defines the regions critical for chaperone and disaggregation activity
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    Adaptor protein MyD88 confers the susceptibility to stress via amplifying immune danger signals
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    R17C Mutation in Photoreceptor Disc-Specific Protein, PRCD, Results in Additional Lipidation Altering Protein Stability and Subcellular Localization
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    Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells
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    DOT1L inhibition does not modify the sensitivity of cutaneous T cell lymphoma to pan-HDAC inhibitors in vitro
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    Dynamic proteomic and phosphoproteomic atlas of corticostriatal axons in neurodevelopment
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    Structure and functionality of a multimeric human COQ7:COQ9 complex
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    Adult Camk2a gene reinstatement restores the learning and plasticity deficits of Camk2a knockout mice
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    Phosphorylation of the DNA repair scaffold SLX4 drives folding of the SAP domain and activation of the MUS81-EME1 endonuclease
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    Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex
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    BK Polyomavirus Requires the Mismatch Repair Pathway for DNA Damage Response Activation
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  195. Sep 2022
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    Enteric VIP-producing neurons maintain gut microbiota homeostasis through regulating epithelium fucosylation
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    Exploring the target scope of KEAP1 E3 ligase-based PROTACs
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    Dual control of formin-nucleated actin assembly by the chromatin and ER in mouse oocytes
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    Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer
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    Determinants of Spike Infectivity, Processing and Neutralization in SARS-CoV-2 Omicron subvariants BA.1 and BA.2
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    Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-low Induction of Therapy Resistance
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  203. Jul 2022
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    EFR3 and phosphatidylinositol 4-kinase IIIα regulate insulin-stimulated glucose transport and GLUT4 dispersal in 3T3-L1 adipocytes
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    Filter trapping protocol to detect aggregated proteins in human cell lines
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    Identification of growth hormone receptor as a relevant target for precision medicine in low-EGFR expressing glioblastoma
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    Genome-wide expression and methylation analyses reveal aberrant cell adhesion signaling in tyrosine kinase inhibitor-resistant CML cells
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  208. Jun 2022
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    MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma
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    MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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    METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance
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    Counteracting chromatin effects of a splicing-correcting antisense oligonucleotide improves its therapeutic efficacy in spinal muscular atrophy
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    How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor
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    Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
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  215. May 2022
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    Disrupting autorepression circuitry generates “open-loop lethality” to yield escape-resistant antiviral agents
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    The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62
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    Loss of PRMT7 reprograms glycine metabolism to selectively eradicate leukemia stem cells in CML
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  219. Apr 2022
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    Copper bis(thiosemicarbazone) complexes modulate P-glycoprotein expression and function in human brain microvascular endothelial cells
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    The lipophilic cyclic peptide cyclosporin A induces aggregation of gel-forming mucins
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    FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer
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      DOI: 10.1016/j.celrep.2022.110584

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  223. Mar 2022
  224. www.sciencedirect.com www.sciencedirect.com
    Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
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    1. scibot 30 Mar 2022
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      DOI: 10.1016/j.molcel.2022.03.005

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    sciencedirect.com/science/article/pii/S1097276522002143
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    Reduced Plasma Extracellular Vesicle CD5L Content in Patients With Acute-On-Chronic Liver Failure: Interplay With Specialized Pro-Resolving Lipid Mediators
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    1. scibot 26 Mar 2022
      AB_621842

      DOI: 10.3389/fimmu.2022.842996

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