277 Matching Annotations
  1. May 2021
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    Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function
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    sciencedirect.com/science/article/pii/S0896627321001562
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    Caspase-1 Engages Full-Length Gasdermin D through Two Distinct Interfaces That Mediate Caspase Recruitment and Substrate Cleavage
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    Programmable Extracellular Vesicles for Macromolecule Delivery and Genome Modifications
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    CRISPR screens in physiologic medium reveal conditionally essential genes in human cells
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  6. Apr 2021
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    Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation
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    sciencedirect.com/science/article/pii/S1550413120305350
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    Human T-bet Governs Innate and Innate-like Adaptive IFN-γ Immunity against Mycobacteria
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    An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
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    Reduction of Liver Metastasis Stiffness Improves Response to Bevacizumab in Metastatic Colorectal Cancer
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    Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion
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    Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms
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  13. Mar 2021
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    MMB-FOXM1-driven premature mitosis is required for CHK1 inhibitor sensitivity
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  15. Feb 2021
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    Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats
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    Cryo-EM Structure of CtBP2 Confirms Tetrameric Architecture
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    Cancer-associated exportin-6 upregulation inhibits the transcriptionally repressive and anticancer effects of nuclear profilin-1
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  19. Jan 2021
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    Golgi-Dependent Copper Homeostasis Sustains Synaptic Development and Mitochondrial Content
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    Piwil1 Regulates Glioma Stem Cell Maintenance and Glioblastoma Progression
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  22. Dec 2020
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    Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer’s Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals
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    Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development
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  25. Oct 2020
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    Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling
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    CRISPR-Csy4-Mediated Editing of Rotavirus Double-Stranded RNA Genome
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    Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis
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  29. Sep 2020
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    CRISPR-Csy4-Mediated Editing of Rotavirus Double-Stranded RNA Genome
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    Global Regulatory DNA Potentiation by SMARCA4 Propagates to Selective Gene Expression Programs via Domain-Level Remodeling
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    Replication Stress Induces Global Chromosome Breakage in the Fragile X Genome
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    Angiotensin II-upregulated MAP kinase phosphatase-3 modulates FOXO1 and p21 in adrenocortical H295R cells
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    Toll-like Receptor 5 Activation by the CagY Repeat Domains of Helicobacter pylori
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    Translational Physiology: Insulin signaling displayed a differential tissue-specific response to low-dose dihydrotestosterone in female mice
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    hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation
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    Autophagy Controls CSL/RBPJκ Stability through a p62/SQSTM1-Dependent Mechanism
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    Conformational Dynamics and Functional Implications of Phosphorylated β-Arrestins
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    RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia
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    p53 orchestrates DNA replication restart homeostasis by suppressing mutagenic RAD52 and POLθ pathways
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    Altered Adhesion and Migration of Human Mesenchymal Stromal Cells under Febrile Temperature Stress Involves NF-κβ Pathway
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    Marine Actinomycetes-Derived Secondary Metabolites Overcome TRAIL-Resistance via the Intrinsic Pathway through Downregulation of Survivin and XIAP
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    Synaptic Vesicle Precursors and Lysosomes Are Transported by Different Mechanisms in the Axon of Mammalian Neurons
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    CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development
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    G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules
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    mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury
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    YAP Regulates Hematopoietic Stem Cell Formation in Response to the Biomechanical Forces of Blood Flow
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  49. Jan 2020
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    The Oncogenic Kaposi’s Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family
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    Regulation of Autophagic Flux by the 20S Proteasome
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    A Receptor of the Immunoglobulin Superfamily Regulates Adaptive Thermogenesis
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    TATA-Box Binding Protein O-GlcNAcylation at T114 Regulates Formation of the B-TFIID Complex and Is Critical for Metabolic Gene Regulation
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    A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
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    Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia
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    Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops
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    Widespread and Functional RNA Circularization in Localized Prostate Cancer
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    Vaccinia‐related kinase 2 modulates role of dysbindin by regulating protein stability
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    Melleolides from Honey Mushroom Inhibit 5-Lipoxygenase via Cys159
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  67. Nov 2018
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    Patient-Derived Xenografts for Prognostication and Personalized Treatment for Head and Neck Squamous Cell Carcinoma
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    Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells
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    Vesicle-Cloaked Virus Clusters Are Optimal Units for Inter-organismal Viral Transmission
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    Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis
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    Nek9 Phosphorylation Defines a New Role for TPX2 in Eg5-Dependent Centrosome Separation before Nuclear Envelope Breakdown
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    A homozygous loss-of-function CAMK2A mutation causes growth delay, frequent seizures and severe intellectual disability
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    METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification
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    The GABAA Receptor α2 Subunit Activates a Neuronal TLR4 Signal in the Ventral Tegmental Area that Regulates Alcohol and Nicotine Abuse
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    Nuclear Receptor Nur77 Facilitates Melanoma Cell Survival under Metabolic Stress by Protecting Fatty Acid Oxidation
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    R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
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    Innately activated TLR4 signal in the nucleus accumbens is sustained by CRF amplification loop and regulates impulsivity
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  83. Nov 2017
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    YAP/TAZ Orchestrate VEGF Signaling during Developmental Angiogenesis
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    Argonaute CLIP Defines a Deregulated miR-122-Bound Transcriptome that Correlates with Patient Survival in Human Liver Cancer
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    Phosphorylation-Dependent Feedback Inhibition of RIG-I by DAPK1 Identified by Kinome-wide siRNA Screening
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    Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity
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    Loss-of-Function Mutations in ELMO2 Cause Intraosseous Vascular Malformation by Impeding RAC1 Signaling
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