347 Matching Annotations
  1. Feb 2023
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    TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away
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    sciencedirect.com/science/article/pii/S2211124723001365
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    The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
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    nature.com/articles/s41467-023-36058-2
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    Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation
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    sciencedirect.com/science/article/pii/S221112472300044X
  5. Jan 2023
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    Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons
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    sciencedirect.com/science/article/pii/S1934590922004945
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    Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging
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    ncbi.nlm.nih.gov/pmc/articles/PMC9933915/
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    Alternative transcribed 3' isoform of long non-coding RNA Malat1 inhibits mouse retinal oxidative stress
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    ncbi.nlm.nih.gov/pmc/articles/PMC9804114/
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    Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response
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    sciencedirect.com/science/article/pii/S1097276522011649
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    ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis
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    sciencedirect.com/science/article/pii/S2211124722018101
  11. Dec 2022
  12. link.springer.com link.springer.com
    Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer’s disease
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    link.springer.com/article/10.1186/s40478-022-01481-x
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    BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9719099/
  14. Nov 2022
  15. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15945
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    LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus
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    embopress.org/doi/10.15252/embj.2022112006
  17. Oct 2022
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    ATP13A1 prevents ERAD of folding-competent mislocalized and misoriented proteins
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    sciencedirect.com/science/article/pii/S109727652200956X
  19. Sep 2022
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    Protocol to detect in vitro and in cell ubiquitylation of mitochondrial DNA polymerase gamma by mitochondrial E3 ligase MITOL
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    sciencedirect.com/science/article/pii/S2666166722005901
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    Targeting the USP7/RRM2 axis drives senescence and sensitizes melanoma cells to HDAC/LSD1 inhibitors
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    sciencedirect.com/science/article/pii/S2211124722012335
  22. Aug 2022
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans
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    ncbi.nlm.nih.gov/pmc/articles/PMC9388098/
  24. Jul 2022
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    Filter trapping protocol to detect aggregated proteins in human cell lines
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    sciencedirect.com/science/article/pii/S2666166722004518
  26. Jun 2022
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    Robust anti-SARS-CoV2 single domain antibodies cross neutralize multiple viruses
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    sciencedirect.com/science/article/pii/S2589004222008215
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    Identification of STAU1 as a regulator of HBV replication by TurboID-based proximity labeling
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    ncbi.nlm.nih.gov/pmc/articles/PMC9156947/
  29. Mar 2022
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    A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis
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    sciencedirect.com/science/article/pii/S2451945622000940
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    Neddylation is essential for β-catenin degradation in Wnt signaling pathway
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    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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    sciencedirect.com/science/article/pii/S2211124722000705
  33. Jan 2022
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    Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses
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    sciencedirect.com/science/article/pii/S2451945621005134
  35. Dec 2021
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    Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase
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    MYC assembles and stimulates topoisomerases 1 and 2 in a “topoisome”
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  38. Oct 2021
  39. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Faim knockout leads to gliosis and late-onset neurodegeneration of photoreceptors in the mouse retina
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    onlinelibrary.wiley.com/doi/10.1002/jnr.24978
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    Tyrosine Phosphorylation of DEPTOR Functions as a Molecular Switch to Activate mTOR Signaling
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  41. Sep 2021
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    The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation
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    Reading ADP-ribosylation signaling using chemical biology and interaction proteomics
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    A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
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    sciencedirect.com/science/article/pii/S2451945621003937
  45. Aug 2021
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    Feedback repression of PPARα signaling by Let-7 microRNA
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    Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway
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    embopress.org/doi/abs/10.15252/embj.2020107413
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetically incorporated crosslinkers reveal NleE attenuates host autophagy dependent on PSMD10
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    ncbi.nlm.nih.gov/pmc/articles/PMC8324295/
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  56. Jul 2021
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Vaccinia‐related kinase 2 modulates role of dysbindin by regulating protein stability
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14562
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    Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes
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    embopress.org/doi/full/10.15252/embr.201947728
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    PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo
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  66. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of ubiquitin recognition by the HECT ligase E6AP provides insight into its linkage specificity
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    ncbi.nlm.nih.gov/pmc/articles/PMC6463701/
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    Quercetin improves the activity of the ubiquitin‐proteasomal system in 150Q mutated huntingtin‐expressing cells but exerts detrimental effects on neuronal survivability
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    onlinelibrary.wiley.com/doi/10.1002/jnr.23618/full
  68. rupress.org rupress.org
    Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination
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    rupress.org/jcb/article/220/6/e202006043/211984/Parkin-independent-mitophagy-via-Drp1-mediated
  69. May 2021
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    The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1
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    UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model
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    Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response
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    Opposing roles of E3 ligases TRIM23 and TRIM21 in regulation of ion channel ANO1 protein levels
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  74. Apr 2021
  75. www.jneurosci.org www.jneurosci.org
    Pathogenic GRM7 mutations associated with neurodevelopmental disorders impair axon outgrowth and presynaptic terminal development
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    jneurosci.org/content/41/11/2344
  76. Feb 2021
  77. www.cell.com www.cell.com
    Ribosome Collision Is Critical for Quality Control during No-Go Decay
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  78. Jan 2021
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    DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks
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    sciencedirect.com/science/article/pii/S2211124720315588
  80. Dec 2020
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    Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer’s Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals
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  82. Nov 2020
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    A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits
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  84. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG
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    pubmed.ncbi.nlm.nih.gov/33158444/
  85. Sep 2020
  86. elifesciences.org elifesciences.org
    Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels
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    elifesciences.org/articles/57951
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    Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice
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    elifesciences.org/articles/44396
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    N‐linked glycosylation of the mGlu7 receptor regulates the forward trafficking and transsynaptic interaction with Elfn1
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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202001544R
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    Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer
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    Differential regulation and targeting of estrogen receptor α turnover in invasive lobular breast carcinoma
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    Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity
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    Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34
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    The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency
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    The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules
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    Threonine ADP-Ribosylation of Ubiquitin by a Bacterial Effector Family Blocks Host Ubiquitination
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    Ubiquitination-dependent control of sexual differentiation in fission yeast
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  97. www.cell.com www.cell.com
    Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating
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    cell.com/cell-reports/abstract/S2211-1247(18)31081-7
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    The Proteasome Governs Fungal Morphogenesis via Functional Connections with Hsp90 and cAMP-Protein Kinase A Signaling
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    The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
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    An Allosteric Interaction Network Promotes Conformation State-Dependent Eviction of the Nas6 Assembly Chaperone from Nascent 26S Proteasomes
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    cell.com/cell-reports/fulltext/S2211-1247(18)31972-7
  101. genesdev.cshlp.org genesdev.cshlp.org
    Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne
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    genesdev.cshlp.org/content/33/23-24/1702.full
  102. insight.jci.org insight.jci.org
    The UPR preserves mature oligodendrocyte viability and function in adults by regulating autophagy of PLP
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    The FTLD Risk Factor TMEM106B Regulates the Transport of Lysosomes at the Axon Initial Segment of Motoneurons
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    Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions
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  105. Jan 2020
  106. www.embopress.org www.embopress.org
    Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes
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    embopress.org/doi/full/10.15252/embr.201947728
  107. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Diethyldithiocarbamate, an anti‐abuse drug, alleviates steatohepatitis and fibrosis in rodents through modulating lipid metabolism and oxidative stress
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.14503
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    lncRNA Sensing of a Viral Suppressor of RNAi Activates Non-canonical Innate Immune Signaling in Drosophila
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    Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination
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    Proteomics Links Ubiquitin Chain Topology Change to Transcription Factor Activation
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    HIV-1 Envelope Overcomes NLRP3-Mediated Inhibition of F-Actin Polymerization for Viral Entry
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