186 Matching Annotations
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    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
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    sciencedirect.com/science/article/pii/S2211124724004777
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    Variant-specific effects of GBA1 mutations on dopaminergic neuron proteostasis
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      DOI: 10.1111/jnc.16114

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16114
  4. Apr 2024
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    FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC11032391/
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    ISGylation by HERCs facilitates STING activation
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    Necrosulfonamide causes oxidation of PCM1 and impairs ciliogenesis and autophagy
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    The SPATA5-SPATA5L1 ATPase complex directs replisome proteostasis to ensure genome integrity
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  9. Mar 2024
  10. www.nature.com www.nature.com
    Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis
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    nature.com/articles/s41388-024-03008-1
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    VCF1 is a p97/VCP cofactor promoting recognition of ubiquitylated p97-UFD1-NPL4 substrates
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    ncbi.nlm.nih.gov/pmc/articles/PMC10950897/
  12. Feb 2024
  13. 52.53.155.43 52.53.155.43
    Regulation of the intestinal Na+/H+ exchanger NHE3 by AMP-activated kinase is dependent on phosphorylation of NHE3 at S555 and S563
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    1. scibot 22 Feb 2024
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      DOI: 10.1152/ajpcell.00540.2023

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  14. Jan 2024
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    Optimizing rice grain size by attenuating phosphorylation-triggered functional impairment of a chromatin modifier ternary complex
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    sciencedirect.com/science/article/pii/S1534580723006937
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    A quantitative model for virus uncoating predicts influenza A infectivity
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    Response to Bruton’s tyrosine kinase inhibitors in aggressive lymphomas linked to chronic selective autophagy
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  18. Dec 2023
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    Protocol for screening α-synuclein PET tracer candidates in vitro and ex vivo
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    sciencedirect.com/science/article/pii/S2666166723007554
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    NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62
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    Characteristics and expression of lncRNA and transposable elements in Drosophila aneuploidy
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  22. Nov 2023
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    RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks
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    sciencedirect.com/science/article/pii/S1097276523008493
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    K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution
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    sciencedirect.com/science/article/pii/S1097276523008481
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    PTIR1 acts as an isoform of DDX58 and promotes tumor immune resistance through activation of UCHL5
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    Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease
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    sciencedirect.com/science/article/pii/S2211124723014481
  27. Oct 2023
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy
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    ncbi.nlm.nih.gov/pmc/articles/PMC10552648/
  29. Sep 2023
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    Analysis of proteome-wide degradation dynamics in ALS SOD1 iPSC-derived patient neurons reveals disrupted VCP homeostasis
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    sciencedirect.com/science/article/pii/S2211124723011725
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    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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    Systematic profiling of dominant ubiquitin variants reveals key functional nodes contributing to evolutionary selection
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    sciencedirect.com/science/article/pii/S2211124723010756
  33. Jul 2023
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    Phosphoribosyl-linked serine ubiquitination of USP14 by the SidE family effectors of Legionella excludes p62 from the bacterial phagosome
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  35. 52.53.155.43 52.53.155.43
    NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62
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      DOI: 10.1101/2023.06.05.543428

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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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    Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies
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    sciencedirect.com/science/article/abs/pii/S009286742300644X
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    Bacterial effector restricts liquid-liquid phase separation of ZPR1 to antagonize host UPRER
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      DOI: 10.1016/j.celrep.2023.112700

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    sciencedirect.com/science/article/pii/S2211124723007118
  39. Jun 2023
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    Stability of Rad51 recombinase and persistence of Rad51 DNA repair foci depends on post-translational modifiers, ubiquitin and SUMO
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    sciencedirect.com/science/article/pii/S0167488923000988
  41. May 2023
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    Integrated proteomics identifies p62-dependent selective autophagy of the supramolecular vault complex
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    Ubiquitin proteomics identifies RNA polymerase I as a target of the Smc5/6 complex
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  44. Apr 2023
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    The UAS thioredoxin-like domain of UBXN7 regulates E3 ubiquitin ligase activity of RNF111/Arkadia
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      DOI: 10.1186/s12915-023-01576-4

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    link.springer.com/article/10.1186/s12915-023-01576-4
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    PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1
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    sciencedirect.com/science/article/pii/S2211124723003510
  47. Mar 2023
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    STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion
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      DOI: 10.1016/j.immuni.2023.02.015

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    sciencedirect.com/science/article/pii/S1074761323000894
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    Endothelial VEGFR Coreceptors Neuropilin-1 and Neuropilin-2 Are Essential for Tumor Angiogenesis
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      DOI: 10.1158/2767-9764.CRC-22-0250

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    ncbi.nlm.nih.gov/pmc/articles/PMC10036134/
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    The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus
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      DOI: 10.1016/j.celrep.2023.112306

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    sciencedirect.com/science/article/pii/S2211124723003170
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    Structural basis for the Rad6 activation by the Bre1 N-terminal domain
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      DOI: 10.7554/eLife.84157

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    ncbi.nlm.nih.gov/pmc/articles/PMC10036116/
  52. Feb 2023
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    Negative regulation of TREM2-mediated C9orf72 poly-GA clearance by the NLRP3 inflammasome
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      DOI: 10.1016/j.celrep.2023.112133

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    TRIM21-dependent target protein ubiquitination mediates cell-free Trim-Away
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    The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
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    Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation
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  57. Jan 2023
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    Artificial extracellular matrix scaffolds of mobile molecules enhance maturation of human stem cell-derived neurons
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    Modulation of protease expression by the transcription factor Ptx1/PITX regulates protein quality control during aging
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    Alternative transcribed 3' isoform of long non-coding RNA Malat1 inhibits mouse retinal oxidative stress
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    ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis
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  63. Dec 2022
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    Cognitively impaired aged Octodon degus recapitulate major neuropathological features of sporadic Alzheimer’s disease
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    LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus
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  69. Oct 2022
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    Protocol to detect in vitro and in cell ubiquitylation of mitochondrial DNA polymerase gamma by mitochondrial E3 ligase MITOL
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  78. Jun 2022
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  81. Mar 2022
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    K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy
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    Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses
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  90. Oct 2021
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    Tyrosine Phosphorylation of DEPTOR Functions as a Molecular Switch to Activate mTOR Signaling
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    Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway
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    Genetically incorporated crosslinkers reveal NleE attenuates host autophagy dependent on PSMD10
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  108. Jul 2021
  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  110. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Vaccinia‐related kinase 2 modulates role of dysbindin by regulating protein stability
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  111. www.embopress.org www.embopress.org
    Parkin‐mediated ubiquitylation redistributes MITOL/March5 from mitochondria to peroxisomes
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      DOI: 10.15252/embr.201947728

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  116. www.sciencedirect.com www.sciencedirect.com
    PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo
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      DOI: 10.1016/j.neuron.2016.03.016

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  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of ubiquitin recognition by the HECT ligase E6AP provides insight into its linkage specificity
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  119. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Quercetin improves the activity of the ubiquitin‐proteasomal system in 150Q mutated huntingtin‐expressing cells but exerts detrimental effects on neuronal survivability
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      DOI: 10.1002/jnr.23618

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  120. rupress.org rupress.org
    Parkin-independent mitophagy via Drp1-mediated outer membrane severing and inner membrane ubiquitination
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  121. May 2021
  122. www.sciencedirect.com www.sciencedirect.com
    The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1
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      DOI: 10.1016/j.jbc.2021.100739

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    UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model
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      DOI: 10.1016/j.neuron.2021.04.023

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    Ubiquitin Phosphorylation at Thr12 Modulates the DNA Damage Response
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      DOI: 10.1016/j.molcel.2020.09.017

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    Opposing roles of E3 ligases TRIM23 and TRIM21 in regulation of ion channel ANO1 protein levels
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      anti-ubiquitin

      DOI: 10.1016/j.jbc.2021.100738

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  126. Apr 2021
  127. www.jneurosci.org www.jneurosci.org
    Pathogenic GRM7 mutations associated with neurodevelopmental disorders impair axon outgrowth and presynaptic terminal development
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      RRID:AB_628423

      DOI: 10.1523/JNEUROSCI.2108-20.2021

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  128. Feb 2021
  129. www.cell.com www.cell.com
    Ribosome Collision Is Critical for Quality Control during No-Go Decay
    1
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      DOI: 10.1016/j.molcel.2017.08.019

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    cell.com/molecular-cell/abstract/S1097-2765(17)30616-0
  130. Jan 2021
  131. www.sciencedirect.com www.sciencedirect.com
    DNA and RNA Cleavage Complexes and Repair Pathway for TOP3B RNA- and DNA-Protein Crosslinks
    1
    1. scibot 05 Jan 2021
      RRID:AB_628423

      DOI: 10.1016/j.celrep.2020.108569

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    sciencedirect.com/science/article/pii/S2211124720315588
  132. Dec 2020
  133. www.sciencedirect.com www.sciencedirect.com
    Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer’s Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals
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      RRID:AB_628423

      DOI: 10.1016/j.cels.2020.11.007

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  134. Nov 2020
  135. www.sciencedirect.com www.sciencedirect.com
    A Selective Autophagy Pathway for Phase-Separated Endocytic Protein Deposits
    1
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      RRID:AB_628423

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  136. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG
    1
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      RRID:AB_628423

      DOI: 10.1186/s12915-020-00877-2

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  137. Sep 2020
  138. elifesciences.org elifesciences.org
    Stress-activated MAPK signaling controls fission yeast actomyosin ring integrity by modulating formin For3 levels
    1
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      DOI: 10.7554/eLife.57951

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  139. elifesciences.org elifesciences.org
    Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice
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      DOI: 10.7554/eLife.44396

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  140. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    N‐linked glycosylation of the mGlu7 receptor regulates the forward trafficking and transsynaptic interaction with Elfn1
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      RRID:AB_628423

      DOI: 10.1096/fj.202001544R

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  141. www.sciencedirect.com www.sciencedirect.com
    Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer
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      DOI: 10.1016/j.ccell.2020.01.011

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  142. academic.oup.com academic.oup.com
    Differential regulation and targeting of estrogen receptor α turnover in invasive lobular breast carcinoma
    1
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      RRID:AB_628423

      DOI: 10.1210/endocr/bqaa109

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    Specific Knockdown of α-Synuclein by Peptide-Directed Proteasome Degradation Rescued Its Associated Neurotoxicity
    1
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      RRID:AB_628423

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  144. www.sciencedirect.com www.sciencedirect.com
    Auto-ubiquitination of NEDD4-1 Recruits USP13 to Facilitate Autophagy through Deubiquitinating VPS34
    1
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      RRID:AB_628423

      DOI: 10.1016/j.celrep.2020.01.088

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    The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency
    1
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      RRID:AB_628423

      DOI: 10.1016/j.celrep.2020.107985

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  146. www.sciencedirect.com www.sciencedirect.com
    The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules
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      RRID:AB_628423

      DOI: 10.1016/j.chom.2020.04.024

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  147. www.sciencedirect.com www.sciencedirect.com
    Threonine ADP-Ribosylation of Ubiquitin by a Bacterial Effector Family Blocks Host Ubiquitination
    1
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      RRID:AB_628423

      DOI: 10.1016/j.molcel.2020.03.016

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  148. elifesciences.org elifesciences.org
    Ubiquitination-dependent control of sexual differentiation in fission yeast
    1
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      RRID:AB_628423

      DOI: 10.7554/eLife.28046

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  149. www.cell.com www.cell.com
    Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating
    1
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      RRID:AB_628423

      DOI: 10.1016/j.celrep.2018.07.004

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    cell.com/cell-reports/abstract/S2211-1247(18)31081-7
  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Proteasome Governs Fungal Morphogenesis via Functional Connections with Hsp90 and cAMP-Protein Kinase A Signaling
    1
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      RRID:AB_628423

      DOI: 10.1128/mBio.00290-20

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  151. www.cell.com www.cell.com
    The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
    1
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      RRID: AB_628423

      DOI: 10.1016/j.celrep.2018.11.097

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    cell.com/cell-reports/fulltext/S2211-1247(18)31888-6
  152. www.cell.com www.cell.com
    An Allosteric Interaction Network Promotes Conformation State-Dependent Eviction of the Nas6 Assembly Chaperone from Nascent 26S Proteasomes
    1
    1. scibot 04 Sep 2020
      RRID: AB_628423

      DOI: 10.1016/j.celrep.2018.12.042

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  153. genesdev.cshlp.org genesdev.cshlp.org
    Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne
    1
    1. scibot 04 Sep 2020
      ubiquitin

      DOI: 10.1101/gad.332395.119

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  154. insight.jci.org insight.jci.org
    The UPR preserves mature oligodendrocyte viability and function in adults by regulating autophagy of PLP
    1
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      ubiquitin

      DOI: 10.1172/jci.insight.132364

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    sciencedirect.com/science/article/pii/S1535610817304129
  197. www.sciencedirect.com www.sciencedirect.com
    Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy
    1
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    sciencedirect.com/science/article/pii/S1550413118303140
  198. www.sciencedirect.com www.sciencedirect.com
    Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia
    1
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  199. elifesciences.org elifesciences.org
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    elifesciences.org/articles/32893
  200. www.sciencedirect.com www.sciencedirect.com
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  201. www.sciencedirect.com www.sciencedirect.com
    MPK3- and MPK6-Mediated ICE1 Phosphorylation Negatively Regulates ICE1 Stability and Freezing Tolerance in Arabidopsis
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  202. www.sciencedirect.com www.sciencedirect.com
    Human Neural Stem Cell Transplantation Rescues Functional Deficits in R6/2 and Q140 Huntington's Disease Mice
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  204. www.sciencedirect.com www.sciencedirect.com
    Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity
    2
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  205. europepmc.org europepmc.org
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  206. Nov 2017
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    Tetherin Suppresses Type I Interferon Signaling by Targeting MAVS for NDP52-Mediated Selective Autophagic Degradation in Human Cells
    1
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  208. www.sciencedirect.com www.sciencedirect.com
    Ribosome Collision Is Critical for Quality Control during No-Go Decay
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    A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN
    1
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  210. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin
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  211. www.sciencedirect.com www.sciencedirect.com
    Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis
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    Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival
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  213. www.sciencedirect.com www.sciencedirect.com
    Proteasome Activation by Small Molecules
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  214. www.sciencedirect.com www.sciencedirect.com
    In Vivo Ubiquitin Linkage-type Analysis Reveals that the Cdc48-Rad23/Dsk2 Axis Contributes to K48-Linked Chain Specificity of the Proteasome
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  215. elifesciences.org elifesciences.org
    YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB
    1
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    elifesciences.org/content/6/e22416
  216. www.sciencedirect.com www.sciencedirect.com
    SINAT E3 Ligases Control the Light-Mediated Stability of the Brassinosteroid-Activated Transcription Factor BES1 in Arabidopsis
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  217. elifesciences.org elifesciences.org
    Chlamydia trachomatis-containing vacuole serves as deubiquitination platform to stabilize Mcl-1 and to interfere with host defense
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      Curator: @Zeljana_Babic

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    elifesciences.org/content/6/e21465
  218. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding
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    ncbi.nlm.nih.gov/pmc/articles/PMC4931344/
  219. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6
    1
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      Curator: @chewbeccax

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    ncbi.nlm.nih.gov/pmc/articles/PMC5102578/
  220. bmcneurosci.biomedcentral.com bmcneurosci.biomedcentral.com
    Expression profiling of the ubiquitin conjugating enzyme UbcM2 in murine brain reveals modest age-dependent decreases in specific neurons
    1
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      AB_628423

      Curator: @gabimpine

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    bmcneurosci.biomedcentral.com/articles/10.1186/s12868-015-0194-y
  221. www.sciencedirect.com www.sciencedirect.com
    PIAS1 Regulates Mutant Huntingtin Accumulation and Huntington’s Disease-Associated Phenotypes In Vivo
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    sciencedirect.com/science/article/pii/S0896627316300058
  222. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SwissPalm: Protein Palmitoylation database
    1
    1. scibot 08 Nov 2017
      AB_628423

      Curator: @jcabotaj

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    ncbi.nlm.nih.gov/pmc/articles/PMC4544385/