492 Matching Annotations
  1. Nov 2022
  2. www.sciencedirect.com www.sciencedirect.com
    NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma
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    1. scibot 09 Nov 2022
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    sciencedirect.com/science/article/pii/S2211124722014942
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    Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin
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    1. scibot 05 Nov 2022
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    link.springer.com/article/10.1007/s13402-022-00737-x
  4. Oct 2022
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    TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways
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    1. scibot 28 Oct 2022
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      DOI: 10.1016/j.cell.2022.09.033

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    sciencedirect.com/science/article/pii/S0092867422012521
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    Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1
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    1. scibot 27 Oct 2022
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      DOI: 10.7554/eLife.80014

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    ncbi.nlm.nih.gov/pmc/articles/PMC9592085/
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    Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation
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    1. scibot 26 Oct 2022
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    sciencedirect.com/science/article/pii/S2451945622003567
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    The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice
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    1. scibot 18 Oct 2022
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    sciencedirect.com/science/article/pii/S1550413122004090
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    En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH
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    sciencedirect.com/science/article/pii/S0092867422012508
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    Schwann cells-derived exosomal miR-21 participates in high glucose regulation of neurite outgrowth
    1
    1. scibot 08 Oct 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC9529988/
  11. Sep 2022
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    The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling
    1
    1. scibot 27 Sep 2022
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    sciencedirect.com/science/article/pii/S0021925822009759
  13. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multiplexed protein profiling reveals spatial subcellular signaling networks
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    ncbi.nlm.nih.gov/pmc/articles/PMC9460555/
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    PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer
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    1. scibot 13 Sep 2022
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    sciencedirect.com/science/article/pii/S2666379122002907
  15. Aug 2022
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    DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting
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  17. 52.53.155.43 52.53.155.43
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    Hepatocyte Rap1a contributes to obesity- and statin-associated hyperglycemia
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    sciencedirect.com/science/article/pii/S2211124722010774
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    MicroRNA-21-5p agomir inhibits apoptosis of oligodendrocyte precursor cell and attenuates white matter injury in neonatal rats
    1
    1. scibot 22 Aug 2022
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    sciencedirect.com/science/article/pii/S0361923022002076
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    EZH2 T367 phosphorylation activates p38 signaling through lysine methylation to promote breast cancer progression
    1
    1. scibot 12 Aug 2022
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  21. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Deletion of serine racemase reverses neuronal insulin signaling inhibition by amyloid-β oligomers
    1
    1. scibot 04 Aug 2022
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    Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis
    1
    1. scibot 04 Aug 2022
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    sciencedirect.com/science/article/pii/S1550413122003059
  23. Jul 2022
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines
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    1. scibot 31 Jul 2022
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      DOI: 10.3390/ijms23147774

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    ncbi.nlm.nih.gov/pmc/articles/PMC9317664/
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    High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition
    1
    1. scibot 30 Jul 2022
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    sciencedirect.com/science/article/pii/S221112472200897X
  26. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2022 - Li - Maresin 1 intervention Reverses Experimental Pulmonary Arterial Hypertension in mice-html.html
    1
    1. scibot 29 Jul 2022
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      DOI: 10.1111/bph.14208

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    52.53.155.43/eeb521b7ce9ed18aede2526ed77220c5d9e406f5/British J Pharmacology - 2022 - Li - Maresin 1 intervention Reverses Experimental Pulmonary Arterial Hypertension in mice-html.html
  27. www.sciencedirect.com www.sciencedirect.com
    Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer
    1
    1. scibot 27 Jul 2022
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      DOI: 10.1016/j.ccell.2022.06.011

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    sciencedirect.com/science/article/pii/S1535610822002756
  28. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer
    1
    1. scibot 12 Jul 2022
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      DOI: 10.3390/cancers14133152

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    Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis
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      DOI: 10.1016/j.stem.2022.06.004

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    sciencedirect.com/science/article/pii/S1934590922002533
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    The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis
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    sciencedirect.com/science/article/pii/S1097276522005445
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    Protocol for assessing ex vivo lipolysis of murine adipose tissue
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      DOI: 10.1016/j.xpro.2022.101518

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    sciencedirect.com/science/article/pii/S2666166722003987
  33. Jun 2022
  34. www.sciencedirect.com www.sciencedirect.com
    Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
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    1. scibot 24 Jun 2022
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    sciencedirect.com/science/article/pii/S0092867422006523
  35. link.springer.com link.springer.com
    The granulosa cell response to luteinizing hormone is partly mediated by YAP1-dependent induction of amphiregulin
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    1. scibot 15 Jun 2022
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      DOI: 10.1186/s12964-022-00843-1

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    MiR-690 treatment causes decreased fibrosis and steatosis and restores specific Kupffer cell functions in NASH
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    CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development
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    ATGL-dependent white adipose tissue lipolysis controls hepatocyte PPARα activity
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    Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses
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    Inhibition of ATP-citrate lyase improves NASH, liver fibrosis, and dyslipidemia
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  41. www.nature.com www.nature.com
    Furin extracellularly cleaves secreted PTENα/β to generate C-terminal fragment with a tumor-suppressive role
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      DOI: 10.1038/s41419-022-04988-2

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  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic screens identify a context-specific PI3K/p27Kip1 node driving extrahepatic biliary cancer
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      DOI: 10.1158/2159-8290.CD-21-0209

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    ncbi.nlm.nih.gov/pmc/articles/PMC7612573/
  43. academic.oup.com academic.oup.com
    Influence of maternal exercise on glucose and lipid metabolism in offspring stem cells: ENHANCED by Mom
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      DOI: 10.1210/clinem/dgac270

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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac270/6577152
  44. academic.oup.com academic.oup.com
    Deficiency of C1QL1 reduced murine ovarian follicle reserve through intraovarian and endocrine control
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      DOI: 10.1210/endocr/bqac048

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    academic.oup.com/endo/article/163/6/bqac048/6569208
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Astilbin Activates the Reactive Oxidative Species/PPARγ Pathway to Suppress Effector CD4+ T Cell Activities via Direct Binding With Cytochrome P450 1B1
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      DOI: 10.3389/fphar.2022.848957

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    ncbi.nlm.nih.gov/pmc/articles/PMC9150850/
  46. May 2022
  47. www.sciencedirect.com www.sciencedirect.com
    DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production
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    sciencedirect.com/science/article/pii/S1097276522003938
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    The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth
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    Tumor Microenvironment Acidity Triggers Lipid Accumulation in Liver Cancer via SCD1 Activation
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  50. Apr 2022
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    Acute deletion of the FOXO1-dependent hepatokine FGF21 does not alter basal glucose homeostasis or lipolysis in mice
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    The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets
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    IP3R-mediated Ca2+ signaling controls B cell proliferation through metabolic reprogramming
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    Microglia/macrophage-derived human CCL18 promotes glioma progression via CCR8-ACP5 axis analyzed in humanized slice model
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  59. Mar 2022
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    Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells
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    Ivermectin represses Wnt/β-catenin signaling by binding to TELO2, a regulator of phosphatidylinositol 3-kinase-related kinases
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    YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
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  65. Feb 2022
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    Supplementing Soy-Based Diet with Creatine in Rats: Implications for Cardiac Cell Signaling and Response to Doxorubicin
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    A mouse model of inherited choline kinase β-deficiency presents with specific cardiac abnormalities and a predisposition to arrhythmia
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    Identification of an endoplasmic reticulum proteostasis modulator that enhances insulin production in pancreatic β cells
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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  72. Jan 2022
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    An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance
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    Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function
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  77. Dec 2021
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    Translational and post-translational control of human naïve versus primed pluripotency
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    MAL2 mediates the formation of stable HER2 signaling complexes within lipid raft-rich membrane protrusions in breast cancer cells
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    GFAT2 mediates cardiac hypertrophy through HBP-O-GlcNAcylation-Akt pathway
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    Efferocytosis induces macrophage proliferation to help resolve tissue injury
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    Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction
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    m6A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity
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    FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
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    Protocol for the assessment of mTOR activity in mouse primary hepatocytes
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  94. Oct 2021
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    Type 2 diabetes sex-specific effects associated with E167K coding variant in TM6SF2
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    An extensive and dynamic trans-omic network illustrating prominent regulatory mechanisms in response to insulin in the liver
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    The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway
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    A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
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    Differential Actions of Estrogen Receptor α and β via Non-Genomic Signaling in Human Prostate Stem and Progenitor Cells
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    Artemisinin inhibits NRas palmitoylation by targeting the protein acyltransferase ZDHHC6
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  123. Jul 2021
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    An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress
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    IL-17 Inhibits Oligodendrocyte Progenitor Cell Proliferation and Differentiation by Increasing K+ Channel Kv1.3
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  136. Jun 2021
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    Reprogramming an energetic AKT-PAK5 axis boosts axon energy supply and facilitates neuron survival and regeneration after injury and ischemia
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  141. May 2021
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    Melanoma-derived extracellular vesicles skew neutrophils into a pro-tumor phenotype
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    The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding
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    PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR
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    The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism
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    Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses
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    Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function
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    Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism
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    SH3BP4 promotes neuropilin-1 and α5-integrin endocytosis and is inhibited by Akt
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    The Rag GTPase Regulates the Dynamic Behavior of TSC Downstream of Both Amino Acid and Growth Factor Restriction
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    Parvalbumin affects skeletal muscle trophism through modulation of mitochondrial calcium uptake
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    Metabolic stress drives sympathetic neuropathy within the liver
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  154. Apr 2021
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    MiR-690, an exosomal-derived miRNA from M2-polarized macrophages, improves insulin sensitivity in obese mice
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    Glutamine deficiency promotes stemness and chemoresistance in tumor cells through DRP1-induced mitochondrial fragmentation
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    Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice
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    Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade
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    Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells
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    mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
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    Blocking Fra-1 sensitizes triple-negative breast cancer to PARP inhibitor
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  162. Mar 2021
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    Metabolomic analysis of a selective ABCA1 inducer in obesogenic challenge provides a rationale for therapeutic development
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    Roles of PINK1 in regulation of systemic growth inhibition induced by mutations of PTEN in Drosophila
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    Primary cilia-dependent lipid raft/caveolin dynamics regulate adipogenesis
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    Isorhamnetin Inhibits Human Gallbladder Cancer Cell Proliferation and Metastasis via PI3K/AKT Signaling Pathway Inactivation
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    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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  168. Feb 2021
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    Exposure to low doses of Dechlorane Plus promotes adipose tissue dysfunction and glucose intolerance in male mice
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    A Gatekeeping Role of ESR2 to Maintain the Primordial Follicle Reserve
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    Mitochondrial Threonyl-tRNA Synthetase TARS2 Is Required for Threonine-Sensitive mTORC1 Activation
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    Suppression of adipocyte differentiation by low‐intensity pulsed ultrasound via inhibition of insulin signaling and promotion of CCN family protein 2
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    Gnrh3 regulates PGC proliferation and sex differentiation in developing zebrafish
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    Asymmetric cell division promotes therapeutic resistance in glioblastoma stem cells
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    Prenatal correction of IGF2 to rescue the growth phenotypes in mouse models of Beckwith-Wiedemann and Silver-Russell syndromes
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  176. Jan 2021
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    Impact of WIN site inhibitor on the WDR5 interactome
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    ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism
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    Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1
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    Microglia induce neurogenic protein expression in primary cortical cells by stimulating PI3K/AKT intracellular signaling in vitro
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  181. Dec 2020
  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RSPO3 is a marker candidate for predicting tumor aggressiveness in ovarian cancer
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    Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions
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    BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages
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    ROS Dynamics Delineate Functional States of Hippocampal Neural Stem Cells and Link to Their Activity-Dependent Exit from Quiescence
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    Deletion of PDK1 in oligodendrocyte lineage cells causes white matter abnormality and myelination defect in the central nervous system
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    Electrical stimulation prevents doxorubicin-induced atrophy and mitochondrial loss in cultured myotubes
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  189. Nov 2020
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    Effect of Hyperbaric Oxygen Therapy on Acute Liver Injury and Survival in a Rat Cecal Slurry Peritonitis Model
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  191. www.sciencedirect.com www.sciencedirect.com
    Overcoming Adaptive Resistance to KRAS and MEK Inhibitors by Co-targeting mTORC1/2 Complexes in Pancreatic Cancer
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    ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation
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  193. www.jneurosci.org www.jneurosci.org
    The γ-Protocadherins Regulate the Survival of GABAergic Interneurons during Developmental Cell Death
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  194. Oct 2020
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    A Regulation Loop between YAP and NR4A1 Balances Cell Proliferation and Apoptosis
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  196. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma
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  197. elifesciences.org elifesciences.org
    Optical control of ERK and AKT signaling promotes axon regeneration and functional recovery of PNS and CNS in Drosophila
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  198. Sep 2020
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    Reducing NADPH Synthesis Counteracts Diabetic Nephropathy through Restoration of AMPK Activity in Type 1 Diabetic Rats
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    TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
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    The Kinase Activity of Drosophila BubR1 Is Required for Insulin Signaling-Dependent Stem Cell Maintenance
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    PTPσ Knockdown in Lampreys Impairs Reticulospinal Axon Regeneration and Neuronal Survival After Spinal Cord Injury
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    ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis
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  204. www.cell.com www.cell.com
    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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    Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras
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    A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3′ End Processing Complex
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      DOI: 10.1016/j.molcel.2019.12.022

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    Targeting the Tie2–α v β 3 integrin axis with bi-specific reagents for the inhibition of angiogenesis
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      DOI: 10.1186/s12915-018-0557-9

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    Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer
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    BCR-Induced Ca2+ Signals Dynamically Tune Survival, Metabolic Reprogramming, and Proliferation of Naive B Cells
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      DOI: 10.1016/j.celrep.2020.03.038

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    Failed Apoptosis Enhances Melanoma Cancer Cell Aggressiveness
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    Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly
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  212. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Muscle function and homeostasis require cytokine inhibition of AKT activity in Drosophila
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  213. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation
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    microRNA‐9‐5p alleviates blood‐brain barrier damage and neuroinflammation after traumatic brain injury
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    Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone
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    Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer
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    PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
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      AKT

      DOI: 10.1016/j.immuni.2018.05.006

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  219. journals.physiology.org journals.physiology.org
    Electrical stimulation prevents doxorubicin-induced atrophy and mitochondrial loss in cultured myotubes | American Journal of Physiology-Cell Physiology
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  220. stke.sciencemag.org stke.sciencemag.org
    Blocking EGFR palmitoylation suppresses PI3K signaling and mutant KRAS lung tumorigenesis
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      AKT

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  221. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    IKKε and TBK1 in diffuse large B‐cell lymphoma: A possible mechanism of action of an IKKε/TBK1 inhibitor to repress NF‐κB and IL‐10 signalling
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    1. scibot 03 Sep 2020
      AKT

      DOI: 10.1111/jcmm.15774

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    High expression of miR-135b predicts malignant transformation and poor prognosis of gastric cancer
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      Akt (pan) (C67E7) rabbit mAb

      DOI: 10.1016/j.lfs.2020.118133

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  223. journals.physiology.org journals.physiology.org
    Lactational metformin exposure programs offspring white adipose tissue glucose homeostasis and resilience to metabolic stress in a sex-dependent manner | American Journal of Physiology-Endocrinology and Metabolism
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      monoclonal rabbit Akt

      DOI: 10.1152/ajpendo.00473.2019

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    Fibroblast-Derived STC-1 Modulates Tumor-Associated Macrophages and Lung Adenocarcinoma Development
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  225. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biallelic Mutations in TSC2 Lead to Abnormalities Associated with Cortical Tubers in Human iPSC-Derived Neurons
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      DOI: 10.1523/JNEUROSCI.0642-19.2019

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