570 Matching Annotations
  1. Sep 2023
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of AKT induces EZH2-mediated β-catenin trimethylation in colorectal cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10475482/
  3. Aug 2023
  4. www.biorxiv.org www.biorxiv.org
    Unraveling Vulnerabilities in Endocrine Therapy-Resistant HER2+/ER+ Breast Cancer
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    biorxiv.org/content/10.1101/2023.08.21.554116v1
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    mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway
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    sciencedirect.com/science/article/pii/S2589004223016176
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    Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties
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    sciencedirect.com/science/article/pii/S221112472300877X
  7. 52.53.155.43 52.53.155.43
    Synergy of 5-aminolevulinate supplement and CX3CR1 suppression promotes liver regeneration via elevated IGF-1 signaling
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    FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress
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    sciencedirect.com/science/article/pii/S221112472300997X
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    Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
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    ncbi.nlm.nih.gov/pmc/articles/PMC10407955/
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    Enhanced glycolysis-mediated energy production in alveolar stem cells is required for alveolar regeneration
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    sciencedirect.com/science/article/pii/S1934590923002539
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    BPS Publications
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    52.53.155.43/d8c850c315bd1ef9a1794152cac296a4123affe5/British J Pharmacology - 2023 - Wang - Sanguinarine induces apoptosis in osteosarcoma by attenuating the binding of STAT3-html.html
  12. Jul 2023
  13. dx.doi.org dx.doi.org
    Pigment Epithelium-Derived Factor, a Novel Adipokine, Contributes to Gestational Diabetes Mellitus
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    dx.doi.org/10.1210/clinem/dgad413
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    Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia
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    sciencedirect.com/science/article/pii/S221112472300880X
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    mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching
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    sciencedirect.com/science/article/pii/S2211124723008793
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    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
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  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell Competition Shapes Metastatic Latency and Relapse
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    ncbi.nlm.nih.gov/pmc/articles/PMC9839468/
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    Increased Cardiac PFK-2 Protects Against High-Fat Diet-Induced Cardiomyopathy and Mediates Beneficial Systemic Metabolic Effects
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    Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH
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    sciencedirect.com/science/article/pii/S2589004223012786
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    Macrophage-mediated extracellular matrix remodeling controls host Staphylococcus aureus susceptibility in the skin
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  21. Jun 2023
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex
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    ncbi.nlm.nih.gov/pmc/articles/PMC10285642/
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    Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer
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  24. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Single-cell RNA-seq uncovers novel metabolic functions of Schwann cells beyond myelination
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    onlinelibrary.wiley.com/doi/10.1111/jnc.15877
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    Acetate controls endothelial-to-mesenchymal transition
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    Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration
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    MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells
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    sciencedirect.com/science/article/pii/S030438352300215X
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    UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
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  29. www.science.org www.science.org
    HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis
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    science.org/doi/10.1126/sciadv.ade1155
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    A Drosophila model of diabetic neuropathy reveals a role of proteasome activity in the glia
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  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N6-methyl-2′-deoxyadenosine promotes self-renewal of BFU-E progenitor in erythropoiesis
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    ncbi.nlm.nih.gov/pmc/articles/PMC10239700/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Evaluation of therapeutic PD-1 antibodies by an advanced single-molecule imaging system detecting human PD-1 microclusters
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    pmc.ncbi.nlm.nih.gov/articles/PMC10244369/
  33. aacrjournals.org aacrjournals.org
    Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer
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    aacrjournals.org/cancerres/article/83/8/1280/725099/Dysregulation-of-Mitochondrial-Translation-Caused
  34. www.cell.com www.cell.com
    Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis
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    cell.com/cell-host-microbe/fulltext/S1931-3128(23)00200-7
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16080
  36. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Targeting formyl peptide receptor 1 by anteiso-C13-surfactin for neutrophil-dominant acute respiratory distress syndrome
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    Chronic neuronal inactivity utilizes the mTOR-TFEB pathway to drive transcription-dependent autophagy for homeostatic up-scaling
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    jneurosci.org/content/43/15/2631
  38. May 2023
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lacking ARHGAP25 mitigates the symptoms of autoantibody-induced arthritis in mice
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    ncbi.nlm.nih.gov/pmc/articles/PMC10208528/
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    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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    Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma
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    sciencedirect.com/science/article/pii/S0006295223002034
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    Salivary gland cancer organoids are valid for preclinical genotype-oriented medical precision trials
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    Trigeminal nerve derived-substance P regulates limbal stem cells by the PI3K-AKT pathway
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    sciencedirect.com/science/article/pii/S2589004223007654
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    VEGFR-3 signaling restrains the neuron-macrophage crosstalk during neurotropic viral infection
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  45. aacrjournals.org aacrjournals.org
    Transcriptional repression by FoxM1 suppresses tumor differentiation and promotes metastasis of breast cancer
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    aacrjournals.org/cancerres/article/82/13/2458/705024/Transcriptional-Repression-by-FoxM1-Suppresses
  46. Apr 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
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    CD36 regulates diurnal glucose metabolism and hepatic clock to maintain glucose homeostasis in mice
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  49. www.sciencedirect.com www.sciencedirect.com
    Autocrine activation of MAPK signaling mediates intrinsic tolerance to androgen deprivation in LY6D prostate cancer cells
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    sciencedirect.com/science/article/pii/S2211124723003881
  50. www.sciencedirect.com www.sciencedirect.com
    A human skeletal muscle stem/myotube model reveals multiple signaling targets of cancer secretome in skeletal muscle
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    sciencedirect.com/science/article/pii/S2589004223006181
  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model
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    ncbi.nlm.nih.gov/pmc/articles/PMC10074152/
  52. Mar 2023
  53. www.sciencedirect.com www.sciencedirect.com
    Epithelial cells activate fibroblasts to promote esophageal cancer development
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    sciencedirect.com/science/article/pii/S1535610823000491
  54. link.springer.com link.springer.com
    VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma
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    link.springer.com/article/10.1007/s13402-023-00793-x
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2
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    ncbi.nlm.nih.gov/pmc/articles/PMC9444962/
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Echinocystic acid alleviated hypoxic-ischemic brain damage in neonatal mice by activating the PI3K/Akt/Nrf2 signaling pathway
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    ncbi.nlm.nih.gov/pmc/articles/PMC9947717/
  57. Feb 2023
  58. www.sciencedirect.com www.sciencedirect.com
    Exercise-activated hepatic autophagy via the FN1-α5β1 integrin pathway drives metabolic benefits of exercise
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    sciencedirect.com/science/article/pii/S1550413123000116
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    NRF3 activates mTORC1 arginine-dependently for cancer cell viability
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    ncbi.nlm.nih.gov/pmc/articles/PMC9932127/
  60. academic.oup.com academic.oup.com
    STRA6 promotes thyroid carcinoma progression via activation of the ILK/AKT/mTOR axis in cells and female nude mice
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    academic.oup.com/endo/article/164/3/bqac215/6967061
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    PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6
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    sciencedirect.com/science/article/pii/S2589004223001475
  62. www.sciencedirect.com www.sciencedirect.com
    Development of a bispecific DNA-aptamer-based lysosome-targeting chimera for HER2 protein degradation
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  63. www.sciencedirect.com www.sciencedirect.com
    Pseudo-temporal dynamics of chemoresistant triple negative breast cancer cells reveal EGFR/HER2 inhibition as synthetic lethal during mid-neoadjuvant chemotherapy
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  64. www.biorxiv.org www.biorxiv.org
    The myocardium utilizes Pdgfra-PI3K signaling to steer towards the midline during heart tube formation
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    biorxiv.org/content/10.1101/2023.01.03.522612v1
  65. www.mdpi.com www.mdpi.com
    Asparagine and Glutamine Deprivation Alters Ionizing Radiation Response, Migration and Adhesion of a p53null Colorectal Cancer Cell Line
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    mdpi.com/1422-0067/24/3/2983
  66. Jan 2023
  67. www.sciencedirect.com www.sciencedirect.com
    Immune checkpoint HLA-E:CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance
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    HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease
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  69. link.springer.com link.springer.com
    The TGR5 Agonist INT-777 Promotes Peripheral Nerve Regeneration by Activating cAMP-dependent Protein Kinase A in Schwann Cells
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    link.springer.com/article/10.1007/s12035-022-03182-x
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    The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region
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    sciencedirect.com/science/article/pii/S2211124722018150
  71. Dec 2022
  72. www.sciencedirect.com www.sciencedirect.com
    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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  73. www.mdpi.com www.mdpi.com
    Neuroprotective and Anti-Neuroinflammatory Properties of Vignae Radiatae Semen in Neuronal HT22 and Microglial BV2 Cell Lines
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    mdpi.com/2072-6643/14/24/5265
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    Human PSEN1 Mutant Glia Improve Spatial Learning and Memory in Aged Mice
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    mdpi.com/2073-4409/11/24/4116
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    AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance
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    sciencedirect.com/science/article/pii/S2211124722017132
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The oncogenic PI3K-induced transcriptomic landscape reveals key functions in splicing and gene expression regulation
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    ncbi.nlm.nih.gov/pmc/articles/PMC9354703/
  77. 52.53.155.43 52.53.155.43
    Selaginella tamariscina Inhibits Glutamate-Induced Autophagic Cell Death by Activating the PI3K/AKT/mTOR Signaling Pathways
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    The Neuroprotective Effects of Arecae Pericarpium against Glutamate-Induced HT22 Cell Cytotoxicity
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    mdpi.com/1467-3045/44/12/402
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    Celecoxib activates autophagy by inhibiting the mTOR signaling pathway and prevents apoptosis in nucleus pulposus cells
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    link.springer.com/article/10.1186/s40360-022-00633-y
  80. Nov 2022
  81. www.sciencedirect.com www.sciencedirect.com
    Reelin regulates the migration of late-born hippocampal CA1 neurons via cofilin phosphorylation
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  82. academic.oup.com academic.oup.com
    Ketone Body Infusion abrogates Growth Hormone Induced Lipolysis and Insulin Resistance
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    academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac595/6761325
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    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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    ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
  84. www.researchsquare.com www.researchsquare.com
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    researchsquare.com/article/rs-6955925/'https://www.researchsquare.com/article/rs-6955925/v1
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    RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation
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    Platelet p110β mediates platelet-leukocyte interaction and curtails bacterial dissemination in pneumococcal pneumonia
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    NF1 loss of function as an alternative initiating event in pancreatic ductal adenocarcinoma
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    Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin
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    link.springer.com/article/10.1007/s13402-022-00737-x
  89. Oct 2022
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    TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways
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    Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1
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    ncbi.nlm.nih.gov/pmc/articles/PMC9592085/
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    Mechanistic insights into cancer drug resistance through optogenetic PI3K signaling hyperactivation
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    sciencedirect.com/science/article/pii/S2451945622003567
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    The rheumatoid arthritis drug auranofin lowers leptin levels and exerts antidiabetic effects in obese mice
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    En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH
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    Schwann cells-derived exosomal miR-21 participates in high glucose regulation of neurite outgrowth
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    ncbi.nlm.nih.gov/pmc/articles/PMC9529988/
  96. Sep 2022
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    The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/ insulin like growth factor receptor signaling
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    Multiplexed protein profiling reveals spatial subcellular signaling networks
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    PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer
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