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Jun 2026
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The E3 ubiquitin ligase HUWE1 is required for KRAS-induced lung cancer

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1. scibot 06 Jun 2026
  
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  Addgene_12259
  
  DOI: 10.1038/s41419-026-08672-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13187489/
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Integrative genomics and single-cell CRISPRi screening dissect Alzheimer GWAS non-coding variants regulating TSPAN14

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pmc.ncbi.nlm.nih.gov/articles/PMC13240668/
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Inhibition of N‐Terminal Acetyltransferase C Mitigates Endoplasmic Reticulum Stress–Mediated Muscle Atrophy in Cancer Cachexia

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  plasmid_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13140329/
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Neuroproteasomes regulate endogenous tau paired helical filament formation in an APOE genotype- and age-dependent manner

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  Addgene plasmid no. 12259
  
  DOI: 10.1038/s41593-026-02297-x
  
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nature.com/articles/s41593-026-02297-x
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Regulation of the proteasome 20S core particle by the Parkinsonism-associated Proteins FBXO7 and PI31

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  Addgene_12259
  
  DOI: 10.64898/2026.05.28.728263
  
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biorxiv.org/content/10.64898/2026.05.28.728263v1
54.241.53.176 54.241.53.176

2026.05.25.727656.full-html.html

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54.241.53.176/32c5a2f4753f61ee28ea249cdeb257eadb13655d/2026.05.25.727656.full-html.html
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DHX36 is a regulatory switch in the interferon-mediated antiviral response

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1. scibot 04 Jun 2026
  
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  DOI: 10.1126/sciadv.aef5520
  
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science.org/doi/10.1126/sciadv.aef5520
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Characterization of a transmembrane-activating STING agonist using genetically humanized mice

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  DOI: 10.1016/j.celrep.2026.117475
  
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sciencedirect.com/science/article/pii/S221112472600553X
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AKT1 glutarylation regulated by GCDH and SIRT5 suppresses oncogenic signaling

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1. scibot 03 Jun 2026
  
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  AddgeneCat# 12259
  
  DOI: 10.1016/j.celrep.2026.117394
  
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sciencedirect.com/science/article/pii/S2211124726004729
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DHX36 is a regulatory switch in the interferon-mediated antiviral response

1
1. scibot 02 Jun 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1126/sciadv.aef5520
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13220864/
May 2026
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Uncovering spatially resolved functional genomics with CRISPR screen sequencing

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1. scibot 29 May 2026
  
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  DOI: 10.1016/j.cell.2026.04.049
  
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sciencedirect.com/science/article/pii/S0092867426005167
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Linking tumor viability and immune infiltration with dual-nucleus MRI in preclinical models

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1. scibot 29 May 2026
  
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  plasmid_12259
  
  DOI: 10.1038/s44303-026-00158-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13201762/
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Design principles of a membrane-spanning ubiquitin ligase

1
1. scibot 29 May 2026
  
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  plasmid_12259
  
  DOI: 10.1016/j.molcel.2026.05.001
  
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sciencedirect.com/science/article/pii/S1097276526003072
elifesciences.org elifesciences.org

Functional Separation of mRNA Domains Coordinates Pluripotent Cell Behavior

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1. scibot 28 May 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.7554/eLife.110994.1
  
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elifesciences.org/reviewed-preprints/110994
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Naturally occurring ZCCHC3 variants modulate antiretroviral activity in cynomolgus macaques

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1. scibot 28 May 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.64898/2026.05.21.726815
  
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biorxiv.org/content/10.64898/2026.05.21.726815v1
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A generalizable system for antigenic peptide targeting across HLA-I allotypes

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  Addgene_12259
  
  DOI: 10.64898/2026.05.21.726655
  
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biorxiv.org/content/10.64898/2026.05.21.726655v1
54.241.53.176 54.241.53.176

2026.05.15.725565.full-html.html

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1. scibot 28 May 2026
  
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  Addgene_12259
  
  DOI: 10.64898/2026.05.15.725565
  
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54.241.53.176/2447a5ced46d9d7e59810e249079117292d6f95a/2026.05.15.725565.full-html.html
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Phenylalanyl-tRNA synthetase FARS-1/FARSA balances longevity and immunity by downregulating endogenous mitochondrial double-stranded RNAs

1
1. scibot 28 May 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.molcel.2026.04.030
  
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sciencedirect.com/science/article/pii/S1097276526002844
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Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability

1
1. scibot 27 May 2026
  
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  Addgene #12259
  
  DOI: 10.1038/s41467-026-70655-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13199580/
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CTSZ-dependent anoikis resistance enhances malignant characters of glioblastoma via NF-κB signaling

1
1. scibot 27 May 2026
  
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  Addgene#12259
  
  DOI: 10.1016/j.isci.2026.115992
  
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sciencedirect.com/science/article/pii/S2589004226013672
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Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in colorectal cancer

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1. scibot 27 May 2026
  
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  Addgene12259
  
  DOI: 10.1016/j.ccell.2026.04.009
  
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sciencedirect.com/science/article/pii/S1535610826002205
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Lung mucosal and systemic responses at single-cell resolution in an aerosolized Mycobacterium bovis BCG human challenge model

2
1. scibot 26 May 2026
  
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  AddgeneCat: 12259
  
  DOI: 10.1016/j.xcrm.2026.102830
  
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  plasmid_12259
  
  DOI: 10.1016/j.xcrm.2026.102830
  
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sciencedirect.com/science/article/pii/S2666379126002478
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Twelve phosphomimetic mutations induce the assembly of recombinant full-length human tau into paired helical filaments

1
1. scibot 22 May 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.7554/eLife.104778
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13189620/
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cGAS/STING sensing in dendritic cells discriminates between daptomycin sensitive and resistant Staphylococcus aureus clinical isolates

1
1. scibot 22 May 2026
  
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  Plasmid_12259
  
  DOI: 10.1016/j.isci.2026.115854
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13186032/
54.241.53.176 54.241.53.176

2026.05.11.724407.full-html.html

1
1. scibot 21 May 2026
  
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  plasmid_12259
  
  DOI: 10.64898/2026.05.11.724407
  
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54.241.53.176/bfcffe42e71061fda5786106304e0751d5cf2645/2026.05.11.724407.full-html.html
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Intrinsic bias of the genetic code shapes the folding and stability landscapes of microproteins

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1. scibot 20 May 2026
  
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  Addgene_12259
  
  DOI: 10.1016/j.molcel.2026.04.021
  
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sciencedirect.com/science/article/pii/S1097276526002753
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A CRISPR activation screen identifies SPART as a pan-orthoflavivirus restriction factor

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1. scibot 20 May 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.chom.2026.04.018
  
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sciencedirect.com/science/article/pii/S1931312826001745
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CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastoma

1
1. scibot 19 May 2026
  
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  Addgene #12259
  
  DOI: 10.1038/s44321-026-00393-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13179391/
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A regulatory circuitry driving a noradrenergic to mesenchymal transition highlights YAP/TAZ as critical players in neuroblastoma plasticity

2
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.celrep.2026.117351
  
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  RRID:Addgene_12259
  
  DOI: 10.1016/j.celrep.2026.117351
  
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sciencedirect.com/science/article/pii/S2211124726004298
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Presentation of identical tumor antigen peptides by canine and human MHC class I

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1. scibot 16 May 2026
  
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  AddgeneCat #122259
  
  DOI: 10.1016/j.isci.2026.115975
  
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sciencedirect.com/science/article/pii/S2589004226013507
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miR-93-mediated PTEN suppression and CNS-specific T cell exhaustion shape the leukemia niche in infant KMT2A::AFF1+ B-ALL

1
1. scibot 16 May 2026
  
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  Addgene Cat#12259
  
  DOI: 10.1016/j.celrep.2026.117353
  
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sciencedirect.com/science/article/pii/S2211124726004316
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Cooperative response loops enhanced by histamine signaling during tumor-neutrophil crosstalk in pleural mesothelioma

1
1. scibot 16 May 2026
  
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  plasmid_12259
  
  DOI: 10.1016/j.celrep.2026.117361
  
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sciencedirect.com/science/article/pii/S2211124726004390
www.nature.com www.nature.com

Ascites protects against ferroptosis and enables the peritoneal growth of ovarian cancer

1
1. scibot 15 May 2026
  
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  Addgene, 12259
  
  DOI: 10.1038/s41467-026-72116-1
  
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nature.com/articles/s41467-026-72116-1
www.biorxiv.org www.biorxiv.org

Human Sperm-Induced Cell-Cell Fusion Requiring JUNO (hSPICER): A paradigm shift to test sperm fertilizing potential

1
1. scibot 15 May 2026
  
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  plasmid_12259
  
  DOI: 10.64898/2026.05.07.723220
  
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biorxiv.org/content/10.64898/2026.05.07.723220v1
www.molbiolcell.org www.molbiolcell.org

Solo regulates the localization and activity of LARG for actin cytoskeletal remodeling in cell-substrate adhesions

1
1. scibot 15 May 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1091/mbc.E25-04-0156
  
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molbiolcell.org/doi/10.1091/mbc.E25-04-0156
www.nature.com www.nature.com

Cannabinoid CB2 receptor drives trastuzumab resistance and predicts durable anti-HER2 response

1
1. scibot 15 May 2026
  
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  Addgene_12259
  
  DOI: 10.1038/s41388-026-03814-9
  
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nature.com/articles/s41388-026-03814-9
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Coronavirus protein interaction mapping in bat and human cells reveals network rewiring governing immune evasion and zoonotic potential

1
1. scibot 14 May 2026
  
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Autophagy-lysosomal dependency defines a vulnerable physiological state in drug-tolerant persister cells of triple-negative breast cancer

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IL-15 and IL-21 synergy improves anti-tumor efficacy of iPSC-derived cytotoxic T cells in solid tumors

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Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects

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Galvanin (TMEM154) is an electric-field sensor for directed cell migration

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Protocol for lentiviral generation and transduction of human-derived endometrial epithelial organoids to study uterine function and pathologies

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Salmonella effector SteE reprograms the macrophage regulatory network to drive specific hyperactivation of STAT3 target genes

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Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics

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CIAPIN1 functions as a redox-sensitive transcriptional repressor of Tp53 during vascular remodeling

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T Cell Receptor Co-Stimulation Through Magnetogenetic Tools: A Platform for Wireless Rewiring of Cellular Signaling

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Whole-genome doubling drives immune evasion by silencing antigen presentation

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www-cell-com.eproxy.lib.hku.hk/cancer-cell/fulltext/S1535-6108(26)00218-7
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Taxane chemotherapy promotes response to TIM-3 checkpoint blockade via STING-mediated ER stress and HMGB1 secretion

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Pertuzumab Enhances the Antitumor Activity of T-DXd in HER2-Positive Gastric Cancer Cells

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Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer

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VSIG4 restricts hepatocellular carcinoma control by suppressing tumor-specific CD8+ T cell immunity in the tumor microenvironment

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aacrjournals.org/cancerimmunolres/article/14/5/718/784454/VSIG4-Restricts-Hepatocellular-Carcinoma-Control
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Protocol for identifying cellular reprogramming minimal networks using combinatorial transcription factor screening

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Structure of zebrafish NLRP3 reveals a novel mode of inflammasome activation

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Systematic design of combination therapy by targeting master regulators of coexisting diffuse midline glioma cell states

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The cytotoxic effect of prexasertib is a consequence of dual inhibition on both CHK1 and AMPK

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BAG6 and RNF126 promote the degradation of cytosolic misfolded proteins that contain buried degron motifs

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An RNA-centric interactomics screen identifies novel proviral and antiviral genome binding interactors for tick-borne encephalitis virus

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The interferon-stimulated gene product HERC5 inhibits human LINE-1 retrotransposition with an ISGylation-independent mechanism

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The circadian gene Dec2 promotes pancreatic cancer progression and dormancy through immune evasion

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Time-resolved proteomics reveals five modules of stress granule disassembly and identifies SYNCRIP as a late-phase clearance factor

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Unbiased niche labeling maps immune-excluded niche in bone metastasis

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Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

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Stabilizing MARCH7 as a ferro-guardian against ferroptosis

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CCDC80 suppresses high-grade serous ovarian cancer migration via negative regulation of B7-H3

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febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70235
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Dual Specificity Phosphatase 4 Enhances Immunotherapy Response by Inhibiting TGF-β1 Secretion in Hepatocellular Carcinoma

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  DOI: 10.3390/cancers18081289
  
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Tuning the sensitivity of mechanosensory receptors through histidine scanning

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cell.com/cell/fulltext/S0092-8674(25)01499-0
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Whole Genome Characterization of the Mechanisms of Daptomycin Resistance in Clinical and Laboratory Derived Isolates of Staphylococcus aureus

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54.241.53.176/67c74b90c3375f7e65bca5ea8c2ee116db2889dc/1-s2.0-S2589004226012290-main-html.html
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Functional Characterization of <i>SDHB</i> Variants Clarifies Hereditary Pheochromocytoma and Paraganglioma Risk and Genotype–Phenotype Relationships

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Sacituzumab Govitecan as an Effective Strategy for Sensitizing Chemoresistant HNSCC Cells to Senolytic Intervention

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ID2 suppresses multiple myeloma cell proliferation by repressing the activity of the transcription factor TCF3

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  DOI: 10.1158/2643-3230.BCD-25-0048
  
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aacrjournals.org/bloodcancerdiscov/article/7/1/129/771360/ID2-Suppresses-Multiple-Myeloma-Cell-Proliferation
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Functional genetic screens reveal key pathways instructing the molecular phenotypes of tumor-associated macrophages

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aacrjournals.org/cancerimmunolres/article/13/12/2054/768330/Functional-Genetic-Screens-Reveal-Key-Pathways
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A universal boosting strategy for adoptive T cell therapy using a paired vaccine/chimeric antigen receptor

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aacrjournals.org/cancerimmunolres/article/14/2/261/771969/A-Universal-Boosting-Strategy-for-Adoptive-T-cell
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Chronic ISG15 Exposure Accelerates CD8+ T-cell Dysfunction while Increasing PD-1 Blockade Sensitivity in Oral Squamous Cell Carcinoma

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aacrjournals.org/cancerimmunolres/article/13/11/1829/766805/Chronic-ISG15-Exposure-Accelerates-CD8-T-cell
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Bicistronic CAR-T Cell against BCMA and CD229 effectively controls myeloma even when BCMA expression is limited

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MTHFD2-mediated ubiquitination and degradation of FOXO1 promote tongue squamous cell carcinoma progression

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Bone Metastatic Progression of Prostate Cancer is Regulated by TRIM28-LDHA Mediated Metabolism

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FcRγ-dependent NK cell licensing through CD244 promotes antitumour immunity

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Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells

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Table 2 Overview of plasmids used.

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Mechanisms of gene regulation by SRCAP and H2A.Z

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CD47 inhibits phagocytosis through Vav dephosphorylation

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Advanced models of lobular breast cancer metastasis capture clinical organ tropism, endocrine response, and bone remodeling

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mTORC1 activity suppresses ferroptosis through a SCARB1-dependent HDL-tocopherol uptake pathway

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Tolerance to extracellular acidic pH facilitates tumor plasticity

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2026.04.04.716465.full-html.html

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Transcription Factor Subtype Governs Response and Resistance to DLL3-Directed T-Cell Engagement in Small Cell Lung Cancer

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A hormetic transcriptional program coregulates invasion, proliferation and dormancy to define metastatic potential

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AMBRA1 enhances Sonic Hedgehog signaling during cerebellar development and in medulloblastoma

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Human immune aging clock identifies RUNX1 as a decelerator of T cell senescence

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Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression

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Development of human monoclonal antibodies against TARM1 by yeast display

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febs.onlinelibrary.wiley.com/doi/full/10.1002/2211-5463.70216
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Genetically encoded manipulation of ATP/ADP ratio in human cells uncovers proteomic and physiological signatures of energy stress

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Activation of neurogenesis improves amyloid-β pathology and cognitive function through AMP kinase signaling in Alzheimer’s disease model mice

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Identification of STMN1 as a lactylation-related driver of lung cancer progression using Mendelian randomization

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Laptm4a mediates renal ischemia-reperfusion injury by regulating the UNC5B-AKT/mTOR signaling pathway

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ONX-0914 Suppresses Hormone-Sensitive Prostate Cancer by Promoting O-GlcNAcylation-Mediated Stabilization of TCF7L1

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APOBEC3B regulates HPV replication by inducing R-loop formation and DNA damage

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MMP14 is a safe target of CAR-T therapy against liver cancer and metastasis

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CD4 T-cell platform for delivering interferons as an antiviral countermeasure with a focus on SARS-CoV-2

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Human NLRP3 inflammasome activation leads to formation of condensate at the microtubule organizing center

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SLC13A2-transported citrate remodels transcriptional regulation through protein acetylation to suppress tumor growth

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mRNA 3′ UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth

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Chromatin architecture reprogramming reveals novel epigenetic dependencies in breast cancer

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Investigating PKD2 deficiency-associated cardiomyopathies using hESC-cardiomyocytes and bioengineered 3D ventricular cardiac tissue strips

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Protocol to identify SINE-VNTR-Alu regulators using genome-wide screening in human K562 cells

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An epigenetic bifunctional that toggles between transactivation and repression

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Therapeutic scheduling of WEE1 inhibition preserves T cell function and promotes immune control of HPV+ tumors

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Integrative screening identifies functional variants and VNTRs underlying GWAS signals at the 5p15.33 multi-cancer susceptibility locus

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circOMA1 delivered by exosomes regulates DRD2-mediated prolactinoma resistance

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Co-delivery of IL-12/IL-15/IL-18 engineered DC vaccines with anti-IL-10R and nanoconjugated methotrexate in melanoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12989403/
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IFNγ-induced antigen loss in chimeric antigen receptor-T cell therapy

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pmc.ncbi.nlm.nih.gov/articles/PMC13036235/
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CENPF Overexpression Induced by HBV Infection Facilitates the G1/S Cell Cycle Transition of Hepatocellular Carcinoma Cells via MYC Pathway

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pmc.ncbi.nlm.nih.gov/articles/PMC13051194/
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Mechanistic dissection of GRHL2 and PR transcriptional co-regulation in breast cells

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pmc.ncbi.nlm.nih.gov/articles/PMC13008249/
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Allele-selective disruption of pathogenic VWF variants in type 2 von Willebrand disease using CRISPR/Cas9

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pmc.ncbi.nlm.nih.gov/articles/PMC12952769/
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IFN signaling is associated with radiotherapy response in malignant peripheral nerve sheath tumors

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pmc.ncbi.nlm.nih.gov/articles/PMC12948414/
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Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12758111/
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Targeted inhibition of Nrf2 potentiates antitumor immunity and enhances the efficacy of immunotherapy in hepatocellular carcinoma

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pmc.ncbi.nlm.nih.gov/articles/PMC13034291/
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Integrative analysis of mRNA stability regulation uncovers a metastasis-suppressive program in breast cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12978252/
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KLF5 controls subtype-independent highly interactive enhancers in pancreatic cancer to regulate cell survival

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pmc.ncbi.nlm.nih.gov/articles/PMC12998525/
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CLOCK-catalyzed histone H3K37 glutarylation suppresses H3K36 trimethylation pathways in glioblastoma

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pmc.ncbi.nlm.nih.gov/articles/PMC13015892/
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Regulation of sodium/calcium homeostasis by BacNav gene therapy rescues cardiac dysfunction in chronic heart failure

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pmc.ncbi.nlm.nih.gov/articles/PMC13004020/
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EP4 influences bortezomib resistance in multiple myeloma by modulating endoplasmic reticulum stress via the phosphatidylinositol 3-kinase/protein kinase B pathway

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pmc.ncbi.nlm.nih.gov/articles/PMC12955957/
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ZXDB Drives Macrophage Inflammatory Programming in Sepsis‐Induced Acute Kidney Injury by Recruiting EIF4A3 to Enhance ACACA Translation

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pmc.ncbi.nlm.nih.gov/articles/PMC13011163/
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HPV16 E6 oncoprotein promotes microhomology-mediated viral integration by increasing PolΘ protein expression

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pmc.ncbi.nlm.nih.gov/articles/PMC12974484/
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A targeting lentiviral vector for generation of CAR-T cells in vivo

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pmc.ncbi.nlm.nih.gov/articles/PMC13009191/
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Loss-of-function variants in ODAD1 disrupt ODA docking and induce actin cytoskeletal remodeling in primary ciliary dyskinesia

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pmc.ncbi.nlm.nih.gov/articles/PMC13039848/
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The EHMT2-MBLAC2 axis suppresses ribosomal DNA transcription in response to nucleolar DNA damage

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pmc.ncbi.nlm.nih.gov/articles/PMC13039405/
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Androgen receptor-dependent DRAM1 activation drives autophagic resistance to BRAF inhibitors in BRAFV600-mutant melanoma

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pmc.ncbi.nlm.nih.gov/articles/PMC13004951/
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CRISPR/Cas-based activation of PPARGC1A boosts endogenous mitochondria and enhances cardiac function and recovery after myocardial infarction

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pmc.ncbi.nlm.nih.gov/articles/PMC13045639/
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CircSMAD4 shapes matrix-remodeling TAMs in lung adenocarcinoma

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pmc.ncbi.nlm.nih.gov/articles/PMC13050104/
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The HIF-2 Transcription Factor Mediates Resistance to Ferroptosis in Pancreatic Cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC13052133/
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SDF2L1 modulates oxLDL-induced endoplasmic reticulum stress, protein aggregation, and O-mannosylation in myocardial infarction and lung cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC13003032/
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Reprogramming mRNA localization by targeted RNA-protein interference

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pmc.ncbi.nlm.nih.gov/articles/PMC12991119/
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Pharmacologic and Oncohistone Inhibition of SETD2 Converge on Genomic Instability

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pmc.ncbi.nlm.nih.gov/articles/PMC12984950/
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Enhancing the transduction efficiency of lentiviral vectors in CAR-T cell therapy through an optimization workflow

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pmc.ncbi.nlm.nih.gov/articles/PMC13018915/
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Development and characterization of chimeric antigen receptor macrophages for amyloid clearance

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pmc.ncbi.nlm.nih.gov/articles/PMC13002434/
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mtDNA-Depleted Mitochondria Form Sites of Contact with the Nucleus and Alter the Cellular Epigenome

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  Plasmid_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13009569/
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Defining the functional role and potential as an immunotherapeutic target of ALCAM in neuroblastoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12729689/
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CHK1 is an integral regulator of DNA replication in human cells

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pmc.ncbi.nlm.nih.gov/articles/PMC13039271/
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PRAS40 activates the IRE1α-XBP-1-mediated unfolded protein response to exacerbate colorectal cancer by enhancing ST6Gal1-dependent α-2, 6 sialylation of GRP78

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pmc.ncbi.nlm.nih.gov/articles/PMC13020080/
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Synthetic budding morphogenesis by optogenetic receptor tyrosine kinase signaling

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biorxiv.org/content/10.64898/2026.03.31.715459v1
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MEX3B is a positive pan-inflammasome regulator

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biorxiv.org/content/10.64898/2026.03.30.714824v1
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Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer

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science.org/doi/10.1126/sciimmunol.adt7832
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Patient-derived kidney organoids recapitulate ADPKD and facilitate the identification of Rho pathway inhibitors as candidate therapeutics

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sciencedirect.com/science/article/pii/S2666379126001370
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AURKA-mediated destabilization of SAPS3 drives ferroptosis evasion via 7-dehydrocholesterol biosynthesis in colorectal cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC13039981/
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Dual function of DOT1L suppresses tumor cell-intrinsic immunogenicity in hepatocellular carcinoma

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nature.com/articles/s41388-026-03744-6
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Cep192 insufficiency underlies haploid instability in human cells

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biorxiv.org/content/10.64898/2026.03.18.712690v1
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Interactome mapping in human excitatory neurons reveals novel risk genes and pathways in Alzheimer’s disease

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Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

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Combined inactivation of MEK and mTOR can lead to synergistic cell death in glioblastoma models and associates with NF1-deficiency and a mesenchymal subtype

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aacrjournals.org/mct/article/24/12/1878/768319/Combined-Inactivation-of-MEK-and-mTOR-Can-Lead-to
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Metabolic Response to CDK4/6 Inhibition in ER+ Breast Cancer Creates a Therapeutic Vulnerability in Drug-Tolerant Persister Cells

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1. scibot 02 Apr 2026
  
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  RRID:Addgene_12
  
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IFIT3 Associates with m⁶A-Modified RNA to Restrict Hepatitis C Virus Infection

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1. scibot 01 Apr 2026
  
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Mar 2026
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Pre-existing cell states predict resistance to multiple treatments

1
1. scibot 31 Mar 2026
  
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Three-dimensional reconstruction of a biliary system in a bioengineered liver using decellularized scaffold

1
1. scibot 29 Mar 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12960976/
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Mechanically-induced Septin Networks Protect Nuclear Integrity

1
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  Plasmid_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12871836/
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Establishment of a 3D Multicellular HCC Tumor Spheroid Model to Unravel Nrf2’s Influence on the Tumor Immune Microenvironment

1
1. scibot 29 Mar 2026
  
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  RRID:Addgene_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13023928/
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Identification and structural characterization of anthrax toxin receptor 2 as the Clostridium perfringens NetF receptor

1
1. scibot 29 Mar 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.1038/s41467-026-69526-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13018213/
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Oncogenic alterations in PI3K signaling emulated optogenetically recapitulates some phenotypic changes in mammary epithelia

1
1. scibot 29 Mar 2026
  
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  plasmid_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13022691/
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CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis

1
1. scibot 29 Mar 2026
  
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  Addgene_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12978015/
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Integrating traditional omics and AI-driven approaches for discovery and validation of novel MicroRNA biomarkers and therapeutic targets in thyroid cancer

1
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pmc.ncbi.nlm.nih.gov/articles/PMC12891075/
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CELF2 Promotes Tau Exon 10 Inclusion via Hinge Domain-Mediated Nuclear Condensation, Driving Cognitive Dysfunction in Tauopathy Models

1
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  pMD2.G
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12869637/
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Integrated phenotypic screening and chemical proteomics identifies ETF1 ligands that modulate viral translation and replication

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pmc.ncbi.nlm.nih.gov/articles/PMC12867696/
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Splice isoform-perturbation coupled to single cell transcriptome profiling reveals functions of microexons in neurogenesis and autism-linked pathways

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  DOI: 10.1038/s41467-025-67931-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12868881/
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Protocol for stable cell line production to express muscle-type nicotinic receptor

1
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  DOI: 10.1016/j.xpro.2026.104427
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12997218/
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Dominant-negative TP53 mutations potentiated by the HSF1-regulated proteostasis network

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  pMDM2.G
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12917913/
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Uev1A counteracts oncogenic Ras stimuli in both polyploid and diploid cells

1
1. scibot 27 Mar 2026
  
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  RRID:Addgene_12259
  
  DOI: 10.7554/eLife.107104
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13016607/
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Dual receptor engagement by mannose-capped lipoarabinomannan reprograms macrophage lipid metabolism in tuberculosis

1
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  plasmid_12259
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12934963/
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CRISPR-Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-deleted cancer

1
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pmc.ncbi.nlm.nih.gov/articles/PMC13014710/
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Protocol to generate immunocompetent human heart-macrophage assembloids for the study of immune-cardiac interactions

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pmc.ncbi.nlm.nih.gov/articles/PMC12992950/
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TIPE2 knockdown enhances the anti-tumor efficacy of NKG2D CAR-T cells against pancreatic cancer via activating NF-κb signaling pathway

1
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pmc.ncbi.nlm.nih.gov/articles/PMC13011749/
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Nanobody-Engineered CLL-1 CAR-T Cells: Optimizing Tumor-Specific Cytotoxicity and Minimizing Off-Tumor Toxicity

1
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pmc.ncbi.nlm.nih.gov/articles/PMC13012018/
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Uncovering NMDA receptor-mediated high firing activity in excitatory human neurons

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pmc.ncbi.nlm.nih.gov/articles/PMC12997311/
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New selective and allosteric FLT3 inhibitors show efficacy against resistant acute myeloid leukemia cells

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  AddgenePlasmid #12259
  
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sciencedirect.com/science/article/pii/S2589004226005948
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Deubiquitinating enzyme MINDY2 regulates TNF-α-induced cell death by targeting RIPK1

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  AddgeneCat#12259
  
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sciencedirect.com/science/article/pii/S2211124726002123
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Autoinhibitory control of MLKL governs pseudokinase domain phosphorylation and oligomerization during necroptosis

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  AddgeneCat# 12259
  
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Radiotherapy synergizes with an inducible AAV-based immunotherapy platform to program local and systemic antitumor immunity

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sciencedirect.com/science/article/pii/S153561082600111X
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Development and validation of a PSMA-positive triple-negative breast cancer mouse model for preclinical targeted radionuclide therapies

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  DOI: 10.1038/s41598-026-36724-7
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13003023/
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RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress response

1
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  Plasmid_12259
  
  DOI: 10.1016/j.molcel.2026.02.024
  
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Distinct synaptic mechanisms underlie NRXN1 variant and disorder background-dependent phenotypes in iPSC-derived neurons

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Plasma extracellular vesicle modulate immune cell transcriptional responses following acute myocardial infarction

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  Plasmid_12259
  
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Functional chromatin signatures premark future lineage-specific enhancers

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  AddgeneCat#12259
  
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A bispecific nanobody-drug conjugate targeting TROP2 and c-Met for low-concentration, single-dose treatment of pancreatic cancer

1
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  addgeneCat#12259
  
  DOI: 10.1016/j.xcrm.2026.102688
  
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1-s2.0-S2589004226007479-main-html.html

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  Addgene Cat# 12259
  
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Mitochondrial control of glycerolipid synthesis by a PEP shuttle

1
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  AddgeneCat# 12259
  
  DOI: 10.1016/j.cell.2026.02.017
  
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sciencedirect.com/science/article/pii/S0092867426002242
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Polθ activity modulates sensitivity to standard therapies in DNMT3A-deficient leukemia

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  DOI: 10.1016/j.xcrm.2026.102687
  
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ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronuclei

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Promoter mutagenesis and a massively parallel reporter screen of the MAPT locus identifies cis-regulatory elements and genetic variation effects

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  DOI: 10.64898/2026.03.06.710116
  
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biorxiv.org/content/10.64898/2026.03.06.710116v1
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NIPAL1 Drives a Metabolic-Epigenetic Feedback Loop to Promote Lactate-Mediated Immune Evasion in Esophageal Cancer

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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202520055
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FEBS Press

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febs.onlinelibrary.wiley.com/doi/10.1002/2211-5463.70226
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Complete definition of how mutations affect antibodies used to prevent RSV

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  DOI: 10.64898/2026.02.12.705519
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12918976/
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A dose-dependent switch in translation capacity controls the transcription factor response to H2O2 stress

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pmc.ncbi.nlm.nih.gov/articles/PMC12873884/
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A developmentally regulated long-range enhancer-promoter contact mediates human neural development

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  DOI: 10.64898/2025.12.01.691702
  
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aGPCR-HEK: A Stable High-Expression Inducible Mammalian Cell Expression System for Adhesion GPCR Structural Biology Applications

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  DOI: 10.21769/BioProtoc.5621
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12971277/
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Stress-specific NONO interactomes reveal a key role of Hsp70 chaperone activity in regulation of paraspeckle formation

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  DOI: 10.1242/jcs.264115
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12863303/
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Comprehensive profiling of CRISPR/dCas9 epigenome editors indicates a complex link between on and off target effects

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pmc.ncbi.nlm.nih.gov/articles/PMC12924462/
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Inhibition of GSK3 and TSC2 Mediates the Oncogenic Activity of AKT in Hepatocellular Carcinoma

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pmc.ncbi.nlm.nih.gov/articles/PMC12500318/
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A Cre-mediated copy number variant compromises the reliability of a LoxP-STOP-LoxP-PLAG1 driven brain tumor model

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  DOI: 10.1093/noajnl/vdaf251
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12932942/

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