3,429 Matching Annotations
  1. Jul 2025
  2. www.science.org www.science.org
    A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage
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    science.org/doi/10.1126/sciadv.ads9164
  3. www.biorxiv.org www.biorxiv.org
    An Iron-regulated Signalling Pathway Controls Adipose Browning and Cancer Cachexia
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    biorxiv.org/content/10.1101/2025.07.16.664180v1
  4. www.biorxiv.org www.biorxiv.org
    Dual Inhibition of CDK4/6 and mTORC1 Establishes a Preclinical Strategy for Translocation Renal Cell Carcinoma
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    biorxiv.org/content/10.1101/2025.07.11.663903v1
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Complete loss of PAX4 causes transient neonatal diabetes in humans
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    pmc.ncbi.nlm.nih.gov/articles/PMC12275979/
  6. www.cell.com www.cell.com
    An SRRM3-regulated neural alternative splicing program is subverted to promote tumor progression in pancreatic neuroendocrine cells
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    cell.com/cell-reports/fulltext/S2211-1247(25)00793-4
  7. www.cell.com www.cell.com
    CRISPR-based screening identifies the role of KRAB-containing transcription factors ZIM3 and ZNF394 in human major zygotic genome activation
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    cell.com/cell-reports/fulltext/S2211-1247(25)00786-7
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CARD8 inflammasome activation during HIV-1 cell-to-cell transmission
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    pmc.ncbi.nlm.nih.gov/articles/PMC12169848/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Coupling of glucose metabolism with mitophagy via O-GlcNAcylation of PINK1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12224001/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    WNT5B regulates myogenesis and fiber type conversion by affecting mRNA stability
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    pmc.ncbi.nlm.nih.gov/articles/PMC12223781/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    METTL3-mediated m6A methylation of lncRNA PVT1 promotes the progression of oral squamous cell carcinoma via the miR-185-5p/SERPINB4 axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12256411/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Synovial sarcoma extracellular vesicles induce fatty liver
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    pmc.ncbi.nlm.nih.gov/articles/PMC12213661/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BLID is a drug-responsive target of FOXO3a and multi-omics analysis reveals survival mechanisms and therapeutic vulnerabilities in BLID-deficient breast cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12217432/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SENP1 promotes p27kip1 nuclear export though enhanced SUMOylation in cholangiocarcinoma leading to increased cell proliferation and chemoresistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12270383/
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Methods for Mitochondrial DNA Damage and Depletion in Immortalized Trabecular Meshwork Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12250015/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Establishing preclinical models for clear cell sarcoma of soft tissue
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    pmc.ncbi.nlm.nih.gov/articles/PMC12213553/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FTO O-GlcNAcylation promotes TRIM21-mediated FTO ubiquitination degradation to sustain the negative feedback control of macrophage inflammation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12240770/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Whole-cell response of coronavirus-infected BMDCs through proteomic and transcriptomic analyses
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    pmc.ncbi.nlm.nih.gov/articles/PMC12180443/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Generation of iPSC Lines with Tagged α-Synuclein for Visualization of Endogenous Protein in Human Cellular Models of Neurodegenerative Disorders
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    pmc.ncbi.nlm.nih.gov/articles/PMC12186606/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SARS-CoV-2 remodels the Golgi apparatus to facilitate viral assembly and secretion
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    pmc.ncbi.nlm.nih.gov/articles/PMC12208438/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    African strains of Zika virus resist ISG-mediated restriction
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    pmc.ncbi.nlm.nih.gov/articles/PMC12270304/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeted inhibition of Ninjurin2 promotes chemosensitivity in chemoresistant gastric cancer by suppressing cancer-initiating cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12168268/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Obesity and cervical intraepithelial neoplasia: regulation of mitochondrial energy metabolism via the Kisspeptin/GPR54 signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12175464/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MSCs engineered with secreted Klotho alleviate blood–brain barrier disruption and reduce neuroinflammation more effectively than MSCs in experimental autoimmune encephalomyelitis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12220179/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CCNY-mediated phosphorylation and TET2-BACH1-driven DNA demethylation activate PRC1 to augment NSCLC progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12261648/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CXCR4/CXCL12 axis promotes lymphatic metastasis in tongue squamous cell carcinoma via PI3K/AKT signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12239490/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ACK1 condensates promote STAT5 signaling in lung squamous cell carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12205516/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel β-TrCP1/NRF2 interaction inhibitor for effective anti-inflammatory therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12247323/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Methodological approach for allele-specific antibody responses to HEK-293T-based cell lines expressing single MHC class I chain-related gene B antigens
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265220/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RSK1-driven TRIM28/E2F1 feedback loop promotes castration-resistant prostate cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12165809/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PPIL2 is a target of the JAK2/STAT5 pathway and promotes myeloproliferation via degradation of p53
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    pmc.ncbi.nlm.nih.gov/articles/PMC12208539/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-Cell and Spatial Transcriptomics Identified Fatty Acid–Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension
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    pmc.ncbi.nlm.nih.gov/articles/PMC12188824/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Neuro-mesenchymal interaction mediated by a β2 adrenergic-nerve growth factor feedforward loop promotes colorectal cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC11729495/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    IFITM proteins are key entry factors for porcine epidemic diarrhea coronavirus
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    pmc.ncbi.nlm.nih.gov/articles/PMC12172462/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    YIPF5 is an essential host factor for porcine epidemic diarrhea virus double-membrane vesicle formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12172457/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Differentiating Peromyscus leucopus bone marrow-derived macrophages for characterization of responses to Borrelia burgdorferi and lipopolysaccharide
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    pmc.ncbi.nlm.nih.gov/articles/PMC12234436/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Selective abrogation of S6K2 identifies lipid homeostasis as a survival vulnerability in MAPK inhibitor-resistant NRAS-mutant melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12258192/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A universal chimeric antigen receptor (CAR)–fragment antibody binder (FAB) split system for cancer immunotherapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227065/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TP53 missense–specific transcriptional plasticity drives resistance against cell cycle inhibitors in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12227071/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage
    1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12273786/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TFEB Orchestrates Stress Recovery and Paves the Way for Senescence Induction in Human Dermal Fibroblasts
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    pmc.ncbi.nlm.nih.gov/articles/PMC12266763/
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A distal enhancer with ETV4 binding is critical for UCP1 expression and thermogenesis in brown fat
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    pmc.ncbi.nlm.nih.gov/articles/PMC12211996/
  43. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Image-based, pooled phenotyping reveals multidimensional, disease-specific variant effects
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    pmc.ncbi.nlm.nih.gov/articles/PMC12236469/
  44. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
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    pmc.ncbi.nlm.nih.gov/articles/PMC12236722/
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Transcriptomic analysis of the m6A reader YTHDF2 in the maintenance and differentiation of human embryonic stem cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12202760/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The lincRNA Pantr1 is a FOXG1 target gene conferring site-specific chromatin binding of FOXG1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12205996/
  47. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DHHC5 regulates lacteal function and intestinal lipid absorption by maintaining VEGFR2 localization in lipid rafts
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    pmc.ncbi.nlm.nih.gov/articles/PMC12207882/
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A transcriptomic, proteomic, and functional genetic atlas dissects neurofibromin function in the peripheral nervous system
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    pmc.ncbi.nlm.nih.gov/articles/PMC12260521/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function
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    pmc.ncbi.nlm.nih.gov/articles/PMC12167974/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Signal peptide–independent secretion of keratin-19 by pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12260553/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pathogenic variants in the polycystin pore helix cause distinct forms of channel dysfunction
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    pmc.ncbi.nlm.nih.gov/articles/PMC12184499/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BaCoN (Balanced Correlation Network) improves prediction of gene buffering
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    pmc.ncbi.nlm.nih.gov/articles/PMC12222496/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Time-resolved mitochondrial screen identifies regulatory components of oxidative metabolism
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    pmc.ncbi.nlm.nih.gov/articles/PMC12187934/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Landscape of the Epstein-Barr virus-host chromatin interactome and gene regulation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12216251/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanistic insight into anaphase bridge signaling to the abscission checkpoint
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    pmc.ncbi.nlm.nih.gov/articles/PMC12217976/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformations
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    pmc.ncbi.nlm.nih.gov/articles/PMC12259471/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CAF-derived GLUT1 and its role in modulating ovarian cancer progression: a multi-dimensional analysis of the tumor microenvironment
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    pmc.ncbi.nlm.nih.gov/articles/PMC12238383/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Development and validation of a basement membrane inflammatory response gene signature in lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219087/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chemosensor receptors are lipid-detecting regulators of macrophage function in cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12208882/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NINJ1 regulates plasma membrane fragility under mechanical strain
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    pmc.ncbi.nlm.nih.gov/articles/PMC12210241/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NR4A3 potentials M1-like macrophage polarization to facilitate anti-tumor immune responses in breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12234874/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human glycogenins maintain glucose homeostasis by regulating glycogen metabolism
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    pmc.ncbi.nlm.nih.gov/articles/PMC12267440/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting CD37 promotes macrophage-dependent phagocytosis of multiple cancer cell types and facilitates tumor clearance in mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12271527/
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The role of gene duplication and paralog specialisation in the evolution of the mammalian PRPS complex
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    pmc.ncbi.nlm.nih.gov/articles/PMC12238573/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanism of EHMT2-mediated genomic imprinting associated with Prader-Willi syndrome
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    pmc.ncbi.nlm.nih.gov/articles/PMC12229668/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC12198384/
  67. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    O-GlcNAcylation of FOXK1 co-opts BAP1 to orchestrate the E2F pathway and promotes oncogenesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219458/
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Evaluating cell cycle- and autophagy-associated cellular accumulation of lipid-based nanoparticles
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    pmc.ncbi.nlm.nih.gov/articles/PMC12216923/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219648/
  70. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Constitutive expression of the transcriptional co-activator IκBζ promotes melanoma growth and immunotherapy resistance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12198385/
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Isoform characterization of m6A in single cells identifies its role in RNA surveillance
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219666/
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219730/
  73. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Klf5-adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12215363/
  74. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    USP37 prevents premature disassembly of stressed replisomes by TRAIP
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    pmc.ncbi.nlm.nih.gov/articles/PMC12177040/
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NXPE1 alters the sialoglycome by acetylating sialic acids in the human colon
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    pmc.ncbi.nlm.nih.gov/articles/PMC12216134/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Spatially resolved C1QC+ macrophage-CD4+ T cell niche in colorectal cancer microenvironment: implications for immunotherapy response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12219098/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    p62 mRNA suppresses NLRP1 expression in cutaneous SCC cells through miR-34a-5p
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    pmc.ncbi.nlm.nih.gov/articles/PMC12218052/
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Repurposing MDM2 inhibitor RG7388 for TP53-mutant NSCLC: a p53-independent pyroptotic mechanism via ROS/p-p38/NOXA/caspase-3/GSDME axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12170848/
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PI3K-dependent GAB1/Erk phosphorylation renders head and neck squamous cell carcinoma sensitive to PI3Kα inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12177050/
  80. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tailoring a novel colorectal cancer stem cell-targeted therapy by inhibiting the SMYD3/c-MYC axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12209437/
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Engineering ARMMs for improved intracellular delivery of CRISPR-Cas9
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    pmc.ncbi.nlm.nih.gov/articles/PMC12245188/
  82. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Endothelial soluble epoxide hydrolase links polyunsaturated fatty acid metabolism to oxidative stress and atherosclerosis progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12214128/
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A proximity-labeling-based approach to directly detect mRNA delivery to specific subcellular locations
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    pmc.ncbi.nlm.nih.gov/articles/PMC12256308/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Role of the Hexosamine-Sialic Acid Metabolic Pathway Mediated by GFPT1/NANS in c-Myc-Driven Hepatocellular Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12269569/
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The molecular basis of T cell receptor recognition of citrullinated tenascin-C presented by HLA-DR4
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