3,652 Matching Annotations
  1. Aug 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Select early growth response (Egr) isoforms augment hypoxia inducible factor 2 (HIF-2) regulation of erythropoietin (Epo) gene expression in mammals[image]
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    pmc.ncbi.nlm.nih.gov/articles/PMC12274846/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genetic transcriptional regulation profiling of cartilage reveals pathogenesis of osteoarthritis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12278629/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    p62/SQSTM1 impairs immunotherapy in lung adenocarcinoma by suppressing immune infiltration and peripheral immune response
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    pmc.ncbi.nlm.nih.gov/articles/PMC12280890/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SGK1 repression by WT1 may confer a survival advantage to leukemic cells under stress conditions
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    pmc.ncbi.nlm.nih.gov/articles/PMC12334445/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UBD‐mediated glycolytic reprogramming promotes M2 macrophage polarization in ovarian cancer immune evasion
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    pmc.ncbi.nlm.nih.gov/articles/PMC12278697/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Feedback Loop Between Fatty Acid Metabolism and Epigenetics in Clear Cell Renal Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12302539/
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting mitochondrial phosphatidylethanolamine alters mitochondrial metabolism and proliferation in hepatocellular carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12288522/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Live Imaging and Interactome Analysis of Zika and Chikungunya Viral RNAs Via Dual-Action Aptamer Tag
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265164/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lysosomal Protease-Mediated APP Degradation is pH-Dependent, Mutation-Sensitive, and Facilitates Tau Proteolysis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265180/
  11. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    GPC2-targeted CAR T cells engineered with NFAT-inducible membrane-tethered IL-15/IL-21 exhibit enhanced activity against neuroblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12278764/
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ZNF865 (BLST) Regulates Human Cell Senescence and DNA Damage
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    pmc.ncbi.nlm.nih.gov/articles/PMC12262657/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Precision targeting of C3+ reactive astrocyte subpopulations with endogenous ADAR in an iPSC-derived model
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    pmc.ncbi.nlm.nih.gov/articles/PMC12259101/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Autocrine TGFβ2 enforces a transcriptionally hybrid cell state in Ewing sarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12259098/
  15. www.biorxiv.org www.biorxiv.org
    JIP4 deficiency causes a lysosomal storage disease arising from impaired cystine efflux
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    biorxiv.org/content/10.1101/2025.06.06.657909v1
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cas13d-mediated isoform-specific RNA knockdown with a unified computational and experimental toolbox
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    pmc.ncbi.nlm.nih.gov/articles/PMC12307810/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proximity Labeling and SILAC-Based Proteomic Approach Identifies Proteins at the Interface of Homotypic and Heterotypic Cancer Cell Interactions
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    pmc.ncbi.nlm.nih.gov/articles/PMC12289527/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Unique compound with anti-allergic action: inhibition of Lyn kinase activity by KIRA6
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    pmc.ncbi.nlm.nih.gov/articles/PMC12331723/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TRABD maintains mitochondrial homeostasis and protects against ischemia reperfusion-induced renal tubular injury
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    pmc.ncbi.nlm.nih.gov/articles/PMC12329661/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    VapC toxins promote the pathogenesis of Rickettsia heilongjiangensis by cleaving essential RNAs from both Rickettsia and its host
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    pmc.ncbi.nlm.nih.gov/articles/PMC12321070/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Bisecting GlcNAc enhances CD8+ T cell-mediated killing of breast cancer by suppressing PD-L1 expression and its binding to PD-1
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    pmc.ncbi.nlm.nih.gov/articles/PMC12323189/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Triptolide targets PPP2CA/ITGA5 axis to suppress lactate-driven ovarian cancer progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12326723/
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Critical amino acid residues in human ACE2 for SARS-CoV-2 spike protein binding and virus entry
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    pmc.ncbi.nlm.nih.gov/articles/PMC12323325/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    HSP90 deficiency promotes cholesteryl ester accumulation in lipid droplets via endocytosis of low-density lipoprotein
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    pmc.ncbi.nlm.nih.gov/articles/PMC12328731/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Translation efficiency covariation identifies conserved coordination patterns across cell types
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    pmc.ncbi.nlm.nih.gov/articles/PMC12329774/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12332072/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lung metastasis and recurrence is mitigated by CAR macrophages, in-situ-generated from mRNA delivered by small extracellular vesicles
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    pmc.ncbi.nlm.nih.gov/articles/PMC12322094/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The spatial landscape of glial pathology and T cell response in Parkinson’s disease substantia nigra
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    pmc.ncbi.nlm.nih.gov/articles/PMC12322057/
  29. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Activation of AKT via a dual mechanism enhances the susceptibility of melanoma cells to glucose deprivation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12331947/
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Drug tolerance and persistence to EGFR inhibitor treatment are mediated by an ILK-SFK-YAP signaling axis in lung adenocarcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12318776/
  31. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    EF1α, rather than CMV promoter, is suitable for luciferase tag expression in target cells for in vitro cytotoxicity assays of CAR-T cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12329255/
  32. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optimizing Proximity Proteomics on the EvoSep-timsTOF LC–MS System
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    pmc.ncbi.nlm.nih.gov/articles/PMC12329395/
  33. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multi‐omics integration analysis identifies INPP4B as a T‐cell‐specific activation suppressor
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    pmc.ncbi.nlm.nih.gov/articles/PMC12318829/
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12319709/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Beta-Catenin Mutations Can Impact on the Interplay Between Tumor and Immune Cells and Hepatic Microbiota in Hepatocellular Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12325116/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CCDC66 regulation of cytoskeleton and cilia stability is important for signaling and epithelial organization
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    pmc.ncbi.nlm.nih.gov/articles/PMC12324684/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Characterization of private mutations in the spike protein of SARS-CoV-2 correlates with viral prevalence
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    pmc.ncbi.nlm.nih.gov/articles/PMC12333205/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    WIP1 mutations suppress DNA damage triggered bypass of the mitotic timer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12316910/
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pathogenic morphological signatures of perturbations in mitochondrial-related genes revealed by pooled imaging assay
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    pmc.ncbi.nlm.nih.gov/articles/PMC12316947/
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Integrated real-time imaging of executioner caspase dynamics, apoptosis-induced proliferation, and immunogenic cell death using a stable fluorescent reporter platform
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    pmc.ncbi.nlm.nih.gov/articles/PMC12328661/
  41. www.cell.com www.cell.com
    Systematic screening for functional exon-skipping isoforms using the CRISPR-RfxCas13d system
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    cell.com/cell-systems/fulltext/S2405-4712(25)00184-X
  42. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform
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    pmc.ncbi.nlm.nih.gov/articles/PMC12324477/
  43. www.sciencedirect.com www.sciencedirect.com
    NRCAM variant defined by microexon skipping is a targetable cell surface proteoform in high-grade gliomas
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    sciencedirect.com/science/article/pii/S2211124725008708
  44. 52.53.155.43 52.53.155.43
    1-s2.0-S2589004225015652-main-html.html
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    52.53.155.43/85cee3d161a0de2e88ed1ed9d4903a9813261aae/1-s2.0-S2589004225015652-main-html.html
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Antibody surface mobility amplifies FcγR signaling via Arp2/3 during phagocytosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC11331046/
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    1-s2.0-S2589004225015664-main-html.html
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    pmc.ncbi.nlm.nih.gov/articles/PMC12396248/
  47. onlinelibrary.wiley.com onlinelibrary.wiley.com
    TP-0903 Suppresses Aurora A–PLK1 Signaling to Inhibit Proliferation of a Myelodysplastic Syndrome-Derived Cell Line
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    onlinelibrary.wiley.com/doi/10.1111/cas.70151
  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TBK1 Targeting is Identified as a Therapeutic Strategy to Enhance CAR T-Cell Efficacy Using Patient-Derived Organotypic Tumor Spheroids
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    pmc.ncbi.nlm.nih.gov/articles/PMC11790382/
  49. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Four Amino Acid Intracellular Motif of VISTA Blocks Growth Receptor Signaling in Cancer Cells to Induce Tumor Suppression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12317733/
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Tumor cell-intrinsic Decr2 regulates ferroptosis and immunotherapy efficacy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12314507/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CTG-Initiated Cryptic Peptide Translation Up- and Downstream of a Canonical ATG Start Codon Is Enhanced by TLR Stimulation and Induces Tumor Regression in Mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC12314520/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Combining Multiplexed CRISPR/Cas9-Nickase and PARP Inhibitors Efficiently and Precisely Targets Cancer Cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12314522/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An enhanced Eco1 retron editor enables precision genome engineering in human cells without double-strand breaks
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    pmc.ncbi.nlm.nih.gov/articles/PMC12311787/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhanced bioluminescence imaging of tumor cells surviving chemotherapy in a murine model of triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12311029/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12311037/
  56. www.biorxiv.org www.biorxiv.org
    Cleavage of the RNA polymerase II general transcription factor TFIIB es transcription during stress
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    biorxiv.org/content/10.1101/2025.07.28.667251v1
  57. 52.53.155.43 52.53.155.43
    2025.07.26.666918v1.full-html.html
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    52.53.155.43/b861d752b12dd67d806a9ddbf467334dbc44c806/2025.07.26.666918v1.full-html.html
  58. www.cell.com www.cell.com
    19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism
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    cell.com/cell-reports/abstract/S2211-1247(25)00812-5
  59. Jul 2025
  60. www.sciencedirect.com www.sciencedirect.com
    Comparative single-cell lineage tracing identifies distinct adipocyte precursor dynamics in skin and inguinal fat
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    sciencedirect.com/science/article/pii/S1934590925002619
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Single-nuclei multiomics analysis identifies abnormal cardiomyocytes in a murine model of cardiac development
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    pmc.ncbi.nlm.nih.gov/articles/PMC12304165/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol for CRISPR-based manipulation and visualization of endogenous α-synuclein in cultured mouse hippocampal neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12305205/
  63. www.sciencedirect.com www.sciencedirect.com
    BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma
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    sciencedirect.com/science/article/pii/S2666379125003313
  64. 52.53.155.43 52.53.155.43
    watanabe-et-al-als-associated-rna-binding-proteins-promote-unc13a-transcription-through-rest-downregulation-html.html
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    52.53.155.43/42423fb21c90eb6b2282f89153f3787d8f44c56d/watanabe-et-al-als-associated-rna-binding-proteins-promote-unc13a-transcription-through-rest-downregulation-html.html
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Triglycerides are an important fuel reserve for synapse function in the brain
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    pmc.ncbi.nlm.nih.gov/articles/PMC12286841/
  66. www.nature.com www.nature.com
    Flower dependent trafficking of lamellar bodies facilitates maturation of the epidermal barrier
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    nature.com/articles/s41467-025-62105-1
  67. www.sciencedirect.com www.sciencedirect.com
    An updated inventory of genes essential for oxidative phosphorylation identifies a mitochondrial origin in familial Ménière’s disease
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    sciencedirect.com/science/article/pii/S221112472500840X
  68. 52.53.155.43 52.53.155.43
    2025.07.14.664742v1.full-html.html
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    52.53.155.43/0ddeb0d5c1e9d78409db30015477d90afb34bbce/2025.07.14.664742v1.full-html.html
  69. www.sciencedirect.com www.sciencedirect.com
    Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer
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    sciencedirect.com/science/article/pii/S1535610825002715
  70. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
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    febs.onlinelibrary.wiley.com/doi/full/10.1002/1878-0261.70085
  71. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loss of Predicted Cell Adhesion Molecule MPZL3 Promotes EMT in Ovarian Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12277487/
  72. www.science.org www.science.org
    High-resolution spatial mapping of cell state and lineage dynamics in vivo with PEtracer
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    science.org/doi/10.1126/science.adx3800
  73. www.science.org www.science.org
    Acute BRCAness induction and AR pathway blockage through CDK12/7/9 degradation enhances PARP inhibitor sensitivity in prostate cancer
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    science.org/doi/10.1126/sciadv.adu0847
  74. www.biorxiv.org www.biorxiv.org
    Mitotic slippage causes nuclear instability in polyploid cells
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    biorxiv.org/content/10.1101/2025.07.21.665898v1
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Co-option of mitochondrial nucleic acid–sensing pathways by HSV-1 UL12.5 for reactivation from latent infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC11789124/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    MSN/STAT3 drives cancer stemness and chemoresistance via IL-6/LPAR1 ligand receptor complex in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12281688/
  77. www.cell.com www.cell.com
    19S proteasome loss regulates mitotic spindle assembly through a ubiquitin-independent degradation mechanism
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    cell.com/cell-reports/abstract/S2211-1247(25)00812-5
  78. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mechanism and Structure-Guided Optimization of SLC1A1/EAAT3-Selective Inhibitors in Kidney Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12265667/
  79. www.science.org www.science.org
    A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage
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    science.org/doi/10.1126/sciadv.ads9164
  80. www.biorxiv.org www.biorxiv.org
    Dual Inhibition of CDK4/6 and mTORC1 Establishes a Preclinical Strategy for Translocation Renal Cell Carcinoma
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    biorxiv.org/content/10.1101/2025.07.11.663903v1
  81. www.cell.com www.cell.com
    CRISPR-based screening identifies the role of KRAB-containing transcription factors ZIM3 and ZNF394 in human major zygotic genome activation
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    cell.com/cell-reports/fulltext/S2211-1247(25)00786-7
  82. www.biorxiv.org www.biorxiv.org
    An Iron-regulated Signalling Pathway Controls Adipose Browning and Cancer Cachexia
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    biorxiv.org/content/10.1101/2025.07.16.664180v1
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATF2 phosphorylation is a core transcriptional driver of neuron apoptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12248030/
  84. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Complete loss of PAX4 causes transient neonatal diabetes in humans
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    pmc.ncbi.nlm.nih.gov/articles/PMC12275979/
  85. www.cell.com www.cell.com
    An SRRM3-regulated neural alternative splicing program is subverted to promote tumor progression in pancreatic neuroendocrine cells
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    cell.com/cell-reports/fulltext/S2211-1247(25)00793-4
  86. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Coupling of glucose metabolism with mitophagy via O-GlcNAcylation of PINK1
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    HBO1 determines epithelial-mesenchymal transition and promotes immunotherapy resistance in ovarian cancer cells
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    Targeting COL5A1 enhances anoikis thus attenuating malignancy of glioblastoma via inhibiting the Wnt/β-catenin signaling pathway
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    HNF4A promotes tumor progression in gastric cancer by transcriptional activation of KIF2C
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  169. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Extracellular vesicles derived from mature dendritic cells loaded with cDC1-specific chemokine XCL1 combined with chemotherapy-induced ICD for the treatment of castration-resistant prostate cancer
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  170. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modulation of RASD2 by miRNA‐485‐5p Drives Thyroid Cancer Progression and Metastasis
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  178. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  179. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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  183. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
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    Expression of DNAJB1-PRKACA oncogene suppresses the differentiation potential of liver progenitor organoids towards a hepatocyte lineage
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    The Integrated Stress Response Pathway Coordinates Translational Control of Multiple Immune Checkpoints in Lung Cancer
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    TAF1 is required for fetal but not adult hematopoiesis in mice
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