3,911 Matching Annotations
  1. Nov 2025
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting myoferlin in ER/Golgi vesicle trafficking reprograms pancreatic cancer-associated fibroblasts
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    pmc.ncbi.nlm.nih.gov/articles/PMC12623807/
  3. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RIOK2 kinase regulates the translocation of the FADD–RIPK1–Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12623739/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Hypoxia promotes airway differentiation in the human lung epithelium
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    pmc.ncbi.nlm.nih.gov/articles/PMC7618356/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12622763/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Chemokine/cytokine-releasing biomaterials induce in situ tertiary lymphoid–like structures and enhance antitumor immunity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12625823/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    UHRF1 restricts HCoV-229E infection through epigenetic silencing of the viral receptor APN
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    pmc.ncbi.nlm.nih.gov/articles/PMC12627610/
  8. journals.sagepub.com journals.sagepub.com
    Combined DNA-PK and PARP Inhibition as a Therapeutic Strategy in BRCA-Mutated Prostate Cancer: An in Vitro Pilot Study
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    journals.sagepub.com/doi/10.1177/15330338251394948
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    UDP-GlcUA triggers PKR kinase activity to promote liquid-liquid phase separation of TOP2A and enhances radioimmunotherapy resistance
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    sciencedirect.com/science/article/pii/S1097276525008287
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting plasticity in the pyrimidine synthesis pathway potentiates macrophage-mediated phagocytosis in pancreatic cancer models
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    pmc.ncbi.nlm.nih.gov/articles/PMC12618067/
  11. www.biorxiv.org www.biorxiv.org
    Therapeutic Inducers of NK cell Killing (ThINKK)-induced NK cell cytotoxicity against childhood acute lymphoblastic leukemia: unraveling the dual role of TRAIL leads to the establishment of an efficacy biomarker
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    biorxiv.org/content/10.1101/2025.11.12.687655v1
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs
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    pmc.ncbi.nlm.nih.gov/articles/PMC12618888/
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    Intermediate filaments promote glioblastoma cell invasion by controlling nuclear deformations and mechanosensitive expression of MMP14
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    sciencedirect.com/science/article/pii/S2211124725013245
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    FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry
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    sciencedirect.com/science/article/pii/S1074761325004741
  15. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12614194/
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    Extracellular vesicle R-Ras is a potential biomarker for human peripheral artery disease
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    sciencedirect.com/science/article/pii/S2589004225021200
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    Protocol for specific induction of apoptosis or necroptosis in established murine tumors
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    sciencedirect.com/science/article/pii/S266616672500591X
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    Feedforward miR-181d degradation modulates population variance of methyl-guanine methyl transferase and temozolomide resistance
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    sciencedirect.com/science/article/pii/S2211124725012872
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    KIF18A promotes chromosome congression in cooperation with CENP-E downstream of CENP-C
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    sciencedirect.com/science/article/pii/S2211124725012860
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    An engineered cysteine sensor optimized for high-throughput screening identifies regulators of intracellular thiol levels
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    sciencedirect.com/science/article/pii/S2451945625003435
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    Endogenous Real Time Imaging Reveals Dynamic Chromosomal Mobility During Ligand-Mediated Transcriptional Burst Events
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    elifesciences.org/reviewed-preprints/108726
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    TAK1 is a key regulator of oncogenic signaling and differentiation blockade in rhabdomyosarcoma
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    biorxiv.org/content/10.1101/2025.11.03.686399v1
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Protocol for simplified parallel perturbations using an abridged long non-coding RNA CRISPR library
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    pmc.ncbi.nlm.nih.gov/articles/PMC12509891/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Optimized pipeline and designer cells for synthetic-biology-based high-throughput screening of viral protease inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12461586/
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    Nuclear-lamin-guided plastic positioning and folding of the human genome
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    sciencedirect.com/science/article/pii/S2211124725013002
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SOCS1 Protects Acute Myeloid Leukemia against Allogeneic T Cell–Mediated Cytotoxicity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12050964/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Delivering Progranulin to Astrocytic Lysosomes Promotes Growth of Co‐Cultured Neurons
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    pmc.ncbi.nlm.nih.gov/articles/PMC12580966/
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    WDFY2 promotes MRN complex formation required for homologous recombination-mediated DNA repair
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    sciencedirect.com/science/article/pii/S2211124725012914
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    IGF2BP2 promotes malignant progression of ovarian cancer by regulating protein synthesis through liquid-liquid phase separation
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    sciencedirect.com/science/article/pii/S2211124725012823
  30. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A calcium-sensing MCTP1/FYN/MEF2C circuit drives therapy-induced neuroendocrine prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12621465/
  31. 54.241.53.176 54.241.53.176
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    Disparate leukemia mutations converge on nuclear phase-separated condensates
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    sciencedirect.com/science/article/pii/S0092867425011493
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    Cystine import and oxidative catabolism fuel vascular growth and repair via nutrient-responsive histone acetylation
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    sciencedirect.com/science/article/pii/S1550413125004371
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    The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts
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    sciencedirect.com/science/article/pii/S2211124725012574
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reporter-Mediated Evaluation of the Circadian Oscillations of SNAIL Across In Vitro Models
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    pmc.ncbi.nlm.nih.gov/articles/PMC12550899/
  37. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Artemis (DCLRE1C) Acts as a Target to Enhance Radiotherapy Response in Triple-Negative Breast Cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12564160/
  38. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Cytidine deaminases APOBEC3C and APOBEC3D promote DNA replication stress resistance in pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC12557688/
  39. Oct 2025
  40. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Mitochondrial ROS Drive Adipogenic Differentiation in Osteoporosis by Suppressing Protein Synthesis
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    faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.202502869R
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    A generalized strategy to kill leukemic cells by targeting the regulatory systems governing mitochondrial membrane potential
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    sciencedirect.com/science/article/pii/S2211124725012677
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    Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle
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    sciencedirect.com/science/article/pii/S1097276525008196
  43. 54.241.53.176 54.241.53.176
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    Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
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    sciencedirect.com/science/article/pii/S1934590925003674
  45. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    XXYLT1 inhibits NOTCH1 activation in Jurkat cells while promoting cell proliferation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12549121/
  46. www.biorxiv.org www.biorxiv.org
    Co-targeting MERTK and EGFR with a Bispecific Antibody Overcomes Drug Resistance Across Mutations in Exons 19, 20, and 21
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    biorxiv.org/content/10.1101/2025.10.16.681972v1
  47. www.nature.com www.nature.com
    Inducible CRISPR–Cas9 screening platform to interrogate non-proliferative cellular states
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    nature.com/articles/s41596-025-01251-8
  48. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    MUC15 Ectodomain Architecture Regulates Integrin Clustering to Control Cancer Metastasis
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    advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202513552
  49. www.nature.com www.nature.com
    Genetically tractable embryonic cell lines from sea urchins Lytechinus variegatus and Strongylocentrotus purpuratus
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    nature.com/articles/s42003-025-08890-3
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    A non-canonical immunometabolic function of BRD3 during sepsis
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    sciencedirect.com/science/article/pii/S153458072500601X
  51. www.biorxiv.org www.biorxiv.org
    The SNCA A53T mutation sensitizes human neurons and microglia to ferroptosis
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    biorxiv.org/content/10.1101/2025.10.13.682089v1
  52. www.nature.com www.nature.com
    Loss of BPTF restores estrogen response and suppresses metastasis of mammary tumors
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    nature.com/articles/s41467-025-64255-8
  53. www.biorxiv.org www.biorxiv.org
    ADAR1p150 RNA binding, independent of A-to-I RNA editing, buffers immunogenicity from the tonic type I IFN induced transcriptome in vivo
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    biorxiv.org/content/10.1101/2025.10.14.682456v1
  54. www.biorxiv.org www.biorxiv.org
    CDK4/6 Inhibition Reverses MEIS2 Suppression of CRL4CRBN to Enhance Immunomodulatory Drug Therapy in Multiple Myeloma
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    biorxiv.org/content/10.1101/2025.10.14.681840v1
  55. www.nature.com www.nature.com
    CRISPR screen reveals SOX2 as a critical regulator of CD133 and cellular stress response in glioblastoma
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    nature.com/articles/s41598-025-20183-7
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Germline-somatic liaison dictates cancer subtype via de novo steroid biosynthesis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12498101/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of GSK3 and TSC2 Mediates the Oncogenic Activity of AKT in Hepatocellular Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12500318/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Overexpression of RUNX2 promotes breast cancer multi-organ metastasis through stabilizing c-Myc
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    pmc.ncbi.nlm.nih.gov/articles/PMC12501288/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    WNK1 promotes head and neck squamous cell carcinoma progression through activation of NF-κB signaling pathway
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    pmc.ncbi.nlm.nih.gov/articles/PMC12500498/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel Frizzled 7 antibody disrupts the Wnt pathway and inhibits Wilms tumor growth
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    pmc.ncbi.nlm.nih.gov/articles/PMC12504202/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Microglial TBK1 Signaling Promotes Breast Cancer Brain Metastasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12516326/
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    Protocol for identifying DNA damage responders through proximity biotinylation of proliferating cell nuclear antigen interactors
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    sciencedirect.com/science/article/pii/S2666166725005428
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    Vitamin C conveys geroprotection on primate ovaries
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    Tuning insulin receptor signaling using de novo-designed agonists
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    sciencedirect.com/science/article/pii/S1097276525007804
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR-Cas9 screening reveals G2E3 as a novel ubiquitin-linked factor controlling autophagosome-lysosome fusion and cancer cell progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12511632/
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    HUWE1 stimulates mTORC1 activity by enhancing Rheb interaction with mTORC1 and supports de novo pyrimidine synthesis
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    sciencedirect.com/science/article/pii/S2211124725011532
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    A nanobody-based tri-specific NK cell engager targeting CD5 triggers antitumor immunity
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    sciencedirect.com/science/article/pii/S2666379125004823
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    The role of MRGPRX1 in the melanogenesis of human primary epidermal melanocytes
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    sciencedirect.com/science/article/pii/S0022202X25024753
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    PHF19 drives the formation of PRC2 clusters to enhance motility in TNBC cells
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    sciencedirect.com/science/article/pii/S2211124725011623
  70. www.science.org www.science.org
    Mechanochemical waves in focal adhesions during cell migration
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    science.org/doi/10.1126/sciadv.adw6425
  71. 54.241.53.176 54.241.53.176
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    Spliceosome inhibition induces Z-RNA and ZBP1-driven cell death in small cell lung cancer
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    sciencedirect.com/science/article/pii/S2211124725011556
  75. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Carbonic Anhydrase Inhibition Sensitizes Group 3 Medulloblastoma to Radiation Therapy
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    pmc.ncbi.nlm.nih.gov/articles/PMC12442109/
  76. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Lung cancer–intrinsic SOX2 expression mediates resistance to checkpoint blockade therapy by inducing Treg cell–dependent CD8+ T-cell exclusion
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    pmc.ncbi.nlm.nih.gov/articles/PMC11964848/
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Urothelial collective-gliding response acts as a toll-like receptor 4-associated defense mechanism
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    pmc.ncbi.nlm.nih.gov/articles/PMC12508895/
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    Biphasic control of the B cell transcriptome by mTORC1 and GSK3
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    sciencedirect.com/science/article/pii/S2211124725011325
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    Antibody-gamma/delta T cell receptors targeting GPC2 regress neuroblastoma with low antigen density
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    sciencedirect.com/science/article/pii/S2666379125004513
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    Non-cell-autonomous tumor promotion in DICER1 cancer predisposition
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  81. Sep 2025
  82. www.nature.com www.nature.com
    Multidimensional analysis of host–virus interactions using the virus-encoded CRISPR-based direct readout system (VECOS)
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    nature.com/articles/s41596-025-01242-9
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    KBTBD11 loss promotes AKT hyperactivation and therapeutic vulnerability in prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12559007/
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    IGF2BP3 redirects glycolytic flux to promote one-carbon metabolism and RNA methylation
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    sciencedirect.com/science/article/pii/S2211124725011015
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Direct Activity Measurement of Heterotrimeric Gi Proteins and Gq Protein By Effector Pulldown
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    pmc.ncbi.nlm.nih.gov/articles/PMC12336858/
  86. www.biorxiv.org www.biorxiv.org
    Dual EZH1/2 inhibition enhances DNMT inhibitor efficacy in colon cancer through targeting H3K27me1
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    biorxiv.org/content/10.1101/2025.09.16.676613v1
  87. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Menin-MLL1 complex cooperates with NF-Y to promote HCC survival
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    pmc.ncbi.nlm.nih.gov/articles/PMC12026816/
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    Neuropeptide adrenomedullin remodels stemness and macrophage dynamics in glioblastoma
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