537 Matching Annotations
  1. Jun 2024
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    Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression
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    sciencedirect.com/science/article/pii/S1534580724003307
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic movement of the Golgi unit and its glycosylation enzyme zones
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    ncbi.nlm.nih.gov/pmc/articles/PMC11130159/
  4. May 2024
  5. www.biorxiv.org www.biorxiv.org
    Proteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer
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    biorxiv.org/content/10.1101/2024.03.05.583460v1
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    Bag1 protein loss sensitizes mouse embryonic fibroblasts to glutathione depletion
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    sciencedirect.com/science/article/pii/S1355814524000750
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    Mammalian RNAi represses pericentromeric lncRNAs to maintain genome stability
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    biorxiv.org/content/10.1101/2024.05.09.593425v1
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD74 supports accumulation and function of regulatory T cells in tumors
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    ncbi.nlm.nih.gov/pmc/articles/PMC11068745/
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HIF-1α participates in the regulation of S100A16-HRD1-GSK3β/CK1α pathway in renal hypoxia injury
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    ncbi.nlm.nih.gov/pmc/articles/PMC11074340/
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    The factor inhibiting HIF regulates T cell differentiation and anti-tumour efficacy
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    ncbi.nlm.nih.gov/pmc/articles/PMC11058823/
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    Coregulation of NDC80 Complex Subunits Determines the Fidelity of the Spindle-Assembly Checkpoint and Mitosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11063766/
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    WNT5B drives osteosarcoma stemness, chemoresistance and metastasis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11061378/
  13. Apr 2024
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Linear interaction between replication and transcription shapes DNA break dynamics at recurrent DNA break Clusters
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    ncbi.nlm.nih.gov/pmc/articles/PMC11055891/
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    Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria
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    ncbi.nlm.nih.gov/pmc/articles/PMC11043412/
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    Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization
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    rupress.org/jcb/article/223/4/e202307026/276570/Tunable-DNMT1-degradation-reveals-DNMT1-DNMT3B
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    Transcriptomic profiling across human serotonin neuron differentiation via the FEV reporter system
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    ncbi.nlm.nih.gov/pmc/articles/PMC11027224/
  18. www.nature.com www.nature.com
    Luciferase- and HaloTag-based reporter assays to measure small-molecule-induced degradation pathway in living cells
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    nature.com/articles/s41596-024-00979-z
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IntAct: A nondisruptive internal tagging strategy to study the organization and function of actin isoforms
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    ncbi.nlm.nih.gov/pmc/articles/PMC10957077/
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    Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL
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    ncbi.nlm.nih.gov/pmc/articles/PMC10959178/
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    Cancer cell genetics shaping of the tumor microenvironment reveals myeloid cell-centric exploitable vulnerabilities in hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC10959959/
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    Molecular basis promoting centriole triplet microtubule assembly
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    ncbi.nlm.nih.gov/pmc/articles/PMC10960023/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oligomerization mediated by the D2 domain of DTX3L is critical for DTX3L‐PARP9 reading function of mono‐ADP‐ribosylated androgen receptor
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10955461/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ER-export and ARFRP1/AP-1–dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication
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    ncbi.nlm.nih.gov/pmc/articles/PMC10990277/
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    PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC11001582/
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure and tethering mechanism of dynein-2 intermediate chains in intraflagellar transport
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    ncbi.nlm.nih.gov/pmc/articles/PMC10987677/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10997609/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The impact of canonical Wnt transcriptional repressors TLE3 and TLE4 on postsynaptic transcription at the neuromuscular junction
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    ncbi.nlm.nih.gov/pmc/articles/PMC11004254/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Trisomy 21-linked Hematopoietic Gene Variant in Microglia Confers Resilience in Human iPSC Models of Alzheimer’s Disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10979994/
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair
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    ncbi.nlm.nih.gov/pmc/articles/PMC10993188/
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    Generation of human cerebral organoids with a structured outer subventricular zone
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    sciencedirect.com/science/article/pii/S2211124724003590
  32. Mar 2024
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Structure and function of Semaphorin-5A glycosaminoglycan interactions
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    ncbi.nlm.nih.gov/pmc/articles/PMC10978931/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mycobacterium tuberculosis inhibits METTL14-mediated m6A methylation of Nox2 mRNA and suppresses anti-TB immunity
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    ncbi.nlm.nih.gov/pmc/articles/PMC10978938/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The genetically modified human foreskin fibroblast cell line (YhFF#8) stably expressing Cas9 gene: A lab resource report
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    ncbi.nlm.nih.gov/pmc/articles/PMC10963875/
  36. onlinelibrary.wiley.com onlinelibrary.wiley.com
    An oocyte-specific Cas9-expressing mouse for germline CRISPR/Cas9-mediated genome editing
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    onlinelibrary.wiley.com/doi/10.1002/dvg.23589
  37. link.springer.com link.springer.com
    Depletion of lamins B1 and B2 promotes chromatin mobility and induces differential gene expression by a mesoscale-motion-dependent mechanism
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    link.springer.com/article/10.1186/s13059-024-03212-y
  38. www.nature.com www.nature.com
    Mitophagy mediated by BNIP3 and NIX protects against ferroptosis by downregulating mitochondrial reactive oxygen species
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    nature.com/articles/s41418-024-01280-y
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    Generation of a homozygous ALX1 knockout human embryonic stem cell line (WAe001-A-060) by a CRISPR/Cas9 system
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    sciencedirect.com/science/article/pii/S1873506121001550
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Engineered FSHD mutations results in D4Z4 heterochromatin disruption and feedforward DUX4 network activation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10951985/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of Fel d 1 chain 2 genome-edited cats by CRISPR-Cas9 system
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    ncbi.nlm.nih.gov/pmc/articles/PMC10904870/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function
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    ncbi.nlm.nih.gov/pmc/articles/PMC10942629/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Prediction and validation of circulating G-quadruplexes as a novel biomarker in colorectal cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC10932654/
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    Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis
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    nature.com/articles/s41467-024-46386-6
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DJ-1 protects proteins from acylation by catalyzing the hydrolysis of highly reactive cyclic 3-phosphoglyceric anhydride
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    ncbi.nlm.nih.gov/pmc/articles/PMC10915168/
  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10917421/
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of protein kinase C increases Prdm14 level to promote self-renewal of embryonic stem cells through reducing Suv39h-induced H3K9 methylation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10909794/
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The transcription factor ChREBP Orchestrates liver carcinogenesis by coordinating the PI3K/AKT signaling and cancer metabolism
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    ncbi.nlm.nih.gov/pmc/articles/PMC10904844/
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    SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions
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    sciencedirect.com/science/article/pii/S1535610824000552
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    A humanized mouse model for adeno-associated viral gene therapy
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  51. www.cell.com www.cell.com
    LncRNA Litchi is a Regulator for Harmonizing Maturity and Resilient Functionality in Spinal Motor Neurons
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    cell.com/iscience/fulltext/S2589-0042(24)00428-0
  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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    ncbi.nlm.nih.gov/pmc/articles/PMC10908796/
  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TREX2 deficiency suppresses spontaneous and genotoxin-associated mutagenesis
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Somatic mouse models of gastric cancer reveal genotype-specific features of metastatic disease
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    ncbi.nlm.nih.gov/pmc/articles/PMC10899107/
  55. Feb 2024
  56. www.biorxiv.org www.biorxiv.org
    Sparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes
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    biorxiv.org/content/10.1101/2024.02.05.578969v1
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Undetectable off-target effects induced by FokI catalytic domain in mouse embryos
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    ncbi.nlm.nih.gov/pmc/articles/PMC10877887/
  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence
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    ncbi.nlm.nih.gov/pmc/articles/PMC10873425/
  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA m6A modification regulates L1 retrotransposons in human spermatogonial stem cell differentiation in vitro and in vivo
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    ncbi.nlm.nih.gov/pmc/articles/PMC10873452/
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    Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting
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    Post-synaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles
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    biorxiv.org/content/10.1101/2023.12.21.572751v1
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    DOT1L stimulates MYC/Mondo transcription factor activity by promoting its degradation cycle on chromatin
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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BCL-XL regulates the timing of mitotic apoptosis independently of BCL2 and MCL1 compensation
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    ncbi.nlm.nih.gov/pmc/articles/PMC10764939/
  64. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An ovalbumin fusion strategy to increase recombinant protein secretion in chicken eggs
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The heterogeneity of signaling pathways and drug responses in intrahepatic cholangiocarcinoma with distinct genetic mutations
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    ncbi.nlm.nih.gov/pmc/articles/PMC10784283/
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    CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs
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  67. Jan 2024
  68. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Methodology to Create Auxin-Inducible Degron Tagging System to Control Expression of a Target Protein in Mammalian Cell Lines
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    ncbi.nlm.nih.gov/pmc/articles/PMC10804242/
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    Generation of a patient-specific iPSC cell line with cardiac arrhythmias and dilated cardiomyopathy (CBRCULi016-A), an isogenic control (CBRCULi016-A-1), and a paternal control (CBRCULi017-A)
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  70. Dec 2023
  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Altered Phenotypes of Breast Epithelial × Breast Cancer Hybrids after ZEB1 Knock-Out
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    ncbi.nlm.nih.gov/pmc/articles/PMC10744253/
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    Highly cooperative chimeric super-SOX induces naive pluripotency across species
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    sciencedirect.com/science/article/pii/S1934590923004022
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    Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation
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    link.springer.com/article/10.1038/s41467-023-43896-7
  74. Nov 2023
  75. www.sciencedirect.com www.sciencedirect.com
    Glycosylated queuosines in tRNAs optimize translational rate and post-embryonic growth
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    sciencedirect.com/science/article/pii/S0092867423011777
  76. Oct 2023
  77. www.sciencedirect.com www.sciencedirect.com
    The intrinsically disordered region of eIF5B stimulates IRES usage and nucleates biological granule formation
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    sciencedirect.com/science/article/pii/S2211124723012950
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    Protocol for auxin-inducible depletion of the RNA-binding protein PTBP1 in mouse embryonic stem cells
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    ncbi.nlm.nih.gov/pmc/articles/PMC10594634/
  79. dx.doi.org dx.doi.org
    Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction
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    dx.doi.org/10.1093/nar/gkad863
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    LINE-1 activation in the cerebellum drives ataxia
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    ncbi.nlm.nih.gov/pmc/articles/PMC9588660/
  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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    ncbi.nlm.nih.gov/pmc/articles/PMC10521973/
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    ZEB2 and MEIS1 independently contribute to hematopoiesis via early hematopoietic enhancer activation
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    sciencedirect.com/science/article/pii/S2589004223019703
  83. Sep 2023
  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8)
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    ncbi.nlm.nih.gov/pmc/articles/PMC10472876/
  85. Aug 2023
  86. www.embopress.org www.embopress.org
    Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome
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    embopress.org/doi/10.15252/embr.202357233
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    Integrating single-cell imaging and RNA sequencing datasets links differentiation and morphogenetic dynamics of human pancreatic endocrine progenitors
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    sciencedirect.com/science/article/pii/S1534580723003660
  88. www.biorxiv.org www.biorxiv.org
    Ubiquitin phosphorylation accelerates protein aggregation and promotes neurodegeneration in the aging brain
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    biorxiv.org/content/10.1101/2023.08.10.552882v1
  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The mitochondrial succinate dehydrogenase complex controls the STAT3-IL-10 pathway in inflammatory macrophages
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    ncbi.nlm.nih.gov/pmc/articles/PMC10416071/
  90. Jul 2023
  91. www.sciencedirect.com www.sciencedirect.com
    Parallel CRISPR-Cas9 screens identify mechanisms of PLIN2 and lipid droplet regulation
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    Optimized CRISPR/Cas9 System for Gene Knockout in Chicken DF1 Cells
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    sciencedirect.com/science/article/pii/S0032579123004893
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    mRNA stability and m6A are major determinants of subcellular mRNA localization in neurons
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    sciencedirect.com/science/article/pii/S1097276523004689
  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic analysis of the molecular and biophysical properties of key DNA damage response factors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10319438/
  95. Jun 2023
  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Method of Monitoring 26S Proteasome in Cells Revealed the Crucial Role of PSMA3 C-Terminus in 26S Integrity
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    ncbi.nlm.nih.gov/pmc/articles/PMC10296302/
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    Tracking the PROTAC degradation pathway in living cells highlights the importance of ternary complex measurement for PROTAC optimization
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    sciencedirect.com/science/article/pii/S2451945623001575
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    Coordinated linear and rotational movements of endothelial cells compartmentalized by VE-cadherin drive angiogenic sprouting
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    sciencedirect.com/science/article/pii/S2589004223011288
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    Centromere/kinetochore is assembled through CENP-C oligomerization
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  100. www.cell.com www.cell.com
    Clearance of senescent macrophages ameliorates tumorigenesis in KRAS-driven lung cancer
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    CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase
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  217. Aug 2021
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