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939 Matching Annotations

Mar 2025
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Bi-allelic KICS2 mutations impair KICSTOR complex-mediated mTORC1 regulation, causing intellectual disability and epilepsy

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  DOI: 10.1016/j.ajhg.2024.12.019
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11866974/
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RNF10 and RIOK3 facilitate 40S ribosomal subunit degradation upon 60S biogenesis disruption or amino acid starvation

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  DOI: 10.1016/j.celrep.2025.115371
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00142-1
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Targeting TUBG1 in RB1-negative tumors

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  DOI: 10.1096/fj.202403180RR
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11869804/
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Inflammatory cytokines mediate the induction of and awakening from metastatic dormancy

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  plasmid_48138
  
  DOI: 10.1016/j.celrep.2025.115388
  
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sciencedirect.com/science/article/pii/S2211124725001597
Feb 2025
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Long-range enhancer-controlled genes are hypersensitive to regulatory factor perturbations

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1. scibot 27 Feb 2025
  
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  Addgene_48138
  
  DOI: 10.1016/j.xgen.2025.100778
  
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sciencedirect.com/science/article/pii/S2666979X25000345
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BACE1-dependent cleavage of GABAA receptor contributes to neural hyperexcitability and disease progression in Alzheimer’s disease

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1. scibot 27 Feb 2025
  
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  Addgene_48138
  
  DOI: 10.1016/j.neuron.2025.01.030
  
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sciencedirect.com/science/article/pii/S0896627325000789
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Endogenous production of nitric oxide by iNOS in human cells restricts inflammatory activation and cholesterol/fatty acid biosynthesis

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1. scibot 25 Feb 2025
  
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  DOI: 10.1016/j.freeradbiomed.2025.02.022
  
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sciencedirect.com/science/article/pii/S0891584925000978
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RIPK1 is required for ZBP1-driven necroptosis in human cells

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1. scibot 24 Feb 2025
  
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  DOI: 10.1371/journal.pbio.3002845
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11844899/
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Direct ionic stress sensing and mitigation by the transcription factor NFAT5

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1. scibot 23 Feb 2025
  
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  DOI: 10.1126/sciadv.adu3194
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11838016/
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Examining the NEUROG2 lineage and associated gene expression in human cortical organoids

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1. scibot 18 Feb 2025
  
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  plasmid_48138
  
  DOI: 10.1242/dev.202703
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11829764/
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Construction of a TAT-Cas9-EGFP Site-Specific Integration Eukaryotic Cell Line Using Efficient PEG10 Modification

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1. scibot 16 Feb 2025
  
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  pX458
  
  DOI: 10.3390/ijms26031331
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11818622/
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NEAT1-mediated regulation of proteostasis and mRNA localization impacts autophagy dysregulation in Rett syndrome

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1. scibot 16 Feb 2025
  
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  DOI: 10.1093/nar/gkaf074
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11806351/
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Development of cell lines with increased susceptibility to diverse adeno-associated viral vectors to enable in vitro potency assays

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  DOI: 10.1016/j.omtm.2025.101416
  
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sciencedirect.com/science/article/pii/S2329050125000117
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The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability

2
1. scibot 04 Feb 2025
  
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  AddgeneCat#48138
  
  DOI: 10.1016/j.celrep.2025.115259
  
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  plasmid_48138
  
  DOI: 10.1016/j.celrep.2025.115259
  
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sciencedirect.com/science/article/pii/S2211124725000300
Jan 2025
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The α-globin super-enhancer acts in an orientation-dependent manner

1
1. scibot 29 Jan 2025
  
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  RRID:Addgene_48138
  
  DOI: 10.1038/s41467-025-56380-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11762767/
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Pol II degradation activates cell death independently from the loss of transcription

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1. scibot 27 Jan 2025
  
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  Addgene
  
  DOI: 10.1101/2024.12.09.627542
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11661175/
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Development of compounds for targeted degradation of mammalian cryptochrome proteins

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1. scibot 27 Jan 2025
  
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  PX458
  
  DOI: 10.1098/rstb.2023.0342
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11753880/
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Tissue-specific modulation of CRISPR activity by miRNA-sensing guide RNAs

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1. scibot 27 Jan 2025
  
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  48138
  
  DOI: 10.1093/nar/gkaf016
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11754125/
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Shared rare genetic variants in multiplex autism families suggest a social memory gene under selection

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1. scibot 27 Jan 2025
  
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  DOI: 10.1038/s41598-024-83839-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11698849/
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Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models

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1. scibot 27 Jan 2025
  
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  pX458
  
  DOI: 10.1038/s41467-024-54791-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11696141/
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Generation of live mice from haploid ESCs with germline-DMR deletions or switch

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  48138
  
  DOI: 10.1038/s41421-024-00757-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11747502/
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Identification of KRT16 and ANXA10 as cell cycle regulation genes for lung adenocarcinoma based on self-transcriptome sequencing of surgical samples and TCGA public data mining

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  48138
  
  DOI: 10.1007/s12672-024-01707-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11754560/
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Structural basis of phosphate export by human XPR1

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  addgene_48138
  
  DOI: 10.1038/s41467-025-55995-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11736019/
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Single-cell RNA sequencing identifies CXADR as a fate determinant of the placental exchange surface

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  Plasmid_48138
  
  DOI: 10.1038/s41467-024-55597-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11695997/
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Proximity‐dependent biotinylation reveals an interaction between ubiquitin‐specific peptidase 46 and centrosome‐related proteins

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1. scibot 25 Jan 2025
  
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  plasmid_48138
  
  DOI: 10.1002/2211-5463.13918
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11705415/
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NRBP1 and TSC22D proteins impact distal convoluted tubule physiology through modulation of the WNK pathway

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1. scibot 24 Jan 2025
  
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  RRID:Addgene_48138
  
  DOI: 10.1101/2024.12.12.628222
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11702584/
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Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase

1
1. scibot 16 Jan 2025
  
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  plasmid_48138
  
  DOI: 10.1101/2024.10.04.616749
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11703149/
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Elevated Ubiquitin Phosphorylation by PINK1 Contributes to Proteasomal Impairment and Promotes Neurodegeneration

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1. scibot 09 Jan 2025
  
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  plasmid_48138
  
  DOI: 10.7554/eLife.103945.1
  
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elifesciences.org/reviewed-preprints/103945
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SLC7A5 is required for cancer cell growth under arginine-limited conditions

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1. scibot 07 Jan 2025
  
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  AddgeneCat#48138
  
  DOI: 10.1016/j.celrep.2024.115130
  
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sciencedirect.com/science/article/pii/S2211124724014815
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The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A

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  Addgene Cat#48138
  
  DOI: 10.7142/igakutoshokan.32.4_454a
  
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cell.com/cell-reports/fulltext/S2211-1247(24)01438-4
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LDB1 establishes multi-enhancer networks to regulate gene expression

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  Addgene48138
  
  DOI: 10.1016/j.molcel.2024.11.037
  
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sciencedirect.com/science/article/pii/S1097276524009924
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Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains

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  DOI: 10.1016/j.molcel.2024.12.002
  
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sciencedirect.com/science/article/pii/S1097276524009973
Dec 2024
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ErbB4 precludes the occurrence of PTSD-like fear responses by supporting the bimodal activity of the central amygdala

1
1. scibot 29 Dec 2024
  
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  plasmid_48138
  
  DOI: 10.1038/s12276-024-01365-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11671592/
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Single-cell analysis of bidirectional reprogramming between early embryonic states identify mechanisms of differential lineage plasticities in mice

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1. scibot 29 Dec 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.devcel.2024.11.022
  
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cell.com/developmental-cell/fulltext/S1534-5807(24)00722-6
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Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera

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1. scibot 28 Dec 2024
  
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  48138
  
  DOI: 10.1021/jacs.4c11556
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11638965/
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Recapitulating the adenoma–carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids

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1. scibot 27 Dec 2024
  
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  48138
  
  DOI: 10.1038/s43018-024-00841-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11663794/
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Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis

1
1. scibot 27 Dec 2024
  
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  48138
  
  DOI: 10.1038/s41589-024-01680-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11666458/
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Hepatitis B Virus-KMT2B Integration Drives Hepatic Oncogenic Processes in a Human Gene-edited Induced Pluripotent Stem Cells-derived Model

1
1. scibot 27 Dec 2024
  
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  pSp-Cas9(BB)-2A-GFP(PX458)
  
  DOI: 10.1016/j.jcmgh.2024.101422
  
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Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1

1
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  AddgeneCat# 48138
  
  DOI: 10.1016/j.ccell.2024.11.008
  
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A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes

1
1. scibot 24 Dec 2024
  
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  plasmid_48138
  
  DOI: 10.1038/s41467-024-55302-x
  
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Forced Overexpression and Knockout Analysis of SLC30A and SLC39A Family Genes Suggests Their Involvement in Establishing Resistance to Cisplatin in Human Cancer Cells

1
1. scibot 22 Dec 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.3390/ijms252212049
  
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PRC1 and CTCF-Mediated Transition from Poised to Active Chromatin Loops Drives Bivalent Gene Activation

1
1. scibot 21 Dec 2024
  
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  Plasmid_48138
  
  DOI: 10.1101/2024.11.13.623456
  
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Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors

1
1. scibot 17 Dec 2024
  
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  Addgene_48138
  
  DOI: 10.1016/j.devcel.2017.02.006
  
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A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer

1
1. scibot 13 Dec 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1080/19420862.2024.2438173
  
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tandfonline.com/doi/full/10.1080/19420862.2024.2438173
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Structure and mechanism of the RalGAP tumor suppressor complex

1
1. scibot 06 Dec 2024
  
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  Addgene plasmids # 48138
  
  DOI: 10.1101/2024.11.25.625123
  
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52.53.155.43 52.53.155.43

Endoplasmic reticulum morphology regulation by RTN4 modulates neuronal regeneration by curbing luminal transport

3
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  Addgene #48138
  
  DOI: 10.1016/j.celrep.2024.114357
  
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  RRID:Addgene_48138
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.celrep.2024.114357
  
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52.53.155.43/a5cd2a76f55670a4ac26cd7a0c2f7cbc81f1256c/Endoplasmic reticulum morphology regulation by RTN4 modulates neu-html.html
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Alternative splicing is an FXRα loss-of-function mechanism and impacts energy metabolism in hepatocarcinoma cells

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  RRID:Addgene_48138
  
  DOI: 10.1016/j.jbc.2024.108022
  
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Self-organized pattern formation in the developing mouse neural tube by a temporal relay of BMP signaling

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  Addgene_48138
  
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Development of MAPT S305 mutation human iPSC lines exhibiting elevated 4R tau expression and functional alterations in neurons and astrocytes

1
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  Addgene_48138
  
  DOI: 10.1016/j.celrep.2024.115013
  
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pubs.acs.org pubs.acs.org

Streamlined Generation of CRISPR/Cas9-Mediated Single-Cell Knockout Clones in Murine Cell Lines

2
1. scibot 29 Nov 2024
  
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  RRID: Addgene_48138
  
  DOI: 10.1021/acsptsci.3c00338
  
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  RRID:Addgene_48138
  
  DOI: 10.1021/acsptsci.3c00338
  
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STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair

1
1. scibot 21 Nov 2024
  
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  Addgene_48138
  
  DOI: 10.1016/j.cell.2024.10.018
  
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Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress

1
1. scibot 16 Nov 2024
  
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  Plasmid_48138
  
  DOI: 10.1016/j.cell.2024.10.012
  
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Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma

1
1. scibot 08 Nov 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1158/0008-5472.CAN-24-0134
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532787/
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Cancer-cell-derived cGAMP limits the activity of tumor-associated CD8+ T cells

1
1. scibot 07 Nov 2024
  
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  Addgene_48138
  
  DOI: 10.1101/2024.10.28.620471
  
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biorxiv.org/content/10.1101/2024.10.28.620471v1
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VPS13B is localized at the interface between Golgi cisternae and is a functional partner of FAM177A1

1
1. scibot 08 Oct 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1083/jcb.202311189
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11451052/
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P16INK4A drives RB1 degradation by UTP14A-catalyzed K810 ubiquitination

1
1. scibot 05 Oct 2024
  
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  Plasmid_48138
  
  DOI: 10.1016/j.isci.2024.110882
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11440251/
onlinelibrary.wiley.com onlinelibrary.wiley.com

Constitutive Androstane Receptor Regulates Germ Cell Homeostasis, Sperm Quality, and Male Fertility via Akt-Foxo1 Pathway

1
1. scibot 03 Oct 2024
  
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  (Addgene Plasmid #48 138)
  
  DOI: 10.1002/advs.202402082
  
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onlinelibrary.wiley.com/doi/full/10.1002/advs.202402082
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TMX1, a disulfide oxidoreductase, is necessary for T cell function through regulation of CD3ζ

1
1. scibot 03 Oct 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1101/2024.09.22.614388
  
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biorxiv.org/content/10.1101/2024.09.22.614388v1
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QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction

1
1. scibot 01 Oct 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1038/s41467-024-52587-w
  
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nature.com/articles/s41467-024-52587-w
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Splice variants of CK1α and CK1α-like: Comparative analysis of subcellular localization, kinase activity, and function in the Wnt signaling pathway

1
1. scibot 29 Sep 2024
  
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  48138
  
  DOI: 10.1016/j.jbc.2024.107407
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11255964/
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Core fucosylation within the Fc-FcγR degradation pathway promotes enhanced IgG levels via exogenous L-fucose

1
1. scibot 29 Sep 2024
  
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  48138
  
  DOI: 10.1016/j.jbc.2024.107558
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11345378/
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Genetically engineered human embryonic kidney cells as a novel vehicle for dual patch clamp study of human gap junction channels

1
1. scibot 29 Sep 2024
  
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  pSpCas9(BB)-2A-GFP plasmid (PX458
  
  DOI: 10.1042/BCJ20240016
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11346430/
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Drp1 depletion protects against ferroptotic cell death by preserving mitochondrial integrity and redox homeostasis

1
1. scibot 29 Sep 2024
  
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  pSpCas9(BB)-2A-GFP
  
  DOI: 10.1038/s41419-024-07015-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11350090/
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Tumor-induced natural killer cell dysfunction is a rapid and reversible process uncoupled from the expression of immune checkpoints

1
1. scibot 29 Sep 2024
  
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  pX458
  
  DOI: 10.1126/sciadv.adn0164
  
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CD47 and IFT57 Are Colinear Genes That Are Highly Coexpressed in Most Cancers and Exhibit Parallel Cancer-Specific Correlations with Survival

1
1. scibot 29 Sep 2024
  
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  pSpCas9(BB)-2A-GFP
  
  DOI: 10.3390/ijms25168956
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11354933/
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CRISPR-based dissection of microRNA-23a ~ 27a ~ 24-2 cluster functionality in hepatocellular carcinoma

1
1. scibot 29 Sep 2024
  
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  pSpCas9(BB)-2A-GFP (PX458
  
  DOI: 10.1038/s41388-024-03115-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11364504/
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Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling

1
1. scibot 29 Sep 2024
  
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  PX458
  
  DOI: 10.1038/s41589-024-01612-6
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11427348/
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ANT-Mediated Inhibition of the Permeability Transition Pore Alleviates Palmitate-Induced Mitochondrial Dysfunction and Lipotoxicity

1
1. scibot 29 Sep 2024
  
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  48138
  
  DOI: 10.3390/biom14091159
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11430505/
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A user-friendly CRISPR/Cas9 system for mutagenesis of Neurospora crassa

1
1. scibot 29 Sep 2024
  
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  pSPCas9(BB)-2A-GFP
  
  DOI: 10.1038/s41598-024-71540-x
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11372047/
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A flexible loop in the paxillin LIM3 domain mediates its direct binding to integrin β subunits

1
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  48138
  
  DOI: 10.1371/journal.pbio.3002757
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11374337/
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A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors

1
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  48138
  
  DOI: 10.1038/s41467-024-51991-6
  
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PUMA/RIP3 mediates chemotherapy response via necroptosis and local immune activation in colorectal cancer

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  DOI: 10.1158/1535-7163.MCT-23-0162
  
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A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus

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  plasmid_48138
  
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Dynamic remodeling of Septin structures fine-tunes myogenic differentiation

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  DOI: 10.1016/j.isci.2024.110630
  
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Molecular and cellular context influences SCN8A variant function

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  DOI: 10.1172/jci.insight.177530
  
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T4 DNA polymerase prevents deleterious on-target DNA damage and enhances precise CRISPR editing

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Hominini-specific regulation of the cell cycle by stop codon readthrough of FEM1B

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  Addgene_48138
  
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WIPI2b recruitment to phagophores and ATG16L1 binding are regulated by ULK1 phosphorylation

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ISGylation enhances dsRNA-induced interferon response and NFκB signaling in fallopian tube epithelial cells

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  DOI: 10.1016/j.jbc.2024.107686
  
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Engineering Oncogenic Hotspot Mutations on SF3B1 via CRISPR-Directed PRECIS Mutagenesis

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  DOI: 10.1158/2767-9764.CRC-24-0145
  
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Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor

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  Addgene
  
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Correction of exon 2, exon 2–9 and exons 8–9 duplications in DMD patient myogenic cells by a single CRISPR/Cas9 system

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  plasmid_48138
  
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The enhancer RNA, AANCR, regulates APOE expression in astrocytes and microglia

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  plasmid_48138
  
  DOI: 10.1093/nar/gkae696
  
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PROTAC‐Mediated HDAC7 Protein Degradation Unveils Its Deacetylase‐Independent Proinflammatory Function in Macrophages

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Reconstitution of BNIP3/NIX-mediated autophagy reveals two pathways and hierarchical flexibility of the initiation machinery

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Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia

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CRISPR-Cas guide RNA indel analysis using CRISPResso2 with Nanopore sequencing data

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  plasmid_48
  
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Mesenchymal Stromal Cells Increase the Natural Killer Resistance of Circulating Tumor Cells via Intercellular Signaling of cGAS‐STING‐IFNβ‐HLA

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  plasmid_48
  
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Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2

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MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation

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Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS

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Impact of protein and small molecule interactions on kinase conformations

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  DOI: 10.7554/eLife.94755
  
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Functional evaluation of novel variants of B4GALNT1 in a patient with hereditary spastic paraplegia and the general population

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  pSpCas9(BB)-2A-GFP
  
  DOI: 10.3389/fnins.2024.1437668
  
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LUZP1 regulates the maturation of contractile actomyosin bundles

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  DOI: 10.1007/s00018-024-05294-0
  
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Crucial role of the NSE1 RING domain in Smc5/6 stability and FANCM-independent fork progression

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  DOI: 10.1007/s00018-024-05275-3
  
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Allele-specific CRISPR-Cas9 editing inactivates a single nucleotide variant associated with collagen VI muscular dystrophy

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  DOI: 10.1016/j.omtn.2024.102269
  
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Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway

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  DOI: 10.1038/s41467-024-50971-0
  
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Lipid Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Against Rubicon Ameliorates NAFLD by Modulating CD36 Along with Glycerophospholipid Metabolism

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  PX458
  
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Glycogen myophosphorylase loss causes increased dependence on glucose in iPSC-derived retinal pigment epithelium

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RNA variant assessment using transactivation and transdifferentiation

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  DOI: 10.1016/j.ajhg.2024.06.018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11339655/
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The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate

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  Addgene_48138
  
  DOI: 10.1101/2024.07.08.602542
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11257442/
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Stem cell-derived cardiomyocytes expressing a dominant negative pacemaker HCN4 channel do not reduce the risk of graft-related arrhythmias

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  plasmid_48138
  
  DOI: 10.3389/fcvm.2024.1374881
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11263024/
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TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions

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ncbi.nlm.nih.gov/pmc/articles/PMC11322606/
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The plasma membrane inner leaflet PI(4,5)P2 is essential for the activation of proton-activated chloride channels

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  plasmid_48138
  
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The zonula adherens matura redefines the apical junction of intestinal epithelia

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  DOI: 10.1073/pnas.2316722121
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10907237/
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Clinical and functional studies of MTOR variants in Smith-Kingsmore syndrome reveal deficits of circadian rhythm and sleep-wake behavior

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  DOI: 10.1016/j.xhgg.2024.100333
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11342114/
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HiPSC-derived 3D neural models reveal neurodevelopmental pathomechanisms of the Cockayne Syndrome B

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  DOI: 10.1007/s00018-024-05406-w
  
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Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries

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  DOI: 10.1016/j.molcel.2024.08.007
  
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Vps13D encodes a ubiquitin binding protein that is required for the regulation of mitochondrial size and clearance

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  DOI: 10.1016/j.cub.2017.11.064
  
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A comprehensive study evaluating germline FANCG variants in predisposition to breast and ovarian cancer

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RAF inhibitors activate the integrated stress response by direct activation of GCN2

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  plasmid_48138
  
  DOI: 10.1101/2024.08.15.607884
  
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A structural peculiarity of Antarctic fish IgM drives the generation of an engineered mAb by CRISPR/Cas9

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Developmental control of rod number via a light-dependent retrograde pathway from intrinsically photosensitive retinal ganglion cells

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ABIN1 is a negative regulator of effector functions in cytotoxic T cells

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1. scibot 21 Aug 2024
  
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  DOI: 10.1038/s44319-024-00179-6
  
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Generation of a ZEB2 deficient human iPSC line (KICRi002A-4)

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  DOI: 10.1016/j.scr.2024.103521
  
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Deciphering the genetics and mechanisms of predisposition to multiple myeloma

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The role of MNK1-mTORC1 pathway in modulating macrophage responses to Vibrio vulnificus infection

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  PX458
  
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Genetic Screening of Haploid Neural Stem Cells Reveals that Nfkbia and Atp2b4 are Key Regulators of Oxidative Stress in Neural Precursors

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  DOI: 10.1002/advs.202309292
  
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Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma

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  DOI: 10.1038/s41467-024-50861-5
  
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CNTN4 modulates neural elongation through interplay with APP

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  DOI: 10.1098/rsob.240018
  
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A mechanistic study on the tolerance of PAM distal end mismatch by SpCas9

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  DOI: 10.1016/j.jbc.2024.107439
  
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Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma

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HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair

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The relationship between nanoscale genome organization and gene expression in mouse embryonic stem cells during pluripotency transition

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Ion channel TRPV2 is critical in enhancing B cell activation and function

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  pSpCas9-2a-GFP
  
  DOI: 10.1084/jem.20221042
  
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Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: Hypersecretion preceded the failure of pancreatic β-cells

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Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation

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Structure of the human 20S U5 snRNP

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2024.04.26.591029v1.full-html.html

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Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses

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Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use

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CRISPR/Cas9-mediated LRP10 Knockout in HuTu-80 and HEK 293T Cell Lines

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  DOI: 10.21769\u002FBioProtoc.4521
  
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Highlights from MBoC Selection: STMND1 is a phylogenetically ancient stathmin which localizes to motile cilia and exhibits nuclear translocation that is inhibited when soluble tubulin concentration increases

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Substrate O‐glycosylation actively regulates extracellular proteolysis

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Phosphatidylserine regulates plasma membrane repair through tetraspanin-enriched macrodomains

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VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

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Isogenic patient-derived organoids reveal early neurodevelopmental defects in spinal muscular atrophy initiation

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A hominoid-specific signaling axis regulating the tempo of synaptic maturation

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The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent noncanonical pathway

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  DOI: 10.1111/acel.14258
  
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onlinelibrary.wiley.com/doi/10.1111/acel.14258
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Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

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  DOI: 10.7554/eLife.91766
  
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An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II

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Activation of Hippo Pathway Damages Slit Diaphragm by Deprivation of Ajuba Proteins

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  plasmid_48138
  
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Endoplasmic reticulum morphology regulation by RTN4 modulates neuronal regeneration by curbing luminal transport

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ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway

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  plasmid_48138
  
  DOI: 10.1038/s41467-019-13781-3
  
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A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence

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cell.com/cell/fulltext/S0092-8674(24)00693-7
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The long non-coding RNA Meg3 mediates imprinted gene expression during stem cell differentiation

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Susceptibility to innate immune activation in genetically mediated myocarditis

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Reduced Protein Import via TIM23 SORT Drives Disease Pathology in TIMM50-Associated Mitochondrial Disease

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Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD

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Reduced surface pH and upregulated AE2 anion exchange in SLC26A3-deleted polarized intestinal epithelial cells

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Fully automated viability and toxicity screening—A reliable all‐in‐one attempt

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Preclinical evidence for the use of anti‐Trop‐2 antibody‐drug conjugate Sacituzumab govitecan in cerebral metastasized castration‐resistant prostate cancer

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Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking

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The homeobox transcription factor DUXBL controls exit from totipotency

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An enhancer RNA recruits KMT2A to regulate transcription of Myb

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Electron transport chain inhibition increases cellular dependence on purine transport and salvage

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Cadherin-11 contributes to the heterogenous and dynamic Wnt-Wnt-β-catenin pathway activation in Ewing sarcoma

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Tissue-intrinsic beta-catenin signals antagonize Nodal-driven anterior visceral endoderm differentiation

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Reduction of Filamin C Results in Altered Proteostasis, Cardiomyopathy, and Arrhythmias

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Transcription decouples estrogen-dependent changes in enhancer-promoter contact frequencies and spatial proximity

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Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration

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An oncogenic enhancer promotes melanoma progression via regulating ETV4 expression

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ATRX guards against aberrant differentiation in mesenchymal progenitor cells

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Limitations of fluorescent timer protein maturation kinetics to isolate transcriptionally synchronized human neural progenitor cells

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Histone deacetylase inhibition sensitizes p53-deficient B-cell precursor acute lymphoblastic leukemia to chemotherapy

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ZNF143 binds DNA and stimulates transcripstion initiation to activate and repress direct target genes

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De novo and salvage purine synthesis pathways across tissues and tumors

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HIF2α-dependent Dock4/Rac1-signaling regulates formation of adherens junctions and cell polarity in normoxia

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Suppression of TCF4 promotes a ZC3H12A-mediated self-sustaining inflammatory feedback cycle involving IL-17RA/IL-17RE epidermal signaling

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DDIT4L regulates mitochondrial and innate immune activities in early life

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The GPI-anchor biosynthesis pathway is critical for syncytiotrophoblast differentiation and placental development

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Enrichment of allelic editing outcomes by Prime Editing in iPS cells

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Roles for CEP170 in cilia function and dynein-2 assembly

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KAT8 compound inhibition inhibits the initial steps of PINK1-dependant mitophagy

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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

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ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity

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CD3 aptamers promote expansion and persistence of tumor-reactive T cells for adoptive T cell therapy in cancer

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Generation of complex bone marrow organoids from human induced pluripotent stem cells

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Sequential glycosylations at the multibasic cleavage site of SARS-CoV-2 spike protein regulate viral activity

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Cerebral organoids display dynamic clonal growth and tunable tissue replenishment

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Transcription-coupled repair of DNA–protein cross-links depends on CSA and CSB

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Platinum-induced upregulation of ITGA6 promotes chemoresistance and spreading in ovarian cancer

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IRF7 from the black flying fox induces a STAT1-independent ISG response in unstimulated cell lines that protects against diverse RNA viruses

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  DOI: 10.1101/2024.05.02.592239
  
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biorxiv.org/content/10.1101/2024.05.02.592239v1
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Disruption of Transmembrane Phosphatidylserine Asymmetry by HIV-1 Incorporated SERINC5 Is Not Responsible for Virus Restriction

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1. scibot 17 May 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.3390/biom14050570
  
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mdpi.com/2218-273X/14/5/570
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Autophagy preferentially degrades non-fibrillar polyQ aggregates

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1. scibot 17 May 2024
  
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  Addgene_48138
  
  DOI: 10.1016/j.molcel.2024.04.018
  
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sciencedirect.com/science/article/pii/S1097276524003836
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A RAB7A phosphoswitch coordinates Rubicon Homology protein regulation of Parkin-dependent mitophagy

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1. scibot 15 May 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1083/jcb.202309015
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11090050/
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USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation

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1. scibot 14 May 2024
  
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  Addgene48138
  
  DOI: 10.1016/j.celrep.2024.114194
  
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sciencedirect.com/science/article/pii/S2211124724005229
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Primordial germ cell DNA demethylation and development require DNA translesion synthesis

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1. scibot 12 May 2024
  
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  48138
  
  DOI: 10.1038/s41467-024-47219-2
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11068800/
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SUMOylated Golgin45 associates with PML-NB to transcriptionally regulate lipid metabolism genes during heat shock stress

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1. scibot 12 May 2024
  
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  48138
  
  DOI: 10.1038/s42003-024-06232-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11074300/
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BRD2 promotes antibody class switch recombination by facilitating DNA repair in collaboration with NIPBL

1
1. scibot 12 May 2024
  
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  PX458
  
  DOI: 10.1093/nar/gkae204
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11077081/
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A regulatory variant impacting TBX1 expression contributes to basicranial morphology in Homo sapiens

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1. scibot 12 May 2024
  
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  48138
  
  DOI: 10.1016/j.ajhg.2024.03.012
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11080286/
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The concerted action of SEPT9 and EPLIN modulates the adhesion and migration of human fibroblasts

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1. scibot 12 May 2024
  
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  plasmid_48138
  
  DOI: 10.26508/lsa.202201686
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11077590/
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The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex

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1. scibot 07 May 2024
  
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  Addgene_48138
  
  DOI: 10.1016/j.molcel.2024.04.007
  
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Cx31.1 can selectively intermix with co-expressed connexins to facilitate its assembly into gap junctions

1
1. scibot 05 May 2024
  
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  48138
  
  DOI: 10.1242/jcs.261631
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11058089/

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