1,167 Matching Annotations
  1. Last 7 days
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Contemporary Endothelial Genome Editing Technologies: Towards Precision Genetic Medicine for Vascular Diseases
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    pmc.ncbi.nlm.nih.gov/articles/PMC13257594/
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    Cell type-dependent suppression of the RNA helicase DDX3Y levels by the close paralog DDX3X
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    pmc.ncbi.nlm.nih.gov/articles/PMC12979491/
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TELO2-interacting protein 1 (TTI1), a novel Wnt/β-catenin target gene, decreases chemo-sensitivity in colorectal cancer by modulating DNA damage responses
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    pmc.ncbi.nlm.nih.gov/articles/PMC13263369/
  5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Structural evolution of the MTCH family of mitochondrial insertases
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    pmc.ncbi.nlm.nih.gov/articles/PMC13274618/
  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Remodeling of XIST regulatory landscape during primate evolution
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    pmc.ncbi.nlm.nih.gov/articles/PMC12810636/
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Repeat-rich RNA guides repetitive genomic elements into biomolecular condensates for heterochromatin organization and muscle integrity
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    pmc.ncbi.nlm.nih.gov/articles/PMC12968391/
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    The Activation of ARF1 Is Dynamically Regulated by its Palmitoylation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13273671/
  9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NUP98 regulates orthoflavivirus replication through interaction with vRNA and can be targeted for antiviral purposes
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    pmc.ncbi.nlm.nih.gov/articles/PMC12839527/
  10. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humans
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    pmc.ncbi.nlm.nih.gov/articles/PMC12979680/
  11. www.nature.com www.nature.com
    Histone readers MLLT1 and MLLT3 concentrate AID to confer locus specificity
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    nature.com/articles/s41586-026-11087-1
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Anti-orthopoxvirus drugs inhibit lumpy skin disease virus replication by targeting viral DNA polymerase
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    pmc.ncbi.nlm.nih.gov/articles/PMC12858068/
  13. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Jagged1 regulates extracellular matrix deposition and remodeling in triple-negative breast cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12998526/
  14. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Plagl1 and Lrrc58 control mammalian body size by triggering target-directed microRNA degradation of miR-322 and miR-503
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    pmc.ncbi.nlm.nih.gov/articles/PMC12863257/
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    LDB1 regulates gene expression and chromatin structure in pluripotency and lineage differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12848946/
  16. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    ATRX loss couples genome instability at a G-rich repeat to dysregulation of human alpha-globin expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13018553/
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis
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    pmc.ncbi.nlm.nih.gov/articles/PMC12992122/
  18. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ribosome Molecular Aging Shapes Translation Dynamics
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    pmc.ncbi.nlm.nih.gov/articles/PMC13014177/
  19. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ribosome-associated quality control of aberrant protein production during amino acid limitation
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    pmc.ncbi.nlm.nih.gov/articles/PMC12871355/
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Modeling Cohen Syndrome in Phoenix Cells: VPS13B Loss Causes Organelle Stress, G1/S Delay, and Fibrillary Inclusion Bodies Formation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13564750/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PIGBOS-CLCC1 interaction shapes cellular calcium dynamics and energy metabolism
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    pmc.ncbi.nlm.nih.gov/articles/PMC13556002/
  22. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR/Cas9-mediated TOP1 knockout in chicken DF-1 cells reveals its critical role in apoptosis regulation and genomic stability
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    pmc.ncbi.nlm.nih.gov/articles/PMC12863936/
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    VAMP7-dependent late endosomal secretion of ER and mitochondrial proteins impacts the tumor microenvironment and macrophage engagement
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    pmc.ncbi.nlm.nih.gov/articles/PMC13035943/
  24. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13013565/
  25. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting fatty acid synthase suppresses tumor development in NF2/CDKN2A-deficient pleural mesothelioma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13031323/
  26. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Ultra-sensitive profiling of CRISPR-Cas off-target effects with Tracking-seq2
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    pmc.ncbi.nlm.nih.gov/articles/PMC13558771/
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13564184/
  28. Oct 2026
  29. link.springer.com link.springer.com
    Clustering of host N-glycans by the microneme MIC1/4/6 complex licenses Toxoplasma rhoptry discharge
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    link.springer.com/article/10.1038/s44318-026-00911-z
  30. www.sciencedirect.com www.sciencedirect.com
    The early RNA decay factor ZC3H18 directs first intron splicing
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    sciencedirect.com/science/article/pii/S1097276526006283
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    ATM safeguards DNA replication by restraining pathological repriming at endogenous base lesions
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    sciencedirect.com/science/article/pii/S109727652600626X
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    A bifunctional ARHGEF17-AS1 locus encodes MSEP, a protein that supports mitotic spindle organization
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    sciencedirect.com/science/article/pii/S2211124726011046
  33. Sep 2026
  34. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A novel rapid host cell entry pathway determines the intracellular fate of Staphylococcus aureus
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    pmc.ncbi.nlm.nih.gov/articles/PMC13600698/
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual E3 ligase recruitment by monovalent degraders for tunable SMARCA 2/4 degradation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13612222/
  36. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Baseline cellular state shapes the molecular impact of mutant Kirsten rat sarcoma viral oncogene homologue (KRAS) alleles in reconstituted pancreatic cancer cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13617562/
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    The spindle-associated antisense RNA ARHGEF17-AS1 functionally contributes to mitotic spindle integrity
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    sciencedirect.com/science/article/pii/S2211124726011010
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    TRRAP enables MMB-dependent mitotic transcription and determines sensitivity to CHK1 inhibition
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    sciencedirect.com/science/article/pii/S2211124726010636
  39. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Multiplexed Simian Immunodeficiency Virus-Specific Paired RNA-Guided Cas9 Nickases Inactivate Proviral DNA
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    pmc.ncbi.nlm.nih.gov/articles/PMC8577357/
  40. 54.241.53.176 54.241.53.176
    PMID_41708330-html.html
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    Insulin receptor substrate 2 regulates placental syncytiotrophoblast differentiation at the maternal-fetal interface
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    sciencedirect.com/science/article/pii/S2213671126002729
  42. Aug 2026
  43. www.biorxiv.org www.biorxiv.org
    Mutagenic bypass of uracil-derived abasic sites underlies the SBS17 mutational signature
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    biorxiv.org/content/10.64898/2026.08.21.746158v1
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    Mitotic single-stranded DNA suppression by DDIAS
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    sciencedirect.com/science/article/pii/S1097276526005204
  45. www.sciencedirect.com www.sciencedirect.com
    DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development
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    sciencedirect.com/science/article/pii/S0092867426008731
  46. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Reassessment of the roles of coronin proteins as actin effectors and in signaling
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    pmc.ncbi.nlm.nih.gov/articles/PMC13485075/
  47. www.biorxiv.org www.biorxiv.org
    Engineered endothelial cell grafts form functional anastomoses and enable recruitment of intravenously delivered human T cells in CAM tumor models
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    biorxiv.org/content/10.64898/2026.07.17.739058v1
  48. aacrjournals.org aacrjournals.org
    Rapid Transcription Dynamics Confers Cytarabine Resistance in Acute Myeloid Leukemia
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    aacrjournals.org/bloodcancerdiscov/article/7/4/624/786176/Rapid-Transcription-Dynamics-Confers-Cytarabine
  49. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
    FEBS Press
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    febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.70428
  50. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Mitochondrial l-2-hydroxyglutarate is a physiological signalling metabolite
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    pmc.ncbi.nlm.nih.gov/articles/PMC13391416/
  51. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CRISPR/Cas9-Engineered HEK293T Cellular Model Harboring the Pathogenic CDKL5 c.172A>T Variant Recapitulates Core Molecular Phenotypes of CDKL5 Deficiency Disorder
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    pmc.ncbi.nlm.nih.gov/articles/PMC13389376/
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and Transcription
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    pmc.ncbi.nlm.nih.gov/articles/PMC13404903/
  53. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TASP1-mediated cleavage of REV3L enhances the activity of DNA polymerase ζ in mammalian cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13408197/
  54. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    TMEM63B regulates nucleocytoplasmic transport and placental development
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    pmc.ncbi.nlm.nih.gov/articles/PMC13396397/
  55. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Loop extrusion by cohesin plays a role in enhancer-activated gene expression early in differentiation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13402345/
  56. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Inhibition of TGM2 enhances cisplatin sensitivity in MSH2-deficient bladder cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13402307/
  57. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Analysis of 14q12 microdeletions reveals novel regulatory loci for the neurodevelopmental disorder-related gene FOXG1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13392037/
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Acetylated mitochondrial MDH2 regulates CTR2 transcription to induce cuproptosis during Escherichia coli infection
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    pmc.ncbi.nlm.nih.gov/articles/PMC13402674/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    FN1 Knockout Inhibits Tumorigenesis but Promotes Lung Metastasis in Hepatocellular Carcinoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC13439100/
  60. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Genotoxic antibody-drug conjugates combined with BCL-XL inhibitors enhance therapeutic efficacy in metastatic castration-resistant prostate cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC13430021/
  61. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    An adaptor for feedback regulation of heme biosynthesis by a mitochondrial protease
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    pmc.ncbi.nlm.nih.gov/articles/PMC13425942/
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual regulation of the unfolded protein response by IGF2BP3 during ER stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC13431160/
  63. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    M1-linked ubiquitination by LUBAC regulates AMPK signalling and the response to energetic stress
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    pmc.ncbi.nlm.nih.gov/articles/PMC13434424/
  64. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The anti-tumour activity of TNF in melanoma is determined by cFLIP
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    pmc.ncbi.nlm.nih.gov/articles/PMC13428747/
  65. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Magnetic Reprogramming of Macrophages Stimulates Phagocytosis of Breast Cancer Cells via a TRPC1‐STING Inflammatory Axis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13431815/
  66. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13398675/
  67. www.sciencedirect.com www.sciencedirect.com
    Nodal/Smad2 signaling sustains developmental pausing by repressing Pparg-mediated lipid metabolism
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    sciencedirect.com/science/article/pii/S1534580726002753
  68. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The bile acid-sensive ion channel (BASIC) is expressed in pancreatic α-cells and involved in glucagon secretion
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    pmc.ncbi.nlm.nih.gov/articles/PMC13415342/
  69. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Temporal Genomic Analysis of Homogeneous Tumor Models Reveals Key Regulators of Immune Evasion in Melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC11873729/
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    PUS7 mRNA pseudouridylation is driven by RNA sequence, structure, and cell-type-specific features
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    sciencedirect.com/science/article/pii/S2666979X26001941
  71. Jul 2026
  72. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Comprehensive mutational characterization of the calcium-sensing STIM1 EF-hand reveals residues essential for structure and function
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    pmc.ncbi.nlm.nih.gov/articles/PMC12505291/
  73. link.springer.com link.springer.com
    cPRC1.2 and CTCF-mediated transition from poised to active chromatin loops at bivalent genes
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    link.springer.com/article/10.1038/s44319-026-00885-3
  74. www.sciencedirect.com www.sciencedirect.com
    SCLC humanized mice identify T cell infiltration phenotypes in response to combination immune-radiation therapies
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    sciencedirect.com/science/article/pii/S258900422602242X
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    The imprinted Peg3 gene is a potent regulator of the DNA methylome in trophoblast cells
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    sciencedirect.com/science/article/pii/S2213671126002328
  76. www.sciencedirect.com www.sciencedirect.com
    Structures of dynamic interactors at native proteasomes by PhIX-MS and cryo-electron microscopy
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    sciencedirect.com/science/article/pii/S1097276526004211
  77. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    L-type voltage-gated Ca2+ channels control T cell killing via non-canonical Hedgehog signalling
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    pmc.ncbi.nlm.nih.gov/articles/PMC13354577/
  78. www.nature.com www.nature.com
    TROP2 targeting reveals therapy-driven cell state dynamics in colorectal cancer
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    nature.com/articles/s41586-026-10705-2
  79. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    PARG regulates the proteasomal degradation of TARG1
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    pmc.ncbi.nlm.nih.gov/articles/PMC13332792/
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    Glycoform engineering of a mammalian platform to sculpt a humanized recombinant bioscavenger
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    sciencedirect.com/science/article/pii/S2405471226001377
  81. Jun 2026
  82. www.sciencedirect.com www.sciencedirect.com
    CRISPR/Cas9-mediated editing of ERCC6 in iPSCs: A disease model for Cockayne Syndrome type B
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    sciencedirect.com/science/article/pii/S1873506126001406
  83. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Patient-specific midbrain organoids with CRISPR correction recapitulate neuronopathic Gaucher disease phenotypes and enable evaluation of novel therapies
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    pmc.ncbi.nlm.nih.gov/articles/PMC13290227/
  84. www.biorxiv.org www.biorxiv.org
    CRISPR-mediated conditional mutagenesis of Smad1/5/8 reveals BMP/GDF signaling restricts postnatal bone overgrowth
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    biorxiv.org/content/10.64898/2026.01.22.701170v1
  85. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    RRAGD p.(Ser76Leu) Variant Causes Dysregulated Expression of Muscle Development and Cytoskeleton Genes in Cardiomyocytes
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    pmc.ncbi.nlm.nih.gov/articles/PMC13285898/
  86. www.biorxiv.org www.biorxiv.org
    Mitochondrial morphology and function are tuned by microtubule association
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    biorxiv.org/content/10.64898/2026.06.13.731791v1
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    Biallelic rescue of CTG18.1 in two Fuchs endothelial corneal dystrophy–derived iPSC lines (SCTCi047-A-2, SCTCi046-A-2) following a two-step gene editing strategy
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    sciencedirect.com/science/article/pii/S1873506126001285
  88. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Enhancing Immunotherapeutic Response in Colorectal Cancer with a Neuropilin-1-Targeting Tumor-Penetrating Peptide
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    pmc.ncbi.nlm.nih.gov/articles/PMC13250810/
  89. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Aberrant methylation limits antitumoral inflammation in lung adenocarcinoma by restricting RIPK3 expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC13249207/
  90. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Baicalin alleviates mastitis in dairy cows by targeting IL-17RA to inhibit IL-17 signaling pathway activation
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    pmc.ncbi.nlm.nih.gov/articles/PMC13085363/
  91. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Compact Cas12f enables genome editing in avian cells
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  120. Apr 2026
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  152. Jan 2026
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  165. Dec 2025
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  172. Nov 2025
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    Validating TDP1 as an Inhibition Target for Lipophilic Nucleoside Derivative in Human Cells
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    A porcine model of Fanconi anemia
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    LUBAC modulates CBM complex functions downstream of TRAF6 in T cells
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    Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions
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  190. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The mitochondrial disulphide relay substrate FAM136A safeguards IMS proteostasis and cellular fitness
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  191. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Generating a Cell Model to Study ER Stress in iPSC-Derived Medium Spiny Neurons from a Patient with Huntington’s Disease
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  193. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    CD46 is a cellular receptor for species D human adenovirus
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    Enhancing macrophage phagocytosis of cancers by disrupting the SIRPα/CD47 signaling axis and targeting MUC1 antigen
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    SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism
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  196. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Disrupted transcriptional networks regulated by CHD1L during neurodevelopment underlie the mirrored neuroanatomical and growth phenotypes of the 1q21.1 copy number variant
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    Highly stable Cas9 promotes HBV genome destruction by antagonizing HSC70-mediated degradation
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    CETN3 deficiency induces microcephaly by disrupting neural stem/progenitor cell fate through impaired centrosome assembly and RNA splicing
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    The actin nucleation promoting factor WASH facilitates clathrin-independent endocytosis of human papillomaviruses
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    DNA2 enables growth by restricting recombination-restarted replication
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    RNA-binding proteins mediate the maturation of chromatin topology during differentiation
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    Temporal control of human DNA replication licensing by CDK4/6-RB signalling and chemical genetics
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    Genetic Engineering of Humanized Telomere Mice
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    EPOP and MTF2 Activate PRC2 Activity through DNA-sequence specificity
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