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IL-18-primed NK cells recruit dendritic cells and potentiate tumor therapy mediated by PD-1 blockade

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1. scibot 02 Apr 2025
  
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  Addgene_48138
  
  DOI: 10.3389/fonc.2025.1533808
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11955453/
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  DOI: 10.1158/2159-8290.cd-24-0807
  
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52.53.155.43/8b47ace97c08a1e30a2c5a11ea44bb6b3019e6b6/PDF-html.html
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The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2

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1. scibot 29 Mar 2025
  
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  AddgeneCat#48138
  
  DOI: 10.1016/j.immuni.2025.02.026
  
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sciencedirect.com/science/article/pii/S1074761325000937
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Single-cut gene therapy in a one-step generated rhesus monkey model of Duchenne muscular dystrophy

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1. scibot 29 Mar 2025
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.xcrm.2025.102037
  
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sciencedirect.com/science/article/pii/S2666379125001107
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Lineage contribution of the mesendoderm progenitors in the gastrulating mouse embryo

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1. scibot 29 Mar 2025
  
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  Plasmid_48138
  
  DOI: 10.1016/j.devcel.2025.02.015
  
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sciencedirect.com/science/article/pii/S1534580725001200
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Transgenic iPSC Lines with Genetically Encoded MitoTimer to Study Mitochondrial Biogenesis in Dopaminergic Neurons with Tauopathy

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1. scibot 28 Mar 2025
  
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  RRID:Addgene_48138
  
  DOI: 10.3390/biomedicines13030550
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11940372/
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Translation dysregulation in cancer as a source for targetable antigens

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1. scibot 28 Mar 2025
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.ccell.2025.03.003
  
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sciencedirect.com/science/article/pii/S1535610825000820
Mar 2025
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LncPrep + 96kb inhibits ovarian fibrosis by upregulating prolyl oligopeptidase expression

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1. scibot 23 Mar 2025
  
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  48138
  
  DOI: 10.3892/mmr.2025.13478
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11894593/
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Podocyte A20/TNFAIP3 Controls Glomerulonephritis Severity via the Regulation of Inflammatory Responses and Effects on the Cytoskeleton

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1. scibot 23 Mar 2025
  
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  PX458
  
  DOI: 10.3390/cells14050381
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11898495/
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Human oncostatin M deficiency underlies an inherited severe bone marrow failure syndrome

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1. scibot 23 Mar 2025
  
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  48138
  
  DOI: 10.1172/JCI180981
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11910226/
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Transfer RNA acetylation regulates in vivo mammalian stress signaling

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1. scibot 23 Mar 2025
  
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  48138
  
  DOI: 10.1126/sciadv.ads2923
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11922055/
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1. scibot 23 Mar 2025
  
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  Addgene 48138
  
  DOI: 10.1101/2025.03.19.643339
  
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52.53.155.43/62d1ab468ae2105585e292a77643013ab01db943/PDF-html.html
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Tubulin Regulates the Stability and Localization of STMN2 by Binding Preferentially to Its Soluble Form

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1. scibot 23 Mar 2025
  
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  48138
  
  DOI: 10.1101/2025.02.27.640326
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11888388/
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Structural mechanisms for centrosomal recruitment and organization of the microtubule nucleator γ-TuRC

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1. scibot 23 Mar 2025
  
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  48138
  
  DOI: 10.1038/s41467-025-57729-2
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11903878/
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CAMKIIδ Reinforces Lipid Metabolism and Promotes the Development of B Cell Lymphoma

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1. scibot 23 Mar 2025
  
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  pX458
  
  DOI: 10.1002/advs.202409513
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11905072/
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CXCR4 Inhibition Enhances the Efficacy of CD19 Monoclonal Antibody-Mediated Extermination of B-Cell Lymphoma

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1. scibot 23 Mar 2025
  
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  Addgene_48138
  
  DOI: 10.3390/ijms26052024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11899823/
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biGMamAct: efficient CRISPR/Cas9-mediated docking of large functional DNA cargoes at the ACTB locus

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1. scibot 23 Mar 2025
  
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  Addgene_48138
  
  DOI: 10.1093/synbio/ysaf003
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11891445/
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Immediate early splicing controls translation in activated T-cells and is mediated by hnRNPC2 phosphorylation

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1. scibot 23 Mar 2025
  
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  Addgene_48138
  
  DOI: 10.1038/s44318-025-00374-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11914300/
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Identifying cross-lineage dependencies of cell-type-specific regulators in mouse gastruloids

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1. scibot 20 Mar 2025
  
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  AddgeneCat #48138
  
  DOI: 10.1016/j.devcel.2025.02.013
  
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sciencedirect.com/science/article/pii/S1534580725001182
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MyoD1 localization at the nuclear periphery is mediated by association of WFS1 with active enhancers

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1. scibot 20 Mar 2025
  
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  plasmid_48138
  
  DOI: 10.1038/s41467-025-57758-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11914251/
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Alternate isoforms of IRF7 Differentially Regulate Interferon Expression to Tune Response to Viral Infection

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1. scibot 14 Mar 2025
  
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  Addgene, 48138
  
  DOI: 10.1101/2025.03.10.642367
  
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biorxiv.org/content/10.1101/2025.03.10.642367v1
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Lipoylation inhibition enhances radiation control of lung cancer by suppressing homologous recombination DNA damage repair

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1. scibot 14 Mar 2025
  
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  plasmid_48138
  
  DOI: 10.1126/sciadv.adt1241
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11900879/
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LETM-domain containing 1 (LETMD1) protects against obesity via enhancing UCP1-independent energy expenditure in human beige adipocytes

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1. scibot 11 Mar 2025
  
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  PX458
  
  DOI: 10.7150/thno.104568
  
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  RRID:Addgene_48138 DOI:10.7150/thno.104568
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pmc.ncbi.nlm.nih.gov/articles/PMC11780525/
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Generation of a Double Reporter mES Cell Line to Simultaneously Trace the Generation of Retinal Progenitors and Photoreceptors

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1. scibot 11 Mar 2025
  
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  PX458
  
  DOI: 10.3390/cells14040252
  
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  RRID:Addgene_48138 DOI:10.3390/cells14040252
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pmc.ncbi.nlm.nih.gov/articles/PMC11854395/
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Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination

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1. scibot 11 Mar 2025
  
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  48138
  
  DOI: 10.3390/biom15010150
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11763143/
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A clinical drug candidate that triggers non-apoptotic cancer cell death

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1. scibot 11 Mar 2025
  
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  48138
  
  DOI: 10.21203/rs.3.rs-4138879/v1
  
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  RRID:Addgene_48138 DOI:10.21203/rs.3.rs-4138879/v1
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pmc.ncbi.nlm.nih.gov/articles/PMC11844650/
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mGBP2 engages Galectin-9 for immunity against Toxoplasma gondii

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1. scibot 11 Mar 2025
  
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  PX458
  
  DOI: 10.1371/journal.pone.0316209
  
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  RRID:Addgene_48138 DOI:10.1371/journal.pone.0316209
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pmc.ncbi.nlm.nih.gov/articles/PMC11761162/
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Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain

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  48138
  
  DOI: 10.1101/gad.352235.124
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11874980/
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Diverse mechanisms of DDX3Y suppression by DDX3X

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1. scibot 11 Mar 2025
  
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  48138
  
  DOI: 10.1101/2025.02.08.637260
  
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  RRID:Addgene_48138 DOI:10.1101/2025.02.08.637260
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pmc.ncbi.nlm.nih.gov/articles/PMC11839027/
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Comprehensive mutational characterization of the calcium-sensing STIM1 EF-hand reveals residues essential for structure and function

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1. scibot 11 Mar 2025
  
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  48138
  
  DOI: 10.1101/2025.01.23.634525
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11785200/
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Argonaute2 modulates megakaryocyte development and sex-specific control of platelet protein expression and reactivity

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1. scibot 11 Mar 2025
  
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  48138
  
  DOI: 10.1038/s41598-025-88106-0
  
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  RRID:Addgene_48138 DOI:10.1038/s41598-025-88106-0
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pmc.ncbi.nlm.nih.gov/articles/PMC11775343/
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Interplay between CTCF-binding and CTCF-lacking regulatory elements in generating an architectural stripe at the Igh locus

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1. scibot 11 Mar 2025
  
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  48138
  
  DOI: 10.1038/s41467-025-57373-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11876664/
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PBRM1 directs PBAF to pericentromeres and protects centromere integrity

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1. scibot 11 Mar 2025
  
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  48138
  
  DOI: 10.1038/s41467-025-57277-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11865495/
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Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe2+ through TRPML1 channel

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  48138
  
  DOI: 10.1038/s41467-025-56403-x
  
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  RRID:Addgene_48138 DOI:10.1038/s41467-025-56403-x
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pmc.ncbi.nlm.nih.gov/articles/PMC11760952/
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Nonenzymatic lysine d-lactylation induced by glyoxalase II substrate SLG dampens inflammatory immune responses

1
1. scibot 11 Mar 2025
  
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  48138
  
  DOI: 10.1038/s41422-024-01060-w
  
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  RRID:Addgene_48138 DOI:10.1038/s41422-024-01060-w
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pmc.ncbi.nlm.nih.gov/articles/PMC11770101/
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Effect of Notch1 signaling on muscle engraftment and maturation from pluripotent stem cells

1
1. scibot 11 Mar 2025
  
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  48138
  
  DOI: 10.1016/j.stemcr.2024.102396
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11864150/
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EPAS1 induction drives myocardial degeneration in desmoplakin-cardiomyopathy

1
1. scibot 11 Mar 2025
  
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  pSpCas9(BB)-2A-GFP
  
  DOI: 10.1016/j.isci.2025.111895
  
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Caspase 3 and caspase 7 promote cytoprotective autophagy and the DNA damage response during non-lethal stress conditions in human breast cancer cells

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A novel KEAP1 inhibitor, tiliroside, activates NRF2 to protect against acetaminophen-induced oxidative stress and acute liver injury

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Proximity proteomics reveals a mechanism of fatty acid transfer at lipid droplet-mitochondria- endoplasmic reticulum contact sites

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Pancreatic alpha and beta cell fate choice is directed by apical-basal polarity dynamics

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Bi-allelic KICS2 mutations impair KICSTOR complex-mediated mTORC1 regulation, causing intellectual disability and epilepsy

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RNF10 and RIOK3 facilitate 40S ribosomal subunit degradation upon 60S biogenesis disruption or amino acid starvation

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Targeting TUBG1 in RB1-negative tumors

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Inflammatory cytokines mediate the induction of and awakening from metastatic dormancy

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Long-range enhancer-controlled genes are hypersensitive to regulatory factor perturbations

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BACE1-dependent cleavage of GABAA receptor contributes to neural hyperexcitability and disease progression in Alzheimer’s disease

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Endogenous production of nitric oxide by iNOS in human cells restricts inflammatory activation and cholesterol/fatty acid biosynthesis

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RIPK1 is required for ZBP1-driven necroptosis in human cells

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Direct ionic stress sensing and mitigation by the transcription factor NFAT5

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Examining the NEUROG2 lineage and associated gene expression in human cortical organoids

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Construction of a TAT-Cas9-EGFP Site-Specific Integration Eukaryotic Cell Line Using Efficient PEG10 Modification

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NEAT1-mediated regulation of proteostasis and mRNA localization impacts autophagy dysregulation in Rett syndrome

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Development of cell lines with increased susceptibility to diverse adeno-associated viral vectors to enable in vitro potency assays

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The homologous recombination factors BRCA2 and PALB2 interplay with mismatch repair pathways to maintain centromere stability and cell viability

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The α-globin super-enhancer acts in an orientation-dependent manner

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Pol II degradation activates cell death independently from the loss of transcription

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Development of compounds for targeted degradation of mammalian cryptochrome proteins

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Tissue-specific modulation of CRISPR activity by miRNA-sensing guide RNAs

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Shared rare genetic variants in multiplex autism families suggest a social memory gene under selection

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Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models

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Generation of live mice from haploid ESCs with germline-DMR deletions or switch

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Identification of KRT16 and ANXA10 as cell cycle regulation genes for lung adenocarcinoma based on self-transcriptome sequencing of surgical samples and TCGA public data mining

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Structural basis of phosphate export by human XPR1

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Single-cell RNA sequencing identifies CXADR as a fate determinant of the placental exchange surface

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Proximity‐dependent biotinylation reveals an interaction between ubiquitin‐specific peptidase 46 and centrosome‐related proteins

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pmc.ncbi.nlm.nih.gov/articles/PMC11705415/
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NRBP1 and TSC22D proteins impact distal convoluted tubule physiology through modulation of the WNK pathway

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Structural basis for a nucleoporin exportin complex between RanBP2, SUMO1-RanGAP1, the E2 Ubc9, Crm1 and the Ran GTPase

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Elevated Ubiquitin Phosphorylation by PINK1 Contributes to Proteasomal Impairment and Promotes Neurodegeneration

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SLC7A5 is required for cancer cell growth under arginine-limited conditions

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The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A

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LDB1 establishes multi-enhancer networks to regulate gene expression

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Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains

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ErbB4 precludes the occurrence of PTSD-like fear responses by supporting the bimodal activity of the central amygdala

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  plasmid_48138
  
  DOI: 10.1038/s12276-024-01365-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11671592/
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Single-cell analysis of bidirectional reprogramming between early embryonic states identify mechanisms of differential lineage plasticities in mice

1
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.devcel.2024.11.022
  
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cell.com/developmental-cell/fulltext/S1534-5807(24)00722-6
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Leveraging Dual-Ligase Recruitment to Enhance Protein Degradation via a Heterotrivalent Proteolysis Targeting Chimera

1
1. scibot 28 Dec 2024
  
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  48138
  
  DOI: 10.1021/jacs.4c11556
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11638965/
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Recapitulating the adenoma–carcinoma sequence by selection of four spontaneous oncogenic mutations in mismatch-repair-deficient human colon organoids

1
1. scibot 27 Dec 2024
  
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  48138
  
  DOI: 10.1038/s43018-024-00841-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11663794/
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Lysine l-lactylation is the dominant lactylation isomer induced by glycolysis

1
1. scibot 27 Dec 2024
  
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  48138
  
  DOI: 10.1038/s41589-024-01680-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11666458/
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Hepatitis B Virus-KMT2B Integration Drives Hepatic Oncogenic Processes in a Human Gene-edited Induced Pluripotent Stem Cells-derived Model

1
1. scibot 27 Dec 2024
  
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  pSp-Cas9(BB)-2A-GFP(PX458)
  
  DOI: 10.1016/j.jcmgh.2024.101422
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11664014/
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Inhibiting intracellular CD28 in cancer cells enhances antitumor immunity and overcomes anti-PD-1 resistance via targeting PD-L1

1
1. scibot 24 Dec 2024
  
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  AddgeneCat# 48138
  
  DOI: 10.1016/j.ccell.2024.11.008
  
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A family of NADPH/NADP+ biosensors reveals in vivo dynamics of central redox metabolism across eukaryotes

1
1. scibot 24 Dec 2024
  
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  plasmid_48138
  
  DOI: 10.1038/s41467-024-55302-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11659435/
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Forced Overexpression and Knockout Analysis of SLC30A and SLC39A Family Genes Suggests Their Involvement in Establishing Resistance to Cisplatin in Human Cancer Cells

1
1. scibot 22 Dec 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.3390/ijms252212049
  
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PRC1 and CTCF-Mediated Transition from Poised to Active Chromatin Loops Drives Bivalent Gene Activation

1
1. scibot 21 Dec 2024
  
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  Plasmid_48138
  
  DOI: 10.1101/2024.11.13.623456
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11601310/
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Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors

1
1. scibot 17 Dec 2024
  
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  Addgene_48138
  
  DOI: 10.1016/j.devcel.2017.02.006
  
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pmc.ncbi.nlm.nih.gov/articles/PMC5517315/
www.tandfonline.com www.tandfonline.com

A TRAILR2/CDH3 bispecific antibody demonstrates selective apoptosis and tumor regression in CDH3-positive pancreatic cancer

1
1. scibot 13 Dec 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1080/19420862.2024.2438173
  
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tandfonline.com/doi/full/10.1080/19420862.2024.2438173
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Structure and mechanism of the RalGAP tumor suppressor complex

1
1. scibot 06 Dec 2024
  
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  Addgene plasmids # 48138
  
  DOI: 10.1101/2024.11.25.625123
  
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52.53.155.43 52.53.155.43

Endoplasmic reticulum morphology regulation by RTN4 modulates neuronal regeneration by curbing luminal transport

3
1. scibot 06 Dec 2024
  
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  Addgene #48138
  
  DOI: 10.1016/j.celrep.2024.114357
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.celrep.2024.114357
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.celrep.2024.114357
  
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52.53.155.43/a5cd2a76f55670a4ac26cd7a0c2f7cbc81f1256c/Endoplasmic reticulum morphology regulation by RTN4 modulates neu-html.html
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Alternative splicing is an FXRα loss-of-function mechanism and impacts energy metabolism in hepatocarcinoma cells

1
1. scibot 02 Dec 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.jbc.2024.108022
  
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sciencedirect.com/science/article/pii/S0021925824025249
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Self-organized pattern formation in the developing mouse neural tube by a temporal relay of BMP signaling

1
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  Addgene_48138
  
  DOI: 10.1016/j.devcel.2024.10.024
  
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sciencedirect.com/science/article/pii/S1534580724006646
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Development of MAPT S305 mutation human iPSC lines exhibiting elevated 4R tau expression and functional alterations in neurons and astrocytes

1
1. scibot 02 Dec 2024
  
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  Addgene_48138
  
  DOI: 10.1016/j.celrep.2024.115013
  
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sciencedirect.com/science/article/pii/S2211124724013640
Nov 2024
pubs.acs.org pubs.acs.org

Streamlined Generation of CRISPR/Cas9-Mediated Single-Cell Knockout Clones in Murine Cell Lines

2
1. scibot 29 Nov 2024
  
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  RRID: Addgene_48138
  
  DOI: 10.1021/acsptsci.3c00338
  
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  RRID:Addgene_48138
  
  DOI: 10.1021/acsptsci.3c00338
  
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pubs.acs.org/doi/10.1021/acsptsci.3c00338
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STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair

1
1. scibot 21 Nov 2024
  
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  Addgene_48138
  
  DOI: 10.1016/j.cell.2024.10.018
  
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sciencedirect.com/science/article/pii/S0092867424012005
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Recognition of BACH1 quaternary structure degrons by two F-box proteins under oxidative stress

1
1. scibot 16 Nov 2024
  
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  Plasmid_48138
  
  DOI: 10.1016/j.cell.2024.10.012
  
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sciencedirect.com/science/article/pii/S0092867424011887
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma

1
1. scibot 08 Nov 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1158/0008-5472.CAN-24-0134
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532787/
www.biorxiv.org www.biorxiv.org

Cancer-cell-derived cGAMP limits the activity of tumor-associated CD8+ T cells

1
1. scibot 07 Nov 2024
  
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  Addgene_48138
  
  DOI: 10.1101/2024.10.28.620471
  
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biorxiv.org/content/10.1101/2024.10.28.620471v1
Oct 2024
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VPS13B is localized at the interface between Golgi cisternae and is a functional partner of FAM177A1

1
1. scibot 08 Oct 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1083/jcb.202311189
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11451052/
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P16INK4A drives RB1 degradation by UTP14A-catalyzed K810 ubiquitination

1
1. scibot 05 Oct 2024
  
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  Plasmid_48138
  
  DOI: 10.1016/j.isci.2024.110882
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11440251/
onlinelibrary.wiley.com onlinelibrary.wiley.com

Constitutive Androstane Receptor Regulates Germ Cell Homeostasis, Sperm Quality, and Male Fertility via Akt-Foxo1 Pathway

1
1. scibot 03 Oct 2024
  
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  (Addgene Plasmid #48 138)
  
  DOI: 10.1002/advs.202402082
  
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onlinelibrary.wiley.com/doi/full/10.1002/advs.202402082
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TMX1, a disulfide oxidoreductase, is necessary for T cell function through regulation of CD3ζ

1
1. scibot 03 Oct 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1101/2024.09.22.614388
  
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biorxiv.org/content/10.1101/2024.09.22.614388v1
www.nature.com www.nature.com

QSOX2 Deficiency-induced short stature, gastrointestinal dysmotility and immune dysfunction

1
1. scibot 01 Oct 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1038/s41467-024-52587-w
  
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nature.com/articles/s41467-024-52587-w
Sep 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Splice variants of CK1α and CK1α-like: Comparative analysis of subcellular localization, kinase activity, and function in the Wnt signaling pathway

1
1. scibot 29 Sep 2024
  
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  48138
  
  DOI: 10.1016/j.jbc.2024.107407
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11255964/
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Core fucosylation within the Fc-FcγR degradation pathway promotes enhanced IgG levels via exogenous L-fucose

1
1. scibot 29 Sep 2024
  
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  48138
  
  DOI: 10.1016/j.jbc.2024.107558
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11345378/
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Genetically engineered human embryonic kidney cells as a novel vehicle for dual patch clamp study of human gap junction channels

1
1. scibot 29 Sep 2024
  
  in Public
  
  pSpCas9(BB)-2A-GFP plasmid (PX458
  
  DOI: 10.1042/BCJ20240016
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11346430/
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Drp1 depletion protects against ferroptotic cell death by preserving mitochondrial integrity and redox homeostasis

1
1. scibot 29 Sep 2024
  
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  pSpCas9(BB)-2A-GFP
  
  DOI: 10.1038/s41419-024-07015-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11350090/
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Tumor-induced natural killer cell dysfunction is a rapid and reversible process uncoupled from the expression of immune checkpoints

1
1. scibot 29 Sep 2024
  
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  pX458
  
  DOI: 10.1126/sciadv.adn0164
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11352832/
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CD47 and IFT57 Are Colinear Genes That Are Highly Coexpressed in Most Cancers and Exhibit Parallel Cancer-Specific Correlations with Survival

1
1. scibot 29 Sep 2024
  
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  pSpCas9(BB)-2A-GFP
  
  DOI: 10.3390/ijms25168956
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11354933/
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CRISPR-based dissection of microRNA-23a ~ 27a ~ 24-2 cluster functionality in hepatocellular carcinoma

1
1. scibot 29 Sep 2024
  
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  pSpCas9(BB)-2A-GFP (PX458
  
  DOI: 10.1038/s41388-024-03115-z
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11364504/
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Tumor-repopulating cells evade ferroptosis via PCK2-dependent phospholipid remodeling

1
1. scibot 29 Sep 2024
  
  in Public
  
  PX458
  
  DOI: 10.1038/s41589-024-01612-6
  
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ANT-Mediated Inhibition of the Permeability Transition Pore Alleviates Palmitate-Induced Mitochondrial Dysfunction and Lipotoxicity

1
1. scibot 29 Sep 2024
  
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  48138
  
  DOI: 10.3390/biom14091159
  
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A user-friendly CRISPR/Cas9 system for mutagenesis of Neurospora crassa

1
1. scibot 29 Sep 2024
  
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  pSPCas9(BB)-2A-GFP
  
  DOI: 10.1038/s41598-024-71540-x
  
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A flexible loop in the paxillin LIM3 domain mediates its direct binding to integrin β subunits

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  48138
  
  DOI: 10.1371/journal.pbio.3002757
  
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A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors

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  48138
  
  DOI: 10.1038/s41467-024-51991-6
  
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PUMA/RIP3 mediates chemotherapy response via necroptosis and local immune activation in colorectal cancer

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  48138
  
  DOI: 10.1158/1535-7163.MCT-23-0162
  
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A Novel Rapid Host Cell Entry Pathway Determines Intracellular Fate of Staphylococcus aureus

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  plasmid_48138
  
  DOI: 10.1101/2024.09.13.612871
  
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Dynamic remodeling of Septin structures fine-tunes myogenic differentiation

2
1. scibot 28 Sep 2024
  
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  48138
  
  DOI: 10.1016/j.isci.2024.110630
  
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Molecular and cellular context influences SCN8A variant function

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  DOI: 10.1172/jci.insight.177530
  
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T4 DNA polymerase prevents deleterious on-target DNA damage and enhances precise CRISPR editing

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  plasmid_48138
  
  DOI: 10.1038/s44318-024-00158-6
  
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Hominini-specific regulation of the cell cycle by stop codon readthrough of FEM1B

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  Addgene_48138
  
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WIPI2b recruitment to phagophores and ATG16L1 binding are regulated by ULK1 phosphorylation

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  48138
  
  DOI: 10.1038/s44319-024-00215-5
  
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ISGylation enhances dsRNA-induced interferon response and NFκB signaling in fallopian tube epithelial cells

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  48138
  
  DOI: 10.1016/j.jbc.2024.107686
  
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Engineering Oncogenic Hotspot Mutations on SF3B1 via CRISPR-Directed PRECIS Mutagenesis

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  48138
  
  DOI: 10.1158/2767-9764.CRC-24-0145
  
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Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor

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  Addgene
  
  DOI: 10.1038/s41380-024-02479-8
  
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Correction of exon 2, exon 2–9 and exons 8–9 duplications in DMD patient myogenic cells by a single CRISPR/Cas9 system

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  plasmid_48138
  
  DOI: 10.1038/s41598-024-70075-5
  
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The enhancer RNA, AANCR, regulates APOE expression in astrocytes and microglia

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  plasmid_48138
  
  DOI: 10.1093/nar/gkae696
  
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PROTAC‐Mediated HDAC7 Protein Degradation Unveils Its Deacetylase‐Independent Proinflammatory Function in Macrophages

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  plasmid_48138
  
  DOI: 10.1002/advs.202309459
  
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Reconstitution of BNIP3/NIX-mediated autophagy reveals two pathways and hierarchical flexibility of the initiation machinery

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  RRID:Addgene_48138
  
  DOI: 10.1101/2024.08.28.609967
  
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Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia

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  pX458
  
  DOI: 10.1038/s41417-024-00785-5
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11405269/
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CRISPR-Cas guide RNA indel analysis using CRISPResso2 with Nanopore sequencing data

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  plasmid_48
  
  DOI: 10.1186/s13104-024-06861-1
  
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Mesenchymal Stromal Cells Increase the Natural Killer Resistance of Circulating Tumor Cells via Intercellular Signaling of cGAS‐STING‐IFNβ‐HLA

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  plasmid_48
  
  DOI: 10.1002/advs.202400888
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11151078/
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Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2

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  Addgene: 48138
  
  DOI: 10.1136/gutjnl-2023-331519
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11347226/
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MOF-mediated PRDX1 acetylation regulates inflammatory macrophage activation

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  Addgene; Cat# 48138
  
  DOI: 10.1016/j.celrep.2024.114682
  
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sciencedirect.com/science/article/pii/S2211124724010337
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Disruption of nuclear speckle integrity dysregulates RNA splicing in C9ORF72-FTD/ALS

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  Addgene_48138
  
  DOI: 10.1016/j.neuron.2024.07.025
  
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sciencedirect.com/science/article/pii/S0896627324005701
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Impact of protein and small molecule interactions on kinase conformations

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1. scibot 26 Aug 2024
  
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  DOI: 10.7554/eLife.94755
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11293870/
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Functional evaluation of novel variants of B4GALNT1 in a patient with hereditary spastic paraplegia and the general population

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  pSpCas9(BB)-2A-GFP
  
  DOI: 10.3389/fnins.2024.1437668
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11322347/
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LUZP1 regulates the maturation of contractile actomyosin bundles

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  48,138
  
  DOI: 10.1007/s00018-024-05294-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11335285/
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Crucial role of the NSE1 RING domain in Smc5/6 stability and FANCM-independent fork progression

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  48,138
  
  DOI: 10.1007/s00018-024-05275-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11335289/
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Allele-specific CRISPR-Cas9 editing inactivates a single nucleotide variant associated with collagen VI muscular dystrophy

1
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  48138
  
  DOI: 10.1016/j.omtn.2024.102269
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11338111/
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Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway

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  48138
  
  DOI: 10.1038/s41467-024-50971-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11339278/
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Lipid Nanoparticle‐Mediated Delivery of CRISPR‐Cas9 Against Rubicon Ameliorates NAFLD by Modulating CD36 Along with Glycerophospholipid Metabolism

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  PX458
  
  DOI: 10.1002/advs.202400493
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11336963/
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Glycogen myophosphorylase loss causes increased dependence on glucose in iPSC-derived retinal pigment epithelium

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  48138
  
  DOI: 10.1016/j.jbc.2024.107569
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11342771/
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RNA variant assessment using transactivation and transdifferentiation

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  48138
  
  DOI: 10.1016/j.ajhg.2024.06.018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11339655/
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The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate

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  Addgene_48138
  
  DOI: 10.1101/2024.07.08.602542
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11257442/
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Stem cell-derived cardiomyocytes expressing a dominant negative pacemaker HCN4 channel do not reduce the risk of graft-related arrhythmias

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  plasmid_48138
  
  DOI: 10.3389/fcvm.2024.1374881
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11263024/
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TFEB activation hallmarks antigenic experience of B lymphocytes and directs germinal center fate decisions

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  Addgene_48138
  
  DOI: 10.1038/s41467-024-51166-3
  
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The plasma membrane inner leaflet PI(4,5)P2 is essential for the activation of proton-activated chloride channels

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The zonula adherens matura redefines the apical junction of intestinal epithelia

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Clinical and functional studies of MTOR variants in Smith-Kingsmore syndrome reveal deficits of circadian rhythm and sleep-wake behavior

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HiPSC-derived 3D neural models reveal neurodevelopmental pathomechanisms of the Cockayne Syndrome B

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Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries

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Vps13D encodes a ubiquitin binding protein that is required for the regulation of mitochondrial size and clearance

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A comprehensive study evaluating germline FANCG variants in predisposition to breast and ovarian cancer

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RAF inhibitors activate the integrated stress response by direct activation of GCN2

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A structural peculiarity of Antarctic fish IgM drives the generation of an engineered mAb by CRISPR/Cas9

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Developmental control of rod number via a light-dependent retrograde pathway from intrinsically photosensitive retinal ganglion cells

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ABIN1 is a negative regulator of effector functions in cytotoxic T cells

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Generation of a ZEB2 deficient human iPSC line (KICRi002A-4)

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Deciphering the genetics and mechanisms of predisposition to multiple myeloma

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The role of MNK1-mTORC1 pathway in modulating macrophage responses to Vibrio vulnificus infection

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  PX458
  
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Genetic Screening of Haploid Neural Stem Cells Reveals that Nfkbia and Atp2b4 are Key Regulators of Oxidative Stress in Neural Precursors

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Histone-methyltransferase KMT2D deficiency impairs the Fanconi anemia/BRCA pathway upon glycolytic inhibition in squamous cell carcinoma

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CNTN4 modulates neural elongation through interplay with APP

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  RRID:Addgene_48138
  
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A mechanistic study on the tolerance of PAM distal end mismatch by SpCas9

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Harnessing DNA replication stress to target RBM10 deficiency in lung adenocarcinoma

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HDAC4 influences the DNA damage response and counteracts senescence by assembling with HDAC1/HDAC2 to control H2BK120 acetylation and homology-directed repair

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The relationship between nanoscale genome organization and gene expression in mouse embryonic stem cells during pluripotency transition

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Ion channel TRPV2 is critical in enhancing B cell activation and function

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  pSpCas9-2a-GFP
  
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Atypical KCNQ1/Kv7 channel function in a neonatal diabetes patient: Hypersecretion preceded the failure of pancreatic β-cells

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Targeted genome editing restores auditory function in adult mice with progressive hearing loss caused by a human microRNA mutation

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Structure of the human 20S U5 snRNP

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2024.04.26.591029v1.full-html.html

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Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses

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Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use

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CRISPR/Cas9-mediated LRP10 Knockout in HuTu-80 and HEK 293T Cell Lines

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  DOI: 10.21769\u002FBioProtoc.4521
  
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Highlights from MBoC Selection: STMND1 is a phylogenetically ancient stathmin which localizes to motile cilia and exhibits nuclear translocation that is inhibited when soluble tubulin concentration increases

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Substrate O‐glycosylation actively regulates extracellular proteolysis

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Phosphatidylserine regulates plasma membrane repair through tetraspanin-enriched macrodomains

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VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

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Isogenic patient-derived organoids reveal early neurodevelopmental defects in spinal muscular atrophy initiation

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A hominoid-specific signaling axis regulating the tempo of synaptic maturation

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The SASP factor IL-6 sustains cell-autonomous senescent cells via a cGAS-STING-NFκB intracrine senescent noncanonical pathway

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Netrin signaling mediates survival of dormant epithelial ovarian cancer cells

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An IDR-dependent mechanism for nuclear receptor control of Mediator interaction with RNA polymerase II

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  DOI: 10.1016/j.molcel.2024.06.006
  
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sciencedirect.com/science/article/pii/S1097276524004842
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Activation of Hippo Pathway Damages Slit Diaphragm by Deprivation of Ajuba Proteins

1
1. scibot 16 Jul 2024
  
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  plasmid_48138
  
  DOI: 10.1681/ASN.0000000000000107
  
  Resource: RRID:Addgene_48138
  
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52.53.155.43 52.53.155.43

Endoplasmic reticulum morphology regulation by RTN4 modulates neuronal regeneration by curbing luminal transport

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1. scibot 16 Jul 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.celrep.2024.114357
  
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52.53.155.43/a5cd2a76f55670a4ac26cd7a0c2f7cbc81f1256c/Endoplasmic reticulum morphology regulation by RTN4 modulates neu-html.html
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ROCK inhibitors upregulate the neuroprotective Parkin-mediated mitophagy pathway

2
1. scibot 13 Jul 2024
  
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  plasmid_48138
  
  DOI: 10.1038/s41467-019-13781-3
  
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2. scibot 13 Jul 2024
  
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  plasmid_48138
  
  DOI: 10.1038/s41467-019-13781-3
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6941965/
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A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence

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1. scibot 11 Jul 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1016/j.cell.2024.06.019
  
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cell.com/cell/fulltext/S0092-8674(24)00693-7
Jun 2024
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The long non-coding RNA Meg3 mediates imprinted gene expression during stem cell differentiation

1
1. scibot 30 Jun 2024
  
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  DOI: 10.1093/nar/gkae247
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11194098/
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Susceptibility to innate immune activation in genetically mediated myocarditis

1
1. scibot 30 Jun 2024
  
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  48138
  
  DOI: 10.1172/JCI180254
  
  Resource: RRID:Addgene_48138
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11213508/
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Reduced Protein Import via TIM23 SORT Drives Disease Pathology in TIMM50-Associated Mitochondrial Disease

1
1. scibot 30 Jun 2024
  
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  Addgene_48138
  
  DOI: 10.1080/10985549.2024.2353652
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11204040/
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Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD

1
1. scibot 28 Jun 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1038/s41594-024-01338-y
  
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nature.com/articles/s41594-024-01338-y
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Reduced surface pH and upregulated AE2 anion exchange in SLC26A3-deleted polarized intestinal epithelial cells

1
1. scibot 25 Jun 2024
  
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  48138
  
  DOI: 10.1152/ajpcell.00590.2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11193482/
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Fully automated viability and toxicity screening—A reliable all‐in‐one attempt

1
1. scibot 25 Jun 2024
  
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  plasmid_48138
  
  DOI: 10.1002/cam4.7392
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11193055/
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Preclinical evidence for the use of anti‐Trop‐2 antibody‐drug conjugate Sacituzumab govitecan in cerebral metastasized castration‐resistant prostate cancer

1
1. scibot 22 Jun 2024
  
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  RRID:Addgene_48138
  
  DOI: 10.1002/cam4.7320
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11185941/
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Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking

1
1. scibot 21 Jun 2024
  
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  48138
  
  DOI: 10.1101/2024.05.06.592780
  
  Resource: RRID:Addgene_48138
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11100758/

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