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  1. Jan 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Investigation of the functional impact of CHED- and FECD4-associated SLC4A11 mutations in human corneal endothelial cells
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    1. scibot 30 Jan 2024
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      DOI: 10.1371/journal.pone.0296928

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    ncbi.nlm.nih.gov/pmc/articles/PMC10802951/
  3. www.sciencedirect.com www.sciencedirect.com
    Intramembrane protease SPP defines a cholesterol-regulated abundance control of the mevalonate pathway enzyme squalene synthase
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    1. scibot 12 Jan 2024
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    sciencedirect.com/science/article/pii/S0021925824000206
  4. www.sciencedirect.com www.sciencedirect.com
    Direct observation of a condensate effect on super-enhancer controlled gene bursting
    1
    1. scibot 09 Jan 2024
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      DOI: 10.1016/j.cell.2023.12.005

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    sciencedirect.com/science/article/pii/S0092867423013375
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope
    1
    1. scibot 05 Jan 2024
      RRID:Addgene_62988

      DOI: 10.1083/jcb.202304026

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    ncbi.nlm.nih.gov/pmc/articles/PMC10309186/
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Leveraging tissue-specific enhancer-target gene regulatory networks identifies enhancer somatic mutations that functionally impact lung cancer
    1
    1. scibot 05 Jan 2024
      plasmid_62988

      DOI: 10.1158/0008-5472.CAN-23-1129

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    ncbi.nlm.nih.gov/pmc/articles/PMC10758689/
  7. www.sciencedirect.com www.sciencedirect.com
    N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy
    1
    1. scibot 03 Jan 2024
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      DOI: 10.1053/j.gastro.2022.11.018

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    sciencedirect.com/science/article/pii/S001650852201294X
  8. www.jneurosci.org www.jneurosci.org
    Nascent Aβ42 Fibrillization in Synaptic Endosomes Precedes Plaque Formation in a Mouse Model of Alzheimer's-like β-Amyloidosis
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    1. scibot 02 Jan 2024
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      DOI: 10.1523/JNEUROSCI.1318-23.2023

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    jneurosci.org/content/43/50/8812
  9. Dec 2023
  10. onlinelibrary.wiley.com onlinelibrary.wiley.com
    REV7 is involved in outcomes of platinum-based chemotherapy in pancreatic cancer by controlling the DNA damage response
    1
    1. scibot 29 Dec 2023
      RRID:Addgene_62988

      DOI: 10.1111/cas.16044

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    onlinelibrary.wiley.com/doi/10.1111/cas.16044
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression
    1
    1. scibot 28 Dec 2023
      RRID:Addgene_62988

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    ncbi.nlm.nih.gov/pmc/articles/PMC10740391/
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Noncoding function of super enhancer derived mRNA in modulating neighboring gene expression and TAD interaction
    1
    1. scibot 28 Dec 2023
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      DOI: 10.1101/2023.12.05.570115

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    ncbi.nlm.nih.gov/pmc/articles/PMC10723268/
  13. www.sciencedirect.com www.sciencedirect.com
    Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome
    1
    1. scibot 22 Dec 2023
      Addgene_62988

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    sciencedirect.com/science/article/pii/S0092867423012734
  14. www.sciencedirect.com www.sciencedirect.com
    Interactome analysis reveals a link of the novel ALMS1-CEP70 complex to centrosomal clusters
    1
    1. scibot 20 Dec 2023
      RRID:Addgene_62988

      DOI: 10.1016/j.mcpro.2023.100701

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    sciencedirect.com/science/article/pii/S1535947623002128
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF524 directly interacts with telomeric DNA and supports telomere integrity
    1
    1. scibot 15 Dec 2023
      RRID:Addgene_62988

      DOI: 10.1038/s41467-023-43397-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC10716145/
  16. www.mdpi.com www.mdpi.com
    Heterozygous Knockout of ARID4B Using CRISPR/Cas9 Attenuates Some Aggressive Phenotypes in a Breast Cancer Cell Line
    1
    1. scibot 14 Dec 2023
      RRID:Addgene_62988

      DOI: 10.3390/genes14122184

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    mdpi.com/2073-4425/14/12/2184
  17. link.springer.com link.springer.com
    The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells
    1
    1. scibot 08 Dec 2023
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      DOI: 10.1038/s41467-023-43775-1

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    link.springer.com/article/10.1038/s41467-023-43775-1
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitotic bookmarking by SWI/SNF subunits
    1
    1. scibot 02 Dec 2023
      RRID:Addgene_62988

      DOI: 10.1038/s41586-023-06085-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC10303083/
  19. www.biorxiv.org www.biorxiv.org
    Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue
    1
    1. scibot 02 Dec 2023
      RRID:Addgene_62988

      DOI: 10.1101/2023.11.28.568893

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    biorxiv.org/content/10.1101/2023.11.28.568893v1
  20. www.sciencedirect.com www.sciencedirect.com
    Nutrient-regulated control of lysosome function by signaling lipid conversion
    1
    1. scibot 02 Dec 2023
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    sciencedirect.com/science/article/pii/S0092867423010814
  21. www.science.org www.science.org
    Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1
    1
    1. scibot 01 Dec 2023
      RRID:Addgene_62988

      DOI: 10.1126/sciimmunol.adj5097

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    science.org/doi/10.1126/sciimmunol.adj5097
  22. www.sciencedirect.com www.sciencedirect.com
    Autophagy is involved in degradation of AQP1 in response to an acute decrement in tonicity
    1
    1. scibot 01 Dec 2023
      RRID:Addgene_62988

      DOI: 10.1016/j.isci.2023.108485

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    sciencedirect.com/science/article/pii/S2589004223025622
  23. 52.53.155.43 52.53.155.43
    can-23-1129-html.html
    1
    1. scibot 01 Dec 2023
      plasmid_62988

      DOI: 10.1158/0008-5472.can-23-1129

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  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for the saturation and multiplexing of genetic variants using CRISPR-Cas9
    1
    1. scibot 01 Dec 2023
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      DOI: 10.1016/j.xpro.2023.102702

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    ncbi.nlm.nih.gov/pmc/articles/PMC10658368/
  25. Nov 2023
  26. www.sciencedirect.com www.sciencedirect.com
    Generation of a CRISPR/Cas9-edited Plakoglobin (JUP)knock-out (JMUi001-A-4) iPSC line to model the cardiac phenotype of arrhythmogenic cardiomyopathy
    1
    1. scibot 17 Nov 2023
      RRID:Addgene_62988

      DOI: 10.1016/j.scr.2023.103240

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    sciencedirect.com/science/article/pii/S187350612300226X
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of porcine PK-15 cells lacking the Ifnar1 or Stat2 gene to optimize the efficiency of viral isolation
    1
    1. scibot 11 Nov 2023
      RRID:Addgene_62988

      DOI: 10.1371/journal.pone.0289863

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    ncbi.nlm.nih.gov/pmc/articles/PMC10631621/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Trapping all ERBB ligands decreases pancreatic lesions in a murine model of pancreatic ductal adenocarcinoma
    1
    1. scibot 09 Nov 2023
      plasmid_62988

      DOI: 10.1002/1878-0261.13473

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    ncbi.nlm.nih.gov/pmc/articles/PMC10620123/
  29. www.sciencedirect.com www.sciencedirect.com
    Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells
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      DOI: 10.1016/j.cmet.2023.09.013

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    sciencedirect.com/science/article/pii/S1550413123003698
  30. www.sciencedirect.com www.sciencedirect.com
    Insulin receptor loss impairs mammary tumorigenesis in mice
    1
    1. scibot 02 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113251

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    sciencedirect.com/science/article/pii/S2211124723012639
  31. Oct 2023
  32. www.sciencedirect.com www.sciencedirect.com
    β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4
    1
    1. scibot 28 Oct 2023
      plasmid_62988

      DOI: 10.1016/j.celrep.2023.113322

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    sciencedirect.com/science/article/pii/S2211124723013347
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of CRISPR/Cas9-Mediated CD73 Knockout in Pancreatic Cancer
    1
    1. scibot 18 Oct 2023
      RRID:Addgene_62988

      DOI: 10.3390/cancers15194842

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    ncbi.nlm.nih.gov/pmc/articles/PMC10572021/
  34. www.biorxiv.org www.biorxiv.org
    Spatially and Functionally Distinct mTORC1 Entities Orchestrate the Cellular Response to Amino Acid Availability
    1
    1. scibot 13 Oct 2023
      plasmid_62988

      DOI: 10.1101/2023.10.03.559930

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    biorxiv.org/content/10.1101/2023.10.03.559930v1
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Interaction between membranous EBP50 and myosin 9 as a favorable prognostic factor in ovarian clear cell carcinoma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10552901/
  36. 52.53.155.43 52.53.155.43
    gene-editing-of-yipf3-yipf4-calcoco1-fip200-and-at-cx6nxrde-html.html
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    1. scibot 06 Oct 2023
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      DOI: 10.17504/protocols.io.6qpvr3462vmk/v1

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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acquisition of Neural Fate by Combination of BMP Blockade and Chromatin Modification
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      DOI: 10.1016/j.isci.2023.107887

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    ncbi.nlm.nih.gov/pmc/articles/PMC10522999/
  38. www.nature.com www.nature.com
    Synthetic circuits based on split Cas9 to detect cellular events
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    1. scibot 06 Oct 2023
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      DOI: 10.1038/s41598-023-41367-z

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    nature.com/articles/s41598-023-41367-z
  39. Sep 2023
  40. www.sciencedirect.com www.sciencedirect.com
    Hyperpolarization-activated cyclic nucleotide-gated cation channel 3 promotes HCC development in a female-biased manner
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      DOI: 10.1016/j.celrep.2023.113157

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    sciencedirect.com/science/article/pii/S2211124723011695
  41. www.biorxiv.org www.biorxiv.org
    Mitochondrial protein FKBP8 captures PDZD8 to form mitochondria-ER contacts
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    1. scibot 29 Sep 2023
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      DOI: 10.1101/2023.08.22.554218

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    biorxiv.org/content/10.1101/2023.08.22.554218v2
  42. www.nature.com www.nature.com
    Synthetic circuits based on split Cas9 to detect cellular events
    1
    1. scibot 17 Sep 2023
      plasmid_6298833

      DOI: 10.1038/s41598-023-41367-z

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  43. www.sciencedirect.com www.sciencedirect.com
    Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
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    1. scibot 08 Sep 2023
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    sciencedirect.com/science/article/pii/S1534580723004094
  44. dx.doi.org dx.doi.org
    HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers
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    1. scibot 08 Sep 2023
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      DOI: 10.1093/nar/gkad700

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    dx.doi.org/10.1093/nar/gkad700
  45. link.springer.com link.springer.com
    SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin
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      DOI: 10.1007/s00018-023-04883-9

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    link.springer.com/article/10.1007/s00018-023-04883-9
  46. Aug 2023
  47. www.science.org www.science.org
    Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion
    1
    1. scibot 29 Aug 2023
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      DOI: 10.1126/sciadv.adh0558

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    science.org/doi/10.1126/sciadv.adh0558
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion
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    Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor
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  50. 52.53.155.43 52.53.155.43
    MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC
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  51. www.biorxiv.org www.biorxiv.org
    Erythroid differentiation dependent interaction of VPS13A with XK at the plasma membrane of K562 cells
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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transposon delivery for CRISPR-based loss-of-function screen in mice identifies NF2 as a cooperating gene involved with the canonical WNT signaling molecular class of hepatocellular carcinoma
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  53. 52.53.155.43 52.53.155.43
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Using a Dual CRISPR/Cas9 Approach to Gain Insight into the Role of LRP1B in Glioblastoma
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  55. Jul 2023
  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Efficient and sensitive profiling of RNA–protein interactions using TLC-CLIP
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  57. www.mdpi.com www.mdpi.com
    Disruption of the Mammalian Ccr4–Not Complex Contributes to Transcription-Mediated Genome Instability
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  58. www.embopress.org www.embopress.org
    An ATG12-ATG5-TECPR1 E3-like complex regulates unconventional LC3 lipidation at damaged lysosomes
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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates
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  60. Jun 2023
  61. www.embopress.org www.embopress.org
    PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems
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  62. www.sciencedirect.com www.sciencedirect.com
    Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control
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    Generation of a human induced pluripotent stem cell line (UQi001-A-1) edited with the CRISPR-Cas9 system to carry the heterozygous TARDBP c.1144G>A (p.A382T) missense mutation
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  64. www.biorxiv.org www.biorxiv.org
    Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells
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    A furin-deficient HEK293 cell line suggests a role for furin trafficking in the intoxication pathway of recombinant immunotoxins based on Pseudomonas exotoxin A
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  66. May 2023
  67. www.nature.com www.nature.com
    Neural crest E-cadherin loss drives cleft lip/palate by epigenetic modulation via pro-inflammatory gene–environment interaction
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  68. 52.53.155.43 52.53.155.43
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  69. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Distinct modulation of cellular immunopeptidome by the allosteric regulatory site of ER aminopeptidase 1
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  70. www.biorxiv.org www.biorxiv.org
    Functional interrogation of twenty type 2 diabetes-associated genes using isogenic hESC-derived β-like cells
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    HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers
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    Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor
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  74. gut.bmj.com gut.bmj.com
    Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities
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  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SMYD2 Regulates Vascular Smooth Muscle Cell Phenotypic Switching and Intimal Hyperplasia via Interaction with Myocardin
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  77. www.biorxiv.org www.biorxiv.org
    Local Monomer Levels and Established Filaments Potentiate Non-Muscle Myosin 2 Assembly
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  78. Apr 2023
  79. www.embopress.org www.embopress.org
    RAF1 deficiency causes a lethal syndrome that underscores RTK signaling during embryogenesis
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  80. link.springer.com link.springer.com
    CRISPR/Cas9 System Mediated SIRT7 Gene Knockout Promotes Melanogenesis by MITF via MAPKS and BMP Activation in Melanoma Cells
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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  82. www.nature.com www.nature.com
    Optimization of Cas9 activity through the addition of cytosine extensions to single-guide RNAs
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  83. reader.elsevier.com reader.elsevier.com
    Phosphorylation barcodes direct biased chemokine signaling at CXCR3
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  84. 52.53.155.43 52.53.155.43
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrated transcriptome and proteome analysis reveals posttranscriptional regulation of ribosomal genes in human brain organoids
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  86. Mar 2023
  87. rupress.org rupress.org
    cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca2+-handling abnormalities
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  88. www.embopress.org www.embopress.org
    Two Hippo signaling modules orchestrate liver size and tumorigenesis
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  89. www.sciencedirect.com www.sciencedirect.com
    Tumor PD-L1 engages myeloid PD-1 to suppress type I interferon to impair cytotoxic T lymphocyte recruitment
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    Generation of an induced pluripotent stem cell line carrying a biallelic deletion (SCTCi019-A) in GCDH using CRISPR/Cas9
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    Aspergillus fumigatus hijacks human p11 to redirect fungal-containing phagosomes to non-degradative pathway
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  92. www.cell.com www.cell.com
    TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1
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    cell.com/molecular-cell/abstract/S1097-2765(23)00150-8
  93. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The Tumorigenic Effect of lncRNA AFAP1-AS1 is Mediated by Translated Peptide ATMLP Under the Control of m6A Methylation
    1
    1. scibot 09 Mar 2023
      RRID:Addgene_62988

      DOI: 10.1002/advs.202300314

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  94. www.sciencedirect.com www.sciencedirect.com
    IFNγ is a central node of cancer immune equilibrium
    1
    1. scibot 09 Mar 2023
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    sciencedirect.com/science/article/pii/S2211124723002309
  95. www.biorxiv.org www.biorxiv.org
    Cross-species transcriptomic analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion
    1
    1. scibot 03 Mar 2023
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      DOI: 10.1101/2023.01.27.525748

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    biorxiv.org/content/10.1101/2023.01.27.525748v1
  96. Feb 2023
  97. www.sciencedirect.com www.sciencedirect.com
    High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells
    1
    1. scibot 23 Feb 2023
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      DOI: 10.1016/j.isci.2023.106156

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    sciencedirect.com/science/article/pii/S258900422300233X
  98. www.sciencedirect.com www.sciencedirect.com
    Generation of induced pluripotent stem cell line carrying frameshift variants in NPHP1 (UCSFi001-A-68) using CRISPR/Cas9
    1
    1. scibot 23 Feb 2023
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    sciencedirect.com/science/article/pii/S1873506123000399
  99. www.biorxiv.org www.biorxiv.org
    Evolutionarily divergent mTOR remodels the translatome to drive rapid wound closure and regeneration
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    biorxiv.org/content/10.1101/2021.10.28.465024v1
  100. www.sciencedirect.com www.sciencedirect.com
    Generation of miR-15a/16-1 cluster-deficient human induced pluripotent stem cell line (DMBi001-A-2) using CRISPR/Cas9 gene editing
    1
    1. scibot 16 Feb 2023
      RRID:Addgene_62988

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    sciencedirect.com/science/article/pii/S1873506123000326
  101. www.sciencedirect.com www.sciencedirect.com
    Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m3C modification
    1
    1. scibot 10 Feb 2023
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    sciencedirect.com/science/article/pii/S1934590923000073
  102. www.sciencedirect.com www.sciencedirect.com
    The mechanosensitive ion channel Piezo1 modulates the migration and immune response of microglia
    1
    1. scibot 09 Feb 2023
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    sciencedirect.com/science/article/pii/S2589004223000706
  103. www.sciencedirect.com www.sciencedirect.com
    Recycling of modified H2A-H2B provides short-term memory of chromatin states
    1
    1. scibot 09 Feb 2023
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Oligodendrogenesis and myelination tracing in a CRISPR/Cas9-engineered brain microphysiological system
    2
    1. scibot 04 Feb 2023
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      DOI: 10.3389/fncel.2022.1094291

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    ncbi.nlm.nih.gov/pmc/articles/PMC9893511/
  105. elifesciences.org elifesciences.org
    T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation
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      DOI: 10.7554/eLife.83077

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    elifesciences.org/articles/83077
  106. www.sciencedirect.com www.sciencedirect.com
    Generation of a ST3GAL3 null mutant induced pluripotent stem cell (iPSC) line (UKWMPi002-A-3) by CRISPR/Cas9 genome editing
    1
    1. scibot 02 Feb 2023
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    sciencedirect.com/science/article/pii/S1873506123000247
  107. Jan 2023
  108. www.sciencedirect.com www.sciencedirect.com
    Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation
    2
    1. scibot 28 Jan 2023
      RRID: Addgene_62988

      DOI: 10.1016/j.celrep.2022.111897

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    sciencedirect.com/science/article/pii/S221112472201796X
  109. www.mdpi.com www.mdpi.com
    Identification of Genes Associated with Liver Metastasis in Pancreatic Cancer Reveals PCSK6 as a Crucial Mediator
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    1. scibot 04 Jan 2023
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      DOI: 10.3390/cancers15010241

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    mdpi.com/2072-6694/15/1/241
  110. Dec 2022
  111. link.springer.com link.springer.com
    Sushi domain-containing protein 4 binds to epithelial growth factor receptor and initiates autophagy in an EGFR phosphorylation independent manner
    1
    1. scibot 30 Dec 2022
      plasmid_62988

      DOI: 10.1186/s13046-022-02565-1

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  112. www.sciencedirect.com www.sciencedirect.com
    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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    1. scibot 24 Dec 2022
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    sciencedirect.com/science/article/pii/S2211124722017260
  113. www.sciencedirect.com www.sciencedirect.com
    Generation of human induced pluripotent stem cell lines with HMOX1 promoter polymorphism and CRISPR/Cas9-mediated deletion of exon 50 of DMD gene
    1
    1. scibot 17 Dec 2022
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    sciencedirect.com/science/article/pii/S1873506122003531
  114. www.sciencedirect.com www.sciencedirect.com
    Generation of a homozygous ABCA7-knockout human iPSC line using the CRISPR/Cas9 system
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    1. scibot 08 Dec 2022
      RRID:Addgene_62988

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    sciencedirect.com/science/article/pii/S187350612200349X
  115. Nov 2022
  116. www.science.org www.science.org
    Intronic enhancers of the human SNCA gene predominantly regulate its expression in brain in vivo
    1
    1. scibot 29 Nov 2022
      plasmid_62988

      DOI: 10.1126/sciadv.abq6324

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    science.org/doi/10.1126/sciadv.abq6324
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GPI-Anchored Ligand-BioID2-Tagging System Identifies Galectin-1 Mediating Zika Virus Entry
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    1. scibot 19 Nov 2022
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      DOI: 10.1016/j.isci.2022.105481

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    ncbi.nlm.nih.gov/pmc/articles/PMC9668739/
  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL
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    1. scibot 18 Nov 2022
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      DOI: 10.7554/eLife.81606

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    ncbi.nlm.nih.gov/pmc/articles/PMC9651953/
  119. 52.53.155.43 52.53.155.43
    Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector
    1
    1. scibot 03 Nov 2022
      RRID:Addgene_62988

      DOI: 10.21203/rs.3.rs-1913714/v1

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    52.53.155.43/dcaead73d85858fbd3a58018d7559608353495d7/7c83488d-0d7f-4b8a-b1aa-e1329998961d-html.html
  120. 52.53.155.43 52.53.155.43
    Lactate as a major epigenetic carbon source for histone acetylation via nuclear LDH metabolism
    2
    1. scibot 03 Nov 2022
      RRID:Addgene_62988

      DOI: 10.21203/rs.3.rs-1698453/v1

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      DOI: 10.21203/rs.3.rs-1698453/v1

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  121. www.sciencedirect.com www.sciencedirect.com
    WNK kinases sense molecular crowding and rescue cell volume via phase separation
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    1. scibot 03 Nov 2022
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      DOI: 10.1016/j.cell.2022.09.042

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    sciencedirect.com/science/article/pii/S0092867422012612
  122. Oct 2022
  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Homozygous CRISPR/Cas9 Knockout Generated a Novel Functionally Active Exon 1 Skipping XPA Variant in Melanoma Cells
    1
    1. scibot 26 Oct 2022
      RRID:Addgene_62988

      DOI: 10.3390/ijms231911649

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  124. www.nature.com www.nature.com
    Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism
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      DOI: 10.1038/s41380-022-01834-x

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  125. link.springer.com link.springer.com
    Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector
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    1. scibot 19 Oct 2022
      RRID:Addgene_62988

      DOI: 10.1038/s41598-022-20970-6

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  126. Sep 2022
  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MeCP2 heterochromatin organization is modulated by arginine methylation and serine phosphorylation
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    1. scibot 30 Sep 2022
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      DOI: 10.3389/fcell.2022.941493

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  128. www.sciencedirect.com www.sciencedirect.com
    GABP couples oncogene signaling to telomere regulation in TERT promoter mutant cancer
    2
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      DOI: 10.1016/j.celrep.2022.111344

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  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ALS-linked loss of Cyclin-F function affects HSP90
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    1. scibot 22 Sep 2022
      RRID:Addgene_62988

      DOI: 10.26508/lsa.202101359

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    ncbi.nlm.nih.gov/pmc/articles/PMC9481933/
  130. www.nature.com www.nature.com
    Quantitative analysis of CRISPR/Cas9-mediated provirus deletion in blue egg layer chicken PGCs by digital PCR
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    1. scibot 18 Sep 2022
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      DOI: 10.1038/s41598-022-19861-7

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  131. www.sciencedirect.com www.sciencedirect.com
    Generation of knock-in degron tags for endogenous proteins in mice using the dTAG system
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    1. scibot 11 Sep 2022
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    sciencedirect.com/science/article/pii/S2666166722005408
  132. www.sciencedirect.com www.sciencedirect.com
    The bacterial effector GarD shields Chlamydia trachomatis inclusions from RNF213-mediated ubiquitylation and destruction
    1
    1. scibot 11 Sep 2022
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      DOI: 10.1016/j.chom.2022.08.008

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    sciencedirect.com/science/article/pii/S1931312822004073
  133. Aug 2022
  134. www.sciencedirect.com www.sciencedirect.com
    Transmembrane protein KIRREL1 regulates Hippo signaling via a feedback loop and represents a therapeutic target in YAP/TAZ-active cancers
    1
    1. scibot 31 Aug 2022
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  135. www.embopress.org www.embopress.org
    Regulation of membrane fluidity by RNF145-triggered degradation of the lipid hydrolase ADIPOR2
    1
    1. scibot 23 Aug 2022
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      DOI: 10.15252/embj.2022110777

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    embopress.org/doi/10.15252/embj.2022110777
  136. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Antibody for Serine 65 Phosphorylated Ubiquitin Identifies PLK1-Mediated Phosphorylation of Mitotic Proteins and APC1
    1
    1. scibot 22 Aug 2022
      RRID:Addgene_62988

      DOI: 10.3390/molecules27154867

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  137. www.sciencedirect.com www.sciencedirect.com
    APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation
    2
    1. scibot 17 Aug 2022
      AddgeneCat#62988

      DOI: 10.1016/j.celrep.2022.111200

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      plasmid_62988

      DOI: 10.1016/j.celrep.2022.111200

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  138. aacrjournals.org aacrjournals.org
    Proteomic mapping and targeting of mitotic pericentriolar material in tumors bearing centrosome amplification
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    TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation
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  140. jasn.asnjournals.org jasn.asnjournals.org
    Channel Function of Polycystin-2 in the Endoplasmic Reticulum Protects against Autosomal Dominant Polycystic Kidney Disease
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    Rhomboid protease RHBDL4 promotes retrotranslocation of aggregation-prone proteins for degradation
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  142. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The selenoprotein P 3’ untranslated region is an RNA binding protein platform that fine tunes selenocysteine incorporation
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  143. Jul 2022
  144. www.sciencedirect.com www.sciencedirect.com
    GPCR kinases generate an APH1A phosphorylation barcode to regulate amyloid-β generation
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    A Progeroid Syndrome Caused by RAF1 deficiency Underscores the importance of RTK signaling for Human Development
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  146. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-Wide CRISPR Screening Identifies DCK and CCNL1 as Genes That Contribute to Gemcitabine Resistance in Pancreatic Cancer
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  147. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The SARS-CoV-2 protein NSP2 impairs the silencing capacity of the human 4EHP-GIGYF2 complex
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  148. Jun 2022
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    Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance
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  150. academic.oup.com academic.oup.com
    mTORC1 functional assay reveals SZT2 loss-of-function variants and a founder in-frame deletion
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  151. www.nature.com www.nature.com
    Control of CRK-RAC1 activity by the miR-1/206/133 miRNA family is essential for neuromuscular junction function
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  152. www.sciencedirect.com www.sciencedirect.com
    The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability
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  153. rupress.org rupress.org
    ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling
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  154. elifesciences.org elifesciences.org
    Typhoid toxin sorting and exocytic transport from Salmonella Typhi-infected cells
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  155. May 2022
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    DDX41 is required for cGAS-STING activation against DNA virus infection
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    Xist-mediated silencing requires additive functions of SPEN and Polycomb together with differentiation-dependent recruitment of SmcHD1
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    IL13Rα2 promotes proliferation and outgrowth of breast cancer brain metastases
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    Loss-of-function variants in the schizophrenia risk gene SETD1A alter neuronal network activity in human neurons through the cAMP/PKA pathway
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  160. www.nature.com www.nature.com
    Saturation variant interpretation using CRISPR prime editing
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  161. Apr 2022
  162. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance
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    Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonization
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    CRISPR/Cas9 treatment partially restores the amyloid-β 42/40 ratio in human fibroblasts carrying the early onset Alzheimer’s disease presenilin 1 M146L mutation
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  165. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells
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    The role of cell-autonomous circadian oscillation of Cry transcription in circadian rhythm generation
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    WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy
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    Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex
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    Rapid and efficient degradation of endogenous proteins in vivo identifies stage-specific roles of RNA Pol II pausing in mammalian development
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    The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
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    Functional redundancy among Polycomb complexes in maintaining the pluripotent state of embryonic stem cells
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  172. Mar 2022
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    Generation of a homozygous ARHGAP11B knockout hiPSC line by CRISPR/Cas9 system
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    SPT16 ubiquitylation by DCAF14-CRL4 regulates FACT binding to histones
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    Generation of induced pluripotent stem cell lines carrying monoallelic (UCSFi001-A-60) or biallelic (UCSFi001-A-61; UCSFi001-A-62) frameshift variants in CACNA1A using CRISPR/Cas9
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  176. Feb 2022
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    C9ORF78 partially localizes to centromeres and plays a role in chromosome segregation
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  178. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    TP53 promotes lineage commitment of human embryonic stem cells through ciliogenesis and sonic hedgehog signaling
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    Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death
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  180. Jan 2022
  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration
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    The mammalian trafficking chaperone protein UNC93B1 maintains the ER calcium sensor STIM1 in a dimeric state primed for translocation to the ER cortex.
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    SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers
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  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer
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    The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation
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  186. www.embopress.org www.embopress.org
    Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency
    1
    1. scibot 13 Jan 2022
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      DOI: 10.15252/embj.2021109108

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    embopress.org/doi/abs/10.15252/embj.2021109108
  187. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hyaluronic acid fuels pancreatic cancer cell growth
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    1. scibot 11 Jan 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC8730721/
  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models
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    1. scibot 07 Jan 2022
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    ncbi.nlm.nih.gov/pmc/articles/PMC8710557/
  189. www.nature.com www.nature.com
    A design optimized prime editor with expanded scope and capability in plants
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      DOI: 10.1038/s41477-021-01043-4

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    nature.com/articles/s41477-021-01043-4
  190. Dec 2021
  191. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface
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    1. scibot 21 Dec 2021
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    ncbi.nlm.nih.gov/pmc/articles/PMC8673838/
  192. www.sciencedirect.com www.sciencedirect.com
    Emergence and patterning dynamics of mouse-definitive endoderm
    2
    1. scibot 21 Dec 2021
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      DOI: 10.1016/j.isci.2021.103556

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      plasmid_62988

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    sciencedirect.com/science/article/pii/S2589004221015261
  193. www.sciencedirect.com www.sciencedirect.com
    TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules
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    sciencedirect.com/science/article/pii/S1534580721009394
  194. www.sciencedirect.com www.sciencedirect.com
    Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation
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    sciencedirect.com/science/article/pii/S1534580721008947
  195. Nov 2021
  196. www.sciencedirect.com www.sciencedirect.com
    Polyphosphate degradation by Nudt3-Zn2+ mediates oxidative stress response
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    1. scibot 17 Nov 2021
      plasmid_62988

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    sciencedirect.com/science/article/pii/S2211124721014820
  197. link.springer.com link.springer.com
    CD109 expression in tumor cells and stroma correlates with progression and prognosis in pancreatic cancer
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  198. www.sciencedirect.com www.sciencedirect.com
    Distinct regulation of tonic GABAergic inhibition by NMDA receptor subtypes
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    sciencedirect.com/science/article/pii/S2211124721014376
  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay
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    ncbi.nlm.nih.gov/pmc/articles/PMC8553338/
  200. www.sciencedirect.com www.sciencedirect.com
    A multi-omic single-cell landscape of human gynecologic malignancies
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    sciencedirect.com/science/article/pii/S109727652100842X
  201. Oct 2021
  202. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Gene trapping reveals a new transcriptionally active genome element: the chromosome-specific clustered trap region
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    onlinelibrary.wiley.com/doi/10.1111/gtc.12890
  203. www.science.org www.science.org
    Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration
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    science.org/doi/abs/10.1126/scisignal.abg3555
  204. Sep 2021
  205. www.sciencedirect.com www.sciencedirect.com
    Co-opting regulation bypass repair as a gene correction strategy for monogenic diseases
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      plasmid_62988

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    sciencedirect.com/science/article/pii/S1525001621002045
  206. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Alternative microexon splicing by RBFOX2 and PTBP1 is associated with metastasis in colorectal cancer
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    onlinelibrary.wiley.com/doi/10.1002/ijc.33758
  207. www.sciencedirect.com www.sciencedirect.com
    ATF3 promotes the serine synthesis pathway and tumor growth under dietary serine restriction
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    sciencedirect.com/science/article/pii/S2211124721011530
  208. www.sciencedirect.com www.sciencedirect.com
    Modeling of dilated cardiomyopathy by establishment of isogenic human iPSC lines carrying phospholamban C25T (R9C) mutation (UPITTi002-A-1) using CRISPR/Cas9 editing
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    1. scibot 21 Sep 2021
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    sciencedirect.com/science/article/pii/S1873506121003913
  209. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Parallel Reporter Assays Identify Altered Regulatory Role of rs684232 in Leading to Prostate Cancer Predisposition
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      DOI: 10.3390/ijms22168792

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    ncbi.nlm.nih.gov/pmc/articles/PMC8395720/
  210. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Distinct roles of nonmuscle myosin II isoforms for establishing tension and elasticity during cell morphodynamics
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  211. www.sciencedirect.com www.sciencedirect.com
    Title: Derivation of human pluripotent stem cell line via CRISPR/Cas9 mediated deletion of exon 3 LAMA2 gene (DMBi001-A-1)
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      DOI: 10.1016/j.scr.2021.102529

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    sciencedirect.com/science/article/pii/S1873506121003767
  212. Aug 2021
  213. www.sciencedirect.com www.sciencedirect.com
    Proteomic analysis demonstrates the role of the quality control protease LONP1 in mitochondrial protein aggregation
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      DOI: 10.1016/j.jbc.2021.101134

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    sciencedirect.com/science/article/pii/S0021925821009352
  214. academic.oup.com academic.oup.com
    Computational resources to define alleles and altered regulatory motifs at genomically edited candidate response elements
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      DOI: 10.1093/nar/gkab700

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    academic.oup.com/nar/advance-article/doi/10.1093/nar/gkab700/6355879
  215. onlinelibrary.wiley.com onlinelibrary.wiley.com
    BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple-negative breast cancer cells
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      DOI: 10.1002/jcb.30073

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    onlinelibrary.wiley.com/doi/10.1002/jcb.30073
  216. elifesciences.org elifesciences.org
    Quantitative live-cell imaging and computational modeling shed new light on endogenous WNT/CTNNB1 signaling dynamics
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      DOI: 10.7554/eLife.66440

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    elifesciences.org/articles/66440
  217. www.sciencedirect.com www.sciencedirect.com
    Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation
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    sciencedirect.com/science/article/pii/S1097276521005931
  218. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation
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      plasmid_62988

      DOI: 10.1093/nar/gkz076

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  219. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    ncbi.nlm.nih.gov/pmc/articles/PMC6458999/
  220. www.biorxiv.org www.biorxiv.org
    Scalable, FACS-Free Genome-Wide Phenotypic Screening
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      DOI: 10.1101/612887

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