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    Impaired phase separation and nucleolar functions in hiPSC models of SNORD118-related ribosomopathies
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    1. scibot 19 Jul 2024
      RRID:Addgene_62988

      DOI: 10.1016/j.isci.2024.110430

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    sciencedirect.com/science/article/pii/S2589004224016559
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    Protocol for establishing knockout cell clones by deletion of a large gene fragment using CRISPR-Cas9 with multiple guide RNAs
    1
    1. scibot 19 Jul 2024
      plasmid_62988

      DOI: 10.1016/j.xpro.2024.103179

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    sciencedirect.com/science/article/pii/S2666166724003447
  4. www.cell.com www.cell.com
    Upregulation of utrophin improves the phenotype of Duchenne muscular dystrophy hiPSC-derived CMs
    1
    1. scibot 18 Jul 2024
      RRID:Addgene_62988

      DOI: 10.1016/j.omtn.2024.102247

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    cell.com/molecular-therapy-family/nucleic-acids/abstract/S2162-2531(24)00134-3
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Functional diversity among cardiolipin binding sites on the mitochondrial ADP/ATP carrier
    1
    1. scibot 18 Jul 2024
      RRID:Addgene_62988

      DOI: 10.1038/s44318-024-00132-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC11251061/
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    FANCM promotes PARP inhibitor resistance by minimizing ssDNA gap formation and counteracting resection inhibition
    2
    1. scibot 17 Jul 2024
      AddgeneCat# 62988

      DOI: 10.1016/j.celrep.2024.114464

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    2. scibot 17 Jul 2024
      Addgene_62988

      DOI: 10.1016/j.celrep.2024.114464

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    sciencedirect.com/science/article/pii/S2211124724007939
  7. www.sciencedirect.com www.sciencedirect.com
    The TSC22D, WNK, and NRBP gene families exhibit functional buffering and evolved with Metazoa for cell volume regulation
    1
    1. scibot 17 Jul 2024
      Plasmid_62988

      DOI: 10.1016/j.celrep.2024.114417

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    sciencedirect.com/science/article/pii/S2211124724007460
  8. onlinelibrary.wiley.com onlinelibrary.wiley.com
    UBX-390: A Novel Androgen Receptor Degrader for Therapeutic Intervention in Prostate Cancer
    1
    1. scibot 16 Jul 2024
      RRID:Addgene_62988

      DOI: 10.1002/advs.202400398

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    onlinelibrary.wiley.com/doi/10.1002/advs.202400398
  9. www.cell.com www.cell.com
    Germline-specific RNA helicase DDX4 forms cytoplasmic granules in cancer cells and promotes tumor growth
    1
    1. scibot 16 Jul 2024
      RRID:Addgene_62988

      DOI: 10.1016/j.celrep.2024.114430

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    cell.com/cell-reports/abstract/S2211-1247(24)00759-9
  10. Jul 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution
    1
    1. scibot 14 Jul 2024
      Addgene_62988

      DOI: 10.1093/nar/gkac404

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    ncbi.nlm.nih.gov/pmc/articles/PMC9226516/
  12. 52.53.155.43 52.53.155.43
    ACKR3 Proximity Labeling Identifies Novel G protein- and β-arrestin-independent GPCR Interacting Proteins
    1
    1. scibot 09 Jul 2024
      RRID:Addgene_62988

      DOI: 10.1101/2024.01.27.577545

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    52.53.155.43/9259a2c14d17bad8b876c3ec82612338ef6bebf1/2024.01.27.577545v1.full-html.html
  13. www.biorxiv.org www.biorxiv.org
    SLC7A5 is required for citrulline-dependent growth in arginine limited conditions
    1
    1. scibot 03 Jul 2024
      Addgene_62988

      DOI: 10.1101/2024.06.27.600869

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    biorxiv.org/content/10.1101/2024.06.27.600869v1
  14. Jun 2024
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel role for KIFC1-MYH9 interaction in triple-negative breast cancer aggressiveness and racial disparity
    1
    1. scibot 30 Jun 2024
      62988

      DOI: 10.1186/s12964-024-01664-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11188183/
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A homogeneous time-resolved fluorescence screen to identify SIRT2 deacetylase and defatty-acylase inhibitors
    1
    1. scibot 30 Jun 2024
      62988

      DOI: 10.1371/journal.pone.0305000

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    ncbi.nlm.nih.gov/pmc/articles/PMC11195995/
  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pharmacological Modulation of the Cytosolic Oscillator Affects Glioblastoma Cell Biology
    1
    1. scibot 30 Jun 2024
      PX459

      DOI: 10.1007/s10571-024-01485-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC11193694/
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Bridge-like lipid transfer protein family member 2 suppresses ciliogenesis
    1
    1. scibot 30 Jun 2024
      62988

      DOI: 10.1091/mbc.E24-02-0065

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    ncbi.nlm.nih.gov/pmc/articles/PMC11151097/
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation
    1
    1. scibot 30 Jun 2024
      62988

      DOI: 10.1038/s41467-024-49739-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC11208438/
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CPEB1 Controls NRF2 Proteostasis and Ferroptosis Susceptibility in Pancreatic Cancer
    1
    1. scibot 30 Jun 2024
      Addgene_62988

      DOI: 10.7150/ijbs.95962

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    ncbi.nlm.nih.gov/pmc/articles/PMC11186365/
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitolnc controls cardiac BCAA metabolism and heart hypertrophy by allosteric activation of BCKDH
    1
    1. scibot 30 Jun 2024
      RRID:Addgene_62988

      DOI: 10.1093/nar/gkae226

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    ncbi.nlm.nih.gov/pmc/articles/PMC11194096/
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    SETDB1 deletion causes DNA demethylation and upregulation of multiple zinc-finger genes
    1
    1. scibot 25 Jun 2024
      pSpCas9(BB)-2 A-Puro

      DOI: 10.1007/s11033-024-09703-2

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    ncbi.nlm.nih.gov/pmc/articles/PMC11192681/
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nucleobindin 2 inhibits senescence in gastric carcinoma
    1
    1. scibot 21 Jun 2024
      62988

      DOI: 10.1038/s41598-024-61111-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC11101443/
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An efficient low cost means of biophysical gene transfection in primary cells
    1
    1. scibot 21 Jun 2024
      62988

      DOI: 10.1038/s41598-024-62996-y

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    ncbi.nlm.nih.gov/pmc/articles/PMC11161637/
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alzheimer’s disease risk allele of PICALM causes detrimental lipid droplets in microglia
    1
    1. scibot 21 Jun 2024
      Addgene_62988

      DOI: 10.21203/rs.3.rs-4407146/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11142308/
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation and characterization of cerebellar granule neurons specific knockout mice of Golli-MBP
    1
    1. scibot 20 Jun 2024
      62988

      DOI: 10.1007/s11248-024-00382-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11176102/
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    All three MutL complexes are required for repeat expansion in a human stem cell model of CAG-repeat expansion mediated glutaminase deficiency
    1
    1. scibot 20 Jun 2024
      62988

      DOI: 10.1038/s41598-024-64480-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC11178883/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Systematic epigenome editing captures the context-dependent instructive function of chromatin modifications
    1
    1. scibot 20 Jun 2024
      62988

      DOI: 10.1038/s41588-024-01706-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC11176084/
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    G6PD and ACSL3 are synthetic lethal partners of NF2 in Schwann cells
    1
    1. scibot 20 Jun 2024
      62988

      DOI: 10.1038/s41467-024-49298-7

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    ncbi.nlm.nih.gov/pmc/articles/PMC11180199/
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Extraembryonic gut endoderm cells undergo programmed cell death during development
    1
    1. scibot 20 Jun 2024
      62988

      DOI: 10.1038/s41556-024-01431-w

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    ncbi.nlm.nih.gov/pmc/articles/PMC11178501/
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sponging of five tumour suppressor miRNAs by lncRNA-KCNQ1OT1 activates BMPR1A/BMPR1B-ACVR2A/ACVR2B signalling and promotes chemoresistance in hepatocellular carcinoma
    1
    1. scibot 15 Jun 2024
      62988

      DOI: 10.1038/s41420-024-02016-0

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    ncbi.nlm.nih.gov/pmc/articles/PMC11162467/
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Planar cell polarity proteins mediate ketamine-induced restoration of glutamatergic synapses in prefrontal cortical neurons in a mouse model for chronic stress
    1
    1. scibot 15 Jun 2024
      62988

      DOI: 10.1038/s41467-024-48257-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC11165002/
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mode of SUV420H2 heterochromatin localization through multiple HP1 binding motifs in the heterochromatic targeting module
    1
    1. scibot 15 Jun 2024
      62988

      DOI: 10.1111/gtc.13109

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    ncbi.nlm.nih.gov/pmc/articles/PMC11163940/
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Base editing strategies to convert CAG to CAA diminish the disease-causing mutation in Huntington’s disease
    1
    1. scibot 15 Jun 2024
      Addgene_62988

      DOI: 10.7554/eLife.89782

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    ncbi.nlm.nih.gov/pmc/articles/PMC11175616/
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tobacco-induced hyperglycemia promotes lung cancer progression via cancer cell-macrophage interaction through paracrine IGF2/IR/NPM1-driven PD-L1 expression
    1
    1. scibot 13 Jun 2024
      plasmid_62988

      DOI: 10.1038/s41467-024-49199-9

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    ncbi.nlm.nih.gov/pmc/articles/PMC11162468/
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genetic Knock-Ins of Endogenous Fluorescent Tags in RAW 264.7 Murine Macrophages Using CRISPR/Cas9 Genome Editing
    1
    1. scibot 10 Jun 2024
      62988

      DOI: 10.21769/BioProtoc.4960

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    ncbi.nlm.nih.gov/pmc/articles/PMC10958172/
  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Unraveling the impact of AXIN1 mutations on HCC development: Insights from CRISPR/Cas9 repaired AXIN1-mutant liver cancer cell lines
    1
    1. scibot 09 Jun 2024
      62988

      DOI: 10.1371/journal.pone.0304607

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    ncbi.nlm.nih.gov/pmc/articles/PMC11161089/
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells
    1
    1. scibot 09 Jun 2024
      62988

      DOI: 10.1038/s41564-024-01672-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC11153131/
  39. www.sciencedirect.com www.sciencedirect.com
    SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms
    3
    1. scibot 08 Jun 2024
      plasmid_62988

      DOI: 10.1016/j.isci.2024.109940

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    2. scibot 07 Jun 2024
      Addgene plasmid # 62988

      DOI: 10.1016/j.isci.2024.109940

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      Curator: @evieth

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      RRID:Addgene_62988 DOI:10.1016/j.isci.2024.109940
    3. scibot 07 Jun 2024
      62988

      DOI: 10.1016/j.isci.2024.109940

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    sciencedirect.com/science/article/pii/S2589004224011623
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting SOX13 inhibits assembly of respiratory chain supercomplexes to overcome ferroptosis resistance in gastric cancer
    1
    1. scibot 07 Jun 2024
      62988

      DOI: 10.1038/s41467-024-48307-z

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    ncbi.nlm.nih.gov/pmc/articles/PMC11106335/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor-Intrinsic Enhancer of Zeste Homolog 2 Controls Immune Cell Infiltration, Tumor Growth, and Lung Metastasis in a Triple-Negative Breast Cancer Model
    1
    1. scibot 07 Jun 2024
      Addgene_62988

      DOI: 10.3390/ijms25105392

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    ncbi.nlm.nih.gov/pmc/articles/PMC11121204/
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for scarless genome editing of human pluripotent stem cell based on orthogonal selective reporters
    1
    1. scibot 06 Jun 2024
      Addgene_62988

      DOI: 10.1016/j.xpro.2024.103084

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    ncbi.nlm.nih.gov/pmc/articles/PMC11145391/
  43. www.sciencedirect.com www.sciencedirect.com
    Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity
    1
    1. scibot 04 Jun 2024
      Addgene_62988

      DOI: 10.1016/j.celrep.2024.114289

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  44. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Simultaneous construction strategy using two types of fluorescent markers for HVT vector vaccine against infectious bursal disease and H9N2 avian influenza virus by NHEJ-CRISPR/Cas9
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    1. scibot 03 Jun 2024
      pSpCas9(BB)-2A-Puro (PX459) V2.0

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  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA splicing analysis deciphers developmental hierarchies and reveals therapeutic targets in adult glioma
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  46. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Limited impact of cancer-derived gangliosides on anti-tumor immunity in colorectal cancer
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  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    HSDL2 links nutritional cues to bile acid and cholesterol homeostasis
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  48. May 2024
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fluorescent fatty acid conjugates for live cell imaging of peroxisomes
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  50. www.biorxiv.org www.biorxiv.org
    ESCRT recruitment to damaged lysosomes is dependent on the ATG8 E3-like ligases
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    Mouse neural tube organoids self-organize floorplate through BMP-mediated cluster competition
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  52. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss-of-function variants affecting the STAGA complex component SUPT7L cause a developmental disorder with generalized lipodystrophy
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  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Fusion of histone variants to Cas9 suppresses non-homologous end joining
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  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    YY1 binding is a gene-intrinsic barrier to Xist-mediated gene silencing
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  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Foxp1 suppresses cortical angiogenesis and attenuates HIF-1alpha signaling to promote neural progenitor cell maintenance
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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Complete male-to-female sex reversal in XY mice lacking the miR-17~92 cluster
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  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genomic context– and H2AK119 ubiquitination–dependent inheritance of human Polycomb silencing
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  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A regulatory variant impacting TBX1 expression contributes to basicranial morphology in Homo sapiens
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  59. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency
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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generating an organ-deficient animal model using a multi-targeted CRISPR-Cas9 system
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  61. www.sciencedirect.com www.sciencedirect.com
    An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins
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  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ATG9B regulates bacterial internalization via actin rearrangement
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  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel cis-regulatory element regulates αD and αA-globin gene expression in chicken erythroid cells
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  64. link.springer.com link.springer.com
    Dual-Luciferase Reporter Assay for Prescreening CRISPR (d)Cas9-Mediated Epigenetic Editing on a Plant Promoter Using Human Cells
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  65. www.mdpi.com www.mdpi.com
    TurboID-Based IRE1 Interactome Reveals Participants of the Endoplasmic Reticulum-Associated Protein Degradation Machinery in the Human Mast Cell Leukemia Cell Line HMC-1.2
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  66. www.biorxiv.org www.biorxiv.org
    The INO80 chromatin remodeling complex regulates histone H2A.Z mobility and the G1-S transition in oligodendrocyte precursors
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  67. www.biorxiv.org www.biorxiv.org
    Stem cell models of TAFAZZIN deficiency reveal novel tissue-specific pathologies in Barth Syndrome
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  68. www.sciencedirect.com www.sciencedirect.com
    Long-term expandable mouse and human-induced nephron progenitor cells enable kidney organoid maturation and modeling of plasticity and disease
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  69. Apr 2024
  70. www.sciencedirect.com www.sciencedirect.com
    O-GlcNAcylation of RBM14 contributes to elevated cellular O-GlcNAc through regulation of OGA protein stability
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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Numb positively regulates Hedgehog signaling at the ciliary pocket
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  72. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RNA structures within Venezuelan equine encephalitis virus E1 alter macrophage replication fitness and contribute to viral emergence
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  73. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer immunotherapy via synergistic co-activation of myeloid receptors CD40 and Dectin-1
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  74. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Differentiation shifts from a reversible to an irreversible heterochromatin state at the DM1 locus
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  75. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Abnormal cell sorting and altered early neurogenesis in a human cortical organoid model of Protocadherin-19 clustering epilepsy
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  76. www.embopress.org www.embopress.org
    Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia
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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The dimeric deubiquitinase USP28 integrates 53BP1 and MYC functions to limit DNA damage
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  78. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutations in the postsynaptic density signaling hub TNIK disrupt PSD signaling in human models of neurodevelopmental disorders
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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Metabolic priming by multiple enzyme systems supports glycolysis, HIF1α stabilisation, and human cancer cell survival in early hypoxia
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  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lysosomal storage disease proteo/lipidomic profiling using nMOST links ferritinophagy with mitochondrial iron deficiencies in cells lacking NPC2
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent manner
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  82. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FOXL2 interaction with different binding partners regulates the dynamics of ovarian development
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  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Filamin B restricts vaccinia virus spread and is targeted by vaccinia virus protein C4
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  84. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An in vitro neurogenetics platform for precision disease modeling in the mouse
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  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Long non-coding RNA LIP interacts with PARP-1 influencing the efficiency of base excision repair
    1
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      pSpCas9(BB)-2A-Puro (PX459) V2.0

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  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing
    1
    1. scibot 14 Apr 2024
      plasmid_62988

      DOI: 10.1038/s41467-024-47107-9

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  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PLD3 and PLD4 synthesize S,S-BMP, a key phospholipid enabling lipid degradation in lysosomes
    1
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      Addgene_62988

      DOI: 10.1101/2024.03.21.586175

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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Melanoma-associated melanocortin 1 receptor variants confer redox signaling-dependent protection against oxidative DNA damage
    1
    1. scibot 13 Apr 2024
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  89. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis
    1
    1. scibot 13 Apr 2024
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      DOI: 10.7554/eLife.89776

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  90. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Crosstalk Between NK Cell Receptors and Tumor Membrane Hsp70‐Derived Peptide: A Combined Computational and Experimental Study
    1
    1. scibot 13 Apr 2024
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      DOI: 10.1002/advs.202305998

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  91. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pancreatic cancer-associated fibroblasts modulate macrophage differentiation via sialic acid-Siglec interactions
    1
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  92. insight.jci.org insight.jci.org
    hsa-miRNA-548v controls the viscoelastic properties of human cardiomyocytes and improves their relaxation rates
    1
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  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Affinity-tagged SMAD1 and SMAD5 mouse lines reveal transcriptional reprogramming mechanisms during early pregnancy
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  94. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Inhibition of cysteine protease cathepsin Lincreases the level and activity of lysosomal glucocerebrosidase
    1
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  95. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DEAD box RNA helicase 5 is a new pro-viral host factor for Sindbis virus infection
    1
    1. scibot 01 Apr 2024
      Plasmid_62988

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  96. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lipid droplet accumulation in Wdr45-deficient cells caused by impairment of chaperone-mediated autophagic degradation of Fasn
    1
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      plasmid_62

      DOI: 10.1186/s12944-024-02088-y

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  97. Mar 2024
  98. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protection of Chickens against H9N2 Avian Influenza Isolates with a Live Vector Vaccine Expressing Influenza Hemagglutinin Gene Derived from Y280 Avian Influenza Virus
    1
    1. scibot 31 Mar 2024
      pSpCas9(BB)-2A-Puro (PX459) V2.0

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  99. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development of a Highly Efficient CRISPR/Cas9-Mediated Herpesvirus of Turkey-Based Vaccine against Novel Variant Infectious Bursal Disease Virus
    1
    1. scibot 31 Mar 2024
      pSpCas9(BB)-2A-Puro (PX459) V2.0

      DOI: 10.3390/vaccines12030226

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  100. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DPY19L3 promotes vasculogenic mimicry by its C-mannosyltransferase activity
    1
    1. scibot 31 Mar 2024
      pSpCas9n(BB)-2A-Puro (PX459) V2.0

      DOI: 10.32604/or.2023.030304

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  101. www.futuremedicine.com www.futuremedicine.com
    Epigenetic disruption of histone deacetylase-2 accelerated apoptotic signaling and retarded malignancy in gastric cells
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    1. scibot 30 Mar 2024
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    futuremedicine.com/doi/10.2217/epi-2023-0350
  102. www.sciencedirect.com www.sciencedirect.com
    Mitotic chromosomes are self-entangled and disentangle through a topoisomerase-II-dependent two-stage exit from mitosis
    1
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  103. link.springer.com link.springer.com
    CRISPR du-HITI an attractive approach to targeting Long Noncoding RNA HCP5 as inhibitory factor for proliferation of ovarian cancer cell
    1
    1. scibot 26 Mar 2024
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  104. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A novel Nav1.8-FLPo driver mouse for intersectional genetics to uncover the functional significance of primary sensory neuron diversity
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    1. scibot 22 Mar 2024
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  105. www.sciencedirect.com www.sciencedirect.com
    De novo steroidogenesis in tumor cells drives bone metastasis and osteoclastogenesis
    1
    1. scibot 19 Mar 2024
      Addgene, Cat# 62988

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    sciencedirect.com/science/article/pii/S221112472400264X
  106. www.sciencedirect.com www.sciencedirect.com
    Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
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      Addgene; 62988

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  107. www.nature.com www.nature.com
    On the genetic basis of tail-loss evolution in humans and apes
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  108. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A common cellular response to broad splicing perturbations is characterized by metabolic transcript downregulation driven by the Mdm2–p53 axis
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  109. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Rare SNP in the HELB gene interferes with RPA interaction and cellular function of HELB
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    1. scibot 16 Mar 2024
      plasmid_62988

      DOI: 10.1101/2024.02.27.582415

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  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The cell fate regulator DACH1 modulates ferroptosis through affecting P53/SLC25A37 signaling in fibrotic disease
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    1. scibot 07 Mar 2024
      pSpCas9 (BB)-2A-Puro (PX459) V2.0

      DOI: 10.1097/HC9.0000000000000396

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  111. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    RTF2 controls replication repriming and ribonucleotide excision at the replisome
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  112. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses
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    1. scibot 05 Mar 2024
      Addgene# 62988

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  113. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Scalable and Efficient Generation of Mouse Primordial Germ Cell-like Cells
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  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Methotrimeprazine is a neuroprotective antiviral in JEV infection via adaptive ER stress and autophagy
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  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cellular transfection using rapid decrease in hydrostatic pressure
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  116. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Enterovirus A71 does not meet the uncoating receptor SCARB2 at the cell surface
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      DOI: 10.1371/journal.ppat.1012022

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  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Consequences of GMPPB deficiency for neuromuscular development and maintenance
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  118. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Development of pathophysiologically relevant models of sickle cell disease and β-thalassemia for therapeutic studies
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  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FANCJ DNA helicase is recruited to the replisome by AND-1 to ensure genome stability
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  120. Feb 2024
  121. www.sciencedirect.com www.sciencedirect.com
    Identification of a distal enhancer regulating hedgehog interacting protein gene in human lung epithelial cells
    2
    1. scibot 29 Feb 2024
      Addgene, 62,988

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      Addgene, 62,988

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  122. www.biorxiv.org www.biorxiv.org
    Sparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes
    1
    1. scibot 29 Feb 2024
      pSpCas9(BB)-2A-Puro (PX459)

      DOI: 10.1101/2024.02.05.578969

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  123. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The methyltransferase N6AMT1 participates in the cell cycle by regulating cyclin E levels
    1
    1. scibot 29 Feb 2024
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  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The nuclear factor ID3 endows macrophages with a potent anti-tumour activity
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  125. www.sciencedirect.com www.sciencedirect.com
    The Rigor and Transparency Index Quality Metric for Assessing Biological and Medical Science Methods
    2
    1. scibot 28 Feb 2024
      RRID:Addgene_62988

      DOI: 10.1016/j.isci.2020.101698

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  126. 52.53.155.43 52.53.155.43
    HERC3 E3 ligase provides an ERAD branch eliminating select membrane proteins
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  127. 52.53.155.43 52.53.155.43
    can-23-1129-html.html
    1
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      plasmid_62988

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  128. www.biorxiv.org www.biorxiv.org
    New submission 11/02/2024, 13:59:09
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  129. www.pnas.org www.pnas.org
    Intracellular C3 protects β-cells from IL-1β-driven cytotoxicity via interaction with Fyn-related kinase
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  130. www.biorxiv.org www.biorxiv.org
    The Vps13-like protein BLTP2 is pro-survival and regulates phosphatidylethanolamine levels in the plasma membrane to maintain its fluidity and function
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  131. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Overcoming therapeutic resistance in oncolytic herpes virotherapy by targeting IGF2BP3-induced NETosis in malignant glioma
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      plasmid_62988

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  132. www.sciencedirect.com www.sciencedirect.com
    Persistence of backtracking by human RNA polymerase II
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  133. www.sciencedirect.com www.sciencedirect.com
    Generation of human induced pluripotent stem cell line derived from Becker muscular dystrophy patient with CRISPR/Cas9-mediated correction of DMD gene mutation
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  134. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nuclear pore protein POM121 regulates subcellular localization and transcriptional activity of PPARγ
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  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Diabetic sensory neuropathy and insulin resistance are induced by loss of UCHL1 in Drosophila
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  136. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury
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  137. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    All three MutL complexes are required for repeat expansion in a human stem cell model of CAG-repeat expansion mediated glutaminase deficiency
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  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cellular Targets and Lysine Selectivity of the HERC5 ISG15 Ligase
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  139. journals.plos.org journals.plos.org
    Flow cytometry-based quantification of genome editing efficiency in human cell lines using the L1CAM gene
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  140. www.mdpi.com www.mdpi.com
    Biomarker RIPK3 Is Silenced by Hypermethylation in Melanoma and Epigenetic Editing Reestablishes Its Tumor Suppressor Function
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  141. Jan 2024
  142. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    iPSC-derived models of PACS1 syndrome reveal transcriptional and functional deficits in neuron activity
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    1. scibot 30 Jan 2024
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  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Strategies for single base gene editing in an immortalized human cell line by CRISPR/Cas9 technology
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      plasmid_62988

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  144. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Investigation of the functional impact of CHED- and FECD4-associated SLC4A11 mutations in human corneal endothelial cells
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  145. www.sciencedirect.com www.sciencedirect.com
    Intramembrane protease SPP defines a cholesterol-regulated abundance control of the mevalonate pathway enzyme squalene synthase
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  146. www.sciencedirect.com www.sciencedirect.com
    Direct observation of a condensate effect on super-enhancer controlled gene bursting
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    1. scibot 09 Jan 2024
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  147. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope
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  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Leveraging tissue-specific enhancer-target gene regulatory networks identifies enhancer somatic mutations that functionally impact lung cancer
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  149. www.sciencedirect.com www.sciencedirect.com
    N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy
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  150. www.jneurosci.org www.jneurosci.org
    Nascent Aβ42 Fibrillization in Synaptic Endosomes Precedes Plaque Formation in a Mouse Model of Alzheimer's-like β-Amyloidosis
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  151. Dec 2023
  152. onlinelibrary.wiley.com onlinelibrary.wiley.com
    REV7 is involved in outcomes of platinum-based chemotherapy in pancreatic cancer by controlling the DNA damage response
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    1. scibot 29 Dec 2023
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  153. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression
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  154. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Noncoding function of super enhancer derived mRNA in modulating neighboring gene expression and TAD interaction
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  155. www.sciencedirect.com www.sciencedirect.com
    Spatially coordinated heterochromatinization of long synaptic genes in fragile X syndrome
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  156. www.sciencedirect.com www.sciencedirect.com
    Interactome analysis reveals a link of the novel ALMS1-CEP70 complex to centrosomal clusters
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  157. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ZNF524 directly interacts with telomeric DNA and supports telomere integrity
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  158. www.mdpi.com www.mdpi.com
    Heterozygous Knockout of ARID4B Using CRISPR/Cas9 Attenuates Some Aggressive Phenotypes in a Breast Cancer Cell Line
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  159. link.springer.com link.springer.com
    The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells
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  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mitotic bookmarking by SWI/SNF subunits
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  161. www.biorxiv.org www.biorxiv.org
    Heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue
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  162. www.sciencedirect.com www.sciencedirect.com
    Nutrient-regulated control of lysosome function by signaling lipid conversion
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  163. www.science.org www.science.org
    Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1
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      DOI: 10.1126/sciimmunol.adj5097

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  164. www.sciencedirect.com www.sciencedirect.com
    Autophagy is involved in degradation of AQP1 in response to an acute decrement in tonicity
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  165. 52.53.155.43 52.53.155.43
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  166. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Protocol for the saturation and multiplexing of genetic variants using CRISPR-Cas9
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  167. Nov 2023
  168. www.sciencedirect.com www.sciencedirect.com
    Generation of a CRISPR/Cas9-edited Plakoglobin (JUP)knock-out (JMUi001-A-4) iPSC line to model the cardiac phenotype of arrhythmogenic cardiomyopathy
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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of porcine PK-15 cells lacking the Ifnar1 or Stat2 gene to optimize the efficiency of viral isolation
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  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Trapping all ERBB ligands decreases pancreatic lesions in a murine model of pancreatic ductal adenocarcinoma
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  171. www.sciencedirect.com www.sciencedirect.com
    Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells
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    Insulin receptor loss impairs mammary tumorigenesis in mice
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  173. Oct 2023
  174. www.sciencedirect.com www.sciencedirect.com
    β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4
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    1. scibot 28 Oct 2023
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  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of CRISPR/Cas9-Mediated CD73 Knockout in Pancreatic Cancer
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      DOI: 10.3390/cancers15194842

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    ncbi.nlm.nih.gov/pmc/articles/PMC10572021/
  176. www.biorxiv.org www.biorxiv.org
    Spatially and Functionally Distinct mTORC1 Entities Orchestrate the Cellular Response to Amino Acid Availability
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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Interaction between membranous EBP50 and myosin 9 as a favorable prognostic factor in ovarian clear cell carcinoma
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  178. 52.53.155.43 52.53.155.43
    gene-editing-of-yipf3-yipf4-calcoco1-fip200-and-at-cx6nxrde-html.html
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  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Acquisition of Neural Fate by Combination of BMP Blockade and Chromatin Modification
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  180. www.nature.com www.nature.com
    Synthetic circuits based on split Cas9 to detect cellular events
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  181. Sep 2023
  182. www.sciencedirect.com www.sciencedirect.com
    Hyperpolarization-activated cyclic nucleotide-gated cation channel 3 promotes HCC development in a female-biased manner
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  183. www.biorxiv.org www.biorxiv.org
    Mitochondrial protein FKBP8 captures PDZD8 to form mitochondria-ER contacts
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  184. www.nature.com www.nature.com
    Synthetic circuits based on split Cas9 to detect cellular events
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  185. www.sciencedirect.com www.sciencedirect.com
    Usp25-Erlin1/2 activity limits cholesterol flux to restrict virus infection
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  186. dx.doi.org dx.doi.org
    HIRA-mediated loading of histone variant H3.3 controls androgen-induced transcription by regulation of AR/BRD4 complex assembly at enhancers
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  187. link.springer.com link.springer.com
    SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin
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  188. Aug 2023
  189. www.science.org www.science.org
    Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion
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  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion
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  191. www.nature.com www.nature.com
    Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor
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  192. 52.53.155.43 52.53.155.43
    MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC
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  193. www.biorxiv.org www.biorxiv.org
    Erythroid differentiation dependent interaction of VPS13A with XK at the plasma membrane of K562 cells
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  194. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Transposon delivery for CRISPR-based loss-of-function screen in mice identifies NF2 as a cooperating gene involved with the canonical WNT signaling molecular class of hepatocellular carcinoma
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  195. 52.53.155.43 52.53.155.43
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  196. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Using a Dual CRISPR/Cas9 Approach to Gain Insight into the Role of LRP1B in Glioblastoma
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  197. Jul 2023
  198. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Efficient and sensitive profiling of RNA–protein interactions using TLC-CLIP
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  199. www.mdpi.com www.mdpi.com
    Disruption of the Mammalian Ccr4–Not Complex Contributes to Transcription-Mediated Genome Instability
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  200. www.embopress.org www.embopress.org
    An ATG12-ATG5-TECPR1 E3-like complex regulates unconventional LC3 lipidation at damaged lysosomes
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  201. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates
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      DOI: 10.7554/eLife.78695

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  202. Jun 2023
  203. www.embopress.org www.embopress.org
    PARK15/FBXO7 is dispensable for PINK1/Parkin mitophagy in iNeurons and HeLa cell systems
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  204. www.sciencedirect.com www.sciencedirect.com
    Mechanisms of readthrough mitigation reveal principles of GCN1-mediated translational quality control
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    Generation of a human induced pluripotent stem cell line (UQi001-A-1) edited with the CRISPR-Cas9 system to carry the heterozygous TARDBP c.1144G>A (p.A382T) missense mutation
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  206. www.biorxiv.org www.biorxiv.org
    Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in UGGT1 knock-out mammalian cells
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