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Apr 2025
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Loss of function of Atrx recapitulates phenotypes of alternative lengthening of telomeres in a primary mouse model of sarcoma

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1. scibot 24 Apr 2025
  
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  U2OS
  
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sciencedirect.com/science/article/pii/S2589004225006182
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RNF144A-VRK2-G3BP1 axis regulates stress granule assembly

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pmc.ncbi.nlm.nih.gov/articles/PMC11982375/
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DM1 repeat-expanded RNAs confer RNA toxicity as individual nuclear-retained RNAs

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  ATCCHTB-96
  
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sciencedirect.com/science/article/pii/S2211124725003535
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Supra-second tracking and live-cell karyotyping reveal principles of mitotic chromosome dynamics

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nature.com/articles/s41556-025-01637-6
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Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration

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pmc.ncbi.nlm.nih.gov/articles/PMC12416146/
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An Aurora kinase A-BOD1L1-PP2A B56 axis promotes chromosome segregation fidelity

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pmc.ncbi.nlm.nih.gov/articles/PMC11962599/
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Deciphering UBE4B phosphorylation dynamics: a key mechanism in p53 accumulation and cancer cell response to DNA damage

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  DOI: 10.1038/s41420-025-02441-9
  
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nature.com/articles/s41420-025-02441-9
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Genetically encoded reporters of actin filament organization in living cells and tissues

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sciencedirect.com/science/article/pii/S0092867425002764
Mar 2025
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TDP-43 seeding induces cytoplasmic aggregation heterogeneity and nuclear loss of function of TDP-43

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1. scibot 29 Mar 2025
  
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  ATCCCat# HTB-96
  
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sciencedirect.com/science/article/pii/S089662732500176X
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Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms

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1. scibot 28 Mar 2025
  
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A niche driven mechanism determines response and a mutation-independent therapeutic approach for myeloid malignancies

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sciencedirect.com/science/article/pii/S1535610825001084
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Homeodomain protein PRRX1 anchors the Ku heterodimers at DNA double-strand breaks to promote nonhomologous end-joining

1
1. scibot 24 Mar 2025
  
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  RRID:CVCL_0042
  
  DOI: 10.1093/nar/gkaf200
  
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academic.oup.com/nar/article/53/6/gkaf200/8089753
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Distinct roles of SARS-CoV-2 N protein and NFP in host cell response modulation

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1. scibot 20 Mar 2025
  
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  ATCC HTB-96
  
  DOI: 10.1016/j.jmb.2025.169094
  
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sciencedirect.com/science/article/pii/S0022283625001603
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Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers

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1. scibot 20 Mar 2025
  
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  DOI: 10.1002/advs.202410718
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202410718
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The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges

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1. scibot 18 Mar 2025
  
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  RRID:CVCL_0042
  
  DOI: 10.1038/s44319-025-00374-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11894219/
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Protocol for single-cell analysis of DNA double-strand break production and repair in cell-cycle phases by automated high-content microscopy

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1. scibot 06 Mar 2025
  
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  DOI: 10.1016/j.xpro.2025.103662
  
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sciencedirect.com/science/article/pii/S2666166725000681
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FEBS Press

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  DOI: 10.1111/febs.70049
  
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febs.onlinelibrary.wiley.com/doi/10.1111/febs.70049
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Radiotherapy resistance driven by Asparagine endopeptidase through ATR pathway modulation in breast cancer

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1. scibot 01 Mar 2025
  
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  RRID:CVCL_0042
  
  DOI: 10.1186/s13046-025-03334-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11866873/
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Discovery and characterization of a novel telomerase alternative splicing isoform that protects lung cancer cells from chemotherapy induced cell death

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1. scibot 01 Mar 2025
  
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  DOI: 10.1038/s41598-025-90639-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11861669/
Feb 2025
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Salicylate-Elicited Activation of AMP-Activated Protein Kinase Directly Triggers Degradation of C-Myc in Colorectal Cancer Cells

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1. scibot 27 Feb 2025
  
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  RRID:CVCL_0042
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11854256/
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OTUD6B regulates KIFC1-dependent centrosome clustering and breast cancer cell survival

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1. scibot 27 Feb 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11850729/
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Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma

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Compositionally unique mitochondria in filopodia support cellular migration

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Circadian period is compensated for repressor protein turnover rates in single cells

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pmc.ncbi.nlm.nih.gov/articles/PMC11348271/
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E6AP is essential for the proliferation of HPV-positive cancer cells by preventing senescence

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pmc.ncbi.nlm.nih.gov/articles/PMC11805377/
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Activating AMPK improves pathological phenotypes due to mtDNA depletion

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febs.onlinelibrary.wiley.com/doi/10.1111/febs.70006
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Ultrasound-assisted synthesis of new bisphosphonate–betulin conjugates and preliminary evaluation of their cytotoxic activity

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Novel Pannexin 1 isoform is increased in cancer

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  DOI: 10.1101/2024.09.09.612143
  
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52.53.155.43/248e2b0e257da849dadde63c071f77bcede2b26b/2024.09.09.612143v3.full-html.html
Jan 2025
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FEBS Press

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febs.onlinelibrary.wiley.com/doi/10.1111/febs.17375
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Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint

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pmc.ncbi.nlm.nih.gov/articles/PMC11735390/
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Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning

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TRMT1L-catalyzed m22G27 on tyrosine tRNA is required for efficient mRNA translation and cell survival under oxidative stress

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  DOI: 10.1016/j.celrep.2024.115167
  
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Chromatin conformation, gene transcription, and nucleosome remodeling as an emergent system

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  DOI: 10.1126/sciadv.adq6652
  
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science.org/doi/10.1126/sciadv.adq6652
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A high-throughput platform for single-molecule tracking identifies drug interaction and cellular mechanisms

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1. scibot 14 Jan 2025
  
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  DOI: 10.7554/eLife.93183
  
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elifesciences.org/articles/93183
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mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase

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  DOI: 10.1016/j.celrep.2024.115179
  
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C9ORF72 poly-PR induces TDP-43 nuclear condensation via NEAT1 and is modulated by HSP70 activity

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  DOI: 10.1016/j.celrep.2024.115173
  
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sciencedirect.com/science/article/pii/S2211124724015249
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The differential interactomes of the KRAS splice variants identify BIRC6 as a ubiquitin ligase for KRAS4A

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  HTB-96
  
  DOI: 10.7142/igakutoshokan.32.4_454a
  
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cell.com/cell-reports/fulltext/S2211-1247(24)01438-4
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Blocking autophagosome closure manifests the roles of mammalian Atg8-family proteins in phagophore formation and expansion during nutrient starvation

1
1. scibot 04 Jan 2025
  
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  HTB-96
  
  DOI: 10.1080/15548627.2024.2443300
  
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tandfonline.com/doi/full/10.1080/15548627.2024.2443300
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FEBS Press

1
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  RRID:CVCL_0042
  
  DOI: 10.1002/1873-3468.15081
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.15081
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Synthetic anti-RNA antibody derivatives for RNA visualization in mammalian cells

1
1. scibot 03 Jan 2025
  
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  HTB-96
  
  DOI: 10.1093/nar/gkae1275
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkae1275/7935008
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Identification of modulators of the ALT pathway through a native FISH-based optical screen

1
1. scibot 03 Jan 2025
  
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  RRID:CVCL_0042
  
  DOI: 10.1016/j.celrep.2024.115114
  
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sciencedirect.com/science/article/pii/S2211124724014657
Dec 2024
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Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents

1
1. scibot 27 Dec 2024
  
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  CVCL_0042
  
  DOI: 10.1016/j.neo.2024.101092
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11648251/
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G3BP1 promotes intermolecular RNA-RNA interactions during RNA condensation

1
1. scibot 24 Dec 2024
  
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  ATCCHTB-96
  
  DOI: 10.1016/j.molcel.2024.11.012
  
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Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A

1
1. scibot 21 Dec 2024
  
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  ATCCHTB-96
  
  DOI: 10.1016/j.molcel.2024.11.034
  
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Tumor-derived G-CSF induces an immunosuppressive microenvironment in an osteosarcoma model, reducing response to CAR.GD2 T-cells

1
1. scibot 21 Dec 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.1186/s13045-024-01641-7
  
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jhoonline.biomedcentral.com/articles/10.1186/s13045-024-01641-7
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ZBTB48 is a priming factor regulating B-cell-specific CIITA expression

1
1. scibot 21 Dec 2024
  
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  CVCL_0042
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11649694/
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Phosphorylation of Optineurin by protein kinase D regulates Parkin-dependent mitophagy

2
1. scibot 14 Dec 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.1016/j.isci.2024.111384
  
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2. scibot 14 Dec 2024
  
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  CVCL_0042
  
  DOI: 10.1016/j.isci.2024.111384
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11634986/
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PNKP safeguards stalled replication forks from nuclease-dependent degradation during replication stress

1
1. scibot 14 Dec 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.1016/j.celrep.2024.115066
  
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sciencedirect.com/science/article/pii/S2211124724014177
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FEBS Press

1
1. scibot 13 Dec 2024
  
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  RRID: CVCL_0042
  
  DOI: 10.1002/1878-0261.13773
  
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febs.onlinelibrary.wiley.com/doi/10.1002/1878-0261.13773
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Circular RNAs trigger nonsense-mediated mRNA decay

1
1. scibot 12 Dec 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.1016/j.molcel.2024.11.022
  
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Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell Lines

1
1. scibot 11 Dec 2024
  
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  RRID: CVCL_0042
  
  DOI: 10.1158/2767-9764.CRC-24-0316
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11621922/
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Optimized reporters for multiplexed detection of transcription factor activity

1
1. scibot 10 Dec 2024
  
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  ATCCCat#HTB-96, RRID:CVCL_0042
  
  DOI: 10.1016/j.cels.2024.11.003
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11667439/
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Dual BACH1 regulation by complementary SCF-type E3 ligases

1
1. scibot 10 Dec 2024
  
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  ATCCCat# HTB-96
  
  DOI: 10.1016/j.cell.2024.11.006
  
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Reactive oxygen species control protein degradation at the mitochondrial import gate

1
1. scibot 06 Dec 2024
  
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  ATCCCat# HTB-96
  
  DOI: 10.1016/j.molcel.2024.11.004
  
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sciencedirect.com/science/article/pii/S1097276524009092
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DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states

1
1. scibot 05 Dec 2024
  
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  ATCCHTB-96
  
  DOI: 10.1016/j.molcel.2024.11.009
  
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sciencedirect.com/science/article/pii/S1097276524009146
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The absence of telomerase leads to immune response and tumor regression in zebrafish melanoma

1
1. scibot 05 Dec 2024
  
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  RRID:HTB-96
  
  DOI: 10.1016/j.celrep.2024.115035
  
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ChromEMT: visualizing and reconstructing chromatin ultrastructure and 3D organization in situ

1
1. scibot 03 Dec 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.1038/s41596-024-01071-2
  
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nature.com/articles/s41596-024-01071-2
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Nuclear Factor I family members are key transcription factors regulating gene expression

1
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  HTB-96
  
  DOI: 10.1016/j.mcpro.2024.100890
  
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sciencedirect.com/science/article/pii/S1535947624001804
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The ribotoxic stress response drives acute inflammation, cell death, and epidermal thickening in UV-irradiated skin in vivo

1
1. scibot 02 Dec 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.1016/j.molcel.2024.10.044
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11671030/
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Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain

1
1. scibot 02 Dec 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.1016/j.celrep.2024.115016
  
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sciencedirect.com/science/article/pii/S2211124724013676
Nov 2024
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CEP192 localises mitotic Aurora-A activity by priming its interaction with TPX2

1
1. scibot 21 Nov 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.1038/s44318-024-00240-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11574021/
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The molecular chaperone ALYREF promotes R-loop resolution and maintains genome stability

1
1. scibot 14 Nov 2024
  
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  92022711
  
  DOI: 10.1016/j.jbc.2024.107996
  
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4’-Ethynyl-2’-Deoxycytidine (EdC) Preferentially Targets Lymphoma and Leukemia Subtypes by Inducing Replicative Stress

1
1. scibot 07 Nov 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.1158/1535-7163.MCT-23-0487
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11286238/
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Design, performance, processing, and validation of a pooled CRISPR perturbation screen for bacterial toxins

1
1. scibot 07 Nov 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.1038/s41596-024-01075-y
  
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nature.com/articles/s41596-024-01075-y
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Moesin contributes to heat shock gene response through direct binding to the Med15 subunit of the Mediator complex in the nucleus

1
1. scibot 04 Oct 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.1098/rsob.240110
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11444770/
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Pervasive mislocalization of pathogenic coding variants underlying human disorders

1
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  RRID:CVCL_0042
  
  DOI: 10.1016/j.cell.2024.09.003
  
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Sep 2024
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Rapid generation of homozygous fluorescent knock-in human cells using CRISPR–Cas9 genome editing and validation by automated imaging and digital PCR screening

1
1. scibot 28 Sep 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.1038/s41596-024-01043-6
  
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nature.com/articles/s41596-024-01043-6
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Strong activation of p53 by actinomycin D and nutlin-3a overcomes the resistance of cancer cells to the pro-apoptotic activity of the FAS ligand

1
1. scibot 26 Sep 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.1007/s10495-024-02000-0
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11416401/
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A TBK1-independent primordial function of STING in lysosomal biogenesis

1
1. scibot 25 Sep 2024
  
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  Cat#HTB-96
  
  DOI: 10.1016/j.molcel.2024.08.026
  
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sciencedirect.com/science/article/pii/S1097276524007032
elifesciences.org elifesciences.org

A mechanism in Agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndrome

1
1. scibot 25 Sep 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.7554/eLife.49180
  
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elifesciences.org/articles/49180
elifesciences.org elifesciences.org

Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice

1
1. scibot 25 Sep 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.7554/eLife.45303
  
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elifesciences.org/articles/45303
elifesciences.org elifesciences.org

Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria

1
1. scibot 25 Sep 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.7554/eLife.34836
  
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  RRID:CVCL_0042 RRID:CVCL_0045 RRIDCUR:Incorrect
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elifesciences.org/articles/34836
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C9orf72 Poly(PR) Dipeptide Repeats Disturb Biomolecular Phase Separation and Disrupt Nucleolar Function

1
1. scibot 25 Sep 2024
  
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  RRID:CVCL_0042
  
  DOI: 10.1016/j.molcel.2019.03.019
  
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Protocol to study the direct binding of proteins to RNA:DNA hybrids or RNA-DNA chimeras in living cells using cross-linking immunoprecipitation

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A nature-inspired HIF stabilizer derived from a highland-adaptation insertion of plateau pika Epas1 protein

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Conserved cysteine-switches for redox sensing operate in the Cyclin-Dependent Kinase Inhibitor p21(CIP/KIP) Protein Family.

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A compact, versatile drug-induced splicing switch system with minimal background expression

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R-loops and impaired autophagy trigger cGAS-dependent inflammation via micronuclei formation in Senataxin-deficient cells

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Condensate interfacial forces reposition DNA loci and probe chromatin viscoelasticity

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Casein kinase 1α mediates phosphorylation of the Merkel cell polyomavirus large T antigen for β-TrCP destruction complex interaction and subsequent degradation

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Optogenetic control of kinesin-1, -2, -3 and dynein reveals their specific roles in vesicular transport

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The Engineered Drug 3′UTRMYC1-18 Degrades the c-MYC-STAT5A/B-PD-L1 Complex In Vivo to Inhibit Metastatic Triple-Negative Breast Cancer

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Structural requirements for activity of Mind bomb1 in Notch signaling

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RTEL1 helicase counteracts RAD51-mediated homologous recombination and fork reversal to safeguard replicating genomes

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Detection of a Mitochondrial Fragmentation and Integrated Stress Response Using the Cell Painting Assay

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Neotelomeres and telomere-spanning chromosomal arm fusions in cancer genomes revealed by long-read sequencing

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HLTF resolves G4s and promotes G4-induced replication fork slowing to maintain genome stability

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MTF2 facilitates the advancement of osteosarcoma through mediating EZH2/SFRP1/Wnt signaling

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Generation of densely labeled oligonucleotides for the detection of small genomic elements

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Modulating tumor-associated macrophage polarization by anti-maRCO mAb exerts anti-osteosarcoma effects through regulating osteosarcoma cell proliferation, migration and apoptosis

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Piperacetazine directly binds to the PAX3::FOXO1 fusion protein and inhibits its transcriptional activity.

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Posttranslational modification of microtubules by the MATCAP detyrosinase

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Parthenolide Destabilizes Microtubules by Covalently Modifying Tubulin

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Diketopiperazine-Based, Flexible Tadalafil Analogues: Synthesis, Crystal Structures and Biological Activity Profile

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Protocol for Establishing a Multiplex Image-based Autophagy ...

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Identification of the main barriers to Ku accumulation in chromatin

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Click-chemistry-aided quantitation and sequencing of oxidized guanines and apurinic sites uncovers their transcription-linked strand bias in human cells

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Loss of ZNF408 attenuates STING-mediated immune surveillance in breast carcinogenesis

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AXIN2 promotes degradation of AXIN1 through tankyrase in colorectal cancer cells

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Miga-mediated endoplasmic reticulum–mitochondria contact sites regulate neuronal homeostasis

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Characterising replisome disassembly in human cells

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The identification of high-performing antibodies for Sequestosome-1 for use in Western blot, immunoprecipitation and immunofluorescence

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Multivalent GU-rich oligonucleotides sequester TDP-43 in the nucleus by inducing high molecular weight RNP complexes

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A high-throughput approach to identify BRCA1-downregulating compounds to enhance PARP inhibitor sensitivity

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A RAD18–UBC13–PALB2–RNF168 axis mediates replication fork recovery in BRCA1-deficient cancer cells

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  DOI: 10.1093/nar/gkae563
  
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Casein kinase 1α mediates phosphorylation of the Merkel cell polyomavirus large T antigen for β-TrCP destruction complex interaction and subsequent degradation

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CRISPR/Cas9 screening reveals a distinct class of MHC-I binders with precise HLA-peptide recognition

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An intermediate Rb–E2F activity state safeguards proliferation commitment

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The TERT Promoter is Polycomb-Repressed in Neuroblastoma Cells with Long Telomeres

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Fully automated viability and toxicity screening—A reliable all‐in‐one attempt

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Illuminating Dark Chemical Matter Using the Cell Painting Assay

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Small-Molecule Inhibition of CBX4/7 Hypersensitises Homologous Recombination-Impaired Cancer to Radiation by Compromising CtIP-Mediated DNA End Resection

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A comparative analysis of paxillin and Hic-5 proximity interactomes

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Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8

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Doxorubicin induces deglycosylation of cancer cell-intrinsic PD-1 by NGLY1

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Applying 3D correlative structured illumination microscopy and X-ray tomography to characterise herpes simplex virus-1 morphogenesis

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mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway

1
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TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks

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Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism

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Centriolar satellites are sites of translation of centrosomal and ciliary proteins

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Ferroptosis induces membrane blebbing in placental trophoblasts

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  U2OS
  
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Intracellular delivery of oncolytic viruses with engineered Salmonella causes viral replication and cell death

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The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ

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A dynamin superfamily-like pseudoenzyme coordinates with MICOS to promote cristae architecture

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Correcting 4sU induced quantification bias in nucleotide conversion RNA-seq data

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Unprocessed genomic uracil as a source of DNA replication stress in cancer cells

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TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis

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miR-217 regulates normal and tumor cell fate following induction of Endoplasmic Reticulum Stress

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RAD51 restricts DNA over-replication from re-activated origins

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DNA-PK and ATM drive phosphorylation signatures that antagonistically regulate cytokine responses to herpesvirus infection or DNA damage

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The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges

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Time-series reconstruction of the molecular architecture of human centriole assembly

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FEBS Press

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RAD51 separation of function mutation disables replication fork maintenance but preserves DSB repair

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TDP-43 deficiency in Suprachiasmatic Nucleus perturbs rhythmicity of neuroactivity in Prefrontal Cortex

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BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response

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Using an ER-specific optogenetic mechanostimulator to understand the mechanosensitivity of the endoplasmic reticulum

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Temporal dynamics and stoichiometry in human Notch signaling from Notch synaptic complex formation to nuclear entry of the Notch intracellular domain

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FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis

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Stabilization of F-actin by Salmonella effector SipA resembles the structural effects of inorganic phosphate and phalloidin

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Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity

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Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH

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The immediate-early protein 1 of human herpesvirus 6B interacts with NBS1 and inhibits ATM signaling

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RAD51 restricts DNA over-replication from re-activated origins

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RAD51 restricts DNA over-replication from re-activated origins

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HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus

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Genome-scale requirements for dynein-based transport revealed by a high-content arrayed CRISPR screen

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CDK-independent role of D-type cyclins in regulating DNA mismatch repair

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Securin acetylation prevents precocious separase activation and premature sister chromatid separation

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Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses

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A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis

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Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection

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53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication

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Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting

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PAF1c links S-phase progression to immune evasion and MYC function in pancreatic carcinoma

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Deposition of onco-histone H3.3-G34W leads to DNA repair deficiency and activates cGAS/STING-mediated immune responses

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Circadian period is compensated for repressor protein turnover rates in single cells

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Human YKT6 forms priming complex with STX17 and SNAP29 to facilitate autophagosome-lysosome fusion

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PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression

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qTAG: An adaptable CRISPR-based endogenous tagging protocol using optimized repair cassettes.

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Dual roles of CCDC102A in governing centrosome duplication and cohesion

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CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs

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SMARCAL1 is a dual regulator of innate immune signaling and PD-L1 expression that promotes tumor immune evasion

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MCAK Inhibitors Induce Aneuploidy in Triple-Negative Breast Cancer Models

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CCDC85A is regulated by miR-224-3p and augments cancer cell resistance to endoplasmic reticulum stress

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SUMO-activated target traps (SATTs) enable the identification of a comprehensive E3-specific SUMO proteome

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  DOI: 10.1126/sciadv.adh2073
  
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Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres

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p300 is an obligate integrator of combinatorial transcription factor inputs

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  DOI: 10.1016/j.molcel.2023.12.004
  
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GRB2 is a BECN1 interacting protein that regulates autophagy.

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1. scibot 11 Jan 2024
  
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  DOI: 10.1038/s41419-023-06387-7
  
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Identification of TNFRSF21 as an inhibitory factor of osteosarcoma based on a necroptosis-related prognostic gene signature and molecular experiments

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1. scibot 10 Jan 2024
  
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  DOI: 10.1186/s12935-023-03198-w
  
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Dec 2023
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Bi-allelic variants in CEP295 cause Seckel-like syndrome presenting with primary microcephaly, developmental delay, intellectual disability, short stature, craniofacial and digital abnormalities

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  DOI: 10.1016/j.ebiom.2023.104940
  
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Metabolic regulation of homologous recombination repair by MRE11 lactylation

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1. scibot 22 Dec 2023
  
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  ATCCCat# HTB-96
  
  DOI: 10.1016/j.cell.2023.11.022
  
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u-track3D: Measuring, navigating, and validating dense particle trajectories in three dimensions

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  DOI: 10.1016/j.crmeth.2023.100655
  
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Irreversible inhibition of TRF2TRFH recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells

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1. scibot 19 Dec 2023
  
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  ATCCCat# HTB-96
  
  DOI: 10.1016/j.chembiol.2023.11.008
  
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Cell stretching activates an ATM mechano-transduction pathway that remodels cytoskeleton and chromatin

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  DOI: 10.1016/j.celrep.2023.113555
  
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53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication

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  DOI: 10.1016/j.celrep.2023.113412
  
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K6-linked ubiquitylation marks formaldehyde-induced RNA-protein crosslinks for resolution

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  DOI: 10.1016/j.molcel.2023.10.011
  
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The RNA helicase DDX39A binds a conserved structure in chikungunya virus RNA to control infection

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Self-reversal facilitates the resolution of HMCES DNA-protein crosslinks in cells

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An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant

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Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication

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  DOI: 10.1016/j.molcel.2021.03.003
  
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A genome-wide CRISPR screen identifies USP1 as a novel regulator of the mammalian circadian clock

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  DOI: 10.1111/febs.16990
  
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Intermittent subdiffusion of short nuclear actin rods due to interactions with chromatin

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  DOI: 10.1101/2023.11.03.565456
  
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Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12

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  DOI: 10.1126/scisignal.adg0485
  
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Inducing Mitotic Catastrophe as a Therapeutic Approach to Improve Outcomes in Ewing Sarcoma

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  RRID:CVCL_0042
  
  DOI: 10.3390/cancers15204911
  
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Lactate activates the mitochondrial electron transport chain independently of its metabolism

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  DOI: 10.1016/j.molcel.2023.09.034
  
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Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method

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  DOI: 10.1016/j.devcel.2023.09.008
  
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Progesterone receptor membrane component 1 facilitates Ca2+ signal amplification between endosomes and the endoplasmic reticulum

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  DOI: 10.1016/j.jbc.2023.105378
  
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FEBS Press

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  DOI: 10.1002/1878-0261.13536
  
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52.53.155.43/7b3101f3d01462bbcf14399b3becbcb8b341bb38/Molecular Oncology - 2023 - Hsieh - Repositioning VU-0365114 as a novel microtubule-destabilizing agent for treating cancer-html.html

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