1,155 Matching Annotations
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    Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis
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    1. scibot 23 Apr 2024
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    sciencedirect.com/science/article/pii/S0092867424003970
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    Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis
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    ncbi.nlm.nih.gov/pmc/articles/PMC11021183/
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    Burkholderia thailandensis uses a type VI secretion system to lyse protrusions without triggering host cell responses
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    sciencedirect.com/science/article/pii/S1931312824001136
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    mcr-23-0478-html.html
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    Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model
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    sciencedirect.com/science/article/pii/S2211124724004455
  7. Apr 2024
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    Global, site-resolved analysis of ubiquitylation occupancy and turnover rate reveals systems properties
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    sciencedirect.com/science/article/pii/S0092867424003155
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    Phosphorylation-dependent allosteric regulation of Cx43 gap junction inhibitor potency
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    sciencedirect.com/science/article/pii/S0753332224004347
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    Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA mimicry and histone chaperone efficiency
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    ncbi.nlm.nih.gov/pmc/articles/PMC10987829/
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    Novel diarylated tacrine derivatives: Synthesis, characterization, anticancer, antiepileptic, antibacterial, and antifungal activities
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      HeLa

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    onlinelibrary.wiley.com/doi/10.1002/jbt.23706
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    A dual role of the conserved PEX19 helix in safeguarding peroxisomal membrane proteins
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    ncbi.nlm.nih.gov/pmc/articles/PMC10995880/
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    Receptor transfer between immune cells by autoantibody-enhanced, CD32-driven trogocytosis is hijacked by HIV-1 to infect resting CD4 T cells
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    sciencedirect.com/science/article/pii/S2666379124001290
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    SRRM2 phase separation drives assembly of nuclear speckle subcompartments
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    sciencedirect.com/science/article/pii/S2211124724001554
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    Genetics of cystogenesis in base-edited human organoids reveal therapeutic strategies for polycystic kidney disease
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    sciencedirect.com/science/article/pii/S1934590924000869
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    Nrf2 pre-recruitment at Enhancer 2 is a hallmark of H2 O2 -induced epigenetic transcriptional memory in the HMOX1 gene in human umbilical artery endothelial cells
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    onlinelibrary.wiley.com/doi/10.1002/jcp.31243
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    Regulation and tumor-suppressive function of the miR-379/miR-656 (C14MC) cluster in cervical cancer
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    Live-cell biosensors based on the fluorescence lifetime of environment-sensing dyes
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    The Legionella pneumophila effector DenR hijacks the host NRas proto-oncoprotein to downregulate MAPK signaling
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    Using an ER-specific optogenetic mechanostimulator to understand the mechanosensitivity of the endoplasmic reticulum
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    sciencedirect.com/science/article/pii/S1534580724001801
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    Microtubule-associated protein MAP7 promotes tubulin posttranslational modifications and cargo transport to enable osmotic adaptation
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    Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator
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    A Non-Viral DNA Delivery System Consisting of Multifunctional Chimaeric Peptide Fused with Zinc Finger Protein
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  24. Mar 2024
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    Discovery of YAP1/TAZ pathway inhibitors through phenotypic screening with potent anti-tumor activity via blockade of Rho-GTPase signaling
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      Cat#CRM-CCL-2

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    sciencedirect.com/science/article/pii/S2451945624000874
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    Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry
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      Japanese Collection of Research BioresourcesJCRB9004

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    RPGR is a guanine nucleotide exchange factor for the small GTPase RAB37 required for retinal function via autophagy regulation
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    Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion
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    CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans
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    CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans
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    Light-mediated intracellular polymerization
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    Paradoxical imbalance between activated lymphocyte protein synthesis capacity and rapid division rate
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    Improved PIEZO1 agonism through 4‐benzoic acid modification of Yoda1
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    Stem-loop-induced ribosome queuing in the uORF2/ATF4 overlap fine-tunes stress-induced human ATF4 translational control
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    FLEX: genetically encodable enzymatic fluorescence signal amplification using engineered peroxidase
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      10002

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  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Golgi checkpoint: Golgi unlinking during G2 is necessary for spindle formation and cytokinesis
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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation
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      DOI: 10.7554/eLife.87386

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    The immediate-early protein 1 of human herpesvirus 6B interacts with NBS1 and inhibits ATM signaling
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    52.53.155.43/85f3cfb5ea69a502f1e71c384533cb9dacfc2966/collin-et-al-2024-the-immediate-early-protein-1-of-human-herpesvirus-6b-interacts-with-nbs1-and-inhibits-atm-signaling-html.html
  39. www.embopress.org www.embopress.org
    1,10-phenanthroline inhibits sumoylation and reveals that yeast SUMO modifications are highly transient
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    Long non-coding RNA MLLT4 antisense RNA 1 induces autophagy to inhibit tumorigenesis of cervical cancer through modulating the myosin-9/ATG14 axis
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    Ankrd26 is a retinoic acid-responsive plasma membrane-binding and -shaping protein critical for proper cell differentiation
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    A gut-derived hormone regulates cholesterol metabolism
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  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thunder-DDA-PASEF enables high-coverage immunopeptidomics and is boosted by MS2Rescore with MS2PIP timsTOF fragmentation prediction model
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  44. www.sciencedirect.com www.sciencedirect.com
    Housekeeping U1 snRNA facilitates antiviral innate immunity by promoting TRIM25-mediated RIG-I activation
    1
    1. scibot 15 Mar 2024
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  45. www.sciencedirect.com www.sciencedirect.com
    A programmable targeted protein-degradation platform for versatile applications in mammalian cells and mice
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    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
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    HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
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    Acetyl-CoA production by Mediator-bound 2-ketoacid dehydrogenases boosts de novo histone acetylation and is regulated by nitric oxide
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    PABPC1 mediates degradation of C9orf72-FTLD/ALS GGGGCC repeat RNA
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    NEMF-mediated Listerin-independent mitochondrial translational surveillance by E3 ligase Pirh2 and mitochondrial protease ClpXP
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    CDK-independent role of D-type cyclins in regulating DNA mismatch repair
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  52. www.nature.com www.nature.com
    A cellular model provides insights into the pathogenicity of the oncogenic FOXL2 somatic variant p.Cys134Trp
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    Securin acetylation prevents precocious separase activation and premature sister chromatid separation
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    MOF-mediated acetylation of UHRF1 enhances UHRF1 E3 ligase activity to facilitate DNA methylation maintenance
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    Non-canonical isoforms of the mRNA polyadenylation factor WDR33 regulate STING-mediated immune responses
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    Human cortical neurogenesis is altered via glucocorticoid-mediated regulation of ZBTB16 expression
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    Oct4 is a gatekeeper of epithelial identity by regulating cytoskeletal organization in skin keratinocytes
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    HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity
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    SNUPN deficiency causes a recessive muscular dystrophy due to RNA mis-splicing and ECM dysregulation
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  60. Feb 2024
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    A di-acetyl-decorated chromatin signature couples liquid condensation to suppress DNA end synapsis
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    Design, synthesis and biological evaluation of novel podophyllotoxin derivatives as tubulin-targeting anticancer agents
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  63. 52.53.155.43 52.53.155.43
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  65. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    First-in-Human Study with preclinical data of BCL-2/BCL-xL Inhibitor Pelcitoclax in Locally Advanced or Metastatic Solid Tumors
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  67. www.nature.com www.nature.com
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  69. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Integrative modelling and analysis of signalling crosstalk reveal molecular switches coordinating YAP transcriptional activities
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    Shigella induces stress granule formation by ADP-riboxanation of the eIF3 complex
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    p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson–Gilford progeria syndrome
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    Mouse oocytes sequester aggregated proteins in degradative super-organelles
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    Deposition of onco-histone H3.3-G34W leads to DNA repair deficiency and activates cGAS/STING-mediated immune responses
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  74. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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    The sequence of events of enteropathogenic E. coli’s type III secretion system translocon assembly
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    Redistribution of the glycocalyx exposes phagocytic determinants on apoptotic cells
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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Aspartate β-hydroxylase Regulates Expression of Ly6 Genes
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  78. febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com
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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore
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  80. 52.53.155.43 52.53.155.43
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  81. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments
    1
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    Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition
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    The GATOR2 complex maintains lysosomal-autophagic function by inhibiting the protein degradation of MiT/TFEs
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    The antiseizure medication valproate increases hemichannel activity found in brain cells, which could worsen disease outcomes
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    DNA damage-induced allosteric activation of protein phosphatase PP1:NIPP1 through Src kinase-induced circularization of NIPP1
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    Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor
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    Dual roles of CCDC102A in governing centrosome duplication and cohesion
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    HECW1 restrains cervical cancer cell growth by promoting DVL1 ubiquitination and downregulating the activation of Wnt/β-catenin signaling
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    FBXL16 promotes cell growth and drug resistance in lung adenocarcinomas with KRAS mutation by stabilizing IRS1 and upregulating IRS1/AKT signaling
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    Increased Serum Interleukin 10 Levels Are Associated with Increased Disease Activity and Increased Risk of Anti-SS-A/Ro Antibody Positivity in Patients with Systemic Lupus Erythematosus
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    Differential Regulation of the Stimulator of Interferon Genes pathway in Human Papillomavirus positive and negative Head and Neck Cancers
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    AQP3 Promotes the Invasion and Metastasis in Cervical Cancer by Regulating NOX4-derived H2O2 Activation of Syk/PI3K/Akt Signaling Axis
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    Distinct modes of telomere synthesis and extension contribute to Alternative Lengthening of Telomeres
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    Elevated Serum Levels of Soluble Transferrin Receptor Are Associated with an Increased Risk of Cardiovascular, Pulmonary, and Hematological Manifestations and a Decreased Risk of Neuropsychiatric Manifestations in Systemic Lupus Erythematosus Patients
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    KH-like domains in PARP9/DTX3L and PARP14 coordinate protein-protein interactions to promote cancer cell survival
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    Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors
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  114. www.sciencedirect.com www.sciencedirect.com
    Direct assessment of nitrative stress in lipid environments: Applications of a designer lipid-based biosensor for peroxynitrite
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    Profiling nuclear cysteine ligandability and effects on nuclear localization using proximity labeling-coupled chemoproteomics
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    ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7 interaction and inflammasome activation
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    SRSF2 plays an unexpected role as reader of m5C on mRNA, linking epitranscriptomics to cancer
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    The roles of FUS-RNA binding domain and low complexity domain in RNA-dependent phase separation
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  124. www.sciencedirect.com www.sciencedirect.com
    IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors
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    Investigation of the mixed origins of the MGC-803 cell line reveals that it is a hybrid cell line derived from HeLa
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  126. www.sciencedirect.com www.sciencedirect.com
    Cell stretching activates an ATM mechano-transduction pathway that remodels cytoskeleton and chromatin
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  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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  128. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    γδ T cell-mediated cytotoxicity against patient-derived healthy and cancer cervical organoids
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  129. onlinelibrary.wiley.com onlinelibrary.wiley.com
    The impact of cycling hypoxia on the phenotype of HPV-positive cervical cancer cells
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  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Highlights from MBoC Selection: Membrane binding of endocytic myosin-1s is inhibited by a class of ankyrin repeat proteins
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  131. www.sciencedirect.com www.sciencedirect.com
    Exploiting the endogenous yeast nuclear proteome to identify short linear motifs in vivo
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  132. www.biorxiv.org www.biorxiv.org
    Spartin-mediated lipid transfer facilitates lipid droplet turnover
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  133. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Revisiting the role of endogenous STAT3 in HPV-positive cervical cancer cells
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  134. Nov 2023
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    Abundant binary promoter switches in lineage-determining transcription factors indicate a digital component of cell fate determination
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    An atypical GABARAP binding module drives the pro-autophagic potential of the AML-associated NPM1c variant
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    Extensive elimination of acinar cells during normal postnatal pancreas growth
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    SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction
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    Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication
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    Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy
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  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Discovery and biological evaluation of a potent small molecule CRM1 inhibitor for its selective ablation of extranodal NK/T cell lymphoma
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  142. www.nature.com www.nature.com
    SARS-CoV-2 hijacks a cell damage response, which induces transcription of a more efficient Spike S-acyltransferase
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  143. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    In Vivo Screening Unveils Pervasive RNA-Binding Protein Dependencies in Leukemic Stem Cells and Identifies ELAVL1 as a Therapeutic Target
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  144. www.sciencedirect.com www.sciencedirect.com
    Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation
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    Molecular Oncology - 2023 - Pohlers - Th17 cells target the metabolic miR‐142‐5p succinate dehydrogenase subunit C D SDHC-html.html
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  146. www.embopress.org www.embopress.org
    Phosphatase specificity principles uncovered by MRBLE:Dephos and global substrate identification
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  147. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The PMA phorbol ester tumor promoter increases canonical Wnt signaling via macropinocytosis
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  148. Oct 2023
  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity
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  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts
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    Single-nucleus RNA sequencing reveals heterogenous microenvironments and specific drug response between cervical squamous cell carcinoma and adenocarcinoma
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    Human MCTS1-dependent translation of JAK2 is essential for IFN-γ immunity to mycobacteria
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    Lactate activates the mitochondrial electron transport chain independently of its metabolism
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    Highly efficient cellular expression of circular mRNA enables prolonged protein expression
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  155. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit
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    An activity-based functional test for identifying homologous recombination deficiencies across cancer types in real time
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    Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring
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    Comparative genomic analysis of Mycoplasma related to cell culture for infB gene-based loop-mediated isothermal amplification
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  160. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX
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  161. 52.53.155.43 52.53.155.43
    Blocking oligomerization is the most viable strategy to inhibit STING
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  162. www.sciencedirect.com www.sciencedirect.com
    Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy
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  163. www.nature.com www.nature.com
    Revealing invisible cell phenotypes with conditional generative modeling
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  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sequence-directed concentration of G protein-coupled receptors in COPII vesicles
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  165. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Schlafen-5 inhibits LINE-1 retrotransposition
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  166. dx.doi.org dx.doi.org
    Piperacetazine directly binds to the PAX3::FOXO1 fusion protein and inhibits its transcriptional activity.
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  167. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hierarchical Phosphorylation of HOXB13 by mTOR Dictates Its Activity and Oncogenic Function in Prostate Cancer
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  168. 52.53.155.43 52.53.155.43
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  169. www.biorxiv.org www.biorxiv.org
    Regulation of human interferon signaling by transposon exonization
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  170. www.embopress.org www.embopress.org
    Hypoxia activates SREBP2 through Golgi disassembly in bone marrow-derived monocytes for enhanced tumor growth
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  171. Sep 2023
  172. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hydrogen peroxide-dependent oxidation of ERK2 within its D-recruitment site alters its substrate selection
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  173. www.sciencedirect.com www.sciencedirect.com
    ActuAtor, a Listeria-inspired molecular tool for physical manipulation of intracellular organizations through de novo actin polymerization
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    Dysregulation of the Progranulin-driven Autophagy-lysosomal Pathway Mediates Secretion of the Nuclear Protein TDP-43
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  175. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  176. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2023 - Benvenutti-html.html
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  177. www.nature.com www.nature.com
    Defining the condensate landscape of fusion oncoproteins
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  178. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dynamic association of the intramembrane proteases SPPL2a/b and their substrates with tetraspanin-enriched microdomains
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  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ESRRB inhibits the TGF-β signaling pathway to drive cell proliferation in cervical cancer
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  180. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2023 - Yin-html.html
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  181. www.nature.com www.nature.com
    m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency
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  182. www.sciencedirect.com www.sciencedirect.com
    Mammalian autophagosomes form from finger-like phagophores
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  183. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The autophagic protein FYCO1 controls TNFRSF10/TRAIL receptor induced apoptosis and is inactivated by CASP8 (caspase 8)
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  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    TECPR1 conjugates LC3 to damaged endomembranes upon detection of sphingomyelin exposure
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  185. 52.53.155.43 52.53.155.43
    British J Pharmacology - 2023 - Kleszcz-html.html
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  186. www.sciencedirect.com www.sciencedirect.com
    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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  187. Aug 2023
  188. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Sources of Calcium at Connexin 36 Gap Junctions in the Retina
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  189. www.sciencedirect.com www.sciencedirect.com
    MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy
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  190. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cas phosphorylation regulates focal adhesion assembly
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  191. 52.53.155.43 52.53.155.43
    Intl Journal of Cancer - 2023 - Cao-html.html
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  192. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alphaherpesvirus-mediated remodeling of the cellular transcriptome results in depletion of m6A-containing transcripts
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  193. www.sciencedirect.com www.sciencedirect.com
    exo-FISH: Protocol for detecting DNA breaks in repetitive regions of mammalian genomes
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  194. 52.53.155.43 52.53.155.43
    16a7c226-f27d-4a9e-9485-8d25fbca685c_130126_-_kathleen_southern-html.html
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  195. www.sciencedirect.com www.sciencedirect.com
    Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging
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  196. Jul 2023
  197. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy
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  198. www.sciencedirect.com www.sciencedirect.com
    FUBP1 is a general splicing factor facilitating 3′ splice site recognition and splicing of long introns
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    Aurora A polyubiquitinates the BRCA1-interacting protein OLA1 to promote centrosome maturation
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  200. www.sciencedirect.com www.sciencedirect.com
    A spatially defined human Notch receptor interaction network reveals Notch intracellular storage and Ataxin-2-mediated fast recycling
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